Article
Infectious Diseases
Anne-Sophie Valentin, Sandra Dos Santos, Florent Goube, Remi Gimenes, Marie Decalonne, Laurent Mereghetti, Come Daniau, Nathalie van der Mee-Marquet
Summary: The study evaluated the incidence of sink contamination by MDR bacteria and its association with clinical infections in intensive care units. It found that sink contamination and splashing are common and multifactorial infectious risks.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Sheng-Huei Wang, Kuang-Yao Yang, Chau-Chyun Sheu, Yu-Chao Lin, Ming-Cheng Chan, Jia-Yih Feng, Chia-Min Chen, Chih-Yu Chen, Zhe-Rong Zheng, Yu-Ching Chou, Chung-Kan Peng
Summary: This study investigated the prevalence of CSO AB pneumonia and compared the presentation and outcome with CRAB-associated pneumonia. The prevalence of CSO AB among CRAB pneumonia cases was 13.74%. CSO AB and CRAB groups had similar demographic characteristics and disease severities at initial presentation, but CSO AB group had better clinical outcomes at day 7 with longer ICU stay.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong, Xin Sun
Summary: Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection in intensive care units (ICUs), but the adoption of ventilator-associated event (VAE) surveillance outside the USA is limited. A study in China found that VAE was common in ICU patients with >= 4 ventilator days, and all tiers of VAEs were associated with poor clinical outcomes, including longer hospital stays and increased risk of mortality. These findings emphasize the importance of VAE surveillance and the development of new strategies to prevent VAEs.
Article
Pharmacology & Pharmacy
Luming Zhang, Shaojin Li, Xuehao Lu, Yu Liu, Yinlong Ren, Tao Huang, Jun Lyu, Haiyan Yin
Summary: The study demonstrated that thiamine supplementation may reduce ICU and in-hospital mortality in patients with VAP, suggesting that further clinical trials should be conducted to provide more-solid evidence on its efficacy in improving patient outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nursing
Eman Arafa Hassan, Suad Elsayed Abdelmotalb Elsaman
Summary: Compliance with the ventilator bundle was found to be associated with a decreased risk of ventilator-associated events (VAEs) occurrence. Mechanically ventilated patients had a lower likelihood of experiencing VAEs when receiving the ventilator bundle.
Article
Medicine, General & Internal
Jerome Rambaud, Masoumeh Sajedi, Sally Al Omar, Maryline Chomtom, Michael Sauthier, Simon De Montigny, Philippe Jouvet
Summary: The objective of this study was to develop a predictive model for early diagnosis of ventilator-associated pneumonia (VAP) in a pediatric intensive care unit. Using machine learning and clinical data, a clinical decision support algorithm was developed and showed good accuracy in predicting VAP.
Article
Pharmacology & Pharmacy
Luming Zhang, Shaojin Li, Shiqi Yuan, Xuehao Lu, Jieyao Li, Yu Liu, Tao Huang, Jun Lyu, Haiyan Yin
Summary: Bronchoscopy during invasive mechanical ventilation (IMV) was found to reduce the risk of ICU and in-hospital mortality in patients with ventilator-associated pneumonia (VAP), and this beneficial effect was partially mediated by changes in red blood cell distribution width (RDW) levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Alex R. Schuurman, Robert F. J. Kullberg, Willem Joost Wiersinga
Summary: There has been significant progress in understanding the gut microbiome in health and disease over the past decade. The gut microbiome interacts with the immune system and plays a crucial role in defending the host against pathogens. However, disturbances in the gut microbiome due to disease or interventions like antibiotic treatment can have negative consequences. This review focuses on the potential role of probiotics in the ICU, summarizes evidence from randomized clinical trials, and discusses challenges and future prospects.
Article
Medicine, General & Internal
Youjin Chang, Kyeongman Jeon, Sang-Min Lee, Young-Jae Cho, Young Sam Kim, Yong Pil Chong, Sang-Bum Hong
Summary: This study investigated the occurrence and causative strains of hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP) in Korea, revealing a high burden of multidrug-resistant pathogens and a significant association between the use of appropriate empirical antibiotics and patient prognosis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Respiratory System
Basem Al-Omari, Peter McMeekin, A. Joy Allen, Ahsan R. Akram, Sara Graziadio, Jana Suklan, William S. Jones, B. Clare Lendrem, Amanda Winter, Milo Cullinan, Joanne Gray, Kevin Dhaliwal, Timothy S. Walsh, Thomas H. Craven
Summary: In VAP research, reference standards typically require microbiological confirmation, with BAL culture being the most commonly used reference standard.
BMC PULMONARY MEDICINE
(2021)
Article
Medicine, General & Internal
Paul-Henri Wicky, Claire Dupuis, Charles Cerf, Shidasp Siami, Yves Cohen, Virginie Laurent, Bruno Mourvillier, Jean Reignier, Dany Goldgran-Toledano, Carole Schwebel, Stephane Ruckly, Etienne de Montmollin, Niccolo Buetti, Jean-Francois Timsit
Summary: This study evaluated the prognosis of VAP in severe COVID-19 cases and the impact of relapse, superinfection, and treatment failure on 60-day mortality. The results showed that the incidence of VAP was high and associated with an increased risk of death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Denise Battaglini, Luca Parodi, Raphael Cinotti, Karim Asehnoune, Fabio Silvio Taccone, Giovanni Orengo, Gianluigi Zona, Antonio Uccelli, Giulio Ferro, Michela Robba, Paolo Pelosi, Chiara Robba
Summary: This study aimed to determine the incidence, risk factors, and effects on outcome of ventilator-associated pneumonia (VAP) in acute brain injured patients. The results showed that VAP is common in this population and is associated with male gender, the use of intraparenchymal probe and external ventricular drain, the presence of tracheobronchitis, and therapeutic hypothermia. VAP does not affect mortality but increases ICU length of stay.
RESPIRATORY RESEARCH
(2023)
Article
Infectious Diseases
D-L Pen, G-F Yan, L-Y He, W-L Yan, W-M Chen, J. Liu, J-Y Ying, C-Q Wang, G-P Lu
Summary: This study revealed the significant role of bacterial colonization in ventilator circuits in the development of VAP in mechanically ventilated children. Early identification and decontamination of contaminated ventilator circuits may play a crucial role in preventing VAP.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Health Care Sciences & Services
Ralitsa Raycheva, Vanya Rangelova, Ani Kevorkyan
Summary: This study aims to assess the direct costs of ventilator-associated pneumonia (VAP) in the neonatal intensive care unit (NICU). The findings confirm that prolonged hospital stays due to VAP result in increased hospital costs.
Article
Infectious Diseases
Alain Lepape, Anais Machut, Cedric Bretonniere, Arnaud Friggeri, Charles-Herve Vacheron, Anne Savey
Summary: This study compared healthcare-associated infections acquired in intensive care units (HAI-ICUs) among patients with and without COVID-19 in France in 2020, and compared them with patients before the COVID-19 pandemic. The results showed that the occurrence of ventilator-associated pneumonia (VAP) was significantly higher in the COVID-19 group, and VAP and blood-stream infections (BSIs) were also higher in the non-COVID-19 group compared to the pre-pandemic group. This suggests that managing patients with severe disease during a pandemic carries risks for all patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)