Article
Cell Biology
Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhang
Summary: Ischemic stroke leads to white matter damage and neurological deficits. In this study, the characteristics of white matter injury and repair after stroke were investigated using a mouse stroke model. The researchers found that white matter damage was most severe on Day 7 after the stroke, and gradually recovered from Day 7 to Day 30. They also discovered that CD11c(+) microglia play critical roles in white matter repair and functional recovery after stroke. These findings suggest that spontaneous white matter repair occurs after ischemic stroke, with CD11c(+) microglia being key players in this restorative process.
CELL DEATH & DISEASE
(2023)
Article
Biology
Ali Abdollahzadeh, Ilya Belevich, Eija Jokitalo, Alejandra Sierra, Jussi Tohka
Summary: DeepACSON is a segmentation software based on deep learning that allows for efficient tracking and segmentation of ultrastructures in brain tissues, providing excellent analysis and evaluation results. By combining existing semantic segmentation methods with a novel shape decomposition technique, DeepACSON achieves effective instance segmentation and white matter morphology quantification in low-resolution 3D-EM datasets.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Arash Nazeri, Zeljka Krsnik, Ivica Kostovi, Sung Min Ha, Janja Kopic, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Joan L. Luby, Barbara B. Warner, Cynthia E. Rogers, Deanna M. Barch, Joshua S. Shimony, Robert C. McKinstr, Jeffrey J. Neil, Christopher D. Smyser, Aristeidis Sotiras
Summary: This study used unsupervised multivariate pattern analysis to analyze a large sample of magnetic resonance imaging data, revealing coordinated patterns of white matter maturation during the early postnatal period and the contributions of microstructural indices. By comparing the findings with histological features, it provides a concise and effective representation of early postnatal white matter reorganization.
Review
Pathology
Katharina Eikermann-Haerter, Susie Y. Huang
Summary: Migraine is a well-known risk factor for subclinical focal deep white matter lesions, with ischemic and inflammatory mechanisms proposed as underlying causes, negatively impacting both physical and cognitive functions.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nemanja Novakovic, Joseph R. Linzey, Thomas L. Chenevert, Joseph J. Gemmete, Jonathan P. Troost, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study attempts to quantify white matter injury within and surrounding hematomas after mild to moderate ICH using DTI MRI, showing varying degrees of changes in white matter injury over time, with a correlation to hematoma size.
Article
Neurosciences
Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. McAllister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Summary: Mild traumatic brain injury (mTBI) is common in military personnel and is associated with age-related neurodegenerative disorders affecting white matter in the brain. Non-negative matrix factorization (NMF) was used to detect covarying patterns of fractional anisotropy (FA) associated with mTBI in a large dataset of military Veterans. The study showed significant age-dependent differences in WM alterations between Veterans with and without TBI, highlighting the importance of considering age in assessing the effects of mTBI.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Xiaoyun Liang, Chun-Hung Yeh, Juan F. D. Dominguez, Govinda Poudel, Stephan P. Swinnen, Karen Caeyenberghs
Summary: The study identified white matter changes in TBI patients and significant increases in macrostructural white matter in left sensorimotor tracts following balance training. However, these changes were not associated with behavioral changes.
