Review
Pediatrics
Sha Li, Wei Zhang, Yan Lin
Summary: Juvenile idiopathic arthritis (JIA) is a common rheumatic disease in pediatrics, and intra-articular corticosteroid injections (IACIs) are an important treatment strategy to reduce systemic adverse reactions and improve joint symptoms, thus enhancing the quality of life for children with JIA.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Tingyan He, Yu Xia, Ying Luo, Jun Yang
Summary: This study aimed to evaluate the efficacy and potential adverse effects of JAKi in patients with systemic juvenile idiopathic arthritis (SJIA). The results showed that JAKi may be an alternative or adjuvant agent for patients with persistently active disease, glucocorticoid-related adverse reactions, or SJIA-MAS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cell Biology
Justine Maller, Terry Morgan, Mayu Morita, Frank McCarthy, Yunshin Jung, Katrin J. Svensson, Joshua E. Elias, Claudia Macaubas, Elizabeth Mellins
Summary: The study suggests that intercellular communication mediated by extracellular vesicles plays an important role in the pathogenesis of systemic juvenile idiopathic arthritis. The number and cellular sources of extracellular vesicles differ between the active and inactive states of the disease and healthy controls.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Immunology
Bert Malengier-Devlies, Mieke Metzemaekers, Carine Wouters, Paul Proost, Patrick Matthys
Summary: Neutrophils play a crucial role in the innate immune system, using both oxidative and non-oxidative defense mechanisms to eradicate pathogens, and also act as decision shaping cells guiding other leukocytes for immune responses. The development and release of neutrophils are tightly regulated under both homeostatic and emergency conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
William G. Ambler, Kabita Nanda, Karen Brandt Onel, Susan Shenoi
Summary: This review focuses on the treatment options and potential future therapeutics for systemic juvenile idiopathic arthritis (SJIA). Recent advancements in targeted therapies have improved patient outcomes, but there are still subsets of patients with refractory disease and severe complications.
ANNALS OF MEDICINE
(2022)
Article
Rheumatology
Chitra Lalloo, Lauren R. Harris, Amos S. Hundert, Roberta Berard, Joseph Cafazzo, Mark Connelly, Brian M. Feldman, Kristin Houghton, Adam Huber, Ronald M. Laxer, Nadia Luca, Heinrike Schmeling, Lynn Spiegel, Lori B. Tucker, Quynh Pham, Cleo C. Davies-Chalmers, Jennifer N. Stinson
Summary: The study evaluated the feasibility and preliminary effectiveness of the iCanCope with Pain smartphone program in adolescents with JIA, showing high rates of participation, successful deployment, and high acceptability. There was a meaningful reduction in pain intensity, but no statistically significant difference was found between the two groups.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Peter Stoustrup, Cory M. Resnick, Shelly Abramowicz, Thomas K. Pedersen, Ambra Michelotti, Annelise Kuseler, Bernd Koos, Carlalberta Verna, Ellen B. Nordal, Eric J. Granquist, Josefine Mareile Halbig, Kasper D. Kristensen, Leonard B. Kaban, Linda Z. Arvidsson, Lynn Spiegel, Matthew L. Stoll, Melissa A. Lerman, Mia Glerup, Patrizia Defabianis, Paula Frid, Per Alstergren, Randy Q. Cron, Sarah Ringold, Sven Erik Norholt, Timo Peltomaki, Tore A. Larheim, Troels Herlin, Zachary S. Peacock, Christian J. Kellenberger, Marinka Twilt
Summary: This study aimed to develop interdisciplinary recommendations for the management of orofacial manifestations of juvenile idiopathic arthritis (JIA) and to create a future research agenda for the treatment of temporomandibular joint (TMJ) arthritis in children with JIA. The recommendations were developed through online surveying, literature review, consensus meetings, and Delphi study iterations. Twelve recommendations and a future research agenda were outlined, filling an important gap in current clinical practice.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Arianna De Matteis, Claudia Bracaglia, Denise Pires Marafon, Anna Lucia Piscitelli, Maria Alessio, Roberta Naddei, Francesca Orlando, Giovanni Filocamo, Francesca Minoia, Angelo Ravelli, Jessica Tibaldi, Rolando Cimaz, Achille Marino, Gabriele Simonini, Maria Vincenza Mastrolia, Francesco La Torre, Ilaria Tricarico, Francesco Licciardi, Davide Montin, Maria Cristina Maggio, Clotilde Alizzi, Giorgia Martini, Adele Civino, Romina Gallizzi, Alma Nunzia Olivieri, Francesca Ardenti Morini, Giovanni Conti, Fabrizio De Benedetti, Manuela Pardeo
Summary: This study used real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with sJIA. The results showed that canakinumab was effective in treating sJIA and had no serious adverse events. The history of MAS and higher number of active joints were associated with poorer treatment outcomes.
