Article
Biochemistry & Molecular Biology
Tohru Ogihara, Makoto Mino
Summary: When evaluating the nutritional status of preterm infants, it is important to compare the data with healthy term infants and consider the gestational age rather than birth weight. There is limited data on the correlation between gestational age and vitamin E concentrations in preterm infants, and the oxidizability of polyunsaturated fatty acids is lower in preterm infants. Clinical trials of vitamin E supplementation in preterm infants have mostly been unsuccessful, and there is a need for further research in modern neonatal medicine.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Nutrition & Dietetics
Debora Gabriela Fernandes Assuncao, Lorena Thalia Pereira da Silva, Juliana Dantas de Araujo Santos Camargo, Ricardo Ney Cobucci, Karla Danielly da Silva Ribeiro
Summary: Vitamin E deficiency is not only associated with preterm newborns but also found in full-term newborns. This deficiency can compromise neurogenesis in children. Further studies are needed to assess the difference in vitamin E status among newborns of different gestational ages to support neonatal monitoring protocols.
Article
Pediatrics
Haiyan Ge, Weina Liu, Huimin Li, Ming Zhang, Mengbin Zhang, Chao Liu, Yanxia Qiao
Summary: This study investigates the relationship between vitamin D/E levels and bronchopulmonary dysplasia (BPD) in preterm infants. Results show that lower serum levels of vitamin D and E at birth are associated with increased severity of BPD. Additionally, vitamin D and E deficiency are correlated with the duration of oxygen support required for premature infants with BPD. This suggests that vitamin D and E may have clinical value in the prognosis and treatment of BPD.
PEDIATRIC PULMONOLOGY
(2021)
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Article
Nutrition & Dietetics
Madelaine Eloranta Rossholt, Kristina Wendel, Marianne Bratlie, Marlen Fossan Aas, Gunnthorunn Gunnarsdottir, Drude Fugelseth, Are Hugo Pripp, Magnus Domellof, Ketil Stordal, Tom Stiris, Sissel Jennifer Moltu
Summary: Vitamin A deficiency is associated with an increased risk of bronchopulmonary dysplasia in preterm infants. This study analyzed the vitamin A status of infants <29 weeks gestation and found that dexamethasone exposure and inflammation can affect vitamin A concentrations. Infants exposed to dexamethasone had higher vitamin A concentrations, but lower pretreatment retinol levels, indicating a risk of deficiency.
Article
Medical Laboratory Technology
Tomas Matejek, Bara Zapletalova, Martin Stepan, Jana Malakova, Vladimir Palicka
Summary: The main objective of this study was to determine the levels of C3-epi-25(OH)D in very low birth weight infants. The study found a significant correlation between 25(OH)D and C3-epi-25(OH)D levels, and showed that C3-epi-25(OH)D accounts for more than 20% of total 25(OH)D at the end of the first month of life.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Hematology
Paul Clarke, Martin J. Shearer, David J. Card, Amy Nichols, Vennila Ponnusamy, Ajit Mahaveer, Kieran Voong, Karen Dockery, Nicky Holland, Shaveta Mulla, Lindsay J. Hall, Cecile Maassen, Petra Lux, Leon J. Schurgers, Dominic J. Harrington
Summary: A study on preterm infants born <33 weeks' gestation found that those who continue to be breastfed after discharge are at high risk of developing subclinical VK deficiency. It is recommended to supplement breastfed infants with VK1 to prevent this deficiency.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Nutrition & Dietetics
Juliana Davini Mori, Milene Saori Kassai, Cibele Wolf Lebra, Fernando Luiz Affonso-Fonseca, Roseli Oselka Saccardo Sarni, Fabiola Isabel Suano-Souza
Summary: This study aimed to evaluate the influence of serum 25-hydroxyvitamin D levels on postnatal growth in preterm infants at discharge and 12 months of corrected age. The results showed that there was a moderate correlation between umbilical cord and maternal serum 25-hydroxyvitamin D levels, but no significant impact on the postnatal growth of preterm infants.
