Article
Biotechnology & Applied Microbiology
Xiping Chen, Huan Xiao, Chunjiang Yang, Jingyu Chen, Yang Gao, Yi Tang, Xiaojuan Ji
Summary: This study investigated hemodynamic changes in infants undergoing living donor liver transplantation due to biliary atresia. Results showed a decrease in hepatic artery peak systolic velocity and resistivity index, and an increase in portal vein velocity and flow on the first day post-transplant. These changes remained stable within the first month after surgery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Kao-Ming Hsu, Pei-Ru Lin, Ping-Fang Chiu, Yao-Peng Hsieh
Summary: This study investigated the subsequent renal function change following incident infectious diseases in living-donor liver transplant recipients. The results showed that hospitalization with major infections or pneumonia increased the risk of eGFR decline and adverse renal outcomes in these patients.
Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Kai-Chieh Chang, Yao-Peng Hsieh, Huan-Nung Chao, Chien-Ming Lin, Kuo-Hua Lin, Chun-Chieh Tsai, Chia-En Heish, Pei-Ru Lin, Chew-Teng Kor, Yao-Li Chen, Ping-Fang Chiu
Summary: The presence of hematuria and preoperative use of NSAIDs in patients who undergo liver transplantation are associated with worse long-term renal function and survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Ramsey Sitta, John Roberts, James Gardner, Nancy Ascher, Merisa Piper
Summary: This is a case report on the successful salvage of a living donor graft with complex arterial dissection in liver transplantation, highlighting the importance of collaboration with a microvascular surgeon.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Immunology
Hillary J. Braun, Joshua D. Grab, Jennifer L. Dodge, Shareef M. Syed, Garrett R. Roll, Marisa P. Schwab, Iris H. Liu, Alexa C. Glencer, Chris E. Freise, John P. Roberts, Nancy L. Ascher
Summary: The study found that approximately 10% of patients who underwent living donor liver transplantation required retransplantation. Patients who received retransplantation had significantly lower survival rates compared to those who only underwent primary transplantation.
Article
Medicine, General & Internal
Seoung Hoon Kim, Jang Ho Park, Byoung Ho An
Summary: This study introduces how to perform LDLT with minimal manpower and evaluates the outcomes in adult patients. It shows that under the supervision of a single expert surgeon, a team of minimal manpower can successfully perform all the main surgical procedures without compromising the results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Biochemistry & Molecular Biology
Merlin Airik, Blake McCourt, Tugba Tastemel Ozturk, Amy B. Huynh, Xiaoyi Zhang, Justin T. Tometich, Rezan Topaloglu, Hasan Ozen, Diclehan Orhan, Kari Nejak-Bowen, Satdarshan P. Monga, Timothy W. Hand, Fatih Ozaltin, Rannar Airik
Summary: This study identifies a novel mutation in the ANKS6 gene associated with congenital hepatic fibrosis (CHF) and demonstrates the important role of macrophages in the development of the disease. The depletion of macrophages effectively reduces fibrosis and improves liver function, suggesting a potential therapeutic approach for CHF.
Article
Gastroenterology & Hepatology
Katherine Duffey, Dina Halegoua-DeMarzio, Ashesh P. Shah, Danielle M. Tholey
Summary: This study aims to examine sex and racial disparities in living donor liver transplantation (LDLT) in the US population. The results show significant disparities in sex and race in LDLT, disadvantaging women, but these disparities are less pronounced than in deceased donor liver transplantation (DDLT). Further research is needed to better understand the factors contributing to these variations.
LIVER TRANSPLANTATION
(2023)
Article
Immunology
Suk Kyun Hong, Nam-Joon Yi, Jae-Hyung Cho, Jeong-Moo Lee, Kwangpyo Hong, Eui Soo Han, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study found that parietal peritoneum may be a novel autologous substitute for MHV reconstruction during LDLT, with high patency and survival rates.
