期刊
TRENDS IN GENETICS
卷 31, 期 6, 页码 282-289出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.03.001
关键词
-
资金
- MRC [U117560541]
- Wellcome Trust [WT098326MA]
- FEBS (Federation of European Biochemical Societies)
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J015539/1]
- BBSRC [BB/J015539/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J015539/1] Funding Source: researchfish
- The Francis Crick Institute [10053, 10051] Funding Source: researchfish
Understanding the mechanisms that control induction and elaboration of the vertebrate central nervous system (CNS) requires an analysis of the extrinsic signals and downstream transcriptional networks that assign cell fates in the correct space and time. We focus on the generation and patterning of the spinal cord. We summarize evidence that the origin of the spinal cord is distinct from the anterior regions of the CNS. We discuss how this affects the gene regulatory networks and cell state transitions that specify spinal cord cell subtypes, and we highlight how the timing of extracellular signals and dynamic control of transcriptional networks contribute to the correct spatiotemporal generation of different neural cell types.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据