Article
Nutrition & Dietetics
Rosalyn J. Singleton, Gretchen M. Day, Timothy K. Thomas, Joseph A. Klejka, Christine A. Desnoyers, Melanie N. P. McIntyre, David M. Compton, Kenneth E. Thummel, Robert J. Schroth, Leanne M. Ward, Dane C. Lenaker, Rachel K. Lescher, Joseph B. McLaughlin
Summary: The study found that prenatal vitamin D supplementation in high-risk populations can improve childhood outcomes regarding rickets and dental caries.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Review
Nutrition & Dietetics
Gianina Tapalaga, Bogdan Andrei Bumbu, Sandhya Rani Reddy, Sai Diksha Vutukuru, Akhila Nalla, Felix Bratosin, Roxana Manuela Fericean, Catalin Dumitru, Doru Ciprian Crisan, Nicoleta Nicolae, Magda Mihaela Luca
Summary: Prenatal Vitamin D levels may have an impact on dental health outcomes in children. The association between Vitamin D levels and enamel defects and tooth erosion varied across different studies. Vitamin D insufficiency was identified as a significant risk factor for enamel defects, while high prenatal Vitamin D levels indicated a protective effect against Hypomineralized Second Primary Molars and Molar Incisor Hypomineralization. However, there were variations in the assessment and prevalence of Vitamin D deficiency or insufficiency, and more research is needed to determine the optimal Vitamin D intake during pregnancy.
Article
Biochemistry & Molecular Biology
Philip R. Fischer, Neamat Almasri
Summary: Nutritional rickets can be caused by either vitamin D deficiency or insufficient dietary intake of calcium, and the combined deficiencies of calcium and vitamin D interact. Other factors also play a role in the pathogenesis of nutritional rickets.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Pediatrics
Noah P. Diminick, Jamie M. Fey, Jonathan Bourque, Patricia Crosby, Leah Fox, Diana Tsai-Leonard, Heidi Morin, Kathleen Cyr, William Hewitt, Lorraine L. McElwain
Summary: This interdisciplinary quality improvement effort aimed to increase the proportion of reported appropriate vitamin D supplementation for infants born at the institution and those who followed up in the resident clinic. Bedside medication delivery and education in the newborn nursery proved to improve reported vitamin D supplementation rates in the first 6 months of life.
Article
Biochemistry & Molecular Biology
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Summary: Vitamin D and VDR play critical roles in maintaining calcium homeostasis, bone formation, and immune response against cancer. Mutations in the VDR gene are associated with manifestations of type II rickets and abnormal bone formation. The unliganded VDR is crucial for maintaining the hair cycle and normal skin.
Article
Multidisciplinary Sciences
Nuttan Kantilal Tanna, Manisha Karki, Iman Webber, Aos Alaa, Austen El-Costa, Mitch Blair
Summary: This study assessed the knowledge, attitudes, and practices of a diverse population regarding vitamin D supplementation and self-care. The findings showed that the community had some awareness of vitamin D, with health professionals and the NHS website being the most trusted sources of information. It was found that the intake of vitamin D supplements decreased with increasing age, which could be a concern for deficiency in the elderly.
Article
Pediatrics
Birger Trollfors
Summary: This study aimed to explore the adherence to vitamin D supplementation recommendations among children aged 0-4 years and compare the serum levels of vitamin D in children and adolescents from different parts of the world. It was found that immigrant children in Sweden commonly had vitamin D deficiency.
Article
Nutrition & Dietetics
Ines Martinez Redondo, Ruth Garcia Romero, Pilar Calmarza, Antonio de Arriba Munoz, Diana Martinez-Redondo, Alejandro Sanz Paris
Summary: This study assessed vitamin D concentration levels in a healthy pediatric population and found that up to 20.9% of the population had insufficient levels. Significant differences in vitamin D levels were observed between different age groups, ethnicities, and skin types. Additionally, children who had never received vitamin D supplementation had a higher prevalence of vitamin D insufficiency compared to those who had received supplementation.
NUTRICION HOSPITALARIA
(2021)
Article
Neurosciences
Suhalika S. Sahni, Shruti Kakkar, Ruchika Kumar, Jatinder S. Goraya
Summary: This study described a cohort of 26 children and adolescents with osteomalacic myopathy, most of whom presented with progressive walking difficulty and signs of rickets. Laboratory and radiographic findings were consistent with vitamin-D deficiency in all cases, and response to vitamin-D treatment was good.
Article
Multidisciplinary Sciences
Girma Teferi Mengistu, Ayana Benti Terefe, Tolesa Gemeda Gudeta, Bizunesh Kefale Mengistu
Summary: This study investigated the practice of infant sunlight exposure among mothers in Ethiopia and found that 67.3% of mothers had good practice. Factors affecting mothers' practice included age and place of residence.
Article
Immunology
Fatima A. H. Al-Jaberi, Cornelia Geisler Crone, Thomas Lindenstrom, Nicolai Skovbjerg Arildsen, Emilia Saederup Lindelov, Louise Aagaard, Eva Gravesen, Rasmus Mortensen, Aase Bengaard Andersen, Klaus Olgaard, Jessica Xin Hjaltelin, Soren Brunak, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Tuberculosis is a serious health issue affecting a significant portion of the global population, with a quarter being infected with Mycobacterium tuberculosis. Vitamin D plays a crucial role in the immune response against M. tuberculosis, but research is hindered by a lack of suitable experimental models. Studying families with hereditary vitamin D-resistant rickets (HVDRR) provides unique insights into the immunoregulatory effects of vitamin D. A case study of an HVDRR patient with impaired cathelicidin production highlights the importance of vitamin D in combating M. tuberculosis pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medical Laboratory Technology
Markus Herrmann
Summary: One hundred years ago, the importance of vitamin D in bone mineralization and prevention of rickets was discovered. The measurement of 25-hydroxyvitamin D (25(OH)D) in human blood has gone through various analytical methods, and the recent standardization of the measurement has improved comparability. The use of liquid chromatography tandem mass spectrometry (LC-MS/MS) has made the accurate determination of 25(OH)D and other metabolites accessible for clinical laboratories.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Pediatrics
Teodoro Dura-Trave, Fidel Gallinas-Victoriano
Summary: Vitamin D deficiency is closely related to dental caries in children, increasing the risk of caries in primary and permanent teeth. Mechanisms such as insufficient activity of antibacterial peptides, decreased saliva secretion, and low calcium level in saliva are also involved.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.