Article
Gastroenterology & Hepatology
Nadine Al-Naamani, Michael J. Krowka, Kimberly A. Forde, Karen L. Krok, Rui Feng, Gustavo A. Heresi, Raed A. Dweik, Sonja Bartolome, Todd M. Bull, Kari E. Roberts, Eric D. Austin, Anna R. Hemnes, Mamta J. Patel, Jae K. Oh, Grace Lin, Margaret F. Doyle, Nina Denver, Ruth Andrew, Margaret R. MacLean, Michael B. Fallon, Steven M. Kawut
Summary: The study found that the risk allele A in rs7175922 (CYP19A1) was significantly associated with higher levels of estradiol and an increased risk of POPH in patients. Other SNPs did not show significant associations, but changes in some estrogen metabolites were correlated with POPH.
Review
Pharmacology & Pharmacy
Magdalena Jasinska-Stroschein
Summary: The study found that metabolic disorders may increase susceptibility to pulmonary hypertension in rodent models and explored the effects of various diabetes (obesity)-related procedures on PH. Factors to consider when selecting a PH research animal model include the molecular background of the disease and the molecular activity of the tested agent.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Kun-Han Chuang, Ru-Hui Yao, Ya-Nan Jiang, Long-Xin Gui, Si-Yi Zheng, Mo-Jun Lin
Summary: This study investigated the effects of magnesium ions on pulmonary arterial calcification and found that high magnesium intake can alleviate pulmonary hypertension index and mitigate the detrimental effects of calcification on proliferation, migration, and apoptosis of pulmonary arterial smooth muscle cells.
JOURNAL OF HYPERTENSION
(2022)
Review
Multidisciplinary Sciences
Andrei A. Karpov, Dariya D. Vaulina, Sergey S. Smirnov, Olga M. Moiseeva, Michael M. Galagudza
Summary: This article provides an overview of the main approaches to modeling pulmonary embolism (PE). It discusses the induction of thromboembolism, the introduction of non-thrombotic particles, and surgical procedures as methods for PE modeling. The choice of a specific model and animal species is determined based on the objectives of the study. The article also describes rodent models of chronic thromboembolic pulmonary hypertension (CTEPH), which is the most devastating complication of PE. Based on available evidence, there is currently no single optimal method for modeling PE and CTEPH.
Article
Cardiac & Cardiovascular Systems
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G. Sellers, Zach L. Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D. Verin, Lin Gan, Quansheng Du, Stephen J. Benkovic, Suowen Xu, John M. Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J. R. Fulton, Yuqing Huo
Summary: This study found that the enzyme ATIC, which mediates de novo purine synthesis, plays a critical role in the proliferation of pulmonary artery smooth muscle cells (PASMCs) and the development of pulmonary hypertension (PH). Targeting ATIC-mediated DNPS reduces the availability of purine nucleotides, leading to decreased PASMC proliferation and amelioration of PH development and progression.
EUROPEAN HEART JOURNAL
(2023)
Letter
Medicine, General & Internal
Trine Munk-Olsen, Veerle Bergink, Anna-Sophie Rommel, Natalie Momen, Xiaoqin Liu
Summary: This population-based cohort study in Denmark explores the risk of persistent pulmonary hypertension among newborns after antidepressant exposure in utero.
Article
Pediatrics
Chenhong Wang, Xiaolu Ma, Yanping Xu, Zheng Chen, Liping Shi, Lizhong Du
Summary: The study aimed to establish a prediction model for bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in preterm infants. Four independent predictive factors were identified, and a prediction model was developed with high accuracy in predicting the development of BPD-PH.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell & Tissue Engineering
Julien Guihaire, Tobias Deuse, Dong Wang, Joshua M. Spin, Francis G. Blankenberg, Elie Fadel, Hermann Reichenspurner, Sonja Schrepfer
Summary: The study found that tolerogenic macrophages can reduce right ventricular pressure and improve myocardial function in a pulmonary hypertension model, reducing the thickness of small arteriole walls and cardiomyocyte area. Compared with the group without toM injection, the group injected with toM showed a trend toward upregulation of genes related to the pathobiology of pulmonary arterial hypertension, but KCNK3 was significantly downregulated.
STEM CELLS AND DEVELOPMENT
(2021)
Review
Pharmacology & Pharmacy
Magdalena Jasinska-Stroschein
Summary: This study examines the advantages and effects of using genetically-modified animals in pulmonary hypertension models, as well as their potential contributions to understanding disease mechanisms and identifying new drug targets.
