Review
Dermatology
Celine Mias, Valerie Mengeaud, Sandrine Bessou-Touya, Helene Duplan
Summary: Acne vulgaris is a common skin disease characterized by inflammation in pilosebaceous units. Recent studies have shown that Cutibacterium acnes plays a crucial role in the pathogenesis of acne, especially through the formation of biofilms, loss of genetic diversity, and activation of the Th17 pathway. This understanding has opened up new possibilities for developing novel treatments and diagnostic biomarkers.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
A. S. Karadag, M. Aslan Kayiran, C-Y Wu, W. Chen, L. C. Parish
Summary: Antibiotic resistance in acne has been a major concern in dermatology since the 1970s, with significant variations in resistance rates and types of antimicrobials globally. While resistance to certain antibiotics remains a problem worldwide, resistance to others has remained low in the past decade.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Brigitte Dreno, Itaru Dekio, Hilary Baldwin, Anne Laure Demessant, Marie-Ange Dagnelie, Amir Khammari, Stephane Corvec
Summary: Acne vulgaris is a chronic inflammatory skin disease caused by altered sebum production, inflammation, excess keratinization, and dysbiosis. Recent studies have shown that Cutibacterium acnes and Staphylococcus epidermidis play important roles in acne development. The use of antibiotics, a common treatment for acne, disrupts the skin microbiota, highlighting the need for alternative management strategies that positively affect the skin microbiome.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jung-Eun Kim, Hengmin Han, Yinzhu Xu, Min-Ho Lee, Hyo-Jeong Lee
Summary: This study evaluated the efficacy of FRO, a formula composed of fermented Rhus verniciflua Stokes and Orostachys japonicus, against acne pathogenesis. The results showed that FRO exhibited antimicrobial and anti-inflammatory effects, inhibiting the growth of Cutibacterium acnes (CA) and reducing inflammation and excess sebum production. Therefore, FRO could be used for functional cosmetics or acne treatments.
Article
Immunology
Tran H. Do, Feiyang Ma, Priscila R. Andrade, Rosane Teles, Bruno J. de Andrade Silva, Chanyue Hu, Alejandro Espinoza, Jer-En Hsu, Chun-Seok Cho, Myungjin Kim, Jingyue Xi, Xianying Xing, Olesya Plazyo, Lam C. Tsoi, Carol Cheng, Jenny Kim, Bryan D. Bryson, Alan M. O'Neill, Marco Colonna, Johann E. Gudjonsson, Eynav Klechevsky, Jun Hee Lee, Richard L. Gallo, Barry R. Bloom, Matteo Pellegrini, Robert L. Modlin
Summary: Acne, a common skin condition affecting 1 in 10 people globally, is characterized by disfiguring facial lesions. This study explored the mechanisms underlying the disease using single-cell and spatial RNA sequencing, as well as ultrahigh-resolution Seq-Scope analysis. The researchers identified TREM2 macrophages expressing lipid metabolism and proinflammatory genes near the hair follicle epithelium, which expressed squalene epoxidase. Through in vitro experiments, it was discovered that squalene induced differentiation of TREM2 macrophages, impairing their ability to kill Cutibacterium acnes. Additionally, the addition of squalene to macrophages inhibited oxidative enzymes and scavenged oxygen free radicals, providing insights into the efficacy of benzoyl peroxide in acne treatment. These findings contribute to our understanding of the role of TREM2 macrophages and unsaturated lipids in the pathogenesis of acne, as well as their similarity to atherosclerosis.
