期刊
TRENDS IN GENETICS
卷 31, 期 9, 页码 516-527出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.07.005
关键词
histone variants; cellular plasticity; development; neuron; brain; epigenetics
资金
- National Institute on Deafness and Other Communication Disorders [R21DC011117]
- National Institute of Mental Health [P50MH094271]
- National Institute of General Medical Sciences [P30GM103398]
- Howard Hughes Medical Institute
The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation. The most basic subunit of chromatin, the nudeosome, consists of DNA wrapped around histones, a set of proteins that play crucial roles as scaffolding molecules and regulators of gene expression. Growing evidence indicates that canonical histones are commonly replaced by protein variants before and during cellular transitions. We highlight exciting new results suggesting that histone variants are essential players in the control of cellular plasticity during development and in the adult nervous system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据