Article
Obstetrics & Gynecology
Jose Uberos, Ana Campos-Martinez, Aida Ruiz-Lopez, Elizabeth Fernandez-Marin, Jose Luis Garcia-Serrano
Summary: This study investigates the sensitivity and specificity of the NIPE index for detecting physiological changes in VLBW infants during painful procedures. The results show that the accuracy of the NIPE index for diagnosing mild nociceptive stimulation is 73.2%.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Mahla Talebi, Seyedeh Roghayeh Jafarian Amiri, Parvin Aziznejad Roshan, Ali Zabihi, Yadollah Zahedpasha, Mohammad Chehrazi
Summary: This study aimed to investigate the effect of concurrent use of swaddle and sucrose taste on the pain intensity during venous blood sampling in neonates. The results showed that the pain severity was lower in the swaddle-sucrose group compared to other groups.
Article
Pediatrics
Zahra Akbarian Rad, Parvin Aziznejadroshan, Adeleh Saebi Amiri, Hemmat Gholinia Ahangar, Zahra Valizadehchari
Summary: The study findings suggest that stimulation with maternal breast milk odor can effectively reduce pain in preterm infants, indicating its potential use in less invasive procedures.
Article
Pediatrics
Paula L. Hedley, Gitte Hedermann, Christian M. Hagen, Marie Baekvad-Hansen, Henrik Hjalgrim, Klaus Rostgaard, Anna D. Laksafoss, Steen Hoffmann, Jorgen Skov Jensen, Morten Breindahl, Mads Melbye, Anders Hviid, David M. Hougaard, Lone Krebs, Ulrik Lausten-Thomsen, Michael Christiansen
Summary: The study conducted in Denmark found that during the COVID-19 restrictions and lockdown, there was a reduction in extremely preterm birth rate and stillbirth rate, suggesting that these measures may provide some level of protection for pregnant women and fetuses. However, no significant difference was observed in perinatal mortality rates. The observational study does not allow for causal inference, but supports the need for further research to determine if behavioral or social changes in pregnant women can improve pregnancy outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Medicine, General & Internal
Robyn Richards, Jann P. Foster, Kim Psaila
Summary: This study aimed to investigate whether continuous or intermittent bolus intragastric tube feeding affects the incidence and severity of gastro-oesophageal reflux disease in preterm and low birth weight infants. However, no randomized trials meeting the inclusion criteria were found. Well-designed and adequately powered trials are needed in the future.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Elisenda Moliner-Calderon, Sergio Verd, Alfonso Leiva, Gemma Ginovart, Pia Moll-McCarthy, Josep Figueras-Aloy
Summary: This study investigated the relationship between human milk feeding and the use of vasopressors in neonates with sepsis. The results showed that compared to exclusively formula-fed newborns, those fed with human milk had a lower need for vasopressors in the management of neonatal septic shock.
FRONTIERS IN PEDIATRICS
(2023)
Article
Clinical Neurology
Anastasis Georgoulas, Laura Jones, Maria Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi, Kimberley Whitehead
Summary: In this study of 175 infants, unique regulation of sleep-wake states was observed, with particularly long durations of active sleep. Stress and nociception were found to impact sleep durations, especially in preterm infants, highlighting the importance of environmental interventions in promoting healthy sleep patterns.
Article
Obstetrics & Gynecology
Aliisa Laitala, Timo Saarela, Marja Vaarasmaki, Mikko Hallman, Outi Aikio
Summary: The use of paracetamol in pregnancy does not have adverse effects on extremely or very preterm infants and may have acute benefits for preterm infants during perinatal transition.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Pediatrics
Emilie Groulx-Boivin, Mariane Paquette, May Khairy, Marc Beltempo, Roy Dudley, Amaryllis Ferrand, Mireille Guillot, Victoria Bizgu, Jarred Garfinkle
Summary: This study investigated the temporal evolution of post-hemorrhagic ventricular dilatation (PHVD) and compared neurodevelopmental impairments in newborns with different outcomes. The results showed that newborns with persistent PHVD without resolution are at higher risk for neurodevelopmental impairments, which may be due to larger ventricular dilatation.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sevag Hamamah, Andras Hajnal, Mihai Covasa
Summary: Alterations in dopamine neurotransmission are associated with obesity and food preferences. OLETF rats with impaired satiation and obesity have a heightened preference for palatable sweet solutions, increased dopamine release, reduced D2R binding, and increased sensitivity to sucrose reward. Basal and stimulated motor activity in OLETF rats are affected by sucrose consumption, and DAT availability is reduced in the nucleus accumbens shell.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Hongyu Chen, Le Dong
Summary: This study investigated the effect of family integrated care on the prognosis of hospitalized preterm infants. The results showed that family integrated care could shorten the duration of nasogastric tube retention, increase the rate of exclusive breastfeeding and weight gain, and have a positive effect on parents.
