期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 8, 页码 445-447出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2015.05.001
关键词
microbicide; semen; HIV-1; transmission; vaginal fluid; amyloids
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI027763, R00AI104262] Funding Source: NIH RePORTER
- NIAID NIH HHS [R00 AI104262, R00 AI 104262, P30 AI027763] Funding Source: Medline
Despite potent in vitro efficacy, most topical microbicides fail to effectively prevent HIV transmission. One reason for clinical failure may be that current microbicide testing does not reflect the environment encountered during sexual virus transmission. We discuss how preclinical microbicide development could be improved by more closely mimicking real-life conditions.
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