Article
Pediatrics
Marilena Savoia, Francesca Rech Morassutti, Luigi Castriotta, Daisy Pavoni, Peter M. Mourani, Paola Freschi, Luigi Cattarossi, Antonio Tonutti
Summary: This study evaluated the feasibility of using neonatologist-performed echocardiography for follow-up of preterm infants with moderate/severe bronchopulmonary dysplasia (BPD) and described the course of pulmonary hypertension (PH) in these infants. NPE follow-up was found to be safe for infants with BPD, aiding in early detection of mild PH.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Simone de Araujo Negreiros Figueira, Allan Chiaratti de Oliveira, Marina Maccagnano Zamith, Cristiane Metolina, Milton Harumi Miyoshi, Adriana Sanudo, Ruth Guinsburg
Summary: This study aimed to assess the impact of neonatologist-performed echocardiography (NPE) on the hemodynamic management of critically ill newborn infants. The results showed that NPE modified the planned approach, especially in assessing pulmonary and systemic flow. This study highlights the importance of NPE in guiding therapeutic planning in the NICU, particularly for unstable newborns with lower birthweight and receiving catecholamines.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Eirik Nestaas
Summary: The interest in using cardiac ultrasound for hemodynamic evaluation in neonates has increased, and neonatologist performed echocardiography provides in-depth information on heart function and hemodynamics. This review gives an overview of relevant assessment methods and suggests future developments might focus on education and the implementation of artificial intelligence.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Steven M. Donn
Summary: This paper reviews the historical aspects of PPHN, providing insights into the progress we have made in treating this condition and the challenges that lie ahead.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sophie Breinig, Odile Dicky, Virginie Ehlinger, Yves Dulac, Marie-Odile Marcoux, Catherine Arnaud
Summary: The aim of the study was to describe echocardiographic parameters in neonates with PH and identify predictors of short-term outcome deterioration. The study found a strong link between right-to-left shunt and death. It is recommended to repeat echocardiography after basic therapeutic optimization for prognostic purposes.
PEDIATRIC CARDIOLOGY
(2021)
Article
Pediatrics
Maria Carmen Bravo, Rebeca Sanchez, Ana Isabel Blanco, Itsaso Losantos, Adelina Pellicer
Summary: The study proposed a predictive model of early spontaneous PDA closure that includes gestational age and screening PDA score to assist clinicians in decision-making for PDA treatment. This model could potentially improve eligibility criteria for future intervention trials aimed at preventing PDA-related complications.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Adrianne Rahde Bischoff, Regan E. Giesinger, Danielle R. Rios, Luc Mertens, Ravi Ashwath, Patrick J. McNamara
Summary: The study showed high concordance in anatomical findings between neonatal hemodynamics specialists and pediatric cardiologists in evaluating infants at low risk for congenital heart disease, indicating that first echocardiograms obtained by subspecialty neonatologists may provide sufficient imaging quality for assessing critically ill neonates with low suspicion for critical CHD lesions.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Pediatrics
Virginie Meau-Petit, Yael Levy, Isabelle Guellec
Summary: This study aimed to evaluate the utilization of NPE in the NICU and the physiological information obtained during shock management. The results showed that trained clinicians were more likely to use NPE to exclude congenital heart disease and provide ongoing therapeutic guidance. Additionally, NICUs with a higher number of doctors able to perform NPE were more inclined to use NPE prior to initiating treatment.
Article
Medicine, General & Internal
Ju-Hee Lee, Jae-Hyeong Park, In-Chang Hwang, Jin Joo Park, Jun-Bean Park
Summary: Pulmonary hypertension associated with left heart disease is the most common form of pulmonary hypertension, which has a significant impact on patients' health. The prevalence of persistent PH-LHD in patients observed on follow-up echocardiography was 21.6% and was associated with decreased left atrial function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Ran Zhou, You-Ning Zheng, Xin-Ying Zhang, Ya-Ying Cheng
Summary: Through a meta-analysis of 22 references, a total of 12 risk factors associated with persistent pulmonary hypertension of the newborn were identified, including factors related to pregnant women and newborns. Some of the most important risk factors identified were smoking during pregnancy, gestational weeks < 37, and perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
Linli Sun, Chunxia Wang, Yulu Zhou, Wei Sun, Chunjiang Wang
