Review
Neurosciences
Cristina Concetti, Denis Burdakov
Summary: The lateral hypothalamus plays a role in sleep-wake control by producing orexin/hypocretin and melanin-concentrating hormone neuropeptides. These neuropeptides can rapidly change their firing in response to external stimuli in awake animals. Optogenetic and chemogenetic manipulations suggest that rapid lateral hypothalamic dynamics shape cognitive and motor processes in the awake brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Xiaoman He, Yuhang Li, Nana Zhang, Jinfang Huang, Xing Ming, Ruixiao Guo, Yang Hu, Pengfei Ji, Feifei Guo
Summary: The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamic area (LHA) project to the basolateral amygdala (BLA) and play a role in regulating anxiety-like behavior in mice. Chronic acute combining stress (CACS) leads to anxiety-like behavior and intestinal dysfunction, which can be improved by blocking MCH receptor 1 (MCHR1) and regulating intestinal permeability and inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Ivan C. Alcantara, Ana Pamela Miranda Tapia, Yeka Aponte, Michael J. Krashes
Summary: This Review discusses the advances in neuroscience that have identified brain regions and neural circuits involved in regulating appetite during different phases of eating, including food procurement, food consumption, and meal termination. Studies have found that not only hypothalamic nuclei, but also other brain regions and circuits beyond the hypothalamus, such as the mesolimbic pathway and nodes in the hindbrain, play a role in modulating appetite. Long-term exposure to a calorically dense diet can also alter feeding circuits and the response of motivational systems to food.
Article
Neurosciences
Wedad Alhassen, Yuki Kobayashi, Jessica Su, Brianna Robbins, Henry Nguyen, Thant Myint, Micah Yu, Surya M. Nauli, Yumiko Saito, Amal Alachkar
Summary: The MCH system plays a crucial role in regulating the length of brain neuronal primary cilia, with activation causing cilia shortening and inactivation leading to cilia lengthening. This suggests that MCHR1 at primary cilia could be a potential therapeutic target for conditions associated with impaired primary cilia function.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biology
Peter R. Strege, Luke M. Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A. Ahern, Lorin S. Milescu, Gianrico Farrugia, Arthur Beyder
Summary: Shear stress and patch suction can reversibly alter the kinetic properties and maximum current of NaChBac, suggesting it is mechanosensitive. Structural analysis reveals a large displacement of the intracellular gate, supporting the proposed mechanosensitive mechanism.
Review
Neurosciences
Lukas T. Oesch, Antoine R. Adamantidis
Summary: This review focuses on the electrical activity of feeding-promoting cells in the lateral hypothalamus across different states of vigilance, with a specific emphasis on REM sleep and its role in brain plasticity related to energy homeostasis and behavioral optimization.
TRENDS IN NEUROSCIENCES
(2021)
Article
Biology
Simon Hess, Helmut Wratil, Peter Kloppenburg
Summary: Intracellular signaling pathways have both direct and indirect effects on neuronal activity. The use of perforated-patch clamp recordings can minimize disturbance to these pathways and accurately measure the electrophysiological properties of neurons. This study presents a superstition-free protocol for routine current and voltage measurements using perforated-patch clamp recordings.
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Article
Neurosciences
Shuntaro Izawa, Takeshi Yoneshiro, Kunio Kondoh, Shohei Nakagiri, Yuko Okamatsu-Ogura, Akira Terao, Yasuhiko Minokoshi, Akihiro Yamanaka, Kazuhiro Kimura
Summary: Research indicates that mice with ablated MCH neurons have reduced body weight, increased BAT activity, and higher energy expenditure, suggesting that MCH neurons negatively modulate energy expenditure through modulating BAT activity. The study also suggests that MCH neurons may suppress BAT activity by providing inhibitory input to MRN neurons.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Victoria Linehan, Michiru Hirasawa
Summary: Orexin and MCH neurons display different activation patterns during fasting, with orexin neurons primarily functioning in the later stage of fasting to promote arousal and foraging behaviors, while MCH neurons are preferentially activated in the early stage of fasting to protect against weight loss. This alternating activation of these neuron groups may optimize energy balance during ongoing fasting.
