Article
Medicine, General & Internal
Peter Wohlfahrt, Dominik Jenca, Vojtech Melenovsky, Janka Franekova, Antonin Jabor, Marek Sramko, Vladimir Stanek, Michael Zelizko, Rudolf Poledne, Jan Pitha, Vera Adamkova, Josef Kautzner
Summary: This study found that both high and low concentrations of Lp(a) were associated with an increased risk of total mortality and recurrent cardiovascular events after MI. The association was partially weakened after adjusting for heart failure signs at the time of hospitalization.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Sujee Lee, Hye Sun Lee, Ji-Won Lee
Summary: This study investigated the daily nutrient intake and dietary patterns of individuals with hyper-low-density lipoprotein cholesterolemia (hLDL) and hypertriglyceridemia (hTG) in a large Korean population-based study using propensity score matching. Results showed differences in intake of carbohydrates, fats, and saturated fatty acids between individuals with different lipid levels. Individualized dietary information and counseling should take into consideration a person's specific lipid levels.
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ian Kwong Yun Phoon, Yi Ling Eileen Koh, Xiaoxuan Guo, Sankari Usha, Ngiap Chuan Tan
Summary: Recent research in Singapore compared fasting and non-fasting lipid profiles in Asian patients with type-2 diabetes mellitus and dyslipidaemia. The study found that the non-fasting lipid profile was similar to the fasting profile in patients taking statin medication, suggesting that non-fasting lipid profiles can be used to assess cholesterol treatment status in this population.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ju Hyeon Kim, Jung-Joon Cha, Subin Lim, Jungseok An, Mi-Na Kim, Soon Jun Hong, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim, Kyeongmin Byeon, Sang-Wook Kim, Eun-Seok Shin, Kwang Soo Cha, Jei Keon Chae, Youngkeun Ahn, Myung Ho Jeong, Tae Hoon Ahn
Summary: This study aimed to investigate recurrent adverse events in post-myocardial infarction patients. The results showed that achieving target LDL-C levels in acute myocardial infarction patients was associated with a lower incidence and reduced hazard of recurrent clinical events, highlighting the need to improve LDL-C level management in real-world settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anna G. Ioannidou, Eleanor J. Watts, Aurora C. Perez-Cornago, Elizabeth K. Platz, Ian Mills, Timothy Key, Ruth Travis, Konstantinos Tsilidis, Verena Zuber
Summary: This study aimed to investigate the relationship between blood lipids and prostate cancer risk, and found that genetically predicted Lp(a) concentrations were associated with an increased risk of PCa, while no significant associations were observed for other lipid concentrations.
Article
Cardiac & Cardiovascular Systems
Richard J. Webb, Mohsen Mazidi, Gregory Y. H. Lip, Andre P. Kengne, Maciej Banach, Ian G. Davies
Summary: This study investigated the impact of adiposity, diet, and inflammation on the discordance between apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C). The results showed that body mass index, dietary saturated fatty acids, dietary fiber, serum C-reactive protein, and uric acid were strongly associated with the discordance. Additionally, Mendelian randomization analysis indicated that higher body fat percentage was causally related to elevated ApoB.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, General & Internal
Lale Dinc Asarcikli, Mehmet Kis, Tolga Sinan Guvenc, Veysel Tosun, Burak Acar, Fulya Avci Demir, Abdulrahman Naser, Mehdi Zoghi
Summary: The study showed that in most cardiology outpatients, the Friedewald equation has excellent agreement with the novel Martin/Hopkins and Sampson equations, and treatment decisions should not change in most patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Clinical Neurology
Pierre C. Amarenco, Philippa S. Lavallee, Jong Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Helene Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Eric Vicaut, Eric Bruckert, Treat Stroke Target Invest
Summary: This study investigated the effects of two different strategies for reducing low-density lipoprotein (LDL) cholesterol on reducing cardiovascular risk. The results showed that among patients with a target LDL cholesterol level of <70 mg/dL, a reduction in LDL cholesterol of >50% from baseline significantly reduced the risk of the primary outcome.
