Article
Nursing
Kayla C. Everhart, Sarah B. Donevant, Victor N. Iskersky, Michael D. Wirth, Robin B. Dail
Summary: This study analyzed the physiological stability of very preterm infants before, during, and after packed red blood cell (PRBC) transfusions. The findings showed that the infants' physiological variables remained within defined limits during the transfusion. PRBC transfusions are necessary for very preterm infants and can prevent complications.
Article
Pediatrics
Hannes Sallmon, Andreas Weimann, Christoph Buehrer, Boris Metze, Christof Dame, Malte Cremer
Summary: The study indicates a relationship between immature platelet counts and thrombopoietin concentrations in preterm neonates, with responsive increases in thrombopoietin and immature platelets possibly being developmentally limited.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Leonid Livshits, Gregory Barshtein, Dan Arbell, Alexander Gural, Carina Levin, Helene Guizouarn
Summary: Red blood cell (RBC) transfusion is common in medicine but can have negative side effects. Cell quality is crucial for transfusion effectiveness and safety. Research suggests that high sugar concentration may damage red blood cells.
Review
Surgery
Amanda R. Phillips, Lillian Tran, Jill E. Foust, Nathan L. Liang
Summary: The study aimed to investigate the benefit of a greater ratio of plasma/packed red blood cells in patients with rAAAs. Some studies found that a higher ratio of plasma to packed red blood cells was associated with decreased mortality, but overall risk of bias was serious and evidence quality was very low.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Fabrice Cognasse, Hind Hamzeh-Cognasse, Mickael Rosa, Delphine Corseaux, Brigitte Bonneaudeau, Chloe Pierre, Julie Huet, Charles Antoine Arthaud, Marie Ange Eyraud, Amelie Prier, Anne Claire Duchez, Theo Ebermeyer, Marco Heestermans, Estelle Audoux-Caire, Quentin Philippot, Tom Le Voyer, Olivier Hequet, Anne-Marie Fillet, Patricia Chavarin, Dominique Legrand, Pascale Richard, France Pirenne, Pierre Gallian, Jean Laurent Casanova, Sophie Susen, Pascal Morel, Karine Lacombe, Paul Bastard, Pierre Tiberghien
Summary: COVID-19 convalescent plasma (CCP) contains neutralising antibodies that may be useful as passive immunotherapy. CCP showed increased levels of IL-6 and TNF-alpha and lower levels of IL-10 compared to control plasma. Auto-Antibodies against type I IFNs in CCP were not associated with reported adverse events. Further studies are needed to define the clinical relevance of these findings.
Review
Hematology
Luise Bellach, Michael Eigenschink, Abtin Hassanein, Danylo Savran, Ulrich Salzer, Ernst W. Muellner, Andreas Repa, Katrin Klebermass-Schrehof, Lukas Wisgrill, Vito Giordano, Angelika Berger
Summary: Transfusion of adult packed red blood cells (pRBCs) into preterm infants may be inappropriate due to differences in erythrocytes. Lack of standardisation in transfusion protocols and differences in study designs hinder the interpretation of clinical data.
LANCET HAEMATOLOGY
(2022)
Article
Hematology
Elsa Garcia Gonzalez, Miguel Alsina Casanova, Dinara Samarkanova, Victoria Aldecoa-Bilbao, Marta Teresa-Palacio, Elisenda Farssac Busquets, Josep Figueras-Aloy, Ma Dolors Salvia-Roiges, Sergi Querol
Summary: This study analyzed the transfusion needs of infants born <32 weeks GA in Hospital Clinic of Barcelona and assessed the feasibility of using UCB-RBC. Results indicated that the ELGAN group had a higher need for UCB-RBC transfusions, and the blood bank's production capacity was deemed sufficient. Randomized controlled trials are needed to further explore the potential benefits of UCB compared to adult blood for RBC transfusions.