Article
Neurosciences
Olga A. Sergeeva, Karolina Mazur, David Reiner-Link, Kiril Lutsenko, Helmut L. Haas, Mercedes Alfonso-Prieto, Holger Stark
Summary: Researchers have found that Nα-oleoylhistamine (OLHA) can modulate the activity of histaminergic (HA) neurons in mice. OLHA has different effects on HA neuron firing depending on its concentration. The excitatory and rise in intracellular calcium caused by OLHA are influenced by specific receptors and inhibitors, possibly related to fatty acid metabolism and the PKA pathway. PPAR-alpha and H3 receptors play important roles in this process.
Article
Biochemistry & Molecular Biology
Yuki Kobayashi, Tomoya Okada, Daisuke Miki, Yuko Sekino, Noriko Koganezawa, Tomoaki Shirao, Giovanne B. Diniz, Yumiko Saito
Summary: The primary cilium is a sensitive signaling hub in cells, capable of changing length to ensure efficient signaling capacity. In hippocampal neurons, MCH triggers cilia length reduction via MCHR1-mediated Gi/o and Akt signaling pathways.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Karl Josef Foehr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Summary: Aripiprazole has been identified as a potent blocker of the dominant voltage-gated sodium channel of heart muscle. Its interactions with the channel differ depending on the state, with weaker affinity for the resting state and stronger affinity for the inactivated state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Meng Wang, Yue Zhai, Xiaowei Lei, Jing Xu, Bopei Jiang, Zhe Kuang, Cong Zhang, Shangyun Liu, Shan Bian, Xiao-Mei Yang, Tao Zan, Li-Na Jin, Qingfeng Li, Chao Zhang
Summary: This study investigated the interaction between MRAP2 and MCHR1, and found that MRAP2 could inhibit the signaling of MCHR1. Functional truncation experiments revealed the importance of the C-terminal domains of MRAP2 in pharmacological modulation. These findings elucidated the broad regulatory profile of MRAP2 in the central nervous system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Sotelo, Jean Tyan, Chelsea Markunas, Bibi A. Sulaman, Lorraine Horwitz, Hankyu Lee, Joshua G. Morrow, Gideon Rothschild, Bo Duan, Ada Eban-Rothschild
Summary: The transition from wakefulness to sleep involves specific behaviors, such as nest-building and grooming, which are associated with stereotypic electroencephalogram (EEG) patterns. The ability to build a nest promotes sleep initiation and consolidation, while the lack of nesting material disrupts sleep. Neuronal ensembles in the lateral hypothalamus regulate the motivation to engage in nest-building behavior and control sleep initiation and intensity.
Article
Immunology
Hadi Zarif, Sarah Nicolas, Melanie Guyot, Salma Hosseiny, Anne Lazzari, Maria Magdalena Canali, Julie Cazareth, Frederic Brau, Valentine Golzne, Elisa Dourneau, Maud Maillaut, Carmelo Luci, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Douglas Daoudlarian, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Review
Medicine, Research & Experimental
Sarah Nicolas, Joelle Chabry, Alice Guyon, Hadi Zarif, Catherine Heurteaux, Agnes Petit-Paitel
M S-MEDECINE SCIENCES
(2018)
Article
Anatomy & Morphology
Giovanne B. Diniz, Paulo L. Candido, Marianne O. Klein, Renato D. Alvisi, Francoise Presse, Jean-Louis Nahon, Luciano F. Felicio, Jackson C. Bittencourt
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Endocrinology & Metabolism
Hadi Zarif, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
NEUROIMMUNOMODULATION
(2019)
Article
Biotechnology & Applied Microbiology
Melanie Guyot, Thomas Simon, Franck Ceppo, Clara Panzolini, Alice Guyon, Julien Lavergne, Emilie Murris, Douglas Daoudlarian, Romain Brusini, Hadi Zarif, Sophie Abelanet, Sandrine Hugues-Ascery, Jean-Louis Divoux, Stephen J. Lewis, Arun Sridhar, Nicolas Glaichenhaus, Philippe Blancou
NATURE BIOTECHNOLOGY
(2019)
Article
Cell Biology
Danae Nuzzaci, Celine Cansell, Fabienne Lienard, Emmanuelle Nedelec, Selma Ben Fradj, Julien Castel, Ewout Foppen, Raphael Denis, Dominique Grouselle, Amelie Laderriere, Aleth Lemoine, Alexia Mathou, Virginie Tolle, Tony Heurtaux, Xavier Fioramonti, Etienne Audinat, Luc Penicaud, Jean-Louis Nahon, Carole Rovere, Alexandre Benani
Article
Neurosciences
Celine Cansell, Katharina Stobbe, Clara Sanchez, Ophelia Le Thuc, Coralie-Anne Mosser, Selma Ben-Fradj, Joris Leredde, Cynthia Lebeaupin, Delphine Debayle, Lucile Fleuriot, Frederic Brau, Nadege Devaux, Alexandre Benani, Etienne Audinat, Nicolas Blondeau, Jean-Louis Nahon, Carole Rovere
Summary: Obesity in humans is associated with brain inflammation, glial reactivity, and immune cell infiltration. Studies in rodents have shown that glial reactivity occurs shortly after consuming a high-fat diet, even before obesity develops, primarily in the hypothalamus. This postprandial inflammation in the brain may contribute to the development of obesity and requires further characterization.
