期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 1, 页码 11-20出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.08.008
关键词
cancer cells of origin; genetic hits; tumor initiation; stem cell niche
类别
资金
- NIAMS NIH HHS [R01 AR057409] Funding Source: Medline
Significant progress has been made to identify the cells at the foundation of tumorigenesis, the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells (ASCs) or primitive progenitors as the CCO for those cancers studied, highlighting the importance of stem cells not only as propagators but also as initiators of cancer. Recent data suggest tumor initiation at the CCOs can be regulated through both intrinsic and extrinsic signals and that the identity of the CCOs and their propensity to initiate tumorigenesis is context dependent. In this review, we summarize some of the recent findings regarding CCOs and solid tumor initiation and highlight its relation with bona fide human cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据