Review
Biochemistry & Molecular Biology
Rory J. Heath, Susanna Klevebro, Thomas R. Wood
Summary: The N3 and N6 long chain polyunsaturated fatty acids (LCPUFA) are essential for proper neurodevelopment in early life. This review suggests that feed comprising 0.3% DHA and 0.6% AA may be associated with more positive neurodevelopmental outcomes in premature infants compared to LCPUFA-deplete feed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Elmira Shokri, Talieh Zarifian, Farin Soleimani, Brenda Lessen Knoll, Ziba Mosayebi, Mahdi Noroozi, Kiana Ghasrhamidi, Michelle Pascoe
Summary: Premature infant oral motor intervention combined with music therapy can effectively improve feeding progression and facilitate earlier discharge for premature infants with gestational ages between 26 and 30 weeks.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Martha G. Welch, Philip G. Grieve, Raymond I. Stark, Joseph R. Isler, Robert J. Ludwig, Amie A. Hane, Alice Gong, Umber Darilek, Judy Austin, Michael M. Myers
Summary: This study replicates the findings of a previous trial, demonstrating that Family Nurture Intervention can increase brain activity in a specific region of preterm infants' EEG. This intervention aims to promote emotional connection between mothers and infants, resulting in significant effects on early brain development.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ashok Chandrasekaran, Prakash Amboiram, Umamaheswari Balakrishnan, Thangaraj Abiramalatha, Govind Rao, Shaik Mohammad Shafi Jan, Usha Devi Rajendran, Uma Sekar, Gayathri Thiruvengadam, Binu Ninan
Summary: A randomized controlled trial conducted in India showed that stable preterm infants could maintain non-inferior thermoregulation in a low-cost incubator compared to a standard single-wall incubator, with a higher incubator temperature. The study demonstrated a lower rate of failed thermoregulation and a relatively higher incubator temperature.
Article
Pediatrics
Rhandi Christensen, Vann Chau, Anne Synnes, Ruth E. Grunau, Steven P. Miller
Summary: Neurodevelopmental outcomes in preterm twins are more strongly influenced by environmental factors than genetics. Discordant twin pairs, born earlier with more perinatal morbidities, become more similar in cognitive and language outcomes over time, possibly reflecting the positive impact of early intervention programs or home environment.
PEDIATRIC RESEARCH
(2021)
Article
Developmental Biology
Mia A. McLean, Nikoo Niknafs, Olivia C. Scoten, Cecil M. Y. Chau, Margot MacKay, Joanne Weinberg, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: Children born preterm may exhibit altered sensory processing, with exposure to neonatal pain-related stress potentially leading to more sensory processing problems, especially in girls. Girls may be more susceptible to the effects of neonatal pain-related stress exposure, particularly in relation to hypersensitivity to sensory input.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Pediatrics
Thiviya Selvanathan, Ting Guo, Eddie Kwan, Vann Chau, Rollin Brant, Anne R. Synnes, Ruth E. Grunau, Steven P. Miller
Summary: Small birth head circumference is associated with poorer neurodevelopment outcomes, while small head circumference at discharge is linked to lower scores in motor, cognitive, and language assessments in children with small birth head circumference. Head circumference strongly correlates with total cerebral volume at term-equivalent age, but total cerebral volume is not associated with developmental outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Anne R. Synnes, Julie Petrie, Ruth E. Grunau, Paige Church, Edmond Kelly, Diane Moddemann, Xiang Ye, Shoo K. Lee, Karel O'Brien
Summary: According to this study, FICare did not have a significant impact on cognitive and language delay in very preterm infants, but did show improvements in motor development.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Obstetrics & Gynecology
Christopher McPherson, Ruth E. Grunau
Summary: Chronic pain and agitation in neonates can affect brain development. Oral sweet-tasting solutions should be used carefully to alleviate behavioral responses to mild pain, with the understanding that long-term effects are unknown. Rapid-acting opioids are recommended for premedication in non-emergent endotracheal intubations. Continuous low-dose morphine or dexmedetomidine can be considered for preterm or term neonates experiencing stress during mechanical ventilation or therapeutic hypothermia. Further research is needed on the pharmacokinetics, pharmacodynamics, safety, and efficacy of pharmacological agents for managing mild, moderate, and chronic pain and stress in neonates.
