Article
Pediatrics
Wenjie Ma, Zhongqiu Wei, Jiayin Guo, Lijuan Lu, Jingjing Li, Jiehao Cai, Xiangshi Wang, Hailing Chang, Zhuoying Huang, Xiang Guo, Qirong Zhu, Jin Xu, Mei Zeng
Summary: This study evaluated the effectiveness of a live oral pentavalent rotavirus vaccine (RV5) in Shanghai, China. The results showed that a 3-dose vaccination of RV5 provided 85% effectiveness against mild to moderate rotavirus gastroenteritis among children aged 14 weeks to <= 4 years and 97% effectiveness among children aged 14 weeks to <= 2 years.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Amir Klivitsky, Salam Algabria, Gideon Paret, Nadav Michaan, Lior Goldberg, Ora Halutz, Galia Grisaru-Soen
Summary: The introduction of the Rotavirus vaccine into the Israeli National Immunisation Programme significantly reduced hospital admissions due to acute gastroenteritis and Rotavirus gastroenteritis in children under 5 years old. However, Rotavirus remains the most common pathogen for hospital admissions due to AGE in this age group.
Article
Immunology
Rachel M. Burke, Shuman Shih, Chao Agnes Hsiung, Catherine Yen, Baoming Jiang, Umesh D. Parashar, Jacqueline E. Tate, Fang-Tzy Wu, Yhu-Chering Huang
Summary: Although Taiwan did not include rotavirus vaccines in the national immunization schedule, the study found that the vaccines still significantly reduced pediatric hospitalization rates associated with rotavirus.
Article
Immunology
Anvar Nazurdinov, Zafarjon Azizov, Manija Mullojonova, Umeda Sadykova, Liudmila Mosina, Simarjit Singh, Sudoba Suleymonova, Farida Tishkova, Dovile Videbaek, Margaret M. Cortese, Danni S. Daniels, Rachel M. Burke
Summary: The study assessed the impact of rotavirus vaccine introduction on the disease burden among children in Tajikistan. It found that the introduction of rotavirus vaccine significantly reduced the hospitalization rate and rotavirus positivity among children. The study also estimated the vaccine effectiveness in Tajik children.
Article
Immunology
Rachel M. Burke, Holly C. Groom, Allison L. Naleway, Eric M. Katz, Bianca Salas, Claire P. Mattison, Judy Donald, Laura Tsaknaridis, Christianne Biggs, Michael D. Bowen, Jacqueline E. Tate, Umesh D. Parashar, Mark Schmidt, Aron J. Hall
Summary: The study demonstrates the high effectiveness of rotavirus vaccination in protecting children from mild to severe diseases. By utilizing different case definitions, the study further confirms the effectiveness of rotavirus vaccination in preventing qRT-PCR-defined illnesses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Chimwemwe Mhango, Jonathan J. Mandolo, End Chinyama, Richard Wachepa, Oscar Kanjerwa, Chikondi Malamba-Banda, Prisca B. Matambo, Kayla G. Barnes, Chrispin Chaguza, Isaac T. Shawa, Martin M. Nyaga, Daniel Hungerford, Umesh D. Parashar, Virginia E. Pitzer, Arox W. Kamng'ona, Miren Iturriza-Gomara, Nigel A. Cunliffe, Khuzwayo C. Jere
Summary: The diversity of G and P genotypes did not change significantly after the introduction of rotavirus vaccine in Malawi, but there was an increase in P genotype diversity in children older than 12 months. G3 rotaviruses reemerged and became the predominant genotype from 2017 onwards, replacing G1P[8] and G2P[4].