Article
Medicine, General & Internal
Yi-Chia Chan, Cheng-Hsi Yeh, Lung-Chih Li, Chao-Long Chen, Chih-Chi Wang, Chih-Chi Lin, Aldwin D. Ong, Ting-Yu Chiou, Chee-Chien Yong
Summary: Acute kidney injury (AKI) after liver transplantation (LT) is associated with major adverse cardiovascular events (MACE) and major adverse kidney events (MAKE). It is also an independent predictor and risk factor for cardiovascular disease and end-stage renal disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study investigated the impact of age differences between older adult living donors and recipients on kidney transplantation outcomes. The results showed that kidney transplants from older adult donors to older adult recipients had the highest risk of graft loss and mortality, with recipients having lower estimated glomerular filtration rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Kandai Nozu, Koichi Nakanishi, Yoshifusa Abe, Tomohiro Udagawa, Shinichi Okada, Takayuki Okamoto, Hiroshi Kaito, Katsuyoshi Kanemoto, Anna Kobayashi, Eriko Tanaka, Kazuki Tanaka, Taketsugu Hama, Rika Fujimaru, Saori Miwa, Tomohiko Yamamura, Natsusmi Yamamura, Tomoko Horinouchi, Shogo Minamikawa, Michio Nagata, Kazumoto Iijima
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Cell Biology
Seiya Urae, Yutaka Harita, Tomohiro Udagawa, Koji L. Ode, Masami Nagahama, Yuko Kajiho, Shoichiro Kanda, Akihiko Saito, Hiroki R. Ueda, Masaomi Nangaku, Akira Oka
JOURNAL OF CELL SCIENCE
(2020)
Article
Urology & Nephrology
Xiaoyuan Jia, Tomohiko Yamamura, Rasheed Gbadegesin, Michelle T. McNulty, Kyuyong Song, China Nagano, Yuki Hitomi, Dongwon Lee, Yoshihiro Aiba, Seik-Soon Khor, Kazuko Ueno, Yosuke Kawai, Masao Nagasaki, Eisei Noiri, Tomoko Horinouchi, Hiroshi Kaito, Riku Hamada, Takayuki Okamoto, Koichi Kamei, Yoshitsugu Kaku, Rika Fujimaru, Ryojiro Tanaka, Yuko Shima, Jiwon Baek, Hee Gyung Kang, Il-Soo Ha, Kyoung Hee Han, Eun Mi Yang, Asiri Abeyagunawardena, Brandon Lane, Megan Chryst-Stangl, Christopher Esezobor, Adaobi Solarin, Claire Dossier, Georges Deschenes, Marina Vivarelli, Hanna Debiec, Kenji Ishikura, Masafumi Matsuo, Kandai Nozu, Pierre Ronco, Hae Il Cheong, Matthew G. Sampson, Katsushi Tokunaga, Kazumoto Iijima
KIDNEY INTERNATIONAL
(2020)
Article
Infectious Diseases
Yohei Yamaguchi, Kei Takasawa, Hitoshi Irabu, Kanako Hiratoko, Yosuke Ichigi, Ko Hirata, Yumie Tamura, Miki Murakoshi, Motoi Yamashita, Hisae Nakatani, Masuhiro Shimoda, Taku Ishii, Tomohiro Udagawa, Masaki Shimizu, Hirokazu Kanegane, Tomohiro Morio
Summary: This case report describes a 15-year-old Japanese boy with refractory MIS-C who was successfully treated with infliximab. The distinctive hyperferritinemia in this case may be associated with refractoriness to IVIG therapy. Early intervention with adjunctive infliximab for MIS-C patients with hyperferritinemia may result in a more rapid resolution of inflammation and improve outcome.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Letter
Pediatrics
Tomohiro Udagawa, Yaeko Motoyoshi
PEDIATRIC NEPHROLOGY
(2022)
Editorial Material
Pediatrics
Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaaki Mori
PEDIATRIC NEPHROLOGY
(2022)
Editorial Material
Pediatrics
Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaaki Mori
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Kisho Shimura, Shotaro Matsumoto, Kentaro Ide, Chiaki Baba, Satoshi Nakagawa, Kensuke Shoji, Hajime Uchida, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
Summary: A 5-month-old girl with biliary atresia experienced acute respiratory distress syndrome (ARDS) and multiple complications while awaiting liver transplantation, which were successfully managed with intraoperative venovenous extracorporeal membrane oxygenation (VV ECMO).
PEDIATRIC TRANSPLANTATION
(2022)
Article
Pediatrics
Jumpei Saito, Miho Yamaguchi, Seiichi Shimizu, Kyoko Chiba, Tomoyuki Utano, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Akimasa Yamatani
Summary: This study aimed to investigate the feasibility of smaller tablets in pediatric patients. The results showed that compared to conventional large tablets and granules, the smaller tablets were better accepted by the patients and reduced the burden of administration.
