Article
Pediatrics
Brooke Gustafson, Rodney D. Britt Jr, Mariah Eisner, Deepika Narayanan, Mitchell H. Grayson
Summary: This retrospective study identified risk factors associated with the development of wheezing in late preterm infants. Positive family history of asthma, receiving antibiotics during the neonatal period, requiring continuous positive airway pressure for less than 24 hours, and receiving supplemental oxygen during the newborn period were associated with the development of wheezing.
PEDIATRIC PULMONOLOGY
(2023)
Article
Psychiatry
Mareike Ernst, Alexander K. Schuster, Eva Mildenberger, Danielle Otten, Elmar Brahler, Jonas Tesarz, Michael S. Urschitz, Norbert Pfeiffer, Manfred E. Beutel, Achim Fiess
Summary: The associations between preterm birth and later-life mental distress are well-established. However, there is a research gap regarding the influence of psychosocial factors, such as the family context. This study found that parental rearing behavior is significantly associated with both preterm birth characteristics and psychological symptom burden later in life.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Michal Zivan, Iris Morag, Jessica Yarmolovsky, Ronny Geva
Summary: This study investigated attention engagement and pupil dilation in 9-month-old infants, finding that at-risk infants showed a preference for simple stimuli and increased pupil dilation. The preference for simple stimuli was related to an increased risk for social difficulties and decreased engagement duration in face-to-face interactions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pediatrics
Matthew D. Wong, Melissa Neylan, Gordon Williams, Syeda F. Zahir, Jasneek Chawla
Summary: Shorter initial NICU stay was the best predictor of earlier home oxygen cessation. Infants with hypercarbia or a higher CGA at discharge may require more home oxygen and experience more respiratory-related hospital admission in the first 2 years of chronological age.
PEDIATRIC PULMONOLOGY
(2021)
Article
Medicine, General & Internal
Eun Sun Kim, Ee-Kyung Kim, Sae Yun Kim, In Gyu Song, Young Hwa Jung, Seung Han Shin, Han-Suk Kim, Johanna Inhyang Kim, Bung Nyun Kim, Min-Sup Shin
Summary: The study showed that children born extremely preterm have significantly lower cognitive and executive function compared to full-term children, with 37% experiencing cognitive problems. However, except for social immaturity, behavioral issues were not significantly different in the extremely preterm children.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Maxwell Mathias, Jill Chang, Marta Perez, Ola Saugstad
Summary: Oxygen is crucial for cell survival, but excessive oxygen delivery can disrupt growth and development, induce inflammation, and cause oxidative damage. Newborns, especially premature infants, are particularly susceptible to hyperoxic injury due to their immature antioxidant defense system.
Article
Immunology
Camila Salazar-Fernandez, Maria Jose Baeza-Rivera, Marcoantonio Villanueva, Joaquin Alberto Padilla Bautista, Regina M. Navarro, Mariana Pino
Summary: The study found that beliefs about negative consequences of the COVID-19 vaccine and social influence were the main predictors of COVID-19 vaccination intention, while conspiracy beliefs did not predict vaccination intention.
Article
Pediatrics
Prachi E. Shah, Julie Poehlmann, Heidi M. Weeks, Maria Spinelli, Blair Richards, Joohee Suh, Niko Kaciroti
Summary: This study investigates the trajectories of late preterm development from infancy to kindergarten reading and math, as well as predictors of academic resilience and risk. The results show that sensitive parenting and preschool attendance are associated with more optimal development trajectories and academic resilience, while suboptimal development and increased academic risk are not related to these factors.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Gemma Mas-Dalmau, Carmen Villanueva Lopez, Pedro Gorrotxategi Gorrotxategi, Emma Arguelles Prendes, Oscar Espinazo Ramos, Teresa Valls Duran, Maria Encarnacion Gonzalo Alonso, Maria Pilar Cortes Viana, Tatiana Menendez Bada, Marta Esther Vazquez Fernandez, Ana Isabel Perez Hernandez, Laura Munoz Ortiz, Paul Little, Mariam de la Poza Abad, Pablo Alonso-Coello
Summary: The study found that there was no statistically significant difference in symptom duration or severity in children with uncomplicated respiratory infections who received delayed antibiotic prescription (DAP) compared to immediate antibiotic prescription (IAP) or no antibiotic prescription (NAP); however, DAP reduced antibiotic use and gastrointestinal adverse effects.
