Article
Multidisciplinary Sciences
Mitsumasa Koyanagi, Baoguo Shen, Takashi Nagata, Lanfang Sun, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Akihisa Terakita
Summary: Optical control of GPCR signaling is a valuable approach for understanding and controlling GPCR-based physiologies. In this study, the performance of two bistable opsins, MosOpn3 and LamPP, in optical control in vivo was systematically investigated using Caenorhabditis elegans. The results demonstrated the advantages of MosOpn3 and LamPP in light-induced behavior and color-dependent control of behavior, respectively. Molecular engineering was also applied to enhance the usability of these opsins. These findings provide numerous strategies for optical control of GPCR-based physiologies and GPCR signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Physiology
Gustavo Jose Justo da Silva, Raffaele Altara, George W. Booz, Alessandro Cataliotti
Summary: Atrial natriuretic peptide is a crucial cardiac hormone that helps maintain heart function through potent natriuretic, diuretic, and vasodilating actions. Its main effects involve promoting the function of different tissues and organs in the body, and it shows potential in cardiorenal protective actions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michal Kacprzak, Magdalena Brzeczek, Marzenna Zielinska
Summary: The study examined the association between atrial infarction (AI) and the prognostic value of N-terminal proANP (NT-proANP) in patients with myocardial infarction (MI) treated with primary percutaneous coronary intervention (PCI). The results showed that AI did not affect the prognosis of patients with MI, while NT-proANP was identified as a strong predictor of death.
Article
Multidisciplinary Sciences
Jun Xu, Nobuo Koizumi, Yusuke V. Morimoto, Ryo Ozuru, Toshiyuki Masuzawa, Shuichi Nakamura
Summary: Nucleotide second messengers play crucial roles in signal transduction in various organisms. A study has found that the swimming motility of the soil bacterium Leptospira kobayashii can be rapidly modulated by light stimulation. Through analysis of a loss-of-photoresponsivity mutant, a novel sensory gene was identified, and the light-dependent synthesis of cyclic adenosine monophosphate (cAMP) was elucidated. These findings reveal a new role for cAMP in controlling the flagella-dependent motility of Leptospira and highlight the global distribution of the newly discovered photoactivated cyclase among diverse microbial species.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Fei Sun, Ke Zhou, Ke-yong Tian, Xin-yu Zhang, Wei Liu, Jie Wang, Cui-ping Zhong, Jian-hua Qiu, Ding-jun Zha
Summary: Strategies using bioactive molecules that regulate neurite regeneration and neuronal survival to reestablish connections between auditory epithelium or implanted electrodes and SGN neurites would become attractive therapeutic candidates for sensorineural hearing loss.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Marcelo Roberto Choi, Belisario Enrique Fernandez
Summary: Atrial natriuretic peptide, part of the natriuretic peptide family, has natriuretic, diuretic, and vasodilator effects that oppose the renin-angiotensin system. It also exerts nephroprotective effects due to its antioxidant and anti-inflammatory properties, making it a beneficial agent against acute and chronic kidney diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Zohreh Khaki, Parviz Nooshirvani, Darioush Shirani, Majid Masoudifard
Summary: This study aimed to assess the serum concentrations of ANP, BNP, and lipoproteins in dogs with MMVD and evaluate their correlation. The results showed that serum BNP has a greater diagnostic value than serum ANP in dogs with MMVD, and it can be used to determine the subclinical stages of B1 and B2 MMVD. Additionally, dogs with subclinical MMVD showed an increase in BNP, a decrease in HDL-C, and an increase in LDL-C, which are known risk factors for cardiovascular diseases in humans.
