期刊
PEPTIDES
卷 32, 期 10, 页码 2127-2130出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.08.016
关键词
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资金
- Japan Society for the Promotion of Science [22603015]
- AIST
- Grants-in-Aid for Scientific Research [22603015] Funding Source: KAKEN
Direct tissue matrix-assisted laser desorption ionization with time-of-flight mass spectrometry analysis provides a selective detection of mass profile for the peptides contained into cell secretory granules. By this mass spectrometry with slice of pituitary, two novel molecular forms of pro-opimelanocrtin related hormone were found in the orange-red strain medaka (Oryzias latipes var.). The structures of [N,O-diacetyl Serine(1), O-acetyl Serine(3)]-alpha-melanocyte-stimulating hormone (MSH) and [hydroxyproline(15)]-beta-MSH, together with [phosphoserine(15)]-corticotropin-like intermediate lobe peptide, were determined for the first time using a collision-induced dissociation with electrospray ionization mass spectrometry. A combination of mass spectrometry analyses is thus a powerful tool to lead to the elucidation of the post-translational processing from the pre-prohormone. (C) 2011 Elsevier Inc. All rights reserved.
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