CLINICS IN PERINATOLOGY
(2022)
Article
Pediatrics
Mia A. Mclean, Olivia C. Scoten, Wayne Yu, Xiang Y. Ye, Julie Petrie, Paige T. Church, Amuchou S. Soraisham, Lucia S. Mirea, Joanne Weinberg, Anne R. Synnes, Karel O'Brien, Ruth E. Grunau
Summary: The study evaluates whether implementing Family Integrated Care (FICare) in the neonatal intensive care unit has a positive impact on the physiological and psychological well-being of premature infants and their mothers. The results indicate that FICare lowers maternal physiological stress and improves child behavior.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Min Sheng, Ting Guo, Connor Mabbott, Vann Chau, Anne Synnes, Linda S. de Vries, Ruth E. Grunau, Steven P. Miller
Summary: This study evaluated the relationship between ventricular volume and neurodevelopmental outcomes in children born very preterm. The results showed that ventricular size at birth was associated with cognitive and motor outcomes at 4.5 years, suggesting abnormal white matter maturation in the setting of enlarged ventricular size.
JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Emma G. Duerden, Mia A. Mclean, Cecil Chau, Ting Guo, Margot Mackay, Vann Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: This study found that in extremely preterm neonates born between 24-28 weeks' gestational age, more invasive procedures were associated with poorer sensory processing. Additionally, in the overall cohort, fewer sensory processing problems were correlated with greater thalamic growth between birth and term-equivalent age.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Matthias W. Wagner, Delvin So, Ting Guo, Lauren Erdman, Min Sheng, S. Ufkes, Ruth E. Grunau, Anne Synnes, Helen M. Branson, Vann Chau, Manohar M. Shroff, Birgit B. Ertl-Wagner, Steven P. Miller
Summary: This study aims to predict adverse neurodevelopmental outcomes in very preterm neonates. By using brain MRI and extracting radiomic features, it was found that radiomic features outperformed clinical variables in predicting motor outcomes, and combining the two improved predictive performance.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Natalie Hoi-Man Chan, Anne Synnes, Ruth E. Grunau, Lindsay Colby, Julie Petrie, Tracy Elfring, Lindsay Richter, Leonora Hendson, Rudaina Banihani, Thuy Mai Luu
Summary: Preterm infants are at risk for language delay, and exposure to multiple languages is associated with lower language scores. Primary language at home has a weaker impact on language development.
Article
Neurosciences
Jillian Vinall Miller, Vann Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: This study suggests that supportive maternal behavior can buffer the association between early brain dysmaturation and cognitive and language performance, providing an opportunity to promote optimal neurodevelopment in children born very preterm.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Mia A. McLean, Olivia C. Scoten, Cecil M. Y. Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: The study investigates the association between neonatal pain-related stress and the development of internalizing behaviors in children born very preterm. It also examines whether supportive parenting behaviors and lower parenting stress can attenuate this association.
Article
Medicine, General & Internal
Noha Gomaa, Chaini Konwar, Nicole Gladish, Stephanie H. Au-Young, Ting Guo, Min Sheng, Sarah M. Merrill, Edmond Kelly, Vann Chau, Helen M. Branson, Linh G. Ly, Emma G. Duerden, Ruth E. Grunau, Michael S. Kobor, Steven P. Miller
Summary: This cohort study of very preterm neonates suggests that biological aging may be associated with impaired brain growth and neurodevelopmental outcomes. The associations between epigenetic aging and adverse neonatal brain health warrant further attention.
Article
Psychiatry
Sarah M. Hutchison, Ursula Brain, Ruth E. Grunau, Boris Kuzeljevic, Mike Irvine, Louise C. Masse, Tim F. Oberlander
Summary: Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with increased internalising and anxious behaviours in young children, but it is unclear whether this association persists into early adolescence. Furthermore, the contribution of in utero SSRI exposure versus underlying maternal mood to these associations is not well established.
Article
Pediatrics
Thiviya Selvanathan, Pearl Zaki, Mia A. McLean, Stephanie H. Au-Young, Cecil M. Y. Chau, Vann Chau, Anne R. Synnes, Linh G. Ly, Edmond Kelly, Ruth E. Grunau, Steven P. Miller
Summary: We assessed variability of analgesic use across three tertiary neonatal intensive care units accounting for early-life pain, and determined whether analgesia exposure modifies associations between early-life pain and neurodevelopment.
PEDIATRIC RESEARCH
(2023)