Article
Biochemistry & Molecular Biology
Marlene C. Gerner, Andrea Bileck, Lukas Janker, Liesa S. Ziegler, Thomas Oehlinger, Pierre Raeven, Ernst W. Muellner, Ulrich Salzer, Christopher Gerner, Klaus G. Schmetterer, David M. Baron
Summary: Research has shown that red blood cells can impact T-cell activation and proliferation, with packed red blood cells inhibiting T-cell activation through direct cell-cell contact and impacting the production of reactive oxygen species. Downstream signaling events requiring reactive oxygen species for full functionality are affected, with PRBCs more efficiently inhibiting T-cell activation compared to antioxidants. These immunomodulating effects may be responsible for clinical observations associated with transfusion of PRBCs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Surgery
Matthew R. Baucom, Taylor E. Wallen, Adam D. Price, Maia P. Smith, Maura Kopchak, Andrew MacKinnon, Nick Weissman, Rebecca M. Schuster, Timothy A. Pritts, Michael D. Goodman
Summary: This study found that IL-1ra, IL-8, IL-10, and IP-10 are useful predictors of 30-d mortality within 6 h of injury. Subgroup analysis suggests that transfusion status does not significantly affect early inflammatory markers.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kamila Czubak-Prowizor, Anna Macieja, Tomasz Poplawski, Halina Malgorzata Zbikowska
Summary: Perioperative blood transfusion in colorectal and some other cancer patients has been associated with increased risk for recurrence, but the exact mechanism is unclear. This study found that the acellular fraction of packed red blood cells (PRBCs), especially from fresh PRBCs, can inhibit the viability and proliferation of tumor cells, but has no effect on non-tumor cells. Additionally, it can increase drug resistance in non-tumor cells.
Article
Nursing
Hande Z. Ulus, Merve Yasemin Tekbudak, Jonathan C. Allen
Summary: The research aimed to concentrate human milk in a milk bank setting by precipitating lactose, in order to increase its caloric and protein density while avoiding the side effects of high osmolality. The results showed that lactose and osmolality were significantly reduced in the concentrated milk without significant protein loss. This method could potentially provide a simple and low-cost solution for feeding preterm infants with higher nutrient density and no non-human components.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Biochemistry & Molecular Biology
Philippe Chadebech, Gwellaouen Bodivit, Gaetana Di Liberto, Alicia Jouard, Corinne Vasseur, France Pirenne, Pablo Bartolucci
Summary: In this study, senescence markers on AA RBCs associated with SCD patients' clinical status and their adhesion to the vessel wall protein thrombospondin were investigated. The results showed that modulators of RBC membrane channels can reproduce the adhesion of senescent RBCs after plasma co-incubations. Clinically modulating RBC adhesion to vascular wall proteins might be a promising avenue for the treatment of painful occlusive events in SCD.
Article
Nutrition & Dietetics
Michaela Minarski, Christoph Maas, Christine Heinrich, Katrin A. Boeckmann, Wolfgang Bernhard, Anna Shunova, Christian F. Poets, Axel R. Franz, Steven Zeisel
Summary: Choline is essential for the development of infants, especially very low birth weight infants. However, the choline content in breast milk is lower after preterm delivery, and current formulas and fortified breast milk do not provide sufficient choline to achieve physiological concentrations. Increasing enteral choline intake is suggested to improve the growth and long-term development of very low birth weight infants.
Article
Surgery
Kasiemobi E. Pulliam, Bernadin Joseph, Amy T. Makley, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
Summary: A novel storage solution for packed red blood cells was developed, which mitigated the storage lesion and inflammatory response after resuscitation. This solution shows promise in improving the storage quality and reducing harm after massive transfusion.
