Review
Medicine, General & Internal
Agnieszka Baranska, Wieslaw Kanadys, Artur Wdowiak, Maria Malm, Agata Blaszczuk, Urszula Religioni, Anita Wdowiak-Filip, Malgorzata Polz-Dacewicz
Summary: This report evaluated the association between in utero exposure to paracetamol and the risk of developing respiratory disorders such as asthma and wheeze after birth. The study included 330,550 women, and the results showed a significant increased risk of asthma and wheezing in children whose mothers were exposed to paracetamol during pregnancy. Therefore, caution should be exercised when using paracetamol during pregnancy, with the lowest effective dose and shortest duration of use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Irene Sartini, Beata Lebkowska-Wieruszewska, Malgorzata Gbylik-Sikorska, Konrad Pietruk, Aleksandra Krawczyk, Anna Gajda, Andrzej Lisowski, Amnart Poapolathep, Mario Giorgi
Summary: This study aimed to evaluate the pharmacokinetics of acetaminophen (APAP) in geese after intravenous and oral administration, and to assess its potential toxicity in various tissues. The results showed that oral administration of APAP resulted in incomplete absorption and slight accumulation in the lung and liver of geese. Tissue alterations were observed in the liver, but no signs of toxicity were found in other tested organs.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Review
Allergy
Dwan Price, Kira M. Hughes, Francis Thien, Cenk Suphioglu
Summary: Identifying characteristics of at-risk individuals can help clinical professionals develop suitable and personalized treatment plans to prevent future loss of life.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Zeyan Liew, Andreas Ernst
Summary: Recent studies have found that maternal use of acetaminophen during pregnancy is associated with increased risks of asthma, neurodevelopmental disorders, behavioral problems, and genital malformations in children, possibly due to oxidative stress and inflammation. Methodological challenges such as confounding and measurement errors were discussed, with novel statistical methods and research designs introduced to mitigate these issues. Research on causal and non-causal mechanisms explaining these associations should be a priority.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2021)
Review
Respiratory System
Kira Morgan Hughes, Dwan Price, Cenk Suphioglu
Summary: Australia has a high rate of allergic rhinitis, also known as hay fever, which affects up to 30% of the population. The increase in atmospheric concentration of airborne allergens due to climate change has led to more frequent extreme weather events and epidemic thunderstorm asthma, posing a potential threat to susceptible populations. The underlying factors influencing these epidemics are still unknown.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Multidisciplinary Sciences
Francesco De Pretis, Juergen Landes
Summary: Real World Evidence (RWE) and its uses are increasingly important in medical research and inference, with the 21st Century Cures Act in the US allowing the introduction of RWE for risk-benefit assessments of medical interventions. This article introduces an evidence appraisal aggregation algorithm called EA(3) that utilizes the softmax function for evaluating RWE and supporting causal inferences within a Bayesian decision making framework.
Article
Environmental Sciences
Zeyan Liew, Yuying Yuan, Qi Meng, Ondine S. von Ehrenstein, Xin Cui, Marie E. S. Flores, Beate Ritz
Summary: The study found that prenatal exposure to acetaminophen in pregnant women is associated with higher risks for asthma diagnosis, wheezing, and dry cough in children. This risk is particularly evident in Black/African American and Asian/Pacific Islander children, as well as when mothers experience high psychosocial stress during pregnancy. Further research is needed to assess the relationship between prenatal acetaminophen exposure and other social/environmental stressors with clinically confirmed outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Respiratory System
Dwan Price, Kira M. Hughes, Dulashi Withanage Dona, Philip E. Taylor, David A. V. Morton, Svetlana Stevanovic, Francis Thien, Jason Choi, Paul Torre, Cenk Suphioglu
Summary: This study found that epidemic thunderstorm asthma events are associated with high pollution levels, high humidity, low temperatures, and low ozone concentrations. The results emphasize the importance of including ruptured pollen and time-resolved analysis to forecast epidemic thunderstorm asthma events and save lives.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Medicine, Research & Experimental
William J. Sheehan, Ian M. Paul, David T. Mauger, James N. Moy, Stanley J. Szefler, Daniel J. Jackson, Anne M. Fitzpatrick, Michael D. Cabana, Ronina Covar, Rachel G. Robison, Wanda Phipatanakul
Summary: The study showed that over 85% of doses of acetaminophen or ibuprofen were adherence to the protocol of blinded study medications, while less than 15% were deviations to OTC medications. Better adherence was observed in the ibuprofen group compared to the acetaminophen group. In individual cases, over 75% of participants remained fully adherent by not receiving any OTC medications.
CONTEMPORARY CLINICAL TRIALS
(2021)
Editorial Material
Pediatrics
Kristin L. Santoro, William Yakah, Pratibha Singh, David Ramiro-Cortijo, Esli Medina-Morales, Steven D. Freedman, Camilia R. Martin
Summary: This study investigated the association between certain xenobiotic metabolites in breast milk and the prevalence of bronchopulmonary dysplasia and retinopathy of prematurity in extremely preterm infants. The findings revealed significant associations between acetaminophen metabolites and increased odds of these disorders, as well as associations between metabolites of certain food products, benzoate, and caffeine and decreased odds.
JOURNAL OF PEDIATRICS
(2022)
Review
Public, Environmental & Occupational Health
Jamal Hisham Hashim, Mohammad Adam Adman, Zailina Hashim, Mohd Firdaus Mohd Radi, Soo Chen Kwan
Summary: The COVID-19 pandemic in Malaysia has caused over 100 deaths and two waves of cases, with the first wave seeing no fatalities and full recoveries, while the second wave was largely driven by the Sri Petaling Tabligh cluster. The country implemented a Movement Control Order to contain the spread of the virus, resulting in economic losses but also successful control of the outbreak. Vaccine development is seen as the best approach to achieving herd immunity against COVID-19.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Christoph Buehrer, Stefanie Endesfelder, Till Scheuer, Thomas Schmitz
Summary: Paracetamol, commonly used during pregnancy for fever and pain, is suspected to increase the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring by about 25% according to epidemiological studies. However, there are still unknown factors and mechanisms that require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Michael Barnett, Greg Buchak, Constantine Yannelis
Summary: This study examines how policymakers respond to uncertainty in key epidemiological and economic parameters during a pandemic. The findings show that uncertainty about disease severity leads to stricter and longer-lasting quarantines, while uncertainty about the economic costs of mitigation leads to less stringent quarantines. Overall, risk-averse planners adopt stronger mitigation measures to avoid the potentially catastrophic consequences of underestimating the pandemic.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Obstetrics & Gynecology
Shadi Mehraban, Sepide Nematian, Shadan S. Mehraban, Samantha Petrucci, Gabrielle Tricorico, Zarina Parnas, Lenny Shats, Tomi Kanninen, Michael Moretti, Michael Cabbad, Nisha Lakhi
Summary: This study compared the efficacy of intravenous and oral acetaminophen in treating intrapartum maternal fever and found no significant differences in time to defervescence, percentage of patients being afebrile, and percent reduction in maternal temperature between the two routes of administration. Additionally, there were no significant differences in histopathological findings, neonatal outcomes, oxidative stress markers, and cytokine levels between intravenous and oral acetaminophen groups.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Allergy
Ambereen S. Farouque, Rae Walker, Bircan Erbas
Summary: The study found that during the 2016 thunderstorm asthma epidemic in Melbourne, general practice (GP) services faced challenges such as personnel, materials, secondary support services, and communication obstacles. Participants had to innovate solutions to deal with the surge in respiratory patients, while also facing resource limitations, lack of information, and communication barriers at an organizational level.