SCIENCE IMMUNOLOGY
(2022)
Article
Dermatology
Edileia Bagatin, Marie Dominique Thouvenin, Adeline Bacquey, Sophie Baradat, Christophe Lauze, Valerie Mengeaud, Juliana L. M. Soares, Leonardo de S. M. Andrade, Helio A. Miot, Marco Alexandre Rocha
Summary: This study evaluated the efficacy and tolerance of a test product containing Myrtus communis extract and azelaic acid compared to a light moisturizing cream in managing adult female acne in the maintenance phase. The results showed that the test product had lower acne relapse rates and was beneficial in maintaining long-term remission of acne.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Flavio De Maio, Federica Lucantoni, Giorgia Cardinali, Martina Pontone, Thierry Bernardi, Maurizio Sanguinetti, Bruno Capitanio, Antonio Cristaudo, Fiorentina Ascenzioni, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study explores the microbiome at different skin sites in adolescent acne and the role of biofilm production in promoting the growth and persistence of Cutibacterium acnes isolates. The findings show that there is lower microbiota diversity in inflammatory lesions compared to non-inflammatory lesions and healthy subjects, and there is an overabundance of C. acnes in inflammatory lesions. Additionally, specific Cutibacterium acnes phylotypes were found to be more represented in the skin of acne patients and were associated with early adhesion, biomass production, and increased antibiotic tolerance.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Mengyuan Shan, Fanqiang Meng, Chao Tang, Libang Zhou, Zhaoxin Lu, Yingjian Lu
Summary: Accumulating evidence suggests that suppressing Propionibacterium acnes-induced inflammation is a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on P. acnes-induced inflammatory acne vulgaris in mice. The results demonstrated that surfactin-oleogel has antibacterial and anti-inflammation activities, making it a potential treatment for P. acnes-induced inflammatory acne vulgaris.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Dermatology
Celine Mias, Nathalie Chansard, Martine Maitre, Marie Florence Galliano, Lucile Garidou, Valerie Mengeaud, Sandrine Bessou-Touya, Helene Duplan
Summary: This study evaluated the pharmacological properties of the plant extracts Myrtus communis and Celastrol enriched plant cell culture (CEE) extracts on the C. acnes/Th17 pathway. The results showed that Myrtacine (R) and CEE can inhibit the virulence of C. acnes IA1 strain and alleviate the inflammatory response, especially the Th17 pathway. These findings suggest that these plant extracts may have beneficial effects in the treatment of acne.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
Tran H. Do, Feiyang Ma, Priscila R. Andrade, Rosane Teles, Bruno J. de Andrade Silva, Chanyue Hu, Alejandro Espinoza, Jer-En Hsu, Chun-Seok Cho, Myungjin Kim, Jingyue Xi, Xianying Xing, Olesya Plazyo, Lam C. Tsoi, Carol Cheng, Jenny Kim, Bryan D. Bryson, Alan M. O'Neill, Marco Colonna, Johann E. Gudjonsson, Eynav Klechevsky, Jun Hee Lee, Richard L. Gallo, Barry R. Bloom, Matteo Pellegrini, Robert L. Modlin
Summary: This study elucidated the role of TREM2 macrophages and unsaturated lipids in the pathogenesis of acne, providing a new theoretical basis for the treatment of acne.
SCIENCE IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Solmaz Asnaashari, Mahsa Kazemnezhad, Farid Masoud, Yousef Javadzadeh
Summary: This article aims to evaluate the effectiveness of herbal oils in preventing and treating acne vulgaris. By studying 32 medicinal herbs, the application and functions of plant oils and aromatherapy in the management of acne vulgaris were summarized. More clinical studies are needed in the future to discover the clinical effects of these oils.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Dermatology
Maria Mayfinna Gozali, Yuli Kurniawati, Mutia Devi, Erial Bahar, Lisa Dewi, Yulia Farida Yahya, Rusmawardiana, Sarah Diba Zulkarnain, Soenarto Kartowigno
Summary: This study demonstrates a correlation between antimicrobial resistance patterns of Propionibacterium acnes to doxycycline, clindamycin, erythromycin, azithromycin and the severity of acne vulgaris. The resistance patterns of clindamycin and doxycycline show a moderate correlation with the severity of acne. Erythromycin and azithromycin resistance patterns exhibit a weak correlation with acne severity.
INDIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Amit Rimon, Chani Rakov, Vanda Lerer, Sivan Sheffer-Levi, Sivan Alkalay Oren, Tehila Shlomov, Lihi Shasha, Ruth Lubin, Khaled Zubeidat, Nora Jaber, Musa Mujahed, Asaf Wilensky, Shunit Coppenhagen-Glazer, Vered Molho-Pessach, Ronen Hazan
Summary: Acne vulgaris is a common inflammatory skin disorder caused by Cutibacterium acnes (C. acnes), which can be effectively treated with phage therapy. In this study, eight novel phages isolated in the laboratory and commonly used antibiotics were able to completely eradicate clinically isolated C. acnes strains. Topical phage therapy also demonstrated superior efficacy in a mouse model of C. acnes-induced acne-like lesions, reducing inflammation and improving clinical and histological scores.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Madisen A. Swallow, Ryan Fan, Jeffrey M. Cohen, Christopher G. Bunick
Summary: Almost 1 billion people worldwide have acne, and oral tetracyclines are commonly prescribed for treatment. However, concerns about antibiotic resistance and side effects have arisen. Sarecycline, a narrow-spectrum tetracycline approved in 2018, shows promise in reducing resistance risk by targeting the pathogenic bacterium in acne vulgaris.