Article
Neurosciences
Giovanne B. Diniz, Daniella S. Battagello, Marianne O. Klein, Bianca S. M. Bono, Jozelia G. P. Ferreira, Livia C. Motta-Teixeira, Jessica C. G. Duarte, Francoise Presse, Jean-Louis Nahon, Antoine Adamantidis, Melissa J. Chee, Luciane V. Sita, Jackson C. Bittencourt
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Guillaume Daziano, Nicolas Blondeau, Sophie Beraud-Dufour, Amar Abderrahmani, Carole Rovere, Catherine Heurteaux, Jean Mazella, Patricia Lebrun, Thierry Coppola
Summary: The study demonstrates that PE and its derivatives can protect beta-cells against death induced by inflammation by inducing a rise of intracellular calcium concentration. In addition, Mini-Spadin promotes beta-cell proliferation, suggesting a possible regenerative effect. The findings highlight the potential roles of PE and its derivatives as pharmacological tools against diabetes.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Philibert Duriez, Ida A. K. Nilsson, Ophelia Le Thuc, David Alexandre, Nicolas Chartrel, Carole Rovere, Christophe Chauveau, Philip Gorwood, Virginie Tolle, Odile Viltart
Summary: Anorexia nervosa is a severe eating disorder that may result in relapses even after treatment; research indicates that weight gain has an impact on the symptoms of patients with acute AN and partial recovery, with physical activity playing a key role in the recovery process.
Article
Social Sciences, Interdisciplinary
Alice Guyon, Jerome Ravenet, Nancy Midol
Summary: The practices of Indian or Chinese energy arts face both taxonomic and axiological challenges, but contribute to bridging the gap between Western and Eastern scientific cultures and promoting sustainable sports through reconciling different paradigms.
STAPS-SCIENCES ET TECHNIQUES DES ACTIVITES PHYSIQUES ET SPORTIVES
(2021)
Article
Biochemistry & Molecular Biology
Selma Ben Fradj, Emmanuelle Nedelec, Juliette Salvi, Melanie Fouesnard, Marine Huillet, Gaetan Pallot, Celine Cansell, Clara Sanchez, Catherine Philippe, Vincent Gigot, Aleth Lemoine, Doriane Trompier, Thomas Henry, Virginie Petrilli, Benedicte F. Py, Herve Guillou, Nicolas Loiseau, Sandrine Ellero-Simatos, Jean-Louis Nahon, Carole Rovere, Jacques Grober, Gaelle Boudry, Veronique Douard, Alexandre Benani
Summary: The gut microbiota plays a role in regulating food intake at the time scale of a meal, especially with high-fat food.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Juliette Salvi, Pierre Andreoletti, Etienne Audinat, Eglantine Balland, Selma Ben Fradj, Mustapha Cherkaoui-Malki, Tony Heurtaux, Fabienne Lienard, Emmanuelle Nedelec, Carole Rovere, Stephane Savary, Anne Vejux, Doriane Trompier, Alexandre Benani
Summary: Maintaining energy balance is crucial for survival and health. The brain receives various signals to regulate food intake based on energy needs. Microglial cell activation in the hypothalamus may affect energy balance, and nutritional lipids can play a role in this process.
Article
Ophthalmology
Mathieu Marconi, Christophe Zimmer, Noelia Do Carmo Blanco, Alice Guyon
Summary: Eyes constantly move to optimize the brain's interpretation of visual scenes. Eye movements are controlled by complex neural networks and can be influenced by cognitive activity. The Neuro Linguistic Programming theory associates gaze directions with specific mental tasks, but few studies have examined its validity.
JOURNAL OF EYE MOVEMENT RESEARCH
(2023)
Article
Neurosciences
Hadi Zarif, Selma Hosseiny, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Julie Cazareth, Anne Lazzari, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.