Summary: Different doses of sildenafil can significantly improve persistent pulmonary hypertension of the newborn (PPHN), with 1.5 mg/kg showing better clinical efficacy in reducing pulmonary artery systolic pressure, increasing oxygen partial pressure, and reducing carbon dioxide partial pressure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Tomohiko Yoshida, Katsuhiro Matsuura, Goya Seijirow, Akiko Uemura, Zeki Yilmaz, Ryou Tanaka
Summary: This study investigated the non-invasive assessment of pulmonary arterial wave reflection in dogs with suspected pulmonary hypertension using Doppler echocardiography. The results showed that dogs with suspected PH had significantly higher RC than dogs without echocardiographic evidence of PH, and dogs with higher RC had shorter survival times. The study also validated the correlation between RC obtained by Doppler echocardiography and RC obtained by cardiac catheterization in dogs with experimentally-induced PH.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Li Wen-ting, Wu Chang-wei, Bian De-jian, Sha Wei
Summary: This study aimed to investigate the correlation between arterial blood gas parameters, inflammatory markers, and coagulation indicators with pulmonary artery systolic pressure (PASP) values in patients with active pulmonary tuberculosis (PTB). The results showed that arterial partial pressure of oxygen (PaO2) and procalcitonin were strongly correlated with PASP values in active PTB patients. The degree of hypoxia and severity of secondary respiratory bacterial infection may influence PASP value in active PTB.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Remigiusz Kazimierczyk, Ewelina Kazimierczyk, Malgorzata Knapp, Bozena Sobkowicz, Lukasz A. Malek, Piotr Blaszczak, Katarzyna Ptaszynska-Kopczynska, Ryszard Grzywna, Karol A. Kaminski
Summary: The study showed that the TAPSE/sPAP ratio in patients with pulmonary arterial hypertension (PAH) is a valuable prognostic parameter for assessing hemodynamic adaptation and predicting outcomes, providing an easy and reliable non-invasive tool for comprehensive evaluation of patients' condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Katharina Meinel, Martin Koestenberger, Hannes Sallmon, Georg Hansmann, Guido E. Pieles
Summary: Invasive assessment in the catheterization laboratory is the gold standard for diagnosing pulmonary hypertension in children, but transthoracic echocardiography (TTE) is the initial diagnostic tool. Guidelines suggest key echocardiographic variables for screening, but these may not apply to patients with congenital heart disease (CHD). Misinterpretation of TTE variables can lead to delayed diagnosis and therapy, or unnecessary invasive procedures with risks in the pediatric age group.
Article
Pediatrics
Aisling Smith, Sean Armstrong, Eugene Dempsey, Afif EL-Khuffash
Summary: This study examined the effects of PRBC transfusion on pulmonary vascular resistance, systemic vascular resistance, myocardial function, and oxygenation in premature babies. The results showed that PRBC transfusion reduced PVR, but the presence of a PDA had differential effects on right ventricular function and splanchnic oxygenation.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Lisa Bjarko, Drude Fugelseth, Nina Harsem, Torvid Kiserud, Guttorm Haugen, Eirik Nestaas
Summary: FGR has a significant impact on cardiac modeling in neonates, and factors such as gestational age, birth weight, sex, and twin/singleton influence the effects. Statistical adjustments are important for accurately analyzing the effects of FGR.
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Afif El-Khuffash, Patrick J. McNamara, Colm Breatnach, Neidin Bussmann, Aisling Smith, Oliver Feeney, Elizabeth Tully, Joanna Griffin, Willem P. de Boode, Brian Cleary, Orla Franklin, Eugene Dempsey
Summary: This study aimed to assess the impact of milrinone administration on time spent on nitric oxide (iNO) in infants with acute pulmonary hypertension (aPH). The results showed that milrinone did not reduce the time on iNO therapy and there were difficulties in recruiting participants. There is still a lack of research in this field regarding acute pulmonary hypertension in infants.
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
R. E. Giesinger, A. F. El-Khuffash, P. J. McNamara
Summary: The aim of this study was to evaluate the correlation between the recovery of arterial pressure and physiological recovery among patients with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia. The results showed that, despite recovered arterial pressure, inotrope-treated patients still had persistent severe right ventricular dysfunction and evidence of abnormal brain tissue oxygen delivery. In conclusion, arterial pressure is not indicative of right ventricular function, and the need for inotropic agents may indicate abnormal brain tissue oxygen delivery.