Article
Multidisciplinary Sciences
Lilly Bogicevic, Marjolein Verhoeven, Anneloes L. van Baar
Summary: This study examined relationships between toddler abilities and attention profiles at 6 years of age, finding that early attention and language abilities could predict attentional functioning in school-age children. Identifying distinct attention profiles early on may be crucial for future research and clinical practices.
Article
Obstetrics & Gynecology
Daiva Bartkeviciene, Ingrida Pilypiene, Danielius Serapinas, Brigita Vaigauskaite, Rasa Aurelija Vankeviciute, Agne Bartkeviciute, Ieva Narkeviciute, Irena Dumalakiene
Summary: This study identified critical levels of IL-6 and TNF-alpha in umbilical cord blood as markers for predicting CNS damage and ROP in preterm infants. IL-6 concentration was found to be related to CNS damage in infants at 36 to 37 weeks, while TNF-alpha and IL-6 levels could predict different stages of ROP.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Medicine, Research & Experimental
Daniel Blumenthal, James A. A. Leonard, Andy Habib, Hengameh Behzadpour, Alexandra Espinel, Diego Preciado
Summary: There has been a notable increase in the number of extremely premature neonates requiring tracheostomy and laryngotracheal reconstruction (LTR). This study aimed to compare the outcomes of LTR in extremely premature infants to those born preterm and term, focusing on decannulation rates, time to decannulation, and complication rates.
Article
Pediatrics
Seha Kamil Saygili, Elif Altinay Kirli, Emre Tasdemir, Nur Canpolat, Salim Caliskan, Lale Sever, Zubeyr Talat, Bulent Onal
Summary: This study identified risk factors for surgical intervention in infants with nephrolithiasis, including stone size larger than 5 mm, stones located in the pelvis, and a history of intensive care unit follow-up. Stone resolution was more likely in patients with stone size <= 5 mm. Surgical intervention was required in 17% of patients, with a higher rate in stones > 5 mm.
PEDIATRIC NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Davide De Francesco, Yair J. Blumenfeld, Ivana Maric, Jonathan A. Mayo, Alan L. Chang, Ramin Fallahzadeh, Thanaphong Phongpreecha, Alex J. Butwick, Maria Xenochristou, Ciaran S. Phibbs, Neda H. Bidoki, Martin Becker, Anthony Culos, Camilo Espinosa, Qun Liu, Karl G. Sylvester, Brice Gaudilliere, Martin S. Angst, David K. Stevenson, Gary M. Shaw, Nima Aghaeepour
Summary: The study introduces a multitask deep neural network model that can predict twelve neonatal morbidities, providing a new data-driven approach to defining prematurity. Analyzing data from 11,594,786 livebirths in California from 1991 to 2012, the model outperformed traditional models in assessing prematurity with better predictive performance.
Article
Pediatrics
Yerin Chung, Suneetha Desiraju, Kopperuncholan Namachivayam, Pierre Guzman, Ling He, Krishnan MohanKumar
Summary: This study comprehensively investigated the hematological changes associated with anemia using a preclinical mouse model. The findings demonstrate that anemia may have an impact on neonatal diseases and provide insights for investigating anemia in preterm infants. The study emphasizes the importance of understanding the pathogenesis of anemia in premature infants.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Amanda Benavides, Edward F. Bell, Michael K. Georgieff, Cassandra D. Josephson, Sean R. Stowell, Henry A. Feldman, Demet Nalbant, Alexander Tereshchenko, Martha Sola-Visner, Peggy Nopoulos
Summary: This study identified sex-specific differences in inflammatory responses to RBC transfusions in preterm infants during the neonatal period, with MCP-1 levels rising only in females and inversely correlating with later neurocognitive status. It suggests that different transfusion thresholds may have a sex-specific effect on neurodevelopment, with females experiencing worse cognitive outcomes with increased number of transfusions and males having worse outcomes with lower number of transfusions.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Ellen van der Plas, Olivia Lullmann, Lauren Hopkins, Jordan L. Schultz, Peggy C. Nopoulos, Lyndsay A. Harshman
Summary: Children with chronic kidney disease exhibit accelerated age-related increases in NfL levels, which are associated with lower kidney function and abnormal brain structure.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Amanda Benavides, Edward F. Bell, Amy L. Conrad, Henry A. Feldman, Michael K. Georgieff, Cassandra D. Josephson, Timothy R. Koscik, Sean R. Stowell, Martha Sola-Visner, Peg Nopoulos
Summary: This study found sex-specific differences in early brain structure and function of preterm infants after red blood cell transfusions. In males, pretransfusion Hb (ptHb) was positively correlated with neonatal cerebral white matter volume. However, no correlation was found in females. Additionally, higher ptHb was associated with significantly lower gross motor scores and pooled mean scores in females, but not in males.
JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Mark J. Hamilton, Antonio Atalaia, John McLean, Sarah A. Cumming, Jonathan J. Evans, Bob Ballantyne, Ravi Jampana, Cheryl Longman, Eric Livingston, Ellen van der Plas, Timothy Koscik, Peggy Nopoulos, Maria Elena Farrugia, Darren G. Monckton
Summary: This study conducted comprehensive sleep monitoring on 39 DM1 patients and found that their sleep efficiency was reduced and sleep architecture was altered. Moderate or severe sleep-disordered breathing was also observed. Furthermore, sleep architecture and sleep quality were associated with brain structure and cognitive performance.
NEUROMUSCULAR DISORDERS
(2022)
Article
Clinical Neurology
Ellen van der Plas, Jeffrey D. Long, Timothy R. Koscik, Vincent Magnotta, Darren G. Monckton, Sarah A. Cumming, Amy C. Gottschalk, Marco Hefti, Laurie Gutmann, Peggy C. Nopoulos
Summary: This study compared neuronal injury markers in individuals with adult-onset myotonic dystrophy type 1 (DM1) and those without, finding that NF-L was sensitive to disease onset and severity. However, the tau assay may have low sensitivity to tau pathology associated with DM1. The interaction between age and CTG repeat was associated with NF-L levels.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pediatrics
Ellen van der Plas, Matthew A. Solomon, Lauren Hopkins, Timothy Koscik, Jordan Schultz, Patrick D. Brophy, Peggy C. Nopoulos, Lyndsay A. Harshman
Summary: The study found that children with congenital kidney diseases have reduced white matter fractional anisotropy compared to typically developing controls, particularly in areas such as the body of the corpus callosum, cerebral peduncle, cingulum (hippocampus), and posterior limb of the internal capsule. Medical variables and neurocognitive abilities were not significantly associated with white matter fractional anisotropy in this population.
JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Lauren M. Byrne, Jordan L. Schultz, Filipe B. Rodrigues, Ellen van Der Plas, Douglas Langbehn, Peggy C. Nopoulos, Edward J. Wild
Summary: This study retrospectively analyzed plasma NfL concentrations in juvenile-onset Huntington's disease (JOHD) patients and Huntington's disease gene mutation carriers, finding increased concentrations in these populations. Additionally, quantifying plasma NfL levels can assist in clinical diagnosis and therapeutic trial design for pediatric Huntington's disease.
MOVEMENT DISORDERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Celia E. Heppner, Canice E. Crerand, Claudia Crilly Bellucci, Farah Sheikh, Suzanne Woodard, Meredith Albert, Amy L. Conrad, Kathleen A. Kapp-Simon
Summary: This observational study examined the health-related quality of life in children with cleft lip and/or palate. The results showed that the ratings for these children were generally higher than those expected for children with chronic illnesses but lower than the ratings for healthy children, particularly in terms of emotional, social, and school functioning.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Clinical Neurology
Jordan L. Schultz, Douglas R. Langbehn, Hend M. Al-Kaylani, Ellen van der Plas, Timothy R. Koscik, Eric A. Epping, Patricia B. Espe-Pfeifer, Erin P. Martin, David J. Moser, Vincent A. Magnotta, Peggy C. Nopoulos
Summary: This study aimed to quantify disease progression in juvenile-onset Huntington's disease (JOHD) and explore its application in clinical trials. The results demonstrate that structural brain imaging and clinical measures in JOHD may serve as potential biomarkers of disease progression.