Article
Cardiac & Cardiovascular Systems
Zhiwen Xiao, Zhongqiu Lin, Lin Xu, Wenlong Xu, Haoxiang Huang, Yuegang Wang, Shiping Cao, Zhiquan Xie, Wangjun Liao, Yulin Liao, Jianping Bin, Weijing Feng, Yanmei Chen
Summary: This study aimed to evaluate the association between long-term cumulative exposure to remnant cholesterol (RC) and major adverse cardiovascular events (MACE) in elderly patients with atherosclerotic cardiovascular diseases (ASCVD). The results suggest that long-term cumulative RC is independently associated with incident MACE in elderly participants with ASCVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Lu Xu, Kai Wang, Shengfeng Wang, Lili Liu, Xiaozhen Lv, Yongfeng Song
Summary: This study revealed that high levels of triglycerides increased the risk of depressive symptoms in men, especially in individuals without hypertension and diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Xiaoqi Wang, Yingqing Feng, Li Yang, Guohui Zhang, Xiaoyuan Tian, Qianhui Ling, Jiangshan Tan, Jun Cai
Summary: Baseline LDL-C and non-HDL-C concentrations have a J-shaped association with cardiovascular disease outcomes. The effects of intensive SBP control on cardiovascular disease outcomes are not influenced by baseline LDL-C and non-HDL-C concentrations.
CHINESE MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Endocrinology & Metabolism
Mika Ala-Korpela, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Johannes Kettunen, Olli T. Raitakari, Ville-Petteri Makinen
Summary: This study tested whether cross-sectional modeling can distinguish slow vs accelerated aging in a human population. A machine learning model was trained to predict age and tested against longitudinal data. The results showed that the cross-sectional proxy failed to predict longitudinal observations, suggesting that differences in starting points may explain diverging aging rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Sport Sciences
Miia Lehtovirta, Feitong Wu, Suvi P. Rovio, Olli J. Heinonen, Tomi T. Laitinen, Harri Niinikoski, Hanna Lagstrom, Jorma S. A. Viikari, Tapani Ronnemaa, Antti Jula, Mika Ala-Korpela, Olli T. Raitakari, Katja Pahkala
Summary: Physical activity during adolescence is significantly associated with the metabolic profile, including serum lipoproteins, amino acids, and glucose metabolism. These results support recommendations for physical activity during adolescence to promote health and reduce future disease risks.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Multidisciplinary Sciences
Mirkka Lahdenpera, Laura Galante, Carlos Gonzales-Inca, Jussi Vahtera, Jaana Pentti, Samuli Rautava, Niina Kayhko, Chloe Yonemitsu, Julia Gupta, Lars Bode, Hanna Lagstrom
Summary: The study suggests that properties of the mother's residential green environment, such as greenness, vegetation cover diversity, and naturalness index, are associated with changes in the composition of human milk oligosaccharides (HMOs), which have health effects on infants. The results highlight the mediating role of breastfeeding between residential green environments and early life health.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Elisa Paavilainen, Harri Niinikoski, Riitta Parkkola, Kalle Koskensalo, Hilkka Nikkinen, Riitta Veijola, Marja Vaarasmaki, Britt-Marie Loo, Paivi Tossavainen, Tapani Ronnemaa, Kristiina Tertti
Summary: This study compared body composition, visceral adiposity, adipocytokines, and low-grade inflammation markers in prepubertal offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM). The results showed that children in the metformin group had higher adiponectin concentration and lower leptin/adiponectin-ratio compared to the insulin group, but there were no significant differences in adiposity, body composition, liver fat, or inflammation markers between the two groups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Environmental Sciences
Alexandra Jurgilevich, Janina Kayhko, Aleksi Rasanen, Saara Porsti, Hanna Lagstrom, Jukka Kayhko, Sirkku Juhola