JOURNAL OF PERINATOLOGY
(2023)
Review
Pediatrics
Aravanan Anbu Chakkarapani, Charles C. Roehr, Stuart B. Hooper, Arjan B. te Pas, Samir Gupta
Summary: Transitional circulation in newborns is temporary but highly variable among infants. It is an intermediate stage between fetal and neonatal circulation. Without definitive clinical trials, information from physiological studies can assist in making clinical decisions when there is hemodynamic compromise. This review summarizes the unique physiological features of transitional circulation in term and preterm infants, discussing common causes of hemodynamic compromise during the transition, intact umbilical cord resuscitation, and advanced hemodynamic monitoring.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Andrew S. J. Marshall, Alexandra Scrivens, Jennifer L. Bell, Louise Linsell, Pollyanna Hardy, Jean Yong, Rachel Williams, Eleri Adams, Manish Sadarangani, Edmund Juszczak, Charles C. Roehr, NeoCLEAR Collaborative Group
Summary: This study found that using a sitting position instead of a lying position during lumbar punctures in newborns can improve success rates. Sitting lumbar punctures are safe, cost-neutral, and well-tolerated. These results strongly support the widespread adoption of sitting technique for neonatal lumbar punctures.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Pediatrics
Marc Paul O. Sullivan, Vicki Livingstone, Irina Korotchikova, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan
Summary: Unconditional reference centiles for sleep parameters were established in infants 4-16 weeks of age based on data from a randomized controlled trial. The results showed that total sleep duration in a 24-hour period, night-time sleep duration in a 12-hour period, and longest sleep episode duration increased from 4 to 16 weeks, while daytime sleep duration in a 12-hour period decreased.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Pediatrics
Rachel Mullaly, Afif Faisal El-Khuffash
Summary: The management of low blood flow states in premature neonates is challenging due to the over-reliance on protocols that do not consider underlying pathophysiology, leading to misuse of vasoactive agents. Understanding the underlying pathophysiology may guide choice of treatment and assess physiological response to intervention.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Natascha Koestlin-Gille, Lina Maria Serna-Higuita, Caren Bubser, Joerg Arand, Laura Haag, Christoph E. Schwarz, Martin Heideking, Christian F. Poets, Christian Gille
Summary: This study investigated whether the timing of antibiotic therapy in preterm infants influenced short-term outcomes. The results showed that early initiation of antibiotic therapy was associated with an increased risk of developing bronchopulmonary dysplasia. Therefore, improved identification of low-risk infants for early-onset sepsis is needed to reduce antibiotic exposure.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Cardiac & Cardiovascular Systems
Aisling Smith, Orla Franklin, Edgar Mocanu, Naomi McCallion, Afif EL-Khuffash
Summary: This study aimed to assess myocardial function and pulmonary hemodynamic measurements in infants conceived via assisted reproductive technologies (ART) and compare them to spontaneously conceived controls. The results showed that infants conceived via ART had higher right ventricular basal and mid cavity diameters, lower pulmonary artery acceleration time, and higher left ventricular eccentricity index. Furthermore, they had lower myocardial strain measurements at different time points. These findings suggest the need for increased cardiovascular surveillance in ART-conceived infants.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Pediatrics
Niklas Breindahl, Martin G. Tolsgaard, Tine B. Henriksen, Charles C. Roehr, Tomasz Szczapa, Luigi Gagliardi, Maximo Vento, Ragnhild Stoen, Kajsa Bohlin, Anton H. van Kaam, Daniel Klotz, Xavier Durrmeyer, Tongyan Han, Anup C. Katheria, Peter A. Dargaville, Lise Aunsholt
Summary: This study established an international consensus on the training curriculum and assessment tool for the less invasive surfactant administration procedure (LISA). The consensus-based expert statement provides content that can optimize and standardize LISA training in the future.
PEDIATRIC RESEARCH
(2023)
Editorial Material
Pediatrics
Cristina Scutariu, Davide Bilardi, Francis I. I. Ayomoh, Charles C. C. Roehr
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jarinda A. Poppe, Sean P. Fitzgibbon, H. Rob Taal, Sjoukje E. Loudon, Angela M. Tjiam, Charles C. Roehr, Irwin K. M. Reiss, Sinno H. P. Simons, Caroline Hartley
Summary: This study examines the ability of physiological data during the first postnatal month to predict laser treatment for retinopathy of prematurity (ROP) in preterm infants. The results show that physiological data already have predictive accuracy, but further validation is needed. These findings suggest the potential of physiological data for future ROP prediction and early interventions to protect infants from abnormal retinal development.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Eirik Nestaas, Lisa Bjarko, Torvid Kiserud, Guttorm Haugen, Drude Fugelseth
Summary: The aim of the study was to assess heart function in FGR neonates during the first three days after birth using echocardiography. The results showed that late-FGR neonates had reduced left diastolic function compared to controls, while there was no significant difference in heart function between early-FGR and late-FGR neonates.
EARLY HUMAN DEVELOPMENT
(2023)
Article
Pediatrics
Richelle A. C. M. Olde Keizer, Abderrahim Marouane, Wilhelmina Kerstjens-Frederikse, A. Chantal Deden, Klaske Lichtenbelt, Tinneke Jonckers, Marieke Vervoorn, Maaike Vreeburg, Lidewij Henneman, Linda de Vries, Richard Sinke, Rolph Pfundt, Servi J. C. Stevens, Peter Andriessen, Richard van Lingen, Marcel Nelen, Hans Scheffer, Daphne Stemkens, Cor Oosterwijk, Hans Kristian Ploos van Amstel, Willem de Boode, Wendy A. G. van Zelst-Stams, Geert W. J. Frederix, Lisenka E. L. M. Vissers
Summary: The introduction of rapid exome sequencing (rES) has improved clinical decision-making for critically ill neonates. A clinical utility study was conducted comparing rES to routine genetic testing, and the results showed that rES detected more conclusive genetic diagnoses in shorter time and reduced genetic diagnostic costs.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)