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Kei Kozawa, Yuki Higashimoto, Yoshiki Kawamura, Hiroki Miura, Takumi Negishi, Fumihiko Hattori, Masaru Ihira, Satoshi Komoto, Koki Taniguchi, Tetsushi Yoshikawa
Summary: This study investigated the molecular epidemiology of rotavirus (RV) among different groups of RV gastroenteritis (RVGE) patients in Japan who received different RV vaccines. The clinical features of the RVGE patients were compared among the groups. Results showed that the severity of illness was significantly lower in vaccinated patients compared to those who were not vaccinated.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Alice Britoh Mlan, Rachel M. Burke, Hamidou Kone, Catherine Boni-Cisse, Rebecca N'Guessan, Flore Zaba, Lepri Nicaise Aka, Kofi N'Zue, San Koffi Adom, Sie Kabran Kouadio, Armel Bherat Kouadio, Syndou Meite, Stephane Koffi, Hortense Faye-Kette, Keith Shaba, Bernard Ntsama, Joseph Biey, Negar Aliabadi, Jason M. Mwenda, Umesh D. Parashar, Jacqueline E. Tate
Summary: Cote d'Ivoire introduced rotavirus vaccine in March 2017 and conducted surveillance at a hospital in Abidjan. The study found that the introduction of the vaccine resulted in a 51% decline in rotavirus-related hospitalizations among children <5 years old, and changes in age distribution and disease severity among rotavirus-positive children.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Tintu Varghese, Gagandeep Kang, Andrew Duncan Steele
Summary: Rotavirus is a major cause of child mortality, especially in low-income countries with limited healthcare access. The efficacy of rotavirus vaccines is lower in low-income settings compared to high-income populations. Despite lower efficacy, rotavirus vaccines significantly reduce diarrheal disease and mortality, and are cost-effective in countries with a high burden. Evaluating the effectiveness and cost-benefit of rotavirus vaccines is crucial for introducing new vaccines or switching vaccine products in resource-limited countries.
Article
Pediatrics
Madhu Gupta, Arun Bansal, Adarsh Bansal, Shivani Aloona, Monica Rana, Jayashree Muralidharan, Ravi P. Kanojia, Kushaljit Singh Sodhi, Akshaya Saxena, Mini P. Singh, Bhavneet Bharti, Nayana P. Nair, Varunkumar Thiyagarajan
Summary: The study revealed a high burden of rotaviral acute gastroenteritis in under-five children in north Indian states, with prevalent strains being G3P[8], G1P[8], and G2P[4], along with mixed strains found in some stool samples. These findings are important for assessing the impact of rotavirus vaccine on the severity of acute gastroenteritis and the evolution of strains post-vaccine introduction in the Universal Immunization Program.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Rachel M. Burke, Jacqueline E. Tate, Umesh D. Parashar
Summary: Rotavirus vaccines have been widely introduced in 106 countries globally, demonstrating effectiveness against severe disease and mortality with a favorable benefit-risk profile. Ongoing research aims to understand geographic disparities in vaccine effectiveness to optimize strategies worldwide.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Louisa Pollock, Aisleen Bennett, Khuzwayo C. Jere, Jonathan Mandolo, Queen Dube, Naor Bar-Zeev, Robert S. Heyderman, Nigel A. Cunliffe, Miren Iturriza-Gomara
Summary: Low plasma RV-specific IgA is strongly associated with rotavirus vaccine failure in Malawian infants. This study provides further evidence that RV-specific IgA is a marker of protection, although the question of reduced rotavirus vaccine efficacy in low-income countries remains unclear.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Jason M. Mwenda, Benjamin D. Hallowell, Umesh Parashar, Keith Shaba, Joseph Nsiari-Muzeyi Biey, Goitom Gebremedhin Weldegebriel, Gilson Kipese Paluku, Bernard Ntsama, Aboubacar N'diaye, Isah Mohammed Bello, Ado Mpia Bwaka, Felicitas R. Zawaira, Richard Mihigo, Jacqueline E. Tate
Summary: Rotavirus is a leading cause of acute gastroenteritis among children globally. The introduction of rotavirus vaccines has led to a significant reduction in the proportion of hospitalized AGE cases that are positive for rotavirus, showing a consistent decline. The impact of rotavirus vaccines has been well-demonstrated in countries where the vaccine has been introduced.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Assucenio Chissaque, Rachel M. Burke, Esperanca L. Guimaraes, Filomena Manjate, Arsenio Nhacolo, Jorfelia Chilaule, Benilde Munlela, Percina Chirinda, Jeronimo S. Langa, Idalecia Cossa-Moiane, Elda Anapakala, Adilson Fernando Loforte Bauhofer, Marcelino Garrine, Eva D. Joao, Julia Sambo, Luzia Goncalves, Goitom Weldegebriel, Keith Shaba, Isah Mohammed Bello, Jason M. Mwenda, Umesh D. Parashar, Jacqueline E. Tate, Inacio Mandomando, Nilsa de Deus
Summary: This study evaluated the effectiveness of Rotarix (R) vaccine in hospitalized children with acute gastroenteritis in Mozambique. The results showed that the vaccine was moderately effective with a VE of 52.0% in children aged 6-11 months and -24.0% in children aged 12-23 months. The VE was lower in stunted children.