Article
Immunology
Prasad T. Oommen, Timmy Strauss, Karen Baltruschat, Ivan Foeldvari, Christoph Deuter, Gerd Ganser, Johannes-Peter Haas, Claas Hinze, Dirk Holzinger, Anton Hospach, Hans-Iko Huppertz, Arnold Illhardt, Michael Jung, Tilmann Kallinich, Ariane Klein, Kirsten Minden, Kirsten Monkemoller, Sonja Mrusek, Ulrich Neudorf, Gregor Dueckers, Tim Niehues, Matthias Schneider, Philipp Schoof, Angelika Thon, Michael Wachowsky, Norbert Wagner, Susanne Bloedt, Michael Hofer, Klaus Tenbrock, Catharina Schuetz
Summary: This article summarizes the recent update of the interdisciplinary, consensus-based German guidelines on the management of juvenile idiopathic arthritis (JIA). Through multi-disciplinary and consensus participation, therapeutic principles and recommendations were proposed, providing physicians with evidence-based tailored treatment approaches.
CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Ellen Go, Mira van Veenendaal, Cedric Manlhiot, Rayfel Schneider, Brian W. McCrindle, Rae S. M. Yeung
Summary: This study describes the disease course of a small proportion of patients with both Kawasaki disease and systemic juvenile idiopathic arthritis, characterized by refractory Kawasaki disease, high prevalence of coronary artery dilatation, and shared immunopathology potentially linking the two conditions.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Duilio Petrongari, Paola Di Filippo, Francesco Misticoni, Giulia Basile, Sabrina Di Pillo, Francesco Chiarelli, Marina Attanasi
Summary: Systemic juvenile idiopathic arthritis associated with lung disorders (sJIA-LD) is a subtype of sJIA characterized by chronic life-threatening pulmonary disorders. It was exceptionally rare before 2013, but the reported prevalence is now approximately 6.8%. Clinically, children with sJIA-LD exhibit relatively mild symptoms, but the severity of pulmonary inflammation is high. sJIA-LD is often associated with early onset, macrophage activation syndrome, and high interleukin-18 circulating levels.
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Athimalaipet Ramanan, Gerd Horneff, Ruben Cuttica, Michael Henrickson, Jordi Anton, Alina Lucica Boteanu, Inmaculada Calvo Penades, Kirsten Minden, Heinrike Schmeling, Markus Hufnagel, Jennifer E. Weiss, Manuela Pardeo, Kabita Nanda, Johannes Roth, Nadina Rubio-Perez, Joy C. Hsu, Sunethra Wimalasundera, Chris Wells, Kamal Bharucha, Wendy Douglass, Min Bao, Navita L. Mallalieu, Alberto Martini, Daniel Lovell, Fabrizio De Benedetti
Summary: The study found that the dosing regimens of s.c. tocilizumab in systemic JIA and polyarticular JIA are similar to i.v. tocilizumab with good efficacy. Additionally, the subcutaneous administration route is more convenient and suitable for at-home use.
