Article
Plant Sciences
Richalynn Leong, Javier Jingheng Tan, Sally Shuxian Koh, Ting-Ying Wu, Kimitsune Ishizaki, Daisuke Urano
Summary: This study investigated the cellular mechanisms of calcium deficiency in plants using the bryophyte Marchantia polymorpha as a model. The results revealed metabolic compounds and genetic pathways involved in the occurrence and expansion of foliar tipburn. Furthermore, comparable changes in gene expression were observed in other plant species, suggesting the conservation of these pathways.
Article
Biochemistry & Molecular Biology
Shuai Fu, Kun Wang, Tingting Ma, Yan Liang, Zhonghua Ma, Jianxiang Wu, Yi Xu, Xueping Zhou
Summary: This study identifies a microtubule-associated E3 ligase (MEL) that promotes the degradation of a serine hydroxymethyltrasferase (SHMT1), resulting in broad-spectrum resistance to pathogens. The findings suggest the potential utility of the MEL-SHMT1 module in generating broad-spectrum resistant rice to global destructive pathogens.
Article
Biochemistry & Molecular Biology
Seiryo Ogata, Tetsuro Matsunaga, Minkyung Jung, Uladzimir Barayeu, Masanobu Morita, Takaaki Akaike
Summary: Persulfides/polysulfides are abundant sulfur-catenated molecular species in mammalian and human cells and tissues. Recent research has identified a novel persulfide synthase and demonstrated the conservation of persulfide synthesis across different domains. Persulfides/polysulfides play important roles in various biological processes such as energy metabolism, infection, inflammation, and cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Sophie Tissot, Lena Guimard, Jordan Meliani, Justine Boutry, Antoine M. Dujon, Jean-Pascal Capp, Jacint Tokolyi, Peter A. Biro, Christa Beckmann, Laura Fontenille, Nam Do Khoa, Rodrigo Hamede, Benjamin Roche, Beata Ujvari, Aurora M. Nedelcu, Frederic Thomas
Summary: Changes in food availability may be an important factor affecting tumor occurrence and progression. Frequent overfeeding promotes tumor emergence, while lean diets may have a protective effect.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thone, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Goncalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J. F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
Summary: This study presents a spatial proteogenomic atlas of the liver, combining multiple omics datasets, and reveals the cellular niches and transcriptomic identities of Kupffer cells and lipid-associated macrophages. It also demonstrates the inducibility of lipid-associated macrophages by local lipid exposure and the crucial role of ALK1-BMP9/10 axis in Kupffer cell development.
Article
Microbiology
Chao Jiang, Miao Mei, Ying Liu, Min Hou, Jun Jiao, Ya Tan, Xu Tan
Summary: The arms race between viruses and their hosts has influenced their evolutionary history and genetic composition. Restriction factors encoded by host genomes serve as the first line of defense against viral infections and are conserved throughout evolution to protect hosts from diseases, death, and even extinction. Recently characterized human restriction factor PSGL-1 demonstrates antiviral function in mice, as shown in vitro and in a knockout mouse model. The interaction between PSGL-1 and glycogag/glycoMA proteins from murine leukemia virus (MLV) demonstrates evidence of positive selection, reflecting the evolutionary pressure between PSGL-1 and its antagonists.
Article
Plant Sciences
Sona Pandey, Swarup Roy Choudhury, Chien Van Ha, Boominathan Mohanasundaram, Mao Li, Audrey Dodds
Summary: The function of G alpha proteins in plants shows some conservation across different lineages, but there are also differences in their effects on plant phenotypes. The ability of different G alpha proteins to complement mutant phenotypes varies, indicating that the functions of G proteins in plants have evolved differently in different plant lineages.
PLANT AND CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Abdelrahman AlOkda, Jeremy M. Van Raamsdonk
Summary: Thioredoxin and thioredoxin reductase are antioxidant enzymes that protect organisms from oxidative stress and play roles in cellular signaling and chaperone functions. Disruption or increased expression of these proteins can affect longevity in various model organisms, indicating their importance in determining lifespan. Additionally, a genetic variant of thioredoxin reductase has been associated with human lifespan. Overall, both cytoplasmic and mitochondrial thioredoxin systems are crucial for longevity.
Article
Multidisciplinary Sciences
Prasanna Katti, Peter T. Ajayi, Angel Aponte, Christopher K. E. Bleck, Brian Glancy
Summary: This study discovered that contractile and mitochondrial network types in Drosophila muscles are regulated differently, and identified transcription factors H15 and cut as potential regulators of mitochondrial network organization. Further experiments showed that H15 regulates both contractile and mitochondrial network types in flight muscles, while only regulating mitochondrial network configuration in jump and leg muscles. Additionally, cut was found to regulate salm expression in flight muscles and mitochondrial network configuration in leg muscles.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maria Breygina, Alexander Voronkov, Tatiana Ivanova, Ksenia Babushkina
Summary: Pollen grains are unique haploid organisms with special composition and structure. Angiosperms and gymnosperms share similar mechanisms for pollen germination but gymnosperms exhibit slower growth rates and reduced reliance on female tissues. The properties of pollen lipids, especially very-long-chain FAs, contribute to these features. By analyzing the absolute content and FA composition of pollen lipids, significant differences were found between species, with spruce pollen exhibiting a higher proportion of saturated and monoene FAs. Lily and tobacco also showed variations in the FA composition between pollen coat and gametophyte cells, with a lower unsaturation index in the coat. Moreover, the absolute content of lipids was highest in lily pollen. This study provides new insights into the FA changes during pollen germination in gymnosperms and angiosperms, and highlights the impact of H2O2 on spruce pollen germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghbi
Summary: Tauopathies are neurodegenerative diseases characterized by the accumulation of tau proteins. A genetic screening of potentially druggable genes identified three genes (USP7, RNF130, and RNF149) that regulate tau levels by targeting the C terminus of CHIP. Knockdown of these genes reduced tau levels and rescued disease phenotypes, suggesting a potential therapeutic strategy for Alzheimer disease and other tauopathies.