NEUROIMAGE-CLINICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Meesters, Maud Landers, Geert-Jan Rutten, Luc Florack
Summary: MRI-based tractography is not widely used in brain tumor surgery due to method heterogeneity and lack of a turn-key system. This work evaluated the robustness and reliability of tractography results in healthy subjects, demonstrating promising potential for future validation and implementation in clinical populations.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Immunology
Mikko T. Huuskonen, Qinghai Liu, Krista Lamorie-Foote, Kristina Shkirkova, Michelle Connor, Arati Patel, Axel Montagne, Hans Baertsch, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Berislav Zlokovic, William J. Mack
Summary: Exposure to air pollution nanoparticles exacerbates cerebrovascular pathology and demyelination, particularly in the presence of cerebral hypoperfusion, suggesting a potential link between air pollution and cognitive decline in elderly populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Liang, Xinyuan Zhang, Yuhao Lin, Gui Fu, Jie Pan, Yanqiu Feng, Xiaofei Lv
Summary: This study used multishell diffusion MRI to investigate the dynamic alterations in the whole brain white matter microstructure in patients with nasopharyngeal carcinoma after radiotherapy. Two different types of white matter injuries were observed, with one being irreversible and the other partially recoverable.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Amaar Marefi, Nafisa Husein, Mary Dunbar, Deborah Dewey, Nicole Letourneau, Maryam Oskoui, Adam Kirton, Michael I. Shevell, Canadian Cerebral Palsy Registry CCPR
Summary: This study aimed to identify potential risk factors associated with periventricular white matter injury (PVWMI) in term-born children with cerebral palsy (CP). The results showed that pregnancy complications, antenatal toxin exposure, perinatal infection, and perinatal adversity were associated with PVWMI in these children.
Article
Neurosciences
Leilei Mao, Limin Sun, Jingyi Sun, Baoliang Sun, Yanqin Gao, Hong Shi
Summary: The study demonstrates that EP treatment can improve sensorimotor function following TBI, reduce white matter injury, and modulate microglia polarization toward the anti-inflammatory M2 phenotype during the acute phase of TBI recovery, improving the release of inflammatory-related factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Pediatrics
Clara Adriana Maria de Bruijn, Stefano Di Michele, Maria Luisa Tataranno, Luca Antonio Ramenghi, Andrea Rossi, Mariya Malova, Manon Benders, Agnes van den Hoogen, Jeroen Dudink
Summary: This study evaluated the influence of punctate white matter lesions (PWML) on long-term neurodevelopmental outcomes in preterm infants. The findings showed a correlation between PWML and motor delay, as well as between PWML and cognitive and behavioral outcomes. The severity and types of impairments were found to be related to the number and location of PWML.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mareike Grotheer, Mona Rosenke, Hua Wu, Holly Kular, Francesca R. Querdasi, Vaidehi S. Natu, Jason D. Yeatman, Kalanit Grill-Spector
Summary: In this study, the development of white matter in infants from 0 to 6 months was investigated using diffusion MRI and quantitative MRI measurements. The researchers found that the longitudinal relaxation rate (R1) of white matter increased over time, with faster development in less mature areas of white matter in newborns.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Michelle Connor, Krista Lamorie-Foote, Qinghai Liu, Kristina Shkirkova, Hans Baertsch, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, William J. Mack
Summary: Exposure to ambient air pollution, specifically particulate matter (PM), has been linked to white matter damage, axonal degradation, and increased inflammatory microglia in the corpus callosum of mice.
Article
Pediatrics
Kristina Wendel, Helle Cecilie Viekilde Pfeiffer, Drude Merete Fugelseth, Eirik Nestaas, Magnus Domelloef, Bjorn Steen Skalhegg, Katja Benedikte Presto Elgstoen, Helge Rootwelt, Rolf Dagfinn Pettersen, Are Hugo Pripp, Tom Stiris, Sissel J. Moltu
Summary: This study aims to investigate the effects of early supply of ARA and DHA on brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Infants will receive a fatty acid supplement from the second day of life to 36 weeks' postmenstrual age, with the primary outcome being brain maturation assessed by MRI.