Article
Rheumatology
Justine Maller, Emily Fox, K. T. Park, Sarah Sertial Paul, Kevin Baszis, Charlotte Borocco, Sampath Prahalad, Pierre Quartier, Adam Reinhardt, Dieneke Schonenberg-Meinema, Lauren Shipman-Duensing, Maria Teresa Terreri, Julia Simard, Idit Lavi, Elizabeth Chalom, Joyces Hsu, Devy Zisman, Elizabeth D. Mellins
Summary: The occurrence of inflammatory bowel disease in the setting of systemic juvenile idiopathic arthritis is rare, with patients showing favorable response to tumor necrosis factor-alpha inhibitors.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Melissa L. Mannion, Fenglong Xie, Daniel B. Horton, Sarah Ringold, Colleen K. Correll, Anne Dennos, Timothy Beukelman
Summary: Biologic medications have greatly improved disease control and outcomes for patients with juvenile idiopathic arthritis (JIA), but a substantial number of patients may require switching to a second biologic. The time to switch has decreased in recent years, and further studies are needed to evaluate outcomes and optimal timing of biologic switching.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Jordan T. Jones, Chelsey Smith, Mara L. Becker, Daniel Lovell
Summary: This study found that patients with Down syndrome-associated arthritis (DA) and juvenile idiopathic arthritis (JIA) had similar therapeutic exposure, but DA patients had higher rates of adverse events and treatment ineffectiveness. At the last visit, DA patients had a greater disease burden compared to JIA patients. More research is needed to determine differences in pathophysiology and optimal therapeutic approaches.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Pediatrics
Chelsea DeCoste, Dimas Mateos-Corral, Bianca Lang
Summary: Shrinking lung syndrome (SLS), a rare complication of systemic lupus erythematosus (SLE) with limited literature on optimal treatment, was reported in a child who fully recovered with rituximab. International lupus registries should document occurrences and outcomes to determine the best treatment for this rare complication.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Rheumatology
Dax G. Rumsey, Aimee Lougee, Roland Matsouaka, David H. Collier, Laura E. Schanberg, Jennifer Schenfeld, Natalie J. Shiff, Matthew L. Stoll, Scott Stryker, Pamela F. Weiss, Timothy Beukelman
Summary: This study described characteristics of over 900 children with ERA or juvenile PsA, highlighting high biologic use, especially in those with sacroiliitis. Equal sex representation was found in children with sacroiliitis.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Ishaan Dave, Brandon Estroff, Talia Gergely, Christina A. Rostad, Lori A. Ponder, Courtney McCracken, Sampath Prahalad
Summary: Children with juvenile idiopathic arthritis are more likely to be born in the winter, specifically in the month of January, compared to the general population. These findings suggest that seasonal variations during gestation and early postnatal periods may play a role in the development of JIA.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Pediatrics
Nayimisha Balmuri, William Daniel Soulsby, Victoria Cooley, Linda Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta
Summary: The study found that higher community poverty levels were associated with a longer time to pediatric rheumatologist presentation after symptom onset in children with polyarticular juvenile idiopathic arthritis.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Pediatrics
Timothy Beukelman, Aimee Lougee, Roland A. Matsouaka, David Collier, Dax G. Rumsey, Jennifer Schenfeld, Scott Stryker, Marinka Twilt, Yukiko Kimura
Summary: This study characterizes contemporary patterns of ETN use in the CARRA Registry. Treatment was largely in keeping with American College of Rheumatology guidelines.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Rheumatology
Mei Sing Ong, Sarah Ringold, Yukiko Kimura, Laura E. Schanberg, George A. Tomlinson, Marc D. Natter