MOVEMENT DISORDERS
(2023)
Article
Psychology, Clinical
Jennifer K. Paternostro, Anusha Kakolu, Willard Boyd, Amy L. Conrad, Tammy Wilgenbusch
Summary: This study examines the impact of chronic illness and parental level of concern on youth-reported traumatic stress during the COVID-19 pandemic. The results show that parental level of concern significantly predicts youth report of posttraumatic stress symptoms, while the presence of chronic medical conditions does not have a significant effect on youth-reported symptoms.
CLINICAL PRACTICE IN PEDIATRIC PSYCHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Canice E. Crerand, Amy L. Conrad, Claudia Crilly Bellucci, Meredith Albert, Celia E. Heppner, Farah Sheikh, Suzanne Woodard, Shivika Udaipuria, Kathleen A. Kapp-Simon
Summary: This study aimed to determine the associations between demographic, morphologic, and treatment protocol parameters and later psychological functioning. Results showed that age, race, and socioeconomic status had significant effects on the outcome measures. Gender, type of cleft, and age also had some influence on psychological and quality of life outcomes. Treatment modalities and number of surgeries were also related to psychological and quality of life outcomes.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Clinical Neurology
Timothy R. Koscik, Ellen van der Plas, Jeffrey D. Long, Stephen Cross, Laurie Gutmann, Sarah A. Cumming, Darren G. Monckton, Richard K. Shields, Vincent Magnotta, Peggy C. Nopoulos
Summary: This study compared the changes in white matter microstructure, functional measures, and clinical symptoms in patients with myotonic dystrophy type 1. The results showed that indices of white matter health were associated with functional performance and could accurately reflect disease progression. These findings are crucial for the design of clinical trials.
NEUROMUSCULAR DISORDERS
(2023)
Article
Nursing
Brandon Rogers, Barbara St. Marie, Daniel Wesemann, Peg Nopoulos
Summary: This study suggests that de-escalation training in long-term care facilities can improve job safety perception, enjoyment of working with HD patients, understanding of HD symptoms, confidence in the ability to care for HD patients, and decrease resident aggression and care refusal.
JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
(2023)
Article
Neurosciences
Louisa P. Selvadurai, Susan L. Perlman, George R. Wilmot, Sub H. Subramony, Christopher M. Gomez, Tetsuo Ashizawa, Henry L. Paulson, Chiadi U. Onyike, Liana S. Rosenthal, Haris Sair, Sheng-Han Kuo, Eva-Maria Ratai, Theresa A. Zesiewicz, Khalaf O. Bushara, Gulin Oz, Cameron Dietiker, Michael D. Geschwind, Alexandra B. Nelson, Puneet Opal, Talene A. Yacoubian, Peggy C. Nopoulos, Vikram G. Shakkottai, Karla P. Figueroa, Stefan M. Pulst, Peter E. Morrison, Jeremy D. Schmahmann
Summary: This study developed a new metric, the Severity Factor (S-Factor), to predict disease severity in Spinocerebellar ataxias (SCAs) and compared it with clinical rating scales. At the group level, the S-Factor showed moderate-to-strong correlations with motor rating scales, but not with cognitive performance. However, longitudinally, the slope of the S-Factor did not consistently correlate with the slope of motor rating scales.
Article
Clinical Neurology
Jordan L. Schultz, Amanda E. Heinzerling, Alivia N. Brinker, Lyndsay A. Harshman, Vincent A. Magnotta, John A. Kamholz, Aaron D. Boes, Peg C. Nopoulos
Summary: Schultz et al. found that autonomic dysfunction in patients with presymptomatic Huntington's disease was associated with decreased functional connectivity within the Central Autonomic Network. These findings provide insight into the underlying pathology of autonomic dysfunction in Huntington's disease and its potential as a marker for disease progression.
BRAIN COMMUNICATIONS
(2022)