期刊
TRENDS IN NEUROSCIENCES
卷 38, 期 6, 页码 336-344出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.04.007
关键词
long-term potentiation; heterosynaptic plasticity; homeostatic plasticity; reconsolidation; protein synthesis; protein degradation
资金
- Pfizer-Fonds de Recherche Quebec-Sante (FRQS) Innovation Fund Award
- Canadian Institutes of Health Research grant [MOP 12942]
- Catherine Bushnell Pain Research Fellowship from Louise and Alan Edwards Foundation
Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength.
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