Article
Immunology
Shaobing Xie, Sijie Jiang, Hua Zhang, Fengjun Wang, Yongzhen Liu, Yongchuan She, Qiancheng Jing, Kelei Gao, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Summary: This study identified several serum biomarkers through metabolomics analysis that can reliably predict the efficacy of ASIT in AR patients, with these biomarkers mainly involving glycolysis, fatty acid metabolism, and other metabolic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Zao Ji, Feifei Jiang
Summary: This study systematically evaluated the clinical efficacy and safety of sublingual immunotherapy for allergic rhinitis. The findings showed that sublingual immunotherapy has better efficacy and safety compared to traditional medicine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yanni Zhang, Kang Zhu, Hui Lv, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Fangli Yang, Lina Fan, Xiaoyong Ren, Cui Xia
Summary: This study found that serum exosome-derived miR-146a-3p may serve as a novel biomarker for predicting the short and long-term efficacies of sublingual immunotherapy (SLIT) in allergic rhinitis (AR) patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Ai-zhi Zhang, Mei-E Liang, Xiao-xue Chen, Yan-fen Wang, Ke Ma, Zhi Lin, Kuan-kuan Xue, Li-ru Cao, Rong Yang, Huan-ping Zhang
Summary: The study demonstrates that patients sensitized to house dust mite with/without other allergens show similar efficacy after 3 years of sublingual immunotherapy. However, patients with three or more allergens show slower initial response during the immunotherapy process.
FRONTIERS IN MEDICINE
(2021)
Article
Allergy
Wenlong Liu, Qingxiang Zeng, Chunhui He, Rongshan Chen, Yiquan Tang, Shengbao Yan, Xi Luo, Renzhong Luo
Summary: The study compared the efficacy, safety, and compliance of SCIT and SLIT in children with allergic rhinitis. Results indicated that SCIT was more effective than SLIT to a certain degree but had higher occurrence of adverse events. Individuals can choose the appropriate AIT route based on their specific conditions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Immunology
Shouming Cao, Haiying Wu, Yan Niu, Lu Wang, Fengjun Wang
Summary: This study found that serum exosome-derived miRNAs have the potential to predict the early effectiveness of SLIT in AR patients. Among them, has-miR-24-3p and has-miR-128-3p showed decreased expression in the effective group, while has-miR-206 showed increased expression, indicating potential as biomarkers for predicting the early efficacy of SLIT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Yinhui Zeng, Haiqing Xiao, Shengli Gao, Jinyuan Li, Chao Yang, Qingxiang Zeng, Xi Luo, Renzhong Luo, Xi Chen, Wenlong Liu
Summary: This study investigated the efficacy and immunological changes of sublingual immunotherapy (SLIT) under different treatment durations. The results showed that patients who received 3 years of SLIT had significantly improved symptom and medication scores, as well as significant changes in immune cell proportions and serum cytokine levels.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Medicine, General & Internal
Baharudin Abdullah, Ruby Pawankar, Amir Hamzah Abdul Latiff, Kent Chee Keen Woo, Eike Wuestenberg, Mohamad Azizul Fitri Khalid, Yeoh Zhi Xiang, Salina Husain, Nurashikin Mohammad, Norasnieda Md Shukri
Summary: Allergic rhinitis is an inflammatory disease of the upper airway, impacting patients' quality of life and increasing the risk for asthma. Allergen-specific immunotherapy is a treatment that induces tolerance to allergens and has been proven to induce disease-modifying effects. It is recommended as a first-line treatment for moderate to severe allergic rhinitis, and guidelines are important for its appropriate indication and application.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yongquan Zhang, Jian Shui, Lu Wang, Fengjun Wang
Summary: This study identifies serum S100A11 and MMP9 as potential biomarkers for early prediction and monitoring of the effectiveness of sublingual immunotherapy (SLIT) in patients with allergic rhinitis (AR). These findings contribute to guiding treatment and understanding the mechanism of SLIT in AR patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Edwin H. Kim, Corinne A. Keet, Yamini V. Virkud, Stacy Chin, Ping Ye, Anusha Penumarti, Johanna Smeekens, Rishu Guo, Xiaohong Yue, Quefeng Li, Michael R. Kosorok, Michael D. Kulis, Wesley Burks
Summary: This study evaluated the efficacy and safety of 4-mg peanut sublingual immunotherapy (SLIT) and the persistence of desensitization after discontinuation of SLIT. The results showed that most children achieved significant desensitization during SLIT and it lasted for more than 17 weeks after discontinuation. This study demonstrates that peanut SLIT is safe and effective.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Yanni Zhang, Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Huihui Zhang, Xiaoyong Ren
Summary: This study found differences in the levels of multiple cytokines in patients with allergic rhinitis and their association with the efficacy of allergen-specific immunotherapy. IL10 and IL33 may serve as novel biomarkers for early prediction of efficacy and be involved in the therapeutic mechanisms of immunotherapy.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Guangjun Tang, Youxing Lan, Bo Do, Jiafeng Lu, Kai Yang, Long Chai, Fangming Chen, Li Tian
Summary: Allergic rhinitis is a globally difficult disease to treat, with significant impact on patients' quality of life and social economy. This study aims to compare the efficacy and mechanism of action of two drugs to determine which treatment is more effective.
Article
Immunology
Mahvash Sadeghi, Sanaz Keshavarz Shahbaz, Sajad Dehnavi, Khadijeh Koushki, Mojtaba Sankian
Summary: For allergen-specific sublingual immunotherapy (SLIT), utilizing appropriate allergen-presentation platforms can improve allergen efficacy, target immune cells, induce regulatory immune responses, enhancing treatment outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shaobing Xie, Hua Zhang, Fengjun Wang, Zhihai Xie, Weihong Jiang, Kelei Gao
Summary: The study found that serum MIF levels were significantly elevated in allergic rhinitis patients, especially in those with severe disease, and MIF levels were positively correlated with clinical symptoms, serum specific IgE, and other markers. In patients with house dust mite-induced AR undergoing SLIT treatment, serum MIF levels had predictive value for clinical response, indicating that MIF could serve as an independent predictor for treatment responsiveness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Feng Liao, Shi Chen, Ling Wang, Ying-yu Quan, Li-li Chen, Guo-hua Lin
Summary: This study suggests that house dust mite SLIT is effective and well-tolerated in children with allergic asthma, regardless of the administration time. SLIT dosing in the evening might result in improved asthma control and reduced FeNO levels compared to dosing in the morning.
FRONTIERS IN PEDIATRICS
(2022)