Article
Nutrition & Dietetics
Jae-Hun Jung, Eun-Ah Kim, Sang-Yoon Lee, Jung-Eun Moon, Eun-Joo Lee, Sook-Hyun Park
Summary: This study aimed to investigate changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) in Korean preterm infants during the first year of life. The study found a high incidence of VDD in these infants, with vitamin D levels at birth being the strongest predictor of VDD during follow-up. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.
Article
Nutrition & Dietetics
Margarita Thanhaeuser, Fabian Eibensteiner, Margit Kornsteiner-Krenn, Melanie Gsoellpointner, Sophia Brandstetter, Ursula Koeller, Wolfgang Huf, Mercedes Huber-Dangl, Christoph Binder, Alexandra Thajer, Bernd Jilma, Angelika Berger, Nadja Haiden
Summary: Preterm infants are at high risk for mineral and micronutrient deficiencies important for bone health. This study found that the timing of introducing solid foods did not have a significant impact on vitamin D status in preterm infants during the first year of life, but the early introduction group had a higher incidence of vitamin D deficiency at 6 months.
Article
Pediatrics
Erik A. Jensen, Erika M. Edwards, Lucy T. Greenberg, Roger F. Soll, Danielle E. Y. Ehret, Jeffrey D. Horbar
Summary: This study provides epidemiological data on very preterm infants born in the US based on severity-based diagnostic criteria for bronchopulmonary dysplasia (BPD). The study found that greater BPD severity was associated with more frequent development of major neonatal morbidities, in-hospital mortality, and use of supplemental respiratory support at discharge.
Article
Nutrition & Dietetics
Maria Gomez-Martin, David Herrero-Morin, Gonzalo Solis, Marta Suarez, Nuria Fernandez, Silvia Arboleya, Miguel Gueimonde, Sonia Gonzalez
Summary: Ensuring the nutritional needs of preterm infants during complementary feeding is crucial for their long-term health. This study assessed food intake and anthropometric parameters in a Mediterranean infant cohort from 6 to 24 months, focusing on late preterm infants. Results showed differences in underweight prevalence between preterm and full-term infants up to 6 months, but this difference disappeared at 12 and 24 months. Protein intake was not correlated with weight gain and growth in preterm infants, and low intake of vitamin D was notable.
Article
Medicine, General & Internal
Mathias L. Hansen, Adelina Pellicer, Simon Hyttel-Srensen, Ebru Ergenekon, Tomasz Szczapa, Cornelia Hagmann, Gunnar Naulaers, Jonathan Mintzer, Monica Fumagalli, Gabriel Dimitriou, Eugene Dempsey, Jakub Tkaczyk, Guoqiang Cheng, Siv Fredly, Anne M. Heuchan, Gerhard Pichler, Hans Fuchs, Saudamini Nesargi, Gitte H. Hahn, Salvador Piris-Borregas, Jan Sirc, Miguel Alsina-Casanova, Martin Stocker, Hilal Ozkan, Kosmas Sarafidis, Andrew O. Hopper, Tanja Karen, Beata Rzepecka-Weglarz, Serife S. Oguz, Luis Arruza, Asli C. Memisoglu, Ruth del Rio Florentino, Mariana Baserga, Pierre Maton, Anita C. Truttmann, Isabel de las Cuevas, Peter Agergaard, Pamela Zafra, Lars Bender, Ryszard Lauterbach, Chantal Lecart, Julie de Buyst, Afif El-Khuffash, Anna Curley, Olalla O. Vaccarello, Jan Miletin, Evangelia Papathoma, Zachary Vesoulis, Giovanni Vento, Luc Cornette, Laura S. Lopez, Beril Yasa, Anja Klamer, Massimo Agosti, Olivier Baud, Emmanuele Mastretta, Merih Cetinkaya, Karen McCall, Shujuan Zeng, Eleftheria Hatzidaki, Agata Bargiel, Sylwia Marciniak, Xiaoyan Gao, Lin Huijia, Lina Chalak, Ling Yang, Shashidhar A. Rao, Xin Xu, Begona L. Gonzalez, Maria Wilinska, Zhaoqing Yin, Iwona Sadowska-Krawczenko, Itziar Serrano-Vinuales, Barbara Krolak-Olejnik, Marta M. Ybarra, Catalina Morales-Betancourt, Peter Korcek, Marta Teresa-Palacio, Fabio Mosca, Anja Hergenhan, Nilgun Koksal, Konstantia Tsoni, Munaf M. Kadri, Claudia Knoepfli, Elzbieta Rafinska-Wazny, Mustafa S. Akin, Tone Nordvik, Zhang Peng, Sinem G. Kersin, Liesbeth Thewissen, Ana Alarcon, David Healy, Berndt Urlesberger, Muenevver Bas, Jana Baumgartner, Eleni Skylogianni, Veronika Karadyova, Eva Valverde, Elena Bergon-Sendin, Jachym Kucera, Silvia Pisoni, Le Wang, Anne Smits, Rebeca Sanchez-Salmador, Marie I. Rasmussen, Markus H. Olsen, Aksel K. Jensen, Christian Gluud, Janus C. Jakobsen, Gorm Greisen
