期刊
PEDIATRICS
卷 142, 期 3, 页码 -出版社
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2018-1076
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资金
- University of California San Diego Center for Better Beginnings
- National Institutes of Health [UL1TR001442, T32 HD087978]
- Gerber Foundation [4998]
- National Institutes of Health (NIH)
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P50HD090259, T32HD087978] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001442] Funding Source: NIH RePORTER
Marijuana is the most commonly used recreational drug among breastfeeding women. With legalization of marijuana in several US states and a 1990 study in which authors documented psychomotor deficits in infants breastfed by mothers using marijuana, there is a need for information on potential exposure to the breastfed infant. Our objective with this study was to quantify cannabinoids in human milk after maternal marijuana use.METHODS:Between 2014 and 2017, 50 breastfeeding women who reported marijuana use provided 54 breast milk samples to a research repository, Mommy's Milk. Concentrations of -9-tetrahydrocannabinol (9-THC), 11-hydroxy--9-tetrahydrocannabinol, cannabidiol, and cannabinol were measured by using liquid chromatography mass spectrometry electrospray ionization.RESULTS:9-THC was detectable in 34 (63%) of the 54 samples up to approximate to 6 days after last reported use; the median concentration of 9-THC was 9.47 ng/mL (range: 1.01-323.00). Five samples had detectable levels of 11-hydroxy--9-tetrahydrocannabinol (range: 1.33-12.80 ng/mL) or cannabidiol (range: 1.32-8.56 ng/mL). The sample with the highest concentration of cannabidiol (8.56 ng/mL) did not have measurable 9-THC. Cannabinol was not detected in any samples. The number of hours since last use was a significant predictor of log 9-THC concentrations (-0.03; 95% confidence interval [CI] -0.04 to -0.01; P = .005). Adjusted for time since last use, the number of daily uses and time from sample collection to analysis were also significant predictors of log 9-THC concentrations (0.51; 95% CI 0.03 to 0.99; P = .039; 0.08; 95% CI 0.00 to 0.15; P = .038, respectively).CONCLUSIONS:9-THC was measurable in a majority of breast milk samples up to approximate to 6 days after maternal marijuana use.
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