Review
Medicine, General & Internal
S. Sharif, P. T. Heath, S. J. Oddie, W. McGuire
Summary: The study aims to evaluate the effect of enteral supplementation with synbiotics versus placebo or no treatment, or versus probiotics or prebiotics alone on the risk of necrotising enterocolitis and associated morbidity and mortality in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Food Science & Technology
Parisa Janmohammadi, Zeinab Nourmohammadi, Siavash Fazelian, Atieh Mirzababaei, Shahab Alizadeh, Mahtab Zarei, Elnaz Daneshzad, Kurosh Djafarian
Summary: Several studies have suggested that formulas containing synbiotics (composed of prebiotics and probiotics) may have a positive effect on anthropometric indices. However, the results of these studies are inconsistent. This meta-analysis found that the consumption of formulas containing synbiotics did not significantly affect the growth of healthy infants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Gabriela Andrea Servin-Casas, Alejandra Romo-Araiza, Gabriela Gutierrez-Salmean, Enrique Martinez-Solis, Andrea Paola Ibarra-Garcia, Yolanda Cruz-Martinez, Roxana Rodriguez-Barrera, Elisa Garcia, Diego Incontri-Abraham, Antonio Ibarra
Summary: Prebiotic and probiotic supplementation can improve spatial memory in senile animals, but this improvement is not correlated with GLP-1 levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Ellen Wilms, Ran An, Agnieszka Smolinska, Yala Stevens, Antje R. Weseler, Montserrat Elizalde, Marie-Jose Drittij, Athanasia Ioannou, Frederik J. van Schooten, Hauke Smidt, Ad A. M. Masclee, Erwin G. Zoetendal, Daisy M. A. E. Jonkers
Summary: The study compared the fecal microbiota composition, metabolite production, immune and oxidative stress markers in prefrail elderly and younger adults, and investigated the effects of GOS supplementation in both groups. Results showed differences in microbial composition between the two age groups, with lower bifidobacteria in elderly at baseline. GOS intake increased bifidobacteria in both groups, but did not significantly impact fecal and breath metabolites, immune function, or oxidative stress markers.
CLINICAL NUTRITION
(2021)
Review
Immunology
Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu, Huaxiang Wu
Summary: This article summarizes the role of gut microbiota in the onset and progression of gout, discusses its importance in the diagnosis and treatment of gout, and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Raakel Luoto, Anna Paertty, Josef K. Vogt, Samuli Rautava, Erika Isolauri
Summary: This study investigated the composition and function of the gut microbiome in moderately and late preterm infants. Probiotic and prebiotic treatments were found to mitigate the changes in the microbiome, indicating their potential in promoting healthy gut microbiome development in preterm infants.
Article
Food Science & Technology
M. Jaagura, N. Part, K. Adamberg, J. Kazantseva, E. Viiard
Summary: This study investigated the effects of daily consumption of fermented yogurt with and without fibers on blood lipids' profile and growth of beneficial bacteria in the gut. The results showed that both interventions of yogurt consumption led to decreases in fasting total cholesterol, LDL cholesterol, and glucose levels. Both interventions also increased the prevalence of butyrate-producers in the gut microbiota. Additionally, yogurt enriched with fibers specifically increased the abundance of Bifidobacterium animalis and Catenibacterium mitsuokai in the fecal microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Jorge Amil Dias, Edmundo Santos, Ines Asseiceira, Sylvia Jacob, Carmen Ribes Koninckx
Summary: The incidence of allergic diseases is increasing globally, and experts discuss the role of infant formulas in preventing allergies in infants who cannot be breastfed and are at risk of developing allergies. They focus on risk assessment, the impact of microbiota on immune tolerance, and the importance of certain formula characteristics. The article provides the latest evidence and recommendations for parents in choosing a formula for infants at risk of allergy.
Article
Biology
Kotryna Simonyte Sjodin, Andreas Sjodin, Marek Ruszczynski, Mette Bach Kristensen, Olle Hernell, Hania Szajewska, Christina E. E. West
Summary: Adding synbiotics to formula milk can prevent infections in infants. This study found that synbiotic feeding led to the development of a healthier gut microbiota, with lower levels of Klebsiella and higher levels of Bifidobacterium. It also increased the production of metabolites associated with immune signaling.
Review
Nutrition & Dietetics
Neelam A. Revankar, Pradeep S. Negi
Summary: The involvement of commensal microbiota in immune function is complex, and biotics such as probiotics, prebiotics, synbiotics, and paraprobiotics have shown associations with immune biomarkers and improved overall health in animal and human trials. However, further research is needed to determine the effectiveness of biotics as alternative therapies for various health conditions. This review provides insights into the immunomodulatory effects of biotics consumption and highlights optimal dosages for maximum health benefits based on evidence from animal models and clinical trials.
NUTRITION IN CLINICAL PRACTICE
(2023)
Review
Medicine, General & Internal
Sahar Sharif, Paul T. Heath, Sam J. Oddie, William McGuire
Summary: Intestinal dysbiosis may contribute to the development of NEC in very preterm or very low birth weight infants. Dietary supplementation with synbiotics, which can modulate the intestinal microbiome, may reduce the risk of NEC and all-cause mortality in these infants. However, the evidence is currently limited and more high-quality trials are needed to confirm these findings.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Pediatrics
C. P. Rath, G. Athalye-Jape, E. Nathan, D. Doherty, S. Rao, S. Patole
Summary: This study compares the outcomes of preterm infants in different epochs and finds that routine probiotic supplementation has sustained benefits in reducing necrotising enterocolitis and mortality.
Article
Pediatrics
David B. Healy, Benjamin Campbell-Green, Vicki Livingstone, C. Anthony Ryan, R. Paul Ross, Catherine Stanton, Eugene M. Dempsey
Summary: The aim of this study was to evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants before and after the introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics. The results showed a reduction in the composite outcome of severe grade NEC and/or death after the introduction of routine administration of probiotics.
Review
Microbiology
Yudie Yang, Xiaoqi Li, Ying Yang, Saeed Shoaie, Cheng Zhang, Boyang Ji, Yongjun Wei
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children, with links to diet, gut microbiota, and interactions between them. Understanding the potential molecular mechanisms of CMPA, including how microbiota can be modulated for treatment, may lead to improved quality of life for CMPA patients in the future.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Gary P. Hubbard, Kiranjit Atwal, Lynne Graham, Sankara Narayanan, Lisa Cooke, Catherine Casewell, Sally-Ann Denton, Joan Gavin, Robert M. Browne, Fiona J. Kinnear, Ailsa J. McHardy, Debbie Evans, Rachel Vallis, Devasmitha Venkataraman, Abbie L. Cawood, Sarah Donohoe, Victoria Steele, Sonia Armstrong, Rebecca J. Stratton
Summary: In this pilot study, the use of a synbiotic-containing, whey-based extensively hydrolyzed formula (SeHF) showed significant improvements in gastrointestinal symptoms, atopic dermatitis, and quality of life in infants with non-IgE mediated cow's milk allergy (CMA). Hospital visits and medication use also significantly decreased in the 6 months after SeHF initiation.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
