Article
Pediatrics
Shan He, Gang Liu, Xueping Zhu
Summary: This study demonstrates the beneficial effects of human breast milk-derived exosomes in preventing necrotizing enterocolitis by reducing inflammation and injury, and restoring intestinal tight-