Article
Cell Biology
Tsung-Chih Tsai, Yi-Syuan Fang, Yu-Chieh Hung, Ling-Chien Hung, Kuei-Sen Hsu
Summary: This study reveals the crucial role of oxytocin receptor signaling in the dorsal hippocampus CA2 region in governing the persistence of long-term social recognition memory (SRM). By investigating the neural circuitry involved, the researchers identify the connection from dorsal CA2 to ventral CA1 as necessary for the formation of long-term SRM.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Haiyan Zheng, Ji Yeon Lim, Yerin Kim, Sang Taek Jung, Sun Wook Hwang
Summary: Oxytocin and vasopressin, neurohypophyseal hormones, play a central role in regulating bodily homeostasis and are strongly involved in downregulating pain. By modulating nociceptors, the first component of the pain signaling pathway, these peptides contribute to pain attenuation, sparking scientific interest in their physiological processes.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Yu-Jie Li, Wei-Jia Du, Rui Liu, Gui-Ying Zan, Bing-Lu Ye, Qian Li, Zhi-Hao Sheng, Ya-Wei Yuan, Yu-Jie Song, Jing-Gen Liu, Zhi-Qiang Liu
Summary: Anxiety-like behaviors induced by inflammatory pain may be associated with oxytocinergic projections from the paraventricular nucleus (PVN) to the central nucleus of the amygdala (CeA). Activation of PVN oxytocin neurons can prevent pain-related anxiety-like behaviors, while inhibition of PVN oxytocin neurons can induce anxiety-like behaviors. Oxytocin exerts its anti-anxiety effects through its projection to the CeA.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Faezeh Tashakori-Sabzevar, Nico Vautrelle, Yiwen Zheng, Paul F. Smith
Summary: This study investigates the effects of electrical stimulation of the peripheral vestibular system on electrophysiological responses in the tail of the rat striatum. Clear triphasic local field potentials (LFPs) were evoked in the bilateral tail of the striatum, with the LFP amplitude increasing with increasing current amplitude. The results suggest a connection between the vestibular system and the tail of the striatum, possibly through the vestibular nucleus or cerebellum and the parafasicular nucleus of the thalamus.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Lixuan Li, Pupu Li, Jing Guo, Yifei Wu, Qian Zeng, Nan Li, Xiaoting Huang, Yongshen He, Wen Ai, Wuping Sun, Tao Liu, Donglin Xiong, Lizu Xiao, Yanyan Sun, Qiming Zhou, Haixia Kuang, Zilong Wang, Changyu Jiang
Summary: This study found that the expression of oxytocin receptors (OXTR) is upregulated in chemotherapy-induced neuropathic pain (CINP), and activation of OXTR can alleviate CINP symptoms by inhibiting neural excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan, H. Bergman
Summary: This study reveals a strong coupling between beta oscillation frequency and dopamine tone in both monkeys and humans, indicating that beta frequency, rather than power, coherence, phase-locking, or PAC, is likely the key property of pathological oscillations in cortical and basal ganglia networks.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Guadalupe Martinez-Lorenzana, Lourdes Palma-Tirado, Carmen Cifuentes-Diaz, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Oxytocin and its receptor play a role in analgesia at the spinal dorsal horn, possibly through a presynaptic mechanism or mediated by GABA interneurons. Additionally, the expression of oxytocin receptor in glial tissue at the spinal dorsal horn requires further investigation in nociception assays.
Article
Biochemistry & Molecular Biology
Connor M. Aitken, Janine C. M. Jaramillo, Warren Davis, Liam Brennan-Xie, Stuart J. Mcdougall, Andrew J. Lawrence, Philip J. Ryan
Summary: Chemogenetic activation of oxytocin receptor-expressing neurons in the parabrachial nucleus acts as a satiation signal for water intake. This research investigates the effect of activating these neurons on satiation for different types of fluids. The results show that activation of these neurons predominantly controls initial fluid-satiation responses after rehydration, but not longer-term intake of highly caloric, palatable solutions.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
Article
Biochemistry & Molecular Biology
Nihal Akcay, Figen Bakirtas Palabiyik, Esra Sevketoglu
Summary: This article discusses the neurological complications of COVID-19 in a 3-year-old patient, who showed bilateral lentiform and caudate nuclei involvement on brain imaging with pathological signal enhancement and edema, which is the first reported case of such association.
BIOMEDICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Junki Imaizumi, Shuhei Kamada, Miyu Taniguchi, Tatsuro Sugimoto, Takaaki Maeda, Ryosuke Arakaki, Shota Yamamoto, Aya Shirakawa, Ayuka Mineda, Atsuko Yoshida, Takeshi Iwasa, Takashi Kaji
Summary: Changes in oxytocin levels and oxytocin receptor mRNA expression were observed in rats with intrauterine undernutrition. These changes could potentially affect nutritional and metabolic regulation systems and contribute to the mechanisms underlying DOHaD.
Article
Biochemistry & Molecular Biology
Peter Bator Kemenesi-Gedei, Krisztina Anna Csabafi, Gyongyi Kis
Summary: This study found that the gene expression of the oxytocin receptor is related to orofacial pain caused by inflammation. Inflammation can activate peptidergic neurons, and it is suggested that oxytocin modulates inflammation-induced nociception by enhancing its expression in sensory ganglion cells.
Article
Biochemistry & Molecular Biology
Mehwish Abbasi, Rachael A. Augustine, Karl J. Iremonger, Colin H. Brown
Summary: Oxytocin neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus secrete oxytocin to induce uterine contractions during parturition. The activation of oxytocin neurons at parturition involves a network of afferent inputs. Kisspeptin, which increases during pregnancy, only excites oxytocin neurons in late pregnancy. However, the excitation of oxytocin neurons by kisspeptin does not appear to involve the ERK1/2-p38 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hidehisa Saito, Shizu Hidema, Ayano Otsuka, Jun Suzuki, Michio Kumagai, Akihiro Kanaya, Toru Murakami, Yusuke Takei, Kazutomo Saito, Shigekazu Sugino, Hiroaki Toyama, Ryuta Saito, Teiji Tominaga, Katsuhiko Nishimori, Masanori Yamauchi
Summary: The study found that oxytocin exerts its analgesic effect on painful stimulation at the supraspinal level through its action on the PAG region, and has a self-protective effect on unpleasant stimulation through the MeA and NAc regions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Masashi Kameda, Koichiro Niikawa, Akiko Uematsu, Masaki Tanaka
Summary: Both the cerebellum and basal ganglia play important roles in rhythm processing, but their specific functions are still unclear. Neurons in both areas exhibit periodic activity during rhythm perception, with the cerebellum involved in multiple stages from sensory prediction to motor control, and the basal ganglia consistently involved in motor preparation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.
