Article
Immunology
Bijaya Sharma, Julie E. McCarthy, Cecily A. Freliech, Morgen M. Clark, Linden T. Hu
Summary: Unrecognized immunodeficiency may contribute to antibiotics' failure in treating Lyme disease symptoms. The study showed that the efficacy of doxycycline was significantly lower in mice lacking adaptive immunity, especially B cells, with the most pronounced effect seen in immunodeficient C3H mice. Additionally, the addition of a single dose of ceftriaxone to doxycycline treatment effectively cleared infection in severely immunodeficient C3H mice.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Bryna L. Fitzgerald, Barbara Graham, Mark J. Delorey, Adoracion Pegalajar-Jurado, M. Nurul Islam, Gary P. Wormser, John N. Aucott, Alison W. Rebman, Mark J. Soloski, John T. Belisle, Claudia R. Molins
Summary: This study used metabolomics to analyze metabolic responses in patients with Post-treatment Lyme disease symptoms/syndrome (PTLDS) compared to clinically cured non-PTLDS patients. The findings revealed observable metabolic differences between PTLDS and non-PTLDS patients at multiple time points, with distinct patterns of metabolite abundance. A small number of metabolites could be used to define PTLDS versus non-PTLDS patients at specific time points, and these findings were validated in a second patient cohort. These results suggest that metabolite-based measurement can help distinguish patients with PTLDS and provide insights into the underlying biochemistry of PTLDS.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Maroun M. Sfeir, Jennifer K. Meece, Elitza S. Theel, Dane Granger, Thomas R. Fritsche, Allen C. Steere, John A. Branda
Summary: Modified two-tiered testing algorithms are acceptable alternatives for Lyme disease diagnosis. The study found that these algorithms showed higher sensitivity in patients with acute erythema migrans and comparable specificity in other types of Lyme disease patients and control subjects.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Finja Huendersen, Stefanie Forst, Erich Kasten
Summary: The study found that patients with Lyme disease have lower quality of life and sleep, as well as cognitive impairments in attention and memory. Depressive symptoms are common among Lyme patients, and the disease is often diagnosed late.
Article
Medicine, General & Internal
Klaudia Sowula, Joanna Szaleniec, Mateusz Dworak, Maria Przeklasa, Malgorzata Maraj, Piotr Ceranowicz, Jerzy Tomik
Summary: The study aimed to evaluate the frequency of vertigo symptoms and potential labyrinth damage in patients diagnosed with Lyme disease (LD). Vertigo is often associated with labyrinth and hearing-organ damage in LD patients, and antibiotic therapy is effective in reducing otoneurological symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Shaghayegh Jahanbani, Paige S. Hansen, Lisa K. Blum, Effie E. Bastounis, Nitya S. Ramadoss, Mallesh Pandrala, Jessica Marie Kirschmann, Grace Sisemore Blacker, Zelda Z. Love, Irving L. Weissman, Fahimeh Nemati, Michal Caspi Tal, William H. Robinson
Summary: This study sequenced the antibody repertoire of plasmablasts in Bb-infected humans and identified their binding specificities. The researchers found that by conjugating a TLR9-agonist CpG oligo to an anti-BmpA monoclonal antibody, they were able to enhance macrophage phagocytosis of Bb.
CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Elisa Kortela, Mari Kanerva, Satu Kurkela, Jarmo Oksi, Asko Jarvinen
Summary: This study evaluated the conditions behind the symptoms in patients with suspected Lyme borreliosis (LB) referred to an infectious diseases clinic. The results showed that LB was unlikely in half of the patients, with most cases having other conditions to explain their symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Christa D. Jackson, Kinsey A. Hilliard, Charles R. Brown
Summary: The deficiency of 12/15-lipoxygenase (12/15-LO) exacerbates ankle swelling and arthritis severity in Lyme arthritis, suggesting that 12/15-LO lipid metabolites play a crucial role in resolving inflammatory arthritis. Therapeutic treatment with lipoxin A4 (LXA(4)) can alleviate joint edema and pain in Lyme arthritis patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sanna Avellan, Daniel Bremell
Summary: The study found that adjunctive corticosteroids do not improve or impair the outcome for patients with LNB PFP treated with doxycycline.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Paul M. Arnaboldi, Adiya S. Katseff, Mariya Sambir, Raymond J. Dattwyler
Summary: This study evaluated the efficacy of using synthetic peptides containing unique epitopes from B. burgdorferi as antigen targets in Lyme disease seroassay. The results showed that combining epitopes from different antigens significantly increased the sensitivity of the assay without compromising specificity. These findings provide a new approach to improve the laboratory diagnosis of Lyme disease.
Article
Immunology
Bharti Bhatia, Chadwick Hillman, Philip E. Stewart, Patricia Rosa
Summary: The highly conserved gene bba30 on the linear plasmid lp54 of Lyme disease spirochetes was found to be not required during the experimental mouse-tick infectious cycle, suggesting its potential role in the natural life cycle of Borrelia burgdorferi remains undefined.
INFECTION AND IMMUNITY
(2021)
Article
Microbiology
Gary P. Wormser, Donna McKenna, Eliana Jacobson, Elayna M. Shanker, Keith D. Shaffer, Carol Scavarda, Paul Visintainer
Summary: The study found that patients with erythema migrans who received antibiotic treatment for less than 7 days were more likely to experience at least one symptom than those treated for 7 days or more. Additionally, there was a significantly lower percentage of males among the treated group compared to untreated study subjects.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Parasitology
Zsuzsa Kalmar, Violeta Briciu, Mircea Coroian, Mirela Flonta, Amanda-Lelia Radulescu, Adriana Topan, Andrei Daniel Mihalca, Mihaela Lupse
Summary: The study in Romania found specific IgG and IgM antibodies to Borrelia burgdorferi s.l. among healthy blood donors. Higher seroprevalence was observed in men, older individuals, and those engaged in outdoor work.
PARASITES & VECTORS
(2021)
Article
Microbiology
Thomas Cafiero, Alvaro Toledo
Summary: The spirochete Borrelia burgdorferi has a variety of membrane proteins involved in its complex life cycle, including GroEL which is a cytoplasmic chaperone protein that binds plasminogen and components of the extracellular matrix to help establish infection and dissemination.
Article
Microbiology
Yasir Alruwaili, Mary B. Jacobs, Nicole R. Hasenkampf, Amanda C. Tardo, Celine E. Mcdaniel, Monica E. Embers
Summary: This study finds that monotherapy is ineffective in eradicating persistent infection in patients with post-treatment Lyme disease. However, combination therapy shows promising results in eradicating the infection. These findings are important for further research and treatment of Lyme disease in humans.
FRONTIERS IN MICROBIOLOGY
(2023)