Article
Dermatology
Peerada Sermswan, Rakwaree Sriharat, Supichcha Saithong, Matchima Laowansiri, Nutchaya Amornruk, Direkrit Chiewchengchol, Nopadon Noppakun, Pravit Asawanonda, Tanittha Chatsuwan, Chanat Kumtornrut
Summary: This study investigated the role of antibiotic-resistant Cutibacterium acnes (C. acnes) in the pathogenesis of acne vulgaris (AV). The findings showed that regardless of acne severity, the prevalence of antibiotic-resistant C. acnes was high. Additionally, it was observed that high-level resistant C. acnes was associated with higher clinical severity of acne in patients taking doxycycline.
JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Marija Petrovic, Suzana Popovic, Dejan Baskic, Milos Todorovic, Predrag Djurdjevic, Aleksandra Ristic-Fira, Otilija Keta, Vladana Petkovic, Lela Koricanac, Danijela Stojkovic, Verica Jevtic, Srecko Trifunovic, Danijela Todorovic
ANTICANCER RESEARCH
(2020)
Article
Infectious Diseases
Gervonne Barran, Jolanta Kolodziejek, Laurent Coquet, Jerome Leprince, Thierry Jouenne, Norbert Nowotny, J. Michael Conlon, Milena Mechkarska
Article
Environmental Sciences
Ana Popovic, Milena Deljanin, Suzana Popovic, Danijela Todorovic, Predrag Djurdjevic, Sanja Matic, Milan Stankovic, Dusko Avramovic, Dejan Baskic
Summary: The study showed that ethanolic extract of Chelidonium majus was able to activate subpopulations of peripheral blood mononuclear cells (PBMNCs), enhance cytotoxic activity, and promote proliferation of immune cells.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Galyna Graham, J. Michael Conlon, R. Charlotte Moffett, Yasser H. Abdel-Wahab, Peter R. Flatt
Summary: The study showed that long-acting, dual-agonist anti-diabetic peptides can induce alpha-cell to beta-cell transdifferentiation, leading to increased pancreatic insulin content and plasma insulin concentrations. This suggests therapeutic potential for using proglucagon-derived peptides from phylogenetical ancient fish in diabetes treatment.
JOURNAL OF PEPTIDE SCIENCE
(2021)
Article
Plant Sciences
Tijana Micovic, Dijana Topalovic, Lada Zivkovic, Biljana Spremo-Potparevic, Vladimir Jakovljevic, Sanja Matic, Suzana Popovic, Dejan Baskic, Danijela Stesevic, Stevan Samardzic, Danilo Stojanovic, Zoran Maksimovic
Summary: This study aimed to assess the antioxidant, genotoxic, antigenotoxic, and cytotoxic properties of hyssop essential oils and methanol extracts, revealing notable medicinal potential of Hyssopus officinalis that calls for further investigation.
Article
Chemistry, Medicinal
Nenad Joksimovic, Jelena Petronijevic, Emilija Milovic, Nenad Jankovic, Dejan Baskic, Suzana Popovic, Danijela Todorovic, Sanja Matic, Milan Vranes, Aleksandar Tot
Summary: The study found that a series of novel 3-hydroxy-3-pyrrolin-2-one compounds exhibit high cytotoxicity on SW480 cancer cells with good selectivity towards MRC-5 cells, indicating their potential as anticancer drugs.
MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
J. Michael Conlon, Finbarr P. M. O'Harte, Peter R. Flatt
Summary: Peptides derived from ancient fish, such as lamprey GLP-1 and paddlefish glucagon, act as naturally occurring dual agonists at GLP1R and GCPR receptors, showing potential in improving glucose tolerance, insulin sensitivity, and beta-cell proliferation. Studies suggest that these fish-derived peptides have therapeutic potential for obesity-related T2DM.
