Review
Genetics & Heredity
Zhengyu Cai, Teng Long, Yaochao Zhao, Ruixin Lin, You Wang
Summary: Osteoarthritis is a disease influenced by both genetic and environmental factors, with epigenetics playing a significant role in its pathogenesis. Recent research has focused on DNA methylation, histone modification, and non-coding RNAs, but further exploration of the interactions between genetics, environmental variables, and epigenetics is needed.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Hui Liu, Huimin Ma, Yang Li, Hua Zhao
Summary: This article reviews the current research status of epigenetic modifications in cervical cancer, including DNA methylation, histone modification, noncoding RNA regulation, and chromatin regulation. The functions and molecular mechanisms of these modifications in the occurrence and progression of cervical cancer are also discussed. This review provides new ideas for early screening, risk assessment, molecular targeted therapy, and prognostic prediction of cervical cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Genetics & Heredity
Haishuang Tang, Zhangwei Zeng, Chenghao Shang, Qiang Li, Jianmin Liu
Summary: Atherosclerosis is a complex pathological process involving various cell types and is considered a chronic inflammatory disease. Recent studies have shown the significant role of epigenetic regulation in atherosclerosis, offering new perspectives for researching mechanisms and identifying therapeutic targets.
FRONTIERS IN GENETICS
(2021)
Review
Nanoscience & Nanotechnology
Qinglin Sun, Tianyu Li, Yang Yu, Yang Li, Zhiwei Sun, Junchao Duan
Summary: The toxicological effects of nanomaterials on health and the environment are gradually attracting attention due to the epigenetic alterations they cause, including DNA methylation, noncoding RNA expression, and histone modifications. These alterations can contribute to the onset and development of various diseases and serve as potential biomarkers for early diagnosis and prevention.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Taixiong Xue, Xingyu Qiu, Hongyao Liu, Cailing Gan, Zui Tan, Yuting Xie, Yuxi Wang, Tinghong Ye
Summary: Fibrosis, a common process of chronic inflammatory diseases, leads to scar formation and functional failure in organs. Epigenetic mechanisms play a crucial role in fibrosis, involving DNA methylation, histone modification, ncRNAs, and m6A modification. Targeted therapy based on epigenetics holds great potential for treating fibrosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Allergy
Sunita Sharma, Ivana Yang, David A. Schwartz
Summary: This review examines the relationship between asthma and three key epigenetic processes: DNA methylation, modification of histone tails, and noncoding RNAs. Epigenetic marks play an important role in the pathogenesis of asthma and can serve as therapeutic targets and biomarkers. There are future directions for studying immune regulation in asthma and investigating epigenetics in allergic airway disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Horticulture
Sadaruddin Chachar, Muzafaruddin Chachar, Adeel Riaz, Aamir Ali Shaikh, Xiulan Li, Xiaoxue Li, Changfei Guan, Pingxian Zhang
Summary: Our era has witnessed significant advancements in plant epigenetics, with recent discoveries of RNA chemical modifications playing a role in gene translation efficiency. The application of epigenetic modifications in horticultural plants has shown promise in studying processes like fruit development, grafting, and bud dormancy. This review highlights the importance of understanding epigenetic regulation mechanisms in plants and the potential for future innovations in computational techniques for research in this field.
SCIENTIA HORTICULTURAE
(2022)
Review
Biochemistry & Molecular Biology
Maochao Luo, Xingyue Yang, Hai-Ning Chen, Edouard C. Nice, Canhua Huang
Summary: Colorectal cancer is a leading cause of cancer-related deaths globally, and epigenetic regulation has been shown to play an important role in CRC drug resistance. The reversibility of epigenetic alterations provides novel therapeutic strategies to overcome drug resistance.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Cell Biology
Luke Twenhafel, DiAnna Moreno, Trista Punt, Madeline Kinney, Rebecca Ryznar
Summary: Osteosarcoma is a common malignant bone tumor in children and adolescents. Despite improvements in clinical outcomes, early detection is crucial for better survival rates and reducing the need for debilitating treatments like amputations. Research in the field of epigenetics, focusing on changes in genetic expression above the genome, shows potential for understanding and improving the treatment of osteosarcoma.
Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Oncology
Wen Zheng, Jia Guo, Zhang-Suo Liu
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, influenced by genetic and environmental factors. Epigenetic modifications play a crucial role in DKD development and may offer new therapeutic avenues for intervention.
CLINICAL EPIGENETICS
(2021)
Review
Chemistry, Medicinal
Pia Loren, Nicolas Saavedra, Kathleen Saavedra, Tomas Zambrano, Patricia Moriel, Luis A. Salazar
Summary: Cisplatin, an antineoplastic drug, is most notably known for its nephrotoxicity among various side effects. Recent research shows that epigenetic regulation plays a key role in cisplatin-induced nephrotoxicity by altering different signaling pathways leading to cell death. Despite the ongoing development in this field, it offers new strategies for the diagnosis and treatment of diseases.
Article
Biochemistry & Molecular Biology
Shashi Kant Tiwari, Brashket Seth, Swati Agarwal, Anuradha Yadav, Madhumita Karmakar, Shailendra Kumar Gupta, Vinay Choubey, Abhay Sharma, Rajnish Kumar Chaturvedi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biology
Abhay Sharma
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Review
Neurosciences
Abhay Sharma
CURRENT NEUROPHARMACOLOGY
(2016)
Editorial Material
Neurosciences
Abhay Sharma
CURRENT NEUROPHARMACOLOGY
(2016)
Article
Cell Biology
Abhay Sharma
MECHANISMS OF AGEING AND DEVELOPMENT
(2017)
Article
Biochemistry & Molecular Biology
Pinreddy Karunakar, Ameek Bhalla, Abhay Sharma
Article
Biotechnology & Applied Microbiology
Manoj Teltumbade, Ameek Bhalla, Abhay Sharma
Article
Biochemistry & Molecular Biology
Abhay Sharma
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Article
Biochemistry & Molecular Biology
Anil K. Giri, Gauri Prasad, Khushdeep Bandesh, Vaisak Parekatt, Anubha Mahajan, Priyanka Banerjee, Yasmeen Kauser, Shraddha Chakraborty, Donaka Rajashekar, Abhay Sharma, Sandeep Kumar Mathur, Analabha Basu, Mark I. McCarthy, Nikhil Tandon, Dwaipayan Bharadwaj
MOLECULAR GENETICS AND GENOMICS
(2020)
Article
Psychiatry
P. N. Suresh Kumar, Abhay Sharma, Chittaranjan Andrade
ASIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Genetics & Heredity
Abhay Sharma
Summary: An integrative analysis of existing data suggests that BCG vaccine may induce long-lasting transcriptomic changes that mimic viral infections and oppose them by modulating antiviral defense responses. These durability and mechanistic insights highlight potential safety concerns associated with the indiscriminate use of the vaccine in COVID-19.
Letter
Genetics & Heredity
Abhay Sharma
Article
Genetics & Heredity
Abhay Sharma
Summary: An analysis of gene expression in severe COVID-19 patients and cells treated with dexamethasone supports the hypothesis that glucocorticoids have broad anti-inflammatory activities. The gene signature related to TNF-α, IL-1β, IFN-γ signaling in severe COVID-19 patients differentiates them from the gene regulation seen with dexamethasone treatment, which does not involve IL-6 signaling.
Article
Genetics & Heredity
Abhay Sharma
ENVIRONMENTAL EPIGENETICS
(2016)