Article
Endocrinology & Metabolism
Ronald Biemann, Matthias Blueher, Berend Isermann
Summary: Research shows that endocrine-disrupting compounds may play a role in the obesity epidemic, especially when prenatal exposure affects metabolism and leads to obesity in later generations.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Environmental Sciences
Wen-Tien Tsai
Summary: This paper surveyed the updated information about the production and environmental distribution of BPA in Taiwan over the past decade, and summarized the regulatory strategies and countermeasures for managing the environmental risks of BPA by the Taiwan government. The findings showed that most monitoring data were below acceptable risks, and recommended some countermeasures to echo international actions.
Article
Environmental Sciences
Ruoyi Lei, Baode Xue, Xiaoyu Tian, Ce Liu, Yanlin Li, Jie Zheng, Bin Luo
Summary: This study analyzed the association between endocrine-disrupting chemicals (EDCs) exposure and metabolic dysfunction-associated fatty liver disease (MAFLD) in American adults. The results showed a significant association between increased exposure to three EDCs metabolites (arsenic, DiNP, and PFOA) and MAFLD. Further analysis revealed that phthalates had a strong impact on MAFLD, particularly in females and the elderly over 65. The study also found that higher body mass index (BMI) and inflammatory diet habits intensified the association between EDCs and MAFLD, while higher insulin sensitivity levels reduced the risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jessica R. Shoaff, Jill Hahn, Antonia M. Calafat, Susan A. Korrick
Summary: This study investigated the impact of exposure to endocrine disrupting chemicals (EDCs) in adolescence. It found that antiandrogenic phthalates are associated with a decrease in math computation scores, particularly among adolescents with greater psychosocial stress.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Pengyu Chen, Jing Yang, Ruihan Wang, Bowen Xiao, Qing Liu, Binbin Sun, Xiaolei Wang, Lingyan Zhu
Summary: In this study, the interaction between graphene oxide (GO) and bisphenol A (BPA) in adult zebrafish was investigated. The results showed that GO enhanced the endocrine disruption effects of BPA in adult zebrafish. Metabolomics analysis supported this conclusion, revealing increased disturbance in metabolic pathways when GO and BPA were combined.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Endocrinology & Metabolism
Shane V. Varghese, Julianne M. Hall
Summary: The prevalence of obesity has increased significantly in recent decades, with endocrine disruptors like Bisphenol A (BPA) and its substitutes being identified as potential obesogens. This review aims to investigate the relationship between BPA substitutes and obesity. Evidence suggests that BPA substitutes, such as BPS, may act as obesogens at the pathophysiological level, while the evidence for BPF and BPAF is inconclusive.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Review
Microbiology
Agnieszka Galazka, Urszula Jankiewicz
Summary: Environmental pollution with organic substances is a major global issue, with particular concern about endocrine disrupting compounds (EDCs) that can harm aquatic species. Alkylphenols, commonly used in households, are a significant source of EDCs in water reservoirs and new methods are being sought for their removal. Bioremediation, using enzymes like laccase from white rot fungi, shows great potential for detoxification and degradation of pollutants in natural and industrial waste.
Article
Environmental Sciences
Inae Lee, Young Joo Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Kyungho Choi, Min Kyong Moon
Summary: This study in the adult Korean population found that the direction of associations between exposure to phthalates, BPA, and parabens and obesity and diabetes mellitus varied depending on the method used to adjust urinary dilution. It highlights the importance of choosing an appropriate adjustment method when studying the associations between these chemical exposures and health outcomes. Further research in other populations is needed to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Karolina Nowak, Ziga Jakopin
Summary: Due to concerns about endocrine disruption, bisphenol A (BPA) is being phased out and replaced with other substances. This study aimed to evaluate the endocrine-disrupting potential of 18 BPA analogues and their halogenated derivatives. The results showed that some BPA analogues displayed higher endocrine disruption potential than BPA itself. Halogenation was predicted to increase the binding affinity of bisphenols for certain nuclear receptors. Further in vitro experiments are needed to confirm these findings and evaluate the safety of BPA substitutes and their halogenated transformation products.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Yu Han, Wei Shi, Yu Tang, Weishang Zhou, Hongxiang Sun, Jiongming Zhang, Maocang Yan, Lihua Hu, Guangxu Liu
Summary: The study investigated the effects of microplastics and bisphenol A on gonadal development in whiteleg shrimp, revealing significant inhibition of gonadal development probably through interfering with metabolism and disrupting endocrine regulation. Co-exposure to both pollutants was more toxic and led to increased accumulation of BPA in shrimp gonads, potentially due to the Trojan horse effect and cumulative toxic impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Linus Wiklund, Anna Beronius
Summary: This study aimed to evaluate evidence on the endocrine disrupting properties of Bisphenol F (BPF) by using a systematic review approach. The study found sufficient evidence to conclude on an endocrine mechanism and postulated two modes of action based on the collected data for BPF.
