Article
Chemistry, Applied
Dominik Rotrekl, Petra Salamunova, Lenka Parakova, Ondrej Bado, Ivan Salon, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Fan Yang, Shang Shang, Mengfei Qi, Yajinjing Xiang, Lingmin Wang, Xinyi Wang, Tao Lin, Doudou Hao, Jiajia Chen, Jia Liu, Qing Wu
Summary: This review summarizes the recent advances in the application of yeast glucan particles (YGPs) in oral targeted delivery systems, including their structure, preparation methods, drug encapsulation, and characterization. It highlights the mechanism and validation of the target recognition interaction between YGPs and macrophages, and presents inspiring cases to demonstrate the promising applications of yeast cells. The future opportunities and challenges that YGPs may face are also emphasized in this article.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zongbao Zhou, Jiangwei Xiao, Sheng Huang, Hengpeng Wu, Shuwen Guan, Tingting Wu, Shan Yu, Shuai Huang, Botao Gao
Summary: In this study, a multifunctional degradable hemostatic sponge based on carboxymethylated yeast beta-glucan (CMYG) was developed. The CMYG sponge demonstrated rapid blood absorption, tissue adhesion, and good in vitro biocompatibility. Compared to a commercial product, the CMYG sponge achieved faster hemostasis and reduced blood loss in liver injury rat models, and also showed outstanding antioxidant, anti-infection, anti-inflammatory, and cell proliferation effects, making it a promising candidate for clinical management of uncontrollable hemorrhage and wound repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Agriculture, Dairy & Animal Science
Hyunjun Choi, Sung Woo Kim
Summary: The use of antibiotics in animal feeds has been phased out, leading to a need for alternative methods to maintain the intestinal health and growth of nursery pigs. Beta-glucans, specifically microbial beta-glucans, have been shown to have positive effects on intestinal health and growth. However, cereal beta-glucans, which are found in high amounts in cereal grains-based diets, can interfere with the positive effects of microbial beta-glucans. The structural differences between cereal and microbial beta-glucans play a crucial role in their functional effects on nursery pigs.
Article
Respiratory System
Shuk Yu Leung, Steven Yuk Fai Lau, Ka Li Kwok, Kirran N. Mohammad, Paul Kay Sheung Chan, Ka Chun Chong
Summary: The study found that acute bronchiolitis-related hospitalisation in children was associated with high temperature, humidity, and exposure to NO2 and PM10, indicating the need for sustainable clean air policies to protect children's health.
Article
Polymer Science
Pilanee Vaithanomsat, Nutthamon Boonlum, Chanaporn Trakunjae, Waraporn Apiwatanapiwat, Phornphimon Janchai, Antika Boondaeng, Kanokwan Phalinphattharakit, Hataitip Nimitkeatkai, Amnat Jarerat
Summary: This study focused on the recovery of beta-glucan (BG) from yeast using alkaline and enzymatic processes. It was found that alkaline treatment resulted in higher purity and solubility of BG compared to enzymatic treatment. Fourier transform infrared and nuclear magnetic resonance spectroscopy confirmed the purity and functional properties of BG obtained from different recovery methods and raw materials.
Article
Food Science & Technology
Ka Lee Ma, Nelson Kei, Fan Yang, Susana Lauw, Po Lam Chan, Lei Chen, Peter Chi Keung Cheung
Summary: Fu Ling contains polysaccharides that can modulate the composition of gut microbiota, increasing the abundance of beneficial bacteria and potentially benefiting human gut health.
Article
Virology
Jun Tachikawa, Yuta Aizawa, Tetsuya Kobayashi, Tatsuki Ikuse, Kazuhiro Kamata, Su Mon Kyaw Win, Lasham Di Ja, Khin Nyo Thein, Nay Chi Win, Aye Thida, Aye Tun, Yuko Suzuki, Ai Ito, Hidekazu Osada, Irina Chon, Wint Wint Phyu, Tomomi Ota, Yadanar Kyaw, Htay Htay Tin, Kanako Watanabe, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh
Summary: This study examined the presence of PeV-A virus in children in Myanmar and found positive samples. The virus was classified into four genotypes, and further evaluation of its clinical impact on children is needed.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Nutrition & Dietetics
Kunxia Zhong, Zhiqin Liu, Yao Lu, Xi Xu
Summary: The study demonstrated that yeast beta-glucan can significantly reduce the incidence, frequency, and duration of URTIs in healthy subjects, as well as improve the severity of symptoms in majority of cases. Overall, yeast beta-glucan was well tolerated and safe.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yujie Guo, Huiyu Ma, Qilin Huang
Summary: This study investigated the adsorption behavior of Pb2+ by oxidized yeast beta-glucans (OYG) and their protective effects on lead-induced cytotoxicity in PC12 cells. The results showed that OYG effectively adsorbed lead and protected cells from its toxic effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Christiane Laue, Yala Stevens, Monique van Erp, Ekaterina Papazova, Edlyn Soeth, Angelika Pannenbeckers, Ellen Stolte, Ruwen Boehm, Sophie Le Gall, Xavier Falourd, Simon Ballance, Svein H. Knutsen, Iris Pinheiro, Sam Possemiers, Paul M. Ryan, R. Paul Ross, Catherine Stanton, Jerry M. Wells, Sylvie van der Werf, Jurriaan J. Mes, Juergen Schrezenmeir
Summary: This study investigated the potential of non-digestible polysaccharide (NPS) preparations to enhance immune response in aged individuals. Results suggest that arabinoxylan (AX) may enhance influenza vaccine efficacy and reduce the incidence of common colds. Further research is warranted to explore AX as an oral adjuvant for vaccine support.
Article
Plant Sciences
Ionut Avramia, Sonia Amariei
Summary: The aim of this study was to develop fast dissolving films based on beta-glucan and bilberry juice for packaging diabetes drugs. The addition of surfactants was found to contribute to the development of the films without affecting water vapor diffusion.
Article
Acoustics
Hongjie Yuan, Yan He, Hua Zhang, Xia Ma
Summary: This study investigated the effects and mechanisms of ultrasound-assisted enzymolysis on the solubilization and modification of yeast beta-glucan. The results showed that ultrasound enhanced the solubility and antioxidant activities of yeast beta-glucan, leading to smaller particles and improved stability in water.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tania Lima, Stefan B. Gunnarsson, Elisabete Coelho, Dmitry Evtuguin, Alexandra Correia, Manuel A. Coimbra, Tommy Cedervall, Manuel Vilanova
Summary: This study developed a method using nanoparticles to modulate the deleterious inflammatory response caused by fungal infection. The results showed that β-Glc-PS nanoparticles can reduce the inflammatory response caused by C. albicans cells and decrease the production of reactive oxygen species. This provides a theoretical basis for the development of targeted therapy for fungal infections.
Article
Virology
Gregory J. Walker, Sacha Stelzer-Braid, Caroline Shorter, Claire Honeywill, Matthew Wynn, Christiana Willenborg, Phillipa Barnes, Janice Kang, Nevil Pierse, Julian Crane, Philippa Howden-Chapman, William D. Rawlinson
Summary: Acute respiratory infections are a common illness among children, with respiratory viruses being detected even in asymptomatic periods. This study aimed to define the rates of infection and community epidemiology of respiratory viruses in healthy children to help interpret molecular diagnostic assays. The results showed that respiratory viruses were more likely to be detected during symptomatic periods, and human rhinovirus was the most common virus identified.
JOURNAL OF MEDICAL VIROLOGY
(2022)