Summary: Climate change will have adverse impacts on human health, especially in cities. While direct impacts are well-studied, the indirect and deferred impacts remain poorly understood. Factors moderating these impacts have received little attention, despite their importance for adaptation. To address this gap, a conceptual framework was developed to understand the pathways and factors influencing the severity of climate-related health impacts in urban environments. This framework provides valuable insights for anticipatory adaptation strategies and highlights the need for an integrated systemic approach to address multiple health risks.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Ville-Petteri Makinen, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This observational study examines the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR), and circulating metabolomics. It uses longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. The results show that age-associated weight variation in adults between 24 and 49 manifests as temporal divergence in BMI and uniform progression of WHR.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Allergy
Minna Lukkarinen, Pirkka V. Kirjavainen, Katri Backman, Carlos Gonzales-Inca, Brandon Hickman, Sampo Kallio, Hasse Karlsson, Linnea Karlsson, Leea Keski-Nisula, Laura S. Korhonen, Katri Korpela, Mikael Kuitunen, Anna Kaarina Kukkonen, Niina Kayhko, Hanna Lagstrom, Heikki Lukkarinen, Ville Peltola, Jaana Pentti, Anne Salonen, Erkki Savilahti, Pauli Tuoresmaki, Martin Taubel, Jussi Vahtera, Willem M. de Vos, Juha Pekkanen, Anne M. Karvonen
Summary: This study evaluated the impact of land cover and greenness around homes on the development of doctor-diagnosed eczema in children by the age of 2 years. The results showed that greenness around the home during early childhood does not protect against eczema, but exposure to coniferous and mixed forests may increase the risk of eczema.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaisa Kaseva, Irinja Lounassalo, Xiaolin Yang, Tuomas Kukko, Harto Hakonen, Janne Kulmala, Katja Pahkala, Suvi Rovio, Mirja Hirvensalo, Olli Raitakari, Tuija H. Tammelin, Kasper Salin
Summary: This study examined the relationship between active commuting to school in childhood and adolescence and active commuting to work and overall physical activity in adulthood. The findings showed that active commuting in childhood was associated with higher levels of leisure-time physical activity and daily steps in adulthood. These results suggest that promoting active commuting from an early age can contribute to physical activity in adulthood.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Kristin Suorsa, Tuija Leskinen, Suvi Rovio, Harri Niinikoski, Jaana Pentti, Jaakko Nevalainen, Olli J. Heinonen, Hanna Lagstrom, Antti Jula, Jorma Viikari, Tapani Ronnemaa, Olli Raitakari, Sari Stenholm, Katja Pahkala
Summary: This study aimed to investigate weekday and weekend physical activity patterns among young adults and examine the correlates of these patterns. The results showed significant heterogeneity in physical activity patterns across the week among young adults. Adolescent leisure time physical activity was associated with physical activity patterns in young adulthood, and women were more likely to belong in the more physically active groups. Education, work status, and occupation were also associated with different physical activity patterns.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Public, Environmental & Occupational Health
Tomi T. Laitinen, Emma Saha, Katja Pahkala, Noora Kartiosuo, Joel Nuotio, Hanna Lagstrom, Jorma Viikari, Tapani Ronnemaa, Antti Jula, Olli Raitakari, Harri Niinikoski
Summary: This study aimed to investigate the long-term associations between breastfeeding duration and lipid levels in children. The results showed that infants who received breast milk at seven months had higher levels of HDL cholesterol, non-HDL cholesterol, and total cholesterol compared to those who did not receive breast milk. However, there were no consistent differences in lipid levels among different breastfeeding duration groups from two to 20 years of age.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Miia Lehtovirta, Katja Pahkala, Suvi P. Rovio, Costan G. Magnussen, Tomi T. Laitinen, Harri Niinikoski, Hanna Lagstrom, Jorma S. A. Viikari, Tapani Ronnemaa, Antti Jula, Mika Ala-Korpela, Olli T. Raitakari
Summary: This study investigates the associations between passive tobacco smoke exposure and daily smoking with metabolic measures indicative of increased cardio-metabolic risk. The results suggest that both passive and active tobacco smoke exposures during childhood and adolescence are detrimental to cardiovascular health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Noora Houttu, Chouaib Benchraka, Mrunalini Lotankar, Ella Muhli, Harri Niinikoski, Leo Lahti, Kirsi Laitinen
Summary: This study investigated the relationship between gut microbiota during pregnancy and the development of prediabetes within two years postpartum, and found that certain bacterial species were associated with prediabetes.
ACTA DIABETOLOGICA
(2023)