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Byungmi Kim, Bohyun Park, Chung Ho Kim, Seyoung Kim, Bomi Park
Summary: This study explored the association between exposure to endocrine-disrupting chemicals (EDCs) and obesity or dyslipidemia, finding that exposure to EDC mixtures is associated with higher BMI and TG/HDL. The association is more significant in adults compared to adolescents, and adolescence may be a critical period for the effects of EDC mixtures on these outcomes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Mary E. Ingle, Lidia Minguez-Alarcon, Courtney C. Carignan, Heather M. Stapleton, Paige L. Williams, Jennifer B. Ford, Molly B. Moravek, Marie S. O'Neill, Lu Wang, Russ Hauser, John D. Meeker
Summary: This study found that there were differences in PBDEs and OH-BDEs concentrations between males and females during IVF, with no clear patterns of adverse IVF outcomes associated with PBDEs and OH-BDEs, but some decreases in associations with IVF outcomes were observed in isolated quartiles.
ENVIRONMENTAL RESEARCH
(2021)
Review
Environmental Sciences
Dana Boyd Barr, Kurunthachalam Kannan, Yuxia Cui, Lori Merrill, Lauren M. Petrick, John D. Meeker, Timothy R. Fennell, Elaine M. Faustman
Summary: Biomonitoring is a commonly used tool for assessing exposure to organic environmental chemicals, with dried blood spots (DBS) considered as a potential matrix for blood collection in children. Studies have evaluated the measurement of organic environmental toxicants in both archived and prospectively collected DBS, but the level of validation varies among these studies.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pahriya Ashrap, Deborah J. Watkins, Ginger L. Milne, Kelly K. Ferguson, Rita Loch-Caruso, Jennifer Fernandez, Zaira Rosario, Carmen M. Velez-Vega, Akram Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study investigated the relationship between maternal metal exposure during pregnancy and markers of oxidative stress, finding that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. The results also suggest a potential vulnerability of women carrying a male fetus.
Article
Environmental Sciences
Zorimar Rivera-Nunez, Pahriya Ashrap, Emily S. Barrett, Deborah J. Watkins, Amber L. Cathey, Carmen M. Velez-Vega, Zaira Rosario, Jose F. Cordero, Akram Alshawabkeh, John D. Meeker
Summary: Metal(loid)s may act as endocrine disruptors by altering prenatal hormone levels, with potential effects depending on specific windows of exposure during pregnancy. Essential metal(loid)s such as manganese and cobalt may also contribute to adverse maternal and fetal outcomes. Future studies are needed to further investigate these associations, as the study of metal(loid)s as endocrine disruptors is still in its early stages of epidemiological research.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Pahriya Ashrap, Amira Aker, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario-Pabon, Carmen M. Velez-Vega, Akram Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: The study in the PROTECT birth cohort in Puerto Rico found that psychosocial stress could modulate the association between metal exposure and adverse birth outcomes, particularly in the relationships between manganese and preterm birth, as well as copper and small for gestation. This suggests that prenatal psychosocial stress may influence vulnerability to metal exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Pahriya Ashrap, Max T. Aung, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario-Pabon, Carmen M. Velez-Vega, Akram Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study identified associations between phthalate metabolite biomarkers and lipidomic profiles among pregnant women. The most strongly associated lipid markers with phthalate exposure were diacylglycerol 40:7 and plasmenyl-phosphatidylcholine 35:1. Understanding these mechanisms is important for maternal and children's health outcomes.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Amber L. Cathey, Deborah J. Watkins, Zaira Y. Rosario, Carmen Velez, Bhramar Mukherjee, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study investigated the association between phthalate metabolite mixtures and pregnancy outcomes using a longitudinal pregnancy cohort in Puerto Rico. The results showed that exposure to phthalate mixtures was associated with increased risk of preterm birth and highlighted the importance of studying mixtures by fetal sex.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Astrid N. Zamora, Deborah J. Watkins, Karen E. Peterson, Martha M. Tellez-Rojo, Howard Hu, John D. Meeker, Alejandra Cantoral, Adriana Mercado-Garcia, Erica C. Jansen
Summary: This study found associations between maternal prenatal pesticide exposure and longer sleep duration and later sleep timing among adolescent offspring within a cohort of mother-adolescent pairs. These associations may be specifically related to female offspring.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Christine Kim, Amber L. L. Cathey, Deborah J. J. Watkins, Bhramar Mukherjee, Zaira Y. Y. Rosario-Pabon, Carmen M. M. Velez-Vega, Akram N. N. Alshawabkeh, Jose F. F. Cordero, John D. D. Meeker
Summary: This study explored the associations between maternal blood metal levels and MMPs among 617 pregnant women in Puerto Rico, revealing significant associations between certain metals and MMPs. These associations varied by fetal sex, indicating potential new avenues for understanding heavy metal-induced adverse birth outcomes and diagnostic tool development.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Lydia M. Louis, Lesliam Quiros-Alcala, Jordan R. Kuiper, Gregory Diette, Nadia N. Hansel, Meredith C. McCormack, John D. Meeker, Jessie P. Buckley
Summary: This study assessed OPE biomarkers among predominantly Black school-aged children and identified factors such as seasonal variation and demographic factors that affect OPE exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Stefanie A. Busgang, Syam S. Andra, Paul Curtin, Elena Colicino, Matthew J. Mazzella, Moira Bixby, Alison P. Sanders, John D. Meeker, Marissa Hauptman, Shirisha Yelamanchili, Wanda Phipatanakul, Chris Gennings
Summary: Environmental research often relies on urinary biomarkers which require dilution correction to accurately measure exposures. Specific gravity (SG) and creatinine (UCr) are commonly measured urinary dilution factors. Epidemiologic studies may assess only one of these measures, making it difficult to pool studies that may otherwise be able to be combined.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
P. A. Bommarito, D. R. Stevens, B. M. Welch, D. Weller, J. D. Meeker, D. E. Cantonwine, T. F. McElrath, K. K. Ferguson
Summary: This study analyzed data from 900 singleton pregnancies in the LIFECODES Fetal Growth Study and found that exposure to phthalate replacements and bisphenol S increased, while exposure to phthalates and most phenols decreased. The study also found that the levels of chemical exposures varied with sociodemographic characteristics, with higher concentrations observed in non-Hispanic Black or Hispanic participants.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Astrid N. Zamora, Erica C. Jansen, Jaclyn M. Goodrich, Martha M. Tellez-Rojo, Peter X. K. Song, John D. Meeker, Dana C. Dolinoy, Libni A. Torres-Olascoaga, Alejandra Cantoral, Karen E. Peterson
Summary: This study examines the relationship between endocrine-disrupting chemicals (EDCs) and metabolic syndrome (MetS) risk in adolescents. The findings from the analysis of data from 344 Mexican youths indicate that exposure to EDCs is associated with an increased risk of MetS and lipid abnormalities in adolescents, especially among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ram C. Siwakoti, Amber Cathey, Kelly K. Ferguson, Wei Hao, David E. Cantonwine, Bhramar Mukherjee, Thomas F. McElrath, John D. Meeker
Summary: This study found that prenatal exposure to PFAS may have an impact on pregnancy outcomes, including preterm birth and large-for-gestational age (LGA). However, the effects of PFAS on these outcomes depend on the fetal sex. Specifically, certain PFAS were associated with placental preterm birth, with stronger associations observed in male fetuses. For LGA, different PFAS had different effects in females and males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Amber Cathey, Marcela Tamayo-Ortiz, Juan Tamayo-Orozco, John D. Meeker, Karen E. Peterson, Belem Trejo-Valdivia, Martha Maria Tellez-Rojo, Deborah J. Watkins
Summary: Phthalates exposure during pregnancy is associated with perinatal bone health, particularly affecting bone remodeling. The study highlights the importance of considering calcium supplementation and body mass index as effect modifiers in understanding the effects of environmental exposures on bone health.
ENVIRONMENTAL RESEARCH
(2023)
