期刊
TRENDS IN GENETICS
卷 31, 期 9, 页码 528-535出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.05.001
关键词
Tasmanian devil; genomics; cancer; MHC; conservation; DFTD
资金
- Australian Research Council (ARC)
- Save the Tasmanian Devil Program and Appeal
- Zoo and Aquarium Association
- University of Sydney
- ARC Future Fellowship
The Tasmanian devil faces extinction due to a contagious cancer. Genetic and genomic technologies revealed that the disease arose in a Schwann cell of a female devil. Instead of dying with the original host, the tumour was passed from animal to animal, slipping under the radar of the immune system. Studying the genomes of the devil and the cancer has driven our understanding of this unique disease. From characterising immune genes and immune responses to studying tumour evolution, we have begun to uncover how a cancer can be 'caught' and are using genomic data to manage an insurance population of disease-free devils for the long-term survival of the species.
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