Summary: The study investigated the effects of early introduction of biologic disease-modifying antirheumatic drugs on untreated polyarticular juvenile idiopathic arthritis. It was found that starting bDMARDs within 3 months of baseline assessment was associated with more rapid achievement of inactive disease. Trajectory analysis of disease course proved to be a useful method for determining treatment efficacy in this context.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Yukiko Kimura, Laura E. Schanberg, George A. Tomlinson, Mary Ellen Riordan, Anne C. Dennos, Vincent Del Gaizo, Katherine L. Murphy, Pamela F. Weiss, Marc D. Natter, Brian M. Feldman, Sarah Ringold
Summary: The optimal timing to initiate biologics in polyarticular juvenile idiopathic arthritis (JIA) remains uncertain. A study compared three different treatment strategies for untreated polyarticular JIA, finding that early combination therapy may be more effective in achieving clinically inactive disease.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Pediatrics
William Daniel Soulsby, Nayimisha Balmuri, Victoria Cooley, Linda M. Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta
Summary: Social determinants of health have a significant impact on the outcomes of rheumatoid arthritis treatment. Our study found that community poverty level, race/ethnicity, and economic factors are associated with disease activity and functional disability in polyarticular juvenile idiopathic arthritis patients.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Pediatrics
Meghan E. Ryan, Andrew Warmin, Bryce A. Binstadt, Colleen K. Correll, Emily Hause, Patricia Hobday, Alison Lerman, Shawn A. Mahmud, Mona M. Riskalla, Zachary Shaheen, Richard K. Vehe, Danielle R. Bullock
Summary: The study aimed to improve documentation of critical data elements by implementing quality improvement methods, and found that virtual visits had lower data capture rates compared to in-person visits.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Pediatrics
Shawn A. Mahmud, Danielle R. Bullock, Colleen K. Correll, Patricia M. Hobday, Mona M. Riskalla, Richard K. Vehe, Bryce A. Binstadt
Summary: Non-criteria antiphospholipid antibodies (NC-aPL) are associated with pediatric patients with antiphospholipid syndrome (APS), and doctors should consider the existence of NC-aPL when there is a high suspicion and routine antiphospholipid antibody tests are negative. Currently, there are no guidelines for NC-aPL in children or adults, so more data needs to be collected.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Bayardo Garay, Denise Erlanson, Bryce A. Binstadt, Colleen K. Correll, Nora Fitzsimmons, Patricia M. Hobday, Allison Hudson, Shawn Mahmud, Mona M. Riskalla, Sara Kramer, Sheng Xiong, Richard K. Vehe, Danielle R. Bullock
Summary: By implementing a checkout sheet and staggered start times, this study effectively reduced patient wait time in a paediatric rheumatology clinic, leading to a decrease in variation and mean wait time.
Article
Rheumatology
Elham Rezaei, Marianna M. Newkirk, Zhenhong Li, John R. Gordon, Kiem G. Oen, Susanne M. Benseler, Gilles Boire, David A. Cabral, Sarah Campillo, Gaelle Chedeville, Anne-Laure Chetaille, Paul Dancey, Ciaran Duffy, Karen Watanabe Duffy, Kristin Houghton, Adam M. Huber, Roman Jurencak, Bianca Lang, Kimberly A. Morishita, Ross E. Petty, Suzanne E. Ramsey, Johannes Roth, Rayfel Schneider, Rosie Scuccimarri, Lynn Spiegel, Elizabeth Stringer, Shirley M. L. Tse, Lori B. Tucker, Stuart E. Turvey, Rae S. M. Yeung, Alan M. Rosenberg
Summary: The study found that plasma sLRP1 levels are associated with clinical conditions and biomarkers in JIA patients. At enrollment, sLRP1 levels were negatively correlated with age and active joint counts, with children showing significantly higher levels than adolescents. Higher sLRP1 levels were positively correlated with 6 anti-inflammatory biomarkers.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Claire E. H. Barber, Marinka Twilt, Tram Pham, Gillian R. Currie, Susanne Benseler, Rae S. M. Yeung, Michelle Batthish, Nicholas Blanchette, Jaime Guzman, Bianca Lang, Claire LeBlanc, Deborah M. Levy, Christine O'Brien, Heinrike Schmeling, Gordon Soon, Lynn Spiegel, Kristi Whitney, Deborah A. Marshall
ARTHRITIS RESEARCH & THERAPY
(2020)