Article
Biochemistry & Molecular Biology
Veronika Rackayova, Dunja Simicic, Guillaume Donati, Olivier Braissant, Rolf Gruetter, Valerie A. McLin, Cristina Cudalbu
Summary: The study revealed significant changes in brain metabolites in both the hippocampus and cerebellum during the later post-natal period of male rats, including decreased taurine and increased glutamate in the hippocampus, as well as a constant increase in myo-inositol and choline-containing compounds. These findings suggest the importance of considering changes in neurometabolites beyond the conventionally accepted cut off for adulthood in experimental design and data interpretation in this animal model.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Joana Sa de Almeida, Djalel-Eddine Meskaldji, Serafeim Loukas, Lara Lordier, Laura Gui, Francois Lazeyras, Petra S. Huppi
Summary: Prematurity disrupts brain development and network organization, leading to increased segregation and decreased integration capacity in preterm infants. Compared to full-term infants, preterm infants demonstrate delayed transition in brain network architecture and decreased connectivity strength in specific regions, potentially underlying behavioral and social cognition difficulties.
Article
Clinical Neurology
N. Ceren Askin Incebacak, Yao Sui, Laura Gui Levy, Laura Merlini, Joana Sa de Almeida, Sebastien Courvoisier, Tess E. Wallace, Antoine Klauser, Onur Afacan, Simon K. Warfield, Petra Huppi, Francois Lazeyras
Summary: The study compares the image quality of 2D high-resolution image acquisition with 3D reconstruction from low-resolution images in neonatal subjects, finding that they have comparable quality for clinical and morphometric assessments, with no loss of anatomical details and similar edge definition. Quantitative assessments show the reconstructed images accurately detect fine anatomical structures and allow for comparable morphometric measurements.
JOURNAL OF NEUROIMAGING
(2022)
Review
Pediatrics
Vaisakh Krishnan, Vijay Kumar, Gabriel Fernando Todeschi Variane, Waldemar A. Carlo, Zulfiqar A. Bhutta, Stephane Sizonenko, Anne Hansen, Seetha Shankaran, Sudhin Thayyil
Summary: Although low- and middle-income countries face a high burden of neonatal encephalopathy, there is limited evidence on prevention and management in these settings. Interventions based on high-income countries' evidence may not always be applicable to LMICs, and more research is needed to evaluate effective treatments specifically for these regions. Careful attention to supportive care is likely to improve outcomes until specific neuroprotective or neurorestorative therapies are available.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2021)
Review
Pediatrics
Elodie Zana-Taieb, Jacques Sizun, Pierre Kuhn, Audrey Reynaud
Summary: This article investigates the impact of neonatal unit design on the neurodevelopment of hospitalized neonates and the well-being of parents and healthcare staff. It provides recommendations regarding the minimum area required for a hospital room for a single neonate and their family.
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt Hager, Markus M. Schreiner, Sonja M. Walzer, Lena Hirtler, Vladimir Mlynarik, Andreas Berg, Xeni Deligianni, Oliver Bieri, Reinhard Windhager, Siegfried Trattnig, Vladimir Juras
Summary: This study analyzed the T-2* anisotropy and T-2* decay of Achilles and patellar tendons using a variable-echo-time sequence. The results showed that changes in fiber-to-field angle significantly affected T-2* values, indicating the importance of being aware of T-2* anisotropy in quantitative T-2* mapping of tendons to avoid misinterpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thanh Phong Le, Rolf Gruetter, Joao Jorge, Oezlem Ipek
Summary: This study thoroughly investigated the RF shielding artifact of a state-of-the-art EEG-fMRI setup at 7T and proposed a practical solution. By segmenting the EEG wiring into shorter lengths, the RF shielding artifacts can be significantly reduced without substantial SAR penalties.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Nutrition & Dietetics
Gabriel Henrique Schirmbeck, Stephane Sizonenko, Eduardo Farias Sanches
Summary: Early adverse fetal environments can disrupt CNS development and breastfeeding, especially with the presence of lactoferrin, plays a crucial role in supporting brain development and preventing neuropsychiatric diseases later in life.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Victor Casula, Jouni Karjalainen, Vladimir Mlynarik, Timo Liimatainen, Matti Hanni, Edwin H. G. Oei, Mikko J. Nissi, Miika T. Nieminen
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Pediatrics
Petra S. Huppi, Manuela Filippa
PEDIATRIC RESEARCH
(2023)