Article
Immunology
Charlotte M. Gower, Julia Stowe, Nick J. Andrews, Jake Dunning, Mary E. Ramsay, Shames N. Ladhani
Summary: There were significant reductions in laboratory-confirmed rotavirus infections and all-cause acute gastroenteritis hospitalizations across all age groups in the UK five years after the introduction of rotavirus vaccination, with reductions of 69-83% and 12-35%, respectively. An estimated 24,474 to 49,278 hospitalizations were averted annually.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Marie R. Griffin, Geoffrey A. Weinberg, Peter G. Szilagyi, Mary A. Staat, Daniel C. Payne, John V. Williams
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2018)
Article
Pediatrics
Geoffrey A. Weinberg
PEDIATRICS IN REVIEW
(2018)
Article
Pediatrics
Negar Aliabadi, Mary E. Wikswo, Jacqueline E. Tate, Margaret M. Cortese, Peter G. Szilagyi, Mary Allen Staat, Geoffrey A. Weinberg, Natasha B. Halasa, Julie A. Boom, Rangaraj Selvarangan, Janet A. Englund, Parvin H. Azimi, Eileen J. Klein, Mary E. Moffatt, Christopher J. Harrison, Leila C. Sahni, Laura S. Stewart, David I. Bernstein, Umesh D. Parashar, Daniel C. Payne
Letter
Hematology
Suzie Noronha, Geoffrey A. Weinberg, Brittney Sorensen, Andrew G. Evans, Neil Blumberg
Article
Public, Environmental & Occupational Health
Stephanie A. Kujawski, Claire M. Midgley, Brian Rha, Joana Y. Lively, W. Allan Nix, Aaron T. Curns, Daniel C. Payne, Janet A. Englund, Julie A. Boom, John Williams, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Eileen J. Klein, Leila C. Sahni, Marian G. Michaels, Lynne Shelley, Monica McNeal, Christopher J. Harrison, Laura S. Stewart, Adriana S. Lopez, Janell A. Routh, Manisha Patel, M. Steven Oberste, John T. Watson, Susan Gerber
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2019)
Article
Infectious Diseases
Brian Rha, Joana Y. Lively, Janet A. Englund, Mary A. Staat, Geoffrey A. Weinberg, Rangaraj Selvarangan, Natasha B. Halasa, John Williams, Julie A. Boom, Leila C. Sahni, Marian G. Michaels, Laura S. Stewart, Christopher J. Harrison, Peter G. Szilagyi, Monica M. McNeal, Eileen J. Klein, Bonnie Strelitz, Kirsten Lacombe, Elizabeth Schlaudecker, Mary E. Moffatt, Jennifer E. Schuster, Barbara A. Pahud, Gina Weddle, Robert W. Hickey, Vasanthi Avadhanula, Mary E. Wikswo, Aron J. Hall, Aaron T. Curns, Susan Gerber, Gayle Langley
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Virology
William R. Otto, Daryl M. Lamson, Gabriel Gonzalez, Geoffrey A. Weinberg, Nicole D. Pecora, Brian T. Fisher, Kirsten St George, Adriana E. Kajon
Summary: HAdV-D56, a novel adenovirus, has been circulating globally since the late 1950s. Recent fatal cases of neonatal sepsis in the United States were associated with infection by HAdV-D strains.