Summary: A multicenter, randomized trial found that treatment guided by cerebral oximetry monitoring for the first 72 hours after birth did not reduce the risk of death or severe brain injury at 36 weeks' postmenstrual age in extremely preterm infants.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pediatrics
Sabrina Malone Jenkins, Gary Chan, Kimberlee Weaver-Lewis, Tyler Bardsley, Jace Felix, Matthew Grinsell
Summary: This study aimed to investigate the effects of vitamin D supplementation on bone density and the development of NC in preterm infants. The results showed that infants receiving vitamin D supplementation according to AAP guidelines had acceptable serum vitamin D levels, but did not show improvement in bone density or mineral content compared to previously reported values. However, infants with lower birth weight and earlier gestational age were at increased risk of developing NC.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Mauras Mathilde, Marine Butin, Roy Pascal, Franck Plaisant, Sophie Laborie, Justine Bacchetta
Summary: The study retrospectively evaluated the effectiveness and safety of a local hospital protocol of vitamin D supplementation for preterm infants in France. The modified protocol successfully prevented underdosing and significant overdosing, but moderate hypervitaminosis D was still frequent. Further urgent studies are needed to determine the optimal supplementation and clinical impact of 25(OH)D on comorbidities in preterm infants.
Article
Obstetrics & Gynecology
Nahed O. ElHassan, Eric W. Schaefer, Basilia Gonzalez, Thomas Nienaber, Luc P. Brion, Jeffrey R. Kaiser
Summary: This study found that early transient neonatal hypoglycemia is associated with decreased literacy proficiency in at-risk infants, but not with mathematics proficiency. The impact of early hypoglycemia on academic performance is similar regardless of the number or category of risk factors.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Jean Lowe, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, Betty R. Vohr, Susan R. Hintz, Kristi L. Watterberg
Summary: This study found that a blunted cortisol awakening response is associated with memory and attention problems in preterm children. This has implications for stress reactivity and learning problems in preterm children.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Sara C. Handley, Neha Kumbhat, Barry Eggleston, Elizabeth E. Foglia, Alexis S. Davis, Krisa Van Meurs, Satyan Lakshminrusimha, Michele Walsh, Kristi L. Watterberg, Myra H. Wyckoff, Abhik Das, Sara B. DeMauro
Summary: Delayed cord clamping is associated with lower rates of death or severe neurodevelopmental impairment among extremely preterm infants, and this relationship is not mediated by severe intraventricular hemorrhage. No significant differences were observed between umbilical cord milking and other methods of cord management.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Neurosciences
Bryan Cruz, Valentina Vozella, Benjamin A. Carper, Joy C. Xu, Dean Kirson, Shawn Hirsch, Tracy Nolen, Lauren Bradley, Katie Fain, Meg Crawford, Thomas R. Kosten, Eric P. Zorrilla, Marisa Roberto