Article
Plant Sciences
Aleksandar Kocovic, Jovana Jeremic, Jovana Bradic, Miroslav Sovrlic, Jovica Tomovic, Perica Vasiljevic, Marijana Andjic, Nevena Draginic, Mirjana Grujovic, Katarina Mladenovic, Dejan Baskic, Suzana Popovic, Sanja Matic, Vladimir Zivkovic, Nevena Jeremic, Vladimir Jakovljevic, Nedeljko Manojlovic
Summary: The aim of this study was to identify the secondary metabolites in extracts of Xanthoparmelia stenophylla lichen and evaluate their antioxidant, antimicrobial, and cytotoxic activity. The study found that acetone extract had the highest phenolic and flavonoid content, as well as the best antioxidant activity. Hexanic extract showed the best antimicrobial activity, particularly against certain strains. Additionally, the acetonic extract exhibited strong cytotoxic effects.
Article
Chemistry, Inorganic & Nuclear
Milica Mededovic, Ana Rilak Simovic, Dusan Cocic, Laura Senft, Sanja Matic, Danijela Todorovic, Suzana Popovic, Dejan Baskic, Biljana Petrovic
Summary: This paper presents the synthesis and structural characterization of a series of new ruthenium(II) complexes. The results showed that the ligand substitution reactions of the complexes were affected by different substituents and the aromaticity of the ligands. The complexes exhibited potential interactions with DNA and human serum albumin, and exerted selective cytotoxic activity against various cancer cell lines.
DALTON TRANSACTIONS
(2023)
Article
Virology
Sanja Matic, Dragan Milovanovic, Zeljko Mijailovic, Predrag Djurdjevic, Predrag Sazdanovic, Srdjan Stefanovic, Danijela Todorovic, Suzana Popovic, Katarina Vitosevic, Vladimir Vukicevic, Milena Vukic, Nenad Vukovic, Nevena Milivojevic, Marko Zivanovic, Vladimir Jakovljevic, Nenad Filipovic, Dejan Baskic, Natasa Djordjevic
Summary: This study investigated the association of IFNL3 and IFNL4 polymorphisms with COVID-19 mortality, and found that increased CCI, N/L, and LDH level were associated with a lethal outcome. Additionally, females and patients with at least one variant allele of IFNL3 rs8099917 were almost 36 times more likely to survive SARS-CoV-2 infection, while the presence of at least one ancestral allele of IFNL4 rs368234815 decreased the likelihood of mortality from COVID-19 by more than 15-fold.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
J. Michael Conlon, Lauren Hunter, Samir Attoub, Bruno Casciaro, Milena Mechkarska, Yasser H. A. Abdel-Wahab
Summary: Ocellatin-3N is a peptide that inhibits the growth of various bacteria and pathogens, and has potential therapeutic effects. It also regulates insulin release and intracellular calcium ion concentration.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Chemistry, Applied
Kristina Mihajlovic, Nenad Joksimovic, Jelena Petronijevic, Ignjat Filipovic, Nenad Jankovic, Emilija Milovic, Suzana Popovic, Sanja Matic, Dejan Baskic
Summary: This study tested a series of beta-diketonate compounds for their cytotoxicity and selectivity against tumor cells and normal cells, and investigated their interactions with biomacromolecules. The results showed that these compounds have great potential for application.
NATURAL PRODUCT RESEARCH
(2023)
Article
Infectious Diseases
J. Michael Conlon, Laure Guilhaudis, Samir Attoub, Laurent Coquet, Jerome Leprince, Thierry Jouenne, Milena Mechkarska
Summary: Peptidomic analysis of skin secretions from Boana boans frogs led to the isolation and structural characterization of five host-defense peptides with limited structural similarity to figainin 2 and picturin peptides. These peptides showed antimicrobial activity and cytotoxicity against human tumor-derived cells.
Article
Infectious Diseases
Milena Mechkarska, Taylor S. Cunning, Megan G. Taggart, Nigel G. Ternan, Jerome Leprince, Laurent Coquet, Thierry Jouenne, Jordi Tena-Garces, Juan J. Calvete, J. Michael Conlon
Summary: The venom of the Trinidad thick-tailed scorpion contains peptides with antimicrobial activity and potassium channel and sodium channel toxins. Among the peptides, TtAP-1 exhibits strong bactericidal activity against various bacteria and can rapidly kill clinically relevant bacteria. However, its high hemolytic activity limits its potential as an anti-infective agent.
Review
Biochemistry & Molecular Biology
Nasrin Abbasi Gharibkandi, J. Michael Conlon, Seyed Jalal Hosseinimehr
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.