Article
Biochemistry & Molecular Biology
Davide Schiroli, Lucia Merolle, Eleonora Quartieri, Roberta Chicchi, Tommaso Fasano, Tiziana De Luca, Giuseppe Molinari, Stefano Pulcini, Thelma A. Pertinhez, Erminia Di Bartolomeo, Rino Biguzzi, Roberto Baricchi, Chiara Marraccini
Summary: This study compared two methods for preparing optimal P-RBCs products for beta-thalassemia major patients, finding that method 1 resulted in higher RBC count and Hb content, while method 2 produced P-RBCs with lower levels of K+, iron, and storage lesions markers. Further clinical studies are needed to determine the impact of these differences on transfusion-related complications and the quality of life of beta TM patients.
Editorial Material
Pediatrics
Alexander Howes, Amy Keir
Editorial Material
Pediatrics
Naomi Spotswood, Erin Grace, Amy K. Keir
Editorial Material
Pediatrics
Cathie Hilditch, Amy Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2018)
Article
Pediatrics
Amy K. Keir, Oliver Karam, Nicolette Hodyl, Michael J. Stark, Helen G. Liley, Prakesh S. Shah, Simon J. Stanworth, Scott Morris, Kathryn Browning Carmo, Koert De Waal, Michelle Stubbs, Helen Liley, Angela Pearson, Holly Campbell, Rodney W. Hunt, Elizabeth Perkins, Sanoj K. M. Ali, Jennifer Bowen, Claire Jacobs, Mary Paradisis, David Osborn, Mark Greenhalgh, Carl Kuschel, Nicolette Hodyl, Michael Stark, Amy Keir, Joseph Ting, Keith Barrington, Anie Lapointe, Kimberly Dow, Helen Coo, Amit Mukerji, Adel Mohamed, Miroslav Stavel, Akhil Deshpandey, Nicole Tucker, Eugene Ng, Carly Diamond, Pierre Bourgoin, Lutz Bindl, Matthieu Maria, Daniele De Luca, Valentina Dell'Orto, Stefano Ghirardello, Kiran More, Liza Edmonds, Lauren Weaver, Emoke Deschmann, Mikael Norman, Owain Thomas, Jonathan Karlsson, Roberta De Luca, Bjarte Rogdo, Rita Moinho, Alexandra Dinis, Dominic Wilkinson, Anshuman Paria, Martha Sola-Visner, Vanessa Young, Cassandra D. Josephson, Jane Skvarich, Matthew Saxonhouse, Rebecca Poliquin, Sherry Courtney, Dalton Janssen, Sarah K. Harm, Allison Bartlett, Dennis Mayock, Gina Lee
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Review
Hematology
A. K. Keir, H. New, N. Robitaille, G. L. Crighton, E. M. Wood, S. J. Stanworth
TRANSFUSION MEDICINE
(2019)
Editorial Material
Pediatrics
Louise Evans, Cathie Hilditch, Amy Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Article
Pediatrics
Safiyyah Abbas, Amy K. Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Article
Pediatrics
Beth Godden, Carmel T. Collins, Cathie Hilditch, Gemma McLeod, Amy Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Review
Pediatrics
Cathie Hilditch, Alexander Howes, Natalie Dempster, Amy Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Editorial Material
Pediatrics
Naomi Spotswood, Amy Keir
Editorial Material
Pediatrics
Alexander Howes, Cathie Hilditch, Amy Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2019)
Article
Pediatrics
Eliza Matthews, Carmel T. Collins, Vanessa Ellison, Lee Hussey, Jo Slade, Amy Keir, Jacqueline Miller
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2020)
Editorial Material
Pediatrics
Elizabeth Allen, Amy Keir
Editorial Material
Pediatrics
Lydia Kennedy, Thomas Rogerson, Amy Kate Keir
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2020)
Review
Pediatrics
Erin Grace, Cathie Hilditch, Judith Gomersall, Carmel T. Collins, Alice Rumbold, Amy K. Keir
Summary: The study found that using human milk-based fortifiers reduced the risk of necrotising enterocolitis compared to cow's milk-based fortifiers. However, there was no clear evidence of an effect on late-onset sepsis or other outcomes. The overall quality of evidence was considered to be low due to imprecision and lack of blinding in one study.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)