BMC VETERINARY RESEARCH
(2022)
Article
Medical Laboratory Technology
Jooyoung Cho, Jong-Han Lee, Sang-Guk Lee
Summary: This study compared the analytical and clinical performance of 3 NT-proBNP immunoassays. The Atellica IM NT-proBNP assay showed acceptable analytical performance, while the Elecsys proBNP II assay may be more suitable for diagnosing heart failure.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhenjiang Yang, Tuerdi Subati, Kyungsoo Kim, Matthew B. Murphy, Owen P. Dougherty, Isis L. Christopher, Joseph C. Van Amburg, Kaylen K. Woodall, Joey Barnett, Katherine T. Murray
Summary: Natriuretic peptide oligomers increase susceptibility to atrial arrhythmia, and the accelerated formation of oligomers by mutANP is associated with familial atrial fibrillation mutations. Oligomers inhibit mitochondrial function and regulate ion currents in atrial cells.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Oleg G. Chepurny, Colin A. Leech, George G. Holz
Summary: Intra-islet glucagon secreted from alpha-cells signals through beta-cell glucagon and GLP-1 receptors, conferring the competence of rat islets to exhibit first-phase glucose-stimulated insulin secretion. Intra-islet glucagon binds with high affinity to GcgR and exerts a spillover effect to bind with low affinity to GLP-1R, enhancing GSIS. The action of intra-islet glucagon to support insulin secretion requires a step-wise increase of glucose concentration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A. Trogisch, Gesine M. Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Volker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O. Nikolaev, Oliver J. Muller, Hugo A. Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C. Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Summary: This study investigated the role of a muscle hormone called Musclin in heart failure. The results showed that decreased expression of Musclin in muscle exacerbates cardiac dysfunction and myocardial fibrosis, while its overexpression in muscle attenuates these symptoms. Mechanistically, Musclin enhances the levels of C-type natriuretic peptide (CNP), which promotes cardiomyocyte contractility through different signaling pathways and inhibits fibroblast activation. Additionally, reduced expression of OSTN, the gene encoding Musclin, was found in skeletal muscle of heart failure patients, suggesting that increasing Musclin levels could be a potential therapeutic strategy.
NATURE COMMUNICATIONS
(2022)
Article
Physiology
Shuxia Cao, Chengyong Han, Chunhua Xuan, Xiangdan Li, Jing Wen, Dongyuan Xu
Summary: This study explored the potential mechanisms of rapid atrial pacing (RAP) in regulating atrial natriuretic peptide (ANP) secretion. The results showed that NPR-A interacts with ANP to regulate particulate guanylate cyclase (PGC) expression and influence cyclic guanosine monophosphate (cGMP) expression during RAP, involving the Akt/GSK-3 beta signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
Felix Hofer, Andreas Hammer, Matthias Steininger, Niema Kazem, Lorenz Koller, Barbara Steinlechner, Gunther Laufer, Martin Andreas, Rodrig Marculescu, Christian Hengstenberg, Johann Wojta, Alexander Niessner, Patrick Sulzgruber
Summary: Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, and the study found that mid-region proANP (MR-proANP) levels were significantly associated with the development of POAF, making it a strong and independent predictor.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Shuyu Li, Heng Pei, Yaomeng Huang, Da Liu, Liqun Yang, Qi Zhang, Zhijun Wang
Summary: An animal model of atrial fibrillation was constructed to observe the effect of acute atrial fibrillation on renal water and sodium metabolism in mice. The expression of TGF-beta and type III collagen in atrial myocardium, as well as the levels of CRP and IL-6 in blood, were examined. Additionally, the protein expression of NF-kappa B, TGF-beta, type III collagen, AQP2, AQP3, ENaC-beta, ENaC-gamma, SGK1, and NKCC in the kidneys were observed. The results showed that acute atrial fibrillation led to renal inflammatory response and fibrosis, hindering water and sodium metabolism, which was associated with the up-regulation of NKCC, ENaC, and AQPs in the kidneys.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Martin A. Daniels, Pamela Fischer-Posovszky, Michael Boschmann, Reiner Jumpertz-von Schwartzenberg, Timo D. Mueller, Leontine Sandforth, Sabine Frank-Podlech, Sonja Huelskaemper, Andreas Peter, Martin Wabitsch, Jens Jordan, Andreas L. Birkenfeld
Summary: This study investigated the effect of ANP on the levels of the anorexigenic adipokine leptin in healthy humans. The results showed that ANP infusion led to a significant decrease in plasma leptin levels and an increase in free fatty acids, indicating enhanced lipolysis. Additionally, ANP was found to suppress leptin release in human SGBS adipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.