Article
Multidisciplinary Sciences
Ibukun Akinrinade, Kyriacos Kareklas, Magda C. Teles, Thais K. Reis, Michael Gliksberg, Giovanni Petri, Gil Levkowitz, Rui F. Oliveira
Summary: Our study shows that the mechanisms of emotional contagion are evolutionarily conserved in zebrafish, and oxytocin plays a role in regulating social fear contagion. Through experiments using oxytocin and oxytocin receptor mutants, we found that oxytocin is both necessary and sufficient for observer zebrafish to imitate the distressed behavior of conspecific demonstrators. The brain regions associated with emotional contagion in zebrafish are homologous to those involved in the same process in rodents, and they receive direct projections from oxytocinergic neurons located in the pre-optic area. Overall, our results support the evolutionary conserved role of oxytocin as a key regulator of basic empathic behaviors across vertebrates.
Article
Multidisciplinary Sciences
Ruinan Yang, Dongzhe LI, Shancheng Yi, Manqun Wang
Summary: This study found that odorant-binding proteins (OBPs) from herbivores and their enemies have a shared chemosensory basis and can detect the same plant volatiles, mediating tritrophic relationships through olfactory mechanisms.
Article
Cell Biology
Kari L. Price, Dyuthi M. Tharakan, Lynn Cooley
Summary: This study uses time-lapse imaging in Drosophila to reveal a process of ring canal formation during germ cell division. The study shows that the reorganization of germ cell midbody cores and changes in centralspindlin dynamics lead to the formation of stable intercellular bridges. This process is conserved in different species and provides insights into the broader functions of incomplete cytokinesis events.
DEVELOPMENTAL CELL
(2023)
Article
Multidisciplinary Sciences
Milan Kumar Samanta, Srimonta Gayen, Clair Harris, Emily Maclary, Yumie Murata-Nakamura, Rebecca M. Malcore, Robert S. Porter, Patricia M. Garay, Christina N. Vallianatos, Paul B. Samollow, Shigeki Iwase, Sundeep Kalantry
Summary: In this study, the researchers discovered an essential role of the X-linked homolog of an ancestral X-Y gene pair, Kdm5c-Kdm5d, in the expression of Xist lncRNA. They found that Kdm5c encodes a demethylase that enhances Xist expression, and this function is strongly conserved in mammals.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Chhana Ullah, Sybille B. Unsicker, Christin Fellenberg, C. Peter Constabel, Axel Schmidt, Jonathan Gershenzon, Almuth Hammerbacher
Article
Biochemistry & Molecular Biology
Christin Fellenberg, Christoph Boettcher, Thomas Vogt
Article
Biotechnology & Applied Microbiology
T. Docimo, A. J. Davis, K. Luck, C. Fellenberg, M. Reichelt, M. Phillips, J. Gershenzon, J. C. D'Auria
PLANT CELL TISSUE AND ORGAN CULTURE
(2015)
Article
Plant Sciences
Christin Fellenberg, Carsten Milkowski, Bettina Hause, Peter-Robert Lange, Christoph Boettcher, Juergen Schmidt, Thomas Vogt
Article
Plant Sciences
Christin Fellenberg, Maike van Ohlen, Vinzenz Handrick, Thomas Vogt
Article
Plant Sciences
Inga Bektas, Christin Fellenberg, Harald Paulsen
Article
Plant Sciences
Christin Fellenberg, Joerg Ziegler, Vinzenz Handrick, Thomas Vogt
FRONTIERS IN PLANT SCIENCE
(2012)
Article
Plant Sciences
Christin Fellenberg, Oliver Corea, Lok-Hang Yan, Finn Archinuk, Eerik-Mikael Piirtola, Harley Gordon, Michael Reichelt, Wolfgang Brandt, Jeremy Wulff, Jurgen Ehlting, C. Peter Constabel
Article
Forestry
Kennedy Boateng, B. J. Hawkins, C. Peter Constabel, Alvin D. Yanchuk, Christin Fellenberg
Summary: The study evaluated the resistance of red alder trees to western tent caterpillars and found variations in leaf area eaten and defense traits among alder clones, with concentrations of total phenolics, condensed tannin, and oregonin negatively correlated to caterpillar feeding. High concentrations of oregonin in red alder leaves were consistently associated with reduced tent caterpillar feeding, representing a novel finding in this study.
CANADIAN JOURNAL OF FOREST RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kennedy Boateng, Barbara J. Hawkins, Alvin Yanchuk, Christin Fellenberg, C. Peter Constabel
Summary: The study investigated the effects of nitrogen availability and wounding on the concentrations of oregonin and condensed tannins in red alder genotypes. It showed that these defense compounds are largely influenced by genotype, with a negative correlation between leaf N concentration and oregonin levels. Additionally, neither of the phenolic compounds responded to wounding, indicating that oregonin and condensed tannins are likely constitutive defenses determined by genotype in red alder.
JOURNAL OF CHEMICAL ECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Harley Gordon, Christin Fellenberg, Nathalie D. Lackus, Finn Archinuk, Amanda Sproule, Yoko Nakamura, Tobias G. Koellner, Jonathan Gershenzon, David P. Overy, C. Peter Constabel
Summary: Knockout of UGT71L1 gene involved in salicinoid biosynthesis in poplars alters salicylic acid and jasmonic acid metabolism and has unexpected effects on plant growth.
