期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 2, 页码 112-120出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.12.003
关键词
Salmonella; immunity; mucosal immunity; immune evasion; inflammation
类别
资金
- National Institutes of Health (NIH) Public Health Service [AI083663, AI101784, AI105374]
- Burroughs Wellcome Fund
- University of California Institute for Mexico
- United States (MEXUS)
- CONACYT (El Consejo Nacional de Ciencia y Tecnologia)
Pathogens have evolved clever strategies to evade and in some cases exploit the attacks of an activated immune system. Salmonella enterica is one such pathogen, exploiting multiple aspects of host defense to promote its replication in the host. Here we review recent findings on the mechanisms by which Salmonella establishes systemic and chronic infection, including strategies involving manipulation of innate immune signaling and inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophages. We also examine recent evidence showing that the oxidative environment and the high levels of antimicrobial proteins produced in response to localized Salmonella gastrointestinal infection enable the pathogen to successfully outcompete the resident gut microbiota.
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