期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 3, 页码 126-133出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2015.01.005
关键词
evolutionary rescue; chemotherapy; antibiotics; mutant selection window
资金
- Natural Sciences and Engineering Research Council of Canada
- Society in Science-Branco Weiss Fellowship
- Marie Curie IIF Fellowship
- National Institute of General Medical Sciences [R01GM089932]
The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.
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