VASCULAR PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andre Balsa, Rui Adao, Carmen Bras-Silva
Summary: This study reviews interventions on pulmonary artery banding (PAB) and pulmonary hypertension (PH) models and finds that many drugs show effective treatment outcomes. However, inconsistencies in methodology may contribute to inconsistent results. Standardizing methods may improve comparability between studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Di Chen, Hui-fang Zhang, Tian-yi Yuan, Shu-chan Sun, Ran-ran Wang, Shou-bao Wang, Lian-hua Fang, Yang Lyu, Guan-hua Du
Summary: In this study, the efficacy of puerarin in the treatment of experimental PH was evaluated. The results showed that puerarin treatment significantly improved symptoms and prognosis of PH, as well as restored normal function of lung tissues and right ventricles.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Karoline Gonzaga-Costa, Alfredo Augusto Vasconcelos-Silva, Matyelle Jussara Rodrigues-Silva, Conceicao da Silva Martins Rebouca, Gloria Pinto Duarte, Rosivaldo Santos Borges, Pedro Jorge Caldas Magalhaes, Saad Lahlou
Summary: The study investigated the effects of novel sGC stimulator T4MN and sildenafil on monocrotaline-induced PAH, showing significant reduction in pulmonary arterial hypertension-related cardiovascular burden and vascular wall thickness.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Respiratory System
Grayson L. Baird, Thomas Walsh, Jason Aliotta, Melissa Allahua, Ruth Andrew, Ghada Bourjeily, Alexander S. Brodsky, Nina Denver, Mark Dooner, Elizabeth O. Harrington, James R. Klinger, Margaret R. MacLean, Christopher J. Mullin, Mandy Pereira, Athena Poppas, Mary Whittenhall, Corey E. Ventetuolo
Summary: In this study, fluctuations in cardiopulmonary function during menstruation in women with PAH were found to be driven by E2 and DHEA-S. These sex hormones influence transcription of extracellular vesicle miRNAs implicated in the pathobiology of pulmonary vascular disease and cancer, and are associated with clinical markers such as 6-minute walk distance and NT-proBNP levels.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Biology
Keiji Kimuro, Kazuya Hosokawa, Kohtaro Abe, Kohei Masaki, Satomi Imakiire, Takafumi Sakamoto, Hiroyuki Tsutsui
Summary: This study evaluated the impact of pulmonary vasodilators on exercise tolerance and pulmonary hemodynamics in patients with chronic kidney disease (CKD) on hemodialysis. The results showed that pulmonary vasodilators can decrease pulmonary vascular resistance and improve exercise tolerance in hemodialysis patients with pre-capillary pulmonary hypertension (PH).
Article
Cardiac & Cardiovascular Systems
J. Deweirdt, T. Ducret, J. -F. Quignard, V. Freund-Michel, S. Lacomme, E. Gontier, B. Muller, R. Marthan, C. Guibert, I. Baudrimont
Summary: Several epidemiological studies have indicated the involvement of nanoparticles (NPs) in respiratory and cardiovascular mortality. This study focused on carbon black NPs and their toxic effects in the pulmonary circulation, particularly under pathological conditions, where oxidative stress, inflammation, and calcium signaling alterations were found to be increased.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Toxicology
David Boels, Arnaud Courtois, Camille Paradis, Pascal Caillet, Magali Labadie
Summary: A retrospective review of Vipera spp. snakebite cases in Bordeaux, France, found good agreement between VipGrade(R) assessments and PCC guidelines, but some discrepancies with toxicologists' assessments. The VipGrade(R) tool may aid in rapid and standardized determination of management and follow-up for viper-bitten patients, supplementing clinical toxicologists' advice.
CLINICAL TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ruth Hornedo-Ortega, Michael Jourdes, Gregory Da Costa, Arnaud Courtois, Julien Gabaston, Pierre-Louis Teissedre, Tristan Richard, Stephanie Krisa
Summary: Stilbene metabolites are of great interest due to their similar or even stronger biological effects compared to their parent compounds. Their study is highly relevant as they are predominant in biological fluids. The metabolism of oxyresveratrol (ORV) and gnetol (GN) resulted in the formation of several glucuronide metabolites, which showed the ability to decrease the production of inflammatory factors in stimulated macrophages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Ophelie Germande, Magalie Baudrimont, Fabien Beaufils, Veronique Freund-Michel, Thomas Ducret, Jean-Francois Quignard, Marie-Helene Errera, Sabrina Lacomme, Etienne Gontier, Stephane Mornet, Megi Bejko, Bernard Muller, Roger Marthan, Christelle Guibert, Juliette Deweirdt, Isabelle Baudrimont
Summary: This study focuses on evaluating the cytotoxic effects of nickel oxide nanoparticles on human pulmonary artery endothelial cells. The results indicate that these nanoparticles induce oxidative stress, inflammation, and mitochondrial dysfunction in the endothelial cells.