Article
Genetics & Heredity
Maho Hatano, Tomohiro Udagawa, Toru Kanamori, Akito Sutani, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Tomohiro Morio, Masato Nishioka
Summary: This study identifies a novel SLC5A2 gene variant in a Japanese family with familial renal glucosuria.
HUMAN GENOME VARIATION
(2022)
Article
Pediatrics
Lijian Chen, Hajime Uchida, Ryuji Komine, Tasuku Kodama, Toshimasa Nakao, Noriki Okada, Yusuke Yanagi, Seiichi Shimizu, Syed Abbas, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
Summary: COACH syndrome is a rare genetic disease characterized by liver fibrosis and severe complications related to portal hypertension. Liver transplantation can be an effective treatment for COACH syndrome in patients with severe portal hypertension, but careful monitoring of renal function is necessary.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Rheumatology
Ryosuke Wakatsuki, Masaki Shimizu, Shimbo Asami, Eriko Adachi, Toru Kanamori, Susumu Yamazaki, Tomohiro Udagawa, Kei Takasawa, Kenichi Kashimada, Tomohiro Morio, Masaaki Mori
Summary: Atrophic autoimmune thyroiditis (AAT) is a rare autoimmune disease that leads to hypothyroidism without thyroid enlargement, distinguishing it from Hashimoto's disease (HD). In this report, a patient with AAT as the initial presentation of systemic lupus erythematosus (SLE) complicated with generalized myxedema is described, highlighting the diagnostic challenge and emphasizing the significance of early recognition of atypical manifestations of autoimmune thyroiditis in SLE patients.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Physiology
Kazuyoshi Yamamoto, Masahiro Okabe, Keiko Tanaka, Takashi Yokoo, Ira Pastan, Toshikazu Araoka, Kenji Osafune, Tomohiro Udagawa, Masahiro Koizumi, Taiji Matsusaka
Summary: This study clarifies why morphologically definitive apoptosis is rarely observed in podocytes in vivo. When caspase-3 is activated in podocytes, these cells are immediately detached from the glomerulus and lost in the urine before DNA fragmentation occurs. Detachment is facilitated by glomerular filtration. This phenomenon explains why podocytes in vivo rarely show TUNEL staining and never apoptotic bodies.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Meeting Abstract
Pediatrics
Katharina Rohner, Matko Marlais, Yo Han Ahn, Alaa Ali, Abrar Alsharief, Biswanath Basu, Anja Blejc, Evrim Kargin Cakici, Nur Canpolat, Eugen Yu-hin Chan, Stephane Decramer, Filipa Durao, Anne M. Durkan, Ali Duzova, Thomas Forbes, Junior Gahona Villegas, Nilufer Goknar, Valentina Gracchi, Tulin Gungor, Tomoko Horinouchi, Belde Kasap Demir, Yasuko Kobayashi, Mikael Koskela, Eda Didem Kurt-Sukur, Claudio La Scola, Dean Langan, Xiaozhong Li, Gabriele Malgieri, Antonio Mastrangelo, Aytul Noyan, Matti Nuutinen, Takayuki Okamoto, Louise Oni, Michiel Oosterveld, Malgorzata Panczyk-Tomaszewska, Gonul Parmaksiz, Andrea Pasini, Pornpimol Rianthavorn, Yunyan Shen, Rajiv Sinha, Rezan Topaloglu, Diletta Domenica Torres, Tomohiro Udagawa, Yok Chin Yap, Kjell Tullus
PEDIATRIC NEPHROLOGY
(2022)
Article
Urology & Nephrology
Tomohiro Udagawa, Yusuke Matsuyama, Mika Okutsu, Yaeko Motoyoshi, Mari Okada, Norimasa Tada, Eriko Kikuchi, Masuhiro Shimoda, Toru Kanamori, Tae Omori, Masaki Takahashi, Kohsuke Imai, Akifumi Endo, Takeo Fujiwara, Tomohiro Morio
Summary: This study investigated 80 Japanese children and found that low levels of serum IgM at initial diagnosis might predict steroid resistance among children with idiopathic nephrotic syndrome.