Article
Infectious Diseases
Mark W. Tenforde, Angela P. Campbell, Marian G. Michaels, Christopher J. Harrison, Eileen J. Klein, Janet A. Englund, Rangaraj Selvarangan, Natasha B. Halasa, Laura S. Stewart, Geoffrey A. Weinberg, John Williams, Peter G. Szilagyi, Mary A. Staat, Julie A. Boom, Leila C. Sahni, Monica N. Singer, Parvin H. Azimi, Richard K. Zimmerman, Monica M. McNeal, H. Keipp Talbot, Arnold S. Monto, Emily T. Martin, Manjusha Gaglani, Fernanda P. Silveira, Donald B. Middleton, Jill M. Ferdinands, Melissa A. Rolfes
Summary: A study conducted in nine US hospitals revealed that during the influenza seasons from 2015-2016 to 2017-2018, 50% of children with acute respiratory illness (ARI) received clinician-initiated testing for influenza, while 35% of cases remained undiagnosed due to lack of clinician-initiated testing. Significant variations in testing practices were observed across different hospital sites.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Infectious Diseases
Constance E. Ogokeh, Angela P. Campbell, Leora R. Feldstein, Geoffrey A. Weinberg, Mary A. Staat, Monica M. McNeal, Rangaraj Selvarangan, Natasha B. Halasa, Janet A. Englund, Julie A. Boom, Parvin H. Azimi, Peter G. Szilagyi, Christopher J. Harrison, John Williams, Eileen J. Klein, Laura S. Stewart, Leila C. Sahni, Monica N. Singer, Joana Y. Lively, Daniel C. Payne, Manish Patel
Summary: The study found that parental report of influenza vaccination history was sensitive but not as specific compared with documented records. However, vaccine effectiveness against influenza-associated hospitalizations did not differ substantially when using either source of vaccination history.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Infectious Diseases
Leora R. Feldstein, Constance Ogokeh, Brian Rha, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Janet A. Englund, Julie A. Boom, Parvin H. Azimi, Peter G. Szilagyi, Monica McNeal, Christopher J. Harrison, John Williams, Eileen J. Klein, Leila C. Sahni, Monica N. Singer, Joana Y. Lively, Daniel C. Payne, Alicia M. Fry, Manish Patel, Angela P. Campbell
Summary: This study estimated the vaccine effectiveness for preventing influenza hospitalizations among children in the US, finding that fully vaccinated children had a moderate level of protection against influenza-associated hospitalizations, especially against the A(H1N1)pdm09 virus. These results highlight the importance of annual influenza vaccination in preventing severe influenza illness.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Pediatrics
Randall S. Porter, Marjorie J. Arca, Geoffrey A. Weinberg, Michael H. Livingston
Summary: A 14-year-old healthy girl presented with left breast pain and erythema, and was treated with antibiotics and warm compresses. She recovered well with no significant scarring to the breast after a four-month course of treatment.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Infectious Diseases
Geoffrey A. Weinberg
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Infectious Diseases
Geoffrey A. Weinberg
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Pediatrics
Brian C. Ayers, Geoffrey A. Weinberg, Mary Caserta, Amy Kauffman, Derek Wakeman
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2019)
Article
Immunology
Stephanie Albin-Leeds, Juliana Ochoa, Harshna Mehta, Beth H. Vogel, Michele Caggana, Vincent Bonagura, Heather Lehman, Mark Ballow, Arye Rubinstein, Subhadra Siegel, Leonard Weiner, Geoffrey A. Weinberg, Charlotte Cunningham-Rundles
CLINICAL IMMUNOLOGY
(2017)