Article
Respiratory System
S. Barbeau, T. Porto Ribeiro, G. Gilbert, G. Cardouat, I Baudrimont, V Freund-Michel, C. Guibert, R. Marthan, P. Vacher, J-F Quignard, T. Ducret
Summary: Pulmonary hypertension is a pulmonary circulation pathology characterized by remodeling and hyperreactivity of the pulmonary arteries. The vasodilatation/vasoconstriction balance is altered, favoring constriction due to the proliferation of smooth muscle cells and the development of endothelial dysfunction. In addition, mechanical forces cause modifications in the pulmonary arteries, leading to changes in the activation of stretch-activated channels such as Piezo1 and TRPV4. These channels, sensitive to stretch, can induce various cellular physiological responses, which significantly contribute to the development and continuation of the pathology.
REVUE DES MALADIES RESPIRATOIRES
(2022)
Article
Cell Biology
Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
Summary: This study shows that asthmatic bronchial smooth muscle (BSM) cells enhance the replication of rhinovirus (RV) in bronchial epithelium through increased production of CCL20. Additionally, these asthmatic BSM cells downregulate the antiviral pathway PKR, leading to increased susceptibility of the bronchial epithelium to RV infection.
Article
Biochemistry & Molecular Biology
Ophelie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Veronique Freund-Michel, Marie-Helene Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont
Summary: This study compared the toxic effects of nickel oxide nanoparticles (NiONPs) on human pulmonary artery endothelial cells (HPAEC) under physiological and pathological conditions. The results showed that under pathological conditions, NiONPs had a more pronounced adverse effect on oxidative stress, inflammation, calcium signaling, and mitochondrial function in the cells compared to physiological conditions.
Correction
Biochemistry & Molecular Biology
Pauline Beaumont, Arnaud Courtois, Claude Atgie, Tristan Richard, Stephanie Krisa
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Cell Biology
Thais Porto Ribeiro, Solene Barbeau, Isabelle Baudrimont, Pierre Vacher, Veronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-Francois Quignard
Summary: In this study, the role of endothelial Piezo1 in intrapulmonary vascular relaxation was investigated in a chronic hypoxia model of pulmonary hypertension (PH). The results showed that endothelial Piezo1 contributes to intrapulmonary vascular relaxation in the early stage of PH by controlling endothelial [Ca2+]i, endothelial-dependent hyperpolarization, and Akt-eNOS pathway activation.
Article
Biochemistry & Molecular Biology
Solene Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Veronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-Francois Quignard, Thomas Ducret
Summary: Cell density is a crucial parameter for the activity of the TRPV4 channel in response to hypoxia. At low density, TRPV4 response to hypoxia is increased, while at high density, TRPV4 response is strongly inhibited.
Review
Food Science & Technology
Jules-Antoine Vaucel, Sebastien Larreche, Camille Paradis, Arnaud Courtois, Jean-Marc Pujo, Narcisse Elenga, Dabor Resiere, Weniko Care, Luc de Haro, Jean-Christophe Gallart, Romain Torrents, Corinne Schmitt, Johan Chevalier, Magali Labadie, Hatem Kallel
Summary: There are 67 scorpion species in France and its territories, with varying distribution. Reunion Island has only one species, while French Guiana has 38 species. The number of scorpion stings varies, with up to 90 stings per 100,000 inhabitants annually. Scorpion venom is composed of enzymes and peptides, and different species have different medical importance. France does not have scorpion antivenom as scorpion stings are generally not fatal.
Article
Multidisciplinary Sciences
Yann Loick Chappe, Sandra Pierredon, Alexandre Joushomme, Pablo Molle, Andre Garenne, Anne Canovi, Solene Barbeau, Florence Poulletier De Gannes, Annabelle Hurtier, Isabelle Lagroye, Thomas Ducret, Jean-Franc Comma Ois Quignard, Vincent Compan, Yann Percherancier
Summary: This study developed highly sensitive bioluminescence resonance energy transfer (BRET) probes to track selective ion permeability in ion channels. The results showed that well-known TRPV1 inhibitors more potently inhibit Ca2+ influx than K+ efflux induced by capsaicin (CAPS). Furthermore, AMG517 was found to be a partial agonist of K+ efflux and triggered TRPV1-dependent cell membrane hyperpolarization. Ligand biases were also observed in other families of cationic channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Sebastien Chaigne, Solene Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
Summary: The TRPV4 channel plays a role in intracellular calcium handling in cardiac cells and is involved in various physiological functions in the cardiovascular system. It modulates mitochondrial activity, calcium homeostasis, electrical activity and contractility of cardiomyocytes, as well as vascular permeability, dilatation and constriction. Furthermore, TRPV4 channels are implicated in cardiac pathological processes such as fibrosis, hypertrophy, ischemia-reperfusion injuries, heart failure, myocardial infarction and arrhythmia. This manuscript provides an overview of the implications of TRPV4 channel in cardiac physiology and discusses its potential as a therapeutic target for cardiovascular diseases.