Summary: Post-traumatic stress disorder (PTSD) leads to increased alcohol intake and development of alcohol use disorder (AUD). By identifying shared neural mechanisms, new therapies for PTSD/AUD can be discovered. This study used a rat model to evaluate compounds that inhibit FK506-binding protein 51 (FKBP5), a co-chaperone modulator of glucocorticoid receptors implicated in stress-related disorders. The results showed that FKBP5 inhibitors can modulate stress-related alcohol intake and trauma-related behaviors.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Luc P. Brion, Lisa M. Scheid, L. Steven Brown, Patti J. Burchfield, Charles R. Rosenfeld
Summary: This study aimed to determine whether late preterm (35-36 weeks' gestational age) and term neonates with early-onset hypoglycemia required continuous glucose infusion to maintain normal blood glucose levels. The need for IV glucose infusion was associated with small size for gestational age, low initial glucose concentration, early-onset infection, and other perinatal variables.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Jordan D. Reis, Timothy Hagan, Roy Heyne, Kristine Tolentino-Plata, Rebekah Clarke, Larry S. Brown, Charles R. Rosenfeld, Patti J. Burchfield, Maria Caraig, Luc P. Brion
Summary: A Ventricle-to-Brain Index (VBI) >0.35 is associated with low scores on the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) in preterm infants with birth weight <1250g. This study aimed to evaluate the reliability of VBI measured at the foramen of Monro and assess its relationship with BSID-III scores at >= 18 months corrected age.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Medicine, General & Internal
Leslie W. Young, Songthip T. Ounpraseuth, Stephanie L. Merhar, Zhuopei Hu, Alan E. Simon, Andrew A. Bremer, Jeannette Y. Lee, Abhik Das, Margaret M. Crawford, Rachel G. Greenberg, P. Brian Smith, Brenda B. Poindexter, Rosemary D. Higgins, Michele C. Walsh, Ward Rice, David A. Paul, Jessie R. Maxwell, Sucheta Telang, Camille M. Fung, Tanner Wright, Anne Marie Reynolds, Devon W. Hahn, Julie Ross, Jennifer M. McAllister, Moira Crowley, Sophie K. Shaikh, Karen M. Puopolo, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F. Braswell, Lauren Tucker, Karen R. McAlmon, Krishna Dummula, Julie Weiner, Jessica R. White, Meghan P. Howell, Sarah Newman, Jessica N. Snowden, Lori A. Devlin
Summary: A study conducted at 26 hospitals in the United States found that the use of the "Eat, Sleep, Console" care approach significantly reduced the time until infants with neonatal opioid withdrawal syndrome were medically ready for discharge, without increasing specified adverse outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Lori A. Devlin, Zhuopei Hu, Songthip Ounpraseuth, Alan E. Simon, Robert D. Annett, Abhik Das, Janell F. Fuller, Rosemary D. Higgins, Stephanie L. Merhar, P. Brian Smith, Margaret M. Crawford, Lesley E. Cottrell, Adam J. Czynski, Sarah Newman, David A. Paul, Pablo J. Sanchez, Erin O. Semmens, M. Cody Smith, Bonny L. Whalen, Jessica N. Snowden, Leslie W. Young
Summary: This study evaluates the direct and indirect relationship between antenatal exposure to opioid agonist medication as treatment for opioid use disorder (MOUD) and the severity of neonatal opioid withdrawal syndrome (NOWS). The study also explores the mediating factors that influence this relationship.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Pediatrics
Abbot R. Laptook, Heather Weydig, Luc P. Brion, Myra H. Wyckoff, Tamara I. Arnautovic, Noelle Younge, William Oh, Dhuly Chowdhury, Martin Keszler, Abhik Das
Summary: This retrospective cohort study examined data of newborns born between 2016 and 2019 and found that the odds of spontaneous intestinal perforation (SIP) were increased when antenatal steroids (ANS) given close to delivery were combined with indomethacin on day 1 after birth (Indo-D1). Rating: 7 out of 10.
JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz, Betty R. Vohr, Carla M. Bann, Abhik Das, Edward F. Bell, Sana Boral Debsareea, Emily Stephens, Marie G. Gantz, Carolyn M. Petrie Huitema, Karen J. Johnson, Kristi L. Watterberg, Ricardo Mosquera, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Tarah T. Colaizy, Nathalie L. Maitre, Stephanie L. Merhar, Ira Adams-Chapman, Janell Fuller, Michelle E. Hartley-McAndrew, William F. Malcolm, Sarah Winter, Andrea F. Duncan, Gary J. Myer, Stephen D. Kicklighter, Myra H. Wyckoff, Sara B. DeMauro, Anna Maria Hibbs, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Pablo J. Sanchez, Abbot R. Laptook, C. Michael Cotten, Carl T. D'Angio, Michele C. Walsh
Summary: The use of Bayley III norm-based thresholds may underestimate the impairment rates of extremely preterm infants. Assessing these rates relative to healthy term infants born in the same hospital may be a better approach.
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Timothy J. Bahr, Sylvia Tan, Emily Smith, Sandra S. Beauman, Kurt R. Schibler, Cathy A. Grisby, Jean R. Lowe, Edward F. Bell, Abbot R. Laptook, Seetha Shankaran, David P. Carlton, Carrie Rau, Mariana C. Baserga, John Flibotte, Kristin Zaterka-Baxter, Michele C. Walsh, Abhik Das, Robert D. Christensen, Robin K. Ohls
Summary: This study compared serum ferritin and RET-He values among extremely low gestational age neonates with other markers of iron-deficient erythropoiesis. The results showed that RET-He was more correlated with the mean corpuscular volume (MCV) than ferritin, suggesting that ferritin is limited as a marker of iron sufficiency in premature infants.
JOURNAL OF PERINATOLOGY
(2023)
Article
Medicine, Research & Experimental
Adam Czynski, Abbot Laptook, Abhik Das, Brian Smith, Alan Simon, Rachel Greenberg, Robert Annett, Jeannette Lee, Jessica Snowden, Claudia Pedroza, Barry Lester, Barry Eggleston, Drew Bremer, Elisabeth McGowan
Summary: The incidence of maternal opioid use in the USA has increased significantly since 2000, resulting in an increase in neonatal opioid withdrawal syndrome (NOWS). Currently, there is variability in strategies for weaning infants off pharmacological treatment for NOWS. This study aims to determine whether rapid-weaning intervention can reduce the duration of opioid treatment compared to slow-weaning intervention.
Article
Medicine, General & Internal
Valerie Y. Chock, Haresh Kirpalani, Edward F. Bell, Sylvia Tan, Susan R. Hintz, M. Bethany Ball, Emily Smith, Abhik Das, Yvonne C. Loggins, Beena G. Sood, Lina F. Chalak, Myra H. Wyckoff, Stephen D. Kicklighter, Kathleen A. Kennedy, Ravi M. Patel, Waldemar A. Carlo, Karen J. Johnson, Kristi L. Watterberg, Pablo J. Sanchez, Abbot R. Laptook, Ruth B. Seabrook, C. Michael Cotten, Toni Mancini, Gregory M. Sokol, Robin K. Ohls, Anna Maria Hibbs, Brenda B. Poindexter, Anne Marie Reynolds, Sara B. DeMauro, Sanjay Chawla, Mariana Baserga, Michele C. Walsh, Rosemary D. Higgins, Krisa P. Van Meurs
Summary: This study investigates the effects of red blood cell transfusion on cerebral and mesenteric tissue saturation in preterm infants and explores the association with degree of anemia and death or neurodevelopmental impairment. The results show an increase in tissue saturation after transfusion, and lower pretransfusion cerebral saturation may be associated with adverse outcomes.
Article
Pediatrics
Jean Lowe, Carla M. Bann, Allison G. Dempsey, Janell Fuller, H. Gerry Taylor, Kathryn E. Gustafson, Victoria E. Watson, Betty R. Vohr, Abhik Das, Seetha Shankaran, Kimberly Yolton, M. Bethany Ball, Susan R. Hintz
Summary: The study found that the Bayley-III cognitive and language scores are correlated with later IQ, but may not accurately predict developmental delay in school-aged children or misclassify those who are not delayed. The Bayley-III can be a useful tool in identifying extremely preterm infants who may be at risk for cognitive difficulties.
JOURNAL OF PEDIATRICS
(2023)