Article
Pediatrics
Vineet Lamba, Oscar Winners, Prem Fort
Summary: The study found that early high-dose caffeine (HD) therapy can reduce the duration of mechanical ventilation in premature infants and decrease the risk of bronchopulmonary dysplasia (BPD).
Review
Medicine, General & Internal
Yueqin Ding, Zhifeng Chen, Yanling Lu
Summary: Vitamin A supplementation is beneficial for the prophylaxis of bronchopulmonary dysplasia in premature infants, but no significant differences were found in the incidence of other complications such as retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, and mortality. Further studies on administration approaches and dosages are warranted.
Article
Pediatrics
Zoe Freislich, Benjamin Stoecklin, Naomi Hemy, J. Jane Pillow, Graham L. L. Hall, Andrew C. C. Wilson, Shannon J. J. Simpson
Summary: Preterm infants continue to have attenuated ventilatory response to hypoxia at 12-15 months corrected postnatal age, especially in males. Predictive factors affect the magnitude of the blunted ventilatory response.
FRONTIERS IN PEDIATRICS
(2022)
Article
Physiology
Kai Foerster, Hanna Marchi, Sophia Stoecklen, Olaf Dietrich, Harald Ehrhardt, Mark O. Welipultz, Andreas W. Flemmer, Benjamin Schubert, A. Marcus Mall, Birgit Ertl-Wagner, Anne Hillgendroff
Summary: This study developed a novel scoring system using MRI to assess lung structural changes in neonatal chronic lung disease. It showed high reproducibility and disease specificity, and has the potential to be used as a quantifiable endpoint in clinical trials and disease monitoring.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maxwell Mathias, Jill Chang, Marta Perez, Ola Saugstad
Summary: Oxygen is crucial for cell survival, but excessive oxygen delivery can disrupt growth and development, induce inflammation, and cause oxidative damage. Newborns, especially premature infants, are particularly susceptible to hyperoxic injury due to their immature antioxidant defense system.
Article
Critical Care Medicine
Namasivayam Ambalavanan, Debra E. Weese-Mayer, Anna Maria Hibbs, Nelson Claure, John L. Carroll, J. Randall Moorman, Eduardo Bancalari, Aaron Hamvas, Richard J. Martin, Juliann M. Di Fiore, Premananda Indic, James S. Kemp, Alaleh Dormishian, Katy N. Krahn, Jiaxing Qiu, Phyllis A. Dennery, Sarah J. Ratcliffe, James F. Troendle, Douglas E. Lake
Summary: Immature control of breathing in extremely preterm infants is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia. Analyzing cardiorespiratory monitoring data can predict unfavorable respiratory outcomes at 40 weeks postmenstrual age and other outcomes such as bronchopulmonary dysplasia at 36 weeks postmenstrual age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Obstetrics & Gynecology
Caren Liviskie, Zachary Vesoulis, Brandy Zeller, Rakesh Rao, Christopher McPherson
Summary: This study found that prolonged prednisolone use in preterm infants was associated with a sustained decrease in pulmonary severity score without adverse effects on growth measurements. These results suggest potential benefit of prednisolone on respiratory outcomes in a subset of preterm infants.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Medical Laboratory Technology
Carlo Dani, Giulia Remaschi, Nicolo Monti, Camilla Pizzetti, Simone Pratesi
Summary: This study aimed to assess the correlation between COHb levels and the risk for prematurity complications. By retrospectively studying 178 preterm infants, it was found that higher COHb levels were associated with an increased risk of BPD and IVH. Logistic regression analysis showed that higher COHb levels on the seventh and fourth day of life increased the risk of BPD and IVH, respectively. Therefore, measuring COHb can be useful in identifying preterm infants at high risk for oxidative stress-related complications.
CLINICA CHIMICA ACTA
(2023)
Article
Respiratory System
Xiaoling Wang, Yan Ma, Shenghui Wang, Wenbin Dong, Xiaoping Lei
Summary: This study investigated the association between bronchopulmonary dysplasia (BPD) and platelet parameters in very premature infants. The results showed that abnormal platelet parameters were observed in BPD infants, and a platelet count ≤ 177*10(9)/L was a potential risk factor for the development of BPD in very premature infants.
BMC PULMONARY MEDICINE
(2022)
Article
Physiology
Daniele De Luca, Raquel Arroyo, Silvia Foligno, Chiara Autilio, Lhousseine Touqui, Paul S. Kingma
Summary: This study aimed to investigate the association between surfactant protein-D (SP-D) expression and clinical outcomes in extremely preterm neonates. The results showed that SP-D levels increased with gestational age and were inversely associated with the development of bronchopulmonary dysplasia (BPD). SP-D was also correlated with the duration of hospital stay, invasive ventilation, and total sPLA2 activity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Pediatrics
Yi Zheng, Qi Wu, Shuping Han
Summary: This meta-analysis found that inhaled nitric oxide (iNO) can significantly reduce the incidence of bronchopulmonary dysplasia (BPD) in premature infants. However, it may increase the risk of necrotizing enterocolitis (NEC). There were no significant differences in the incidence of in-hospital mortality and adverse events between the overall iNO group and control.
Article
Nutrition & Dietetics
Sophie Laborie, Maxime Bonjour, Justine Bacchetta, Mathilde Mauras, Marine Butin
Summary: Low 25-hydroxyvitamin D (25(OH)D) levels in preterm infants is a risk factor for bronchopulmonary dysplasia (BPD), but increased supplementation does not have a beneficial effect. This study shows that 25(OH)D levels >= 120 nmol/L are not significantly associated with BPD or death.
Review
Biochemistry & Molecular Biology
Ying Dong, Stefano Rivetti, Arun Lingampally, Sabine Tacke, Baktybek Kojonazarov, Saverio Bellusci, Harald Ehrhardt
Summary: Intra-amniotic infection (IAI) is a major cause of preterm birth and can have both positive and negative effects on premature lung development. Animal models are essential for studying the pathogenesis of bronchopulmonary dysplasia (BPD), as the intra-amniotic cavity is inaccessible during pregnancies. Imbalanced inflammation, regulated by lung immune cells such as macrophages, may lead to abnormal lung development, while excessive suppression of inflammation can also cause lung injury. Effective strategies for preventing and treating BPD are currently scarce.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
A. Ioana Cristea, Clement L. Ren, Reshma Amin, Laurie C. Eldredge, Jonathan C. Levin, Parevi P. Majmudar, Anne E. May, Rebecca S. Rose, Michael C. Tracy, Karen F. Watters, Julian Allen, Eric D. Austin, Mary E. Cataletto, Joseph M. Collaco, Robert J. Fleck, Andrew Gelfand, Don Hayes, Marcus H. Jones, Sheila S. Kun, Erica W. Mandell, Sharon A. McGrath-Morrow, Howard B. Panitch, Rizwana Popatia, Lawrence M. Rhein, Alejandro Teper, Jason C. Woods, Narayan Iyer, Christopher D. Baker
Summary: This document provides an evidence-based clinical practice guideline on the outpatient management of premature infants, children, and adolescents with post-prematurity respiratory disease (PPRD), including recommendations for common medical therapies and diagnostic evaluations to improve patient care. The recommendations were developed based on limited evidence and expert opinion, with important areas for future research identified.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
A. Ioana Cristea, Clement L. Ren, Reshma Amin, Laurie C. Eldredge, Jonathan C. Levin, Parevi P. Majmudar, Anne E. May, Rebecca S. Rose, Michael C. Tracy, Karen F. Watters, Julian Allen, Eric D. Austin, Mary E. Cataletto, Joseph M. Collaco, Robert J. Fleck, Andrew Gelfand, Don Hayes, Marcus H. Jones, Sheila S. Kun, Erica W. Mandell, Sharon A. McGrath-Morrow, Howard B. Panitch, Rizwana Popatia, Lawrence M. Rhein, Alejandro Teper, Jason C. Woods, Narayan Iyer, Christopher D. Baker
Summary: This document provides an evidence-based clinical practice guideline on the outpatient management of infants, children, and adolescents with post-prematurity respiratory disease (PPRD). Recommendations were developed for or against three common medical therapies and four diagnostic evaluations in the context of outpatient management of PPRD. Expert panel formulated recommendations based on limited evidence and expert opinion for the outpatient management of patients with PPRD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)