Article
Peripheral Vascular Disease
Andrew D. Kane, Emilio A. Herrera, Youguo Niu, Emily J. Camm, Beth J. Allison, Deodata Tijsseling, Ciara Lusby, Jan B. Derks, Kirsty L. Brain, Inge M. Bronckers, Christine M. Cross, Lindsey Berends, Dino A. Giussani
Summary: Prematurity is associated with poor respiratory function, and glucocorticoids are used as rescue therapy. However, glucocorticoid treatment in infants can increase the risk of long-term cardiovascular complications. The depletion of nitric oxide (NO) bioavailability is suggested as a molecular link between glucocorticoid excess and cardiovascular dysfunction. Combined glucocorticoid and statin therapy may protect the developing cardiovascular system by increasing NO bioavailability.
Review
Medicine, General & Internal
Robyn Richards, Jann P. Foster, Kim Psaila
Summary: This study aimed to investigate whether continuous or intermittent bolus intragastric tube feeding affects the incidence and severity of gastro-oesophageal reflux disease in preterm and low birth weight infants. However, no randomized trials meeting the inclusion criteria were found. Well-designed and adequately powered trials are needed in the future.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Jose Uberos, Ana Campos-Martinez, Aida Ruiz-Lopez, Elizabeth Fernandez-Marin, Jose Luis Garcia-Serrano
Summary: This study investigates the sensitivity and specificity of the NIPE index for detecting physiological changes in VLBW infants during painful procedures. The results show that the accuracy of the NIPE index for diagnosing mild nociceptive stimulation is 73.2%.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Ruth Guinsburg, Adriana Sanudo, Carlos Roberto Kiffer, Ana Silvia S. Marinonio, Daniela T. Costa-Nobre, Kelsy N. Areco, Mandira D. Kawakami, Milton H. Miyoshi, Paulo Bandiera-Paiva, Rita de Cassia X. Balda, Tulio Konstantyner, Liliam C. C. Morais, Rosa M. Freitas, Monica L. P. Teixeira, Bernadette Waldvogel, Maria Fernanda B. Almeida
Summary: A population-based study in Sao Paulo State, Brazil, over a 10-year period revealed a significant decrease in neonatal mortality rate. However, there is a need for improved access to qualified health care to prevent avoidable neonatal deaths and increase survival rates for infants in need of more complex levels of assistance.
Article
Neuroimaging
Tim Vanderhasselt, Roya Zolfaghari, Maarten Naeyaert, Jeroen Dudink, Nico Buls, Gert-Jan Allemeersch, Hubert Raeymaekers, Filip Cools, Johan de Mey
Summary: Synthetic MRI is sensitive to age-related changes in brain tissue relaxation times in preterm born neonates close to term equivalent age (TEA). Severe postnatal morbidity results in prolonged relaxation times in specific brain regions, which can accurately predict high-risk status.
NEUROIMAGE-CLINICAL
(2021)
Article
Multidisciplinary Sciences
Dina Angelika, Risa Etika, Martono Tri Utomo, Loysa Ladydi, Mahendra Tri Arif Sampurna, Kartika Darma Handayani, I. Dewa Gede Ugrasena, Pieter J. J. Sauer
Summary: This study analyzed the incidence and risk factors of hyperglycemia and hypoglycemia in preterm infants receiving early-aggressive parenteral nutrition. Most cases occurred within the first week of life. Hypoglycemia was associated with low glucose intake, while hyperglycemia was associated with sepsis. Monitoring blood glucose levels in preterm infants receiving parenteral nutrition, especially in the first weeks of life, may decrease morbidity associated with hyperglycemia or hypoglycemia.
Article
Medicine, General & Internal
Hyun Jeong Do, Kyoung Min Moon, Hyun-Seung Jin
Summary: This study compared the performance of machine learning methods and logistic regression in predicting mortality of very low birth weight infants. The results showed that artificial neural network, random forest, and logistic regression had similar predictive performance, while support vector machine performed lower.
Article
Gastroenterology & Hepatology
Lauren E. E. Lynch, Amy B. B. Hair, Krishnakant G. G. Soni, Heeju Yang, Laura A. A. Gollins, Monica Narvaez-Rivas, Kenneth D. R. Setchell, Geoffrey A. A. Preidis
Summary: Cholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death. This study examined the development of the liver-gut-microbiome axis and the effects of cholestasis on this development in extremely preterm infants. The results showed that cholestasis interrupts the development of the secondary bile acid biosynthesis pathway and bile salt hydrolase genes, which are important for normal bile flow.
Article
Pediatrics
Xinzhuo Zhang, Jinyue Yu, Zhuang Wei, Mary Fewtrell
Summary: This study investigated the impact of maternal and infant characteristics, feeding practices, and breastmilk composition on infant behavior following late preterm and early term delivery. The results showed that exclusive breastfeeding was associated with longer sleep duration and shorter crying duration. Certain maternal characteristics (education and annual income) were associated with infant distress behaviors. However, the use of more objective measures in larger samples is recommended to assess factors influencing infant behavior.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Thea Tagliaferro, Rowena Cayabyab, Rangasamy Ramanathan
Summary: The study aimed to evaluate the relationship between blood CO-Hb levels in the first 14 days of life in ELBW infants and the development of BPD at 36 weeks PMA. It was found that FiO(2) levels at DOL 11-14 were fairly effective in discriminating different severity of BPD, while CO-Hb levels did not show this ability. Further research on the role and mechanism of CO-Hb production in this population is needed.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Pediatrics
Cheryl Anne Mackay, James Stephanus Smit, Farhaad Khan, Fazana Dessai, Refiloe Masekela
Summary: The study reported significant extra-uterine growth restriction (EUGR) in preterm infants. Elevated IL-6 was associated with growth restriction at 40 weeks but not at 12 months postmenstrual age (PMA).
JOURNAL OF TROPICAL PEDIATRICS
(2021)
Review
Hematology
Carmel Maria Moore, Anna E. Curley
Summary: There is variation in the practice of platelet transfusion in neonatology, with lack of evidence support. The mechanism of harm from platelet transfusions is not well understood, emphasizing the importance of avoiding transfusion-related harm in neonates.
TRANSFUSION MEDICINE REVIEWS
(2021)
Article
Health Care Sciences & Services
Daniela-Loredana Bujorescu, Adrian Ratiu, Cosmin Citu, Florin Gorun, Oana Maria Gorun, Doru Ciprian Crisan, Alina-Ramona Cozlac, Ioana Chiorean-Cojocaru, Mihaela Tunescu, Zoran Laurentiu Popa, Roxana Folescu, Andrei Motoc
Summary: The optimal timing of delivery in cases of early onset fetal growth restriction is challenging to determine due to the opposing risks of stillbirth and prematurity. This study aimed to assess the likelihood of neonatal complications based on the time of birth, using Doppler parameters in fetuses with early onset fetal growth restriction. The findings suggest that infants delivered at the onset of umbilical arteries absent/reversed end-diastolic flow are less likely to develop intraventricular hemorrhage grades III/IV and bronchopulmonary dysplasia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Michelle C. Starr, Jennifer R. Charlton, Ronnie Guillet, Kimberly Reidy, Trent E. Tipple, Jennifer G. Jetton, Alison L. Kent, Carolyn L. Abitbol, Namasivayam Ambalavanan, Maroun J. Mhanna, David J. Askenazi, David T. Selewski, Matthew W. Harer
Summary: Significant advances have been made in the field of neonatal acute kidney injury over the past 5 years, with large multicenter studies revealing the association of AKI with increased morbidity and mortality. Preventive strategies and new technologies have shown promise in the management of AKI, and there is a growing recognition of the importance of kidney function in the development and injury of other organs. Future research is needed to focus on optimal follow-up strategies for neonates with a history of AKI to detect chronic kidney disease.
Article
Nutrition & Dietetics
Marine Baillat, Vanessa Pauly, Gina Dagau, Julie Berbis, Farid Boubred, Laurence Fayol
Summary: The study found that inadequate energy and protein intake in the first week of life negatively affected neonatal growth in moderate preterm infants. Therefore, nutritional support should be optimized from birth onwards to improve neonatal weight gain.