期刊
TRENDS IN PARASITOLOGY
卷 31, 期 2, 页码 60-71出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2014.12.002
关键词
dense granules; GRA proteins; protozoa; Toxoplasma gondii
类别
资金
- Labex Parafrap [ANR-11-LABX-0024]
- Fondation pour la Recherche Medicale
- ANR [ANR-11-BSV3-010-02, ANR 11 EMMA 032-01]
In Toxoplasma gondii, dense granules are known as the storage secretory organelles of the so-called GRA proteins (for dense granule proteins), which are destined to the parasitophorous vacuole (PV) and the PV-derived cyst wall. Recently, newly annotated GRA proteins targeted to the host cell nucleus have enlarged this view. Here we provide an update on the latest developments on the Toxoplasma secreted proteins, which to date have been mainly studied at both the tachyzoite and bradyzoite stages, and we point out that recent discoveries could open the issue of a possible, yet uncharacterized, distinct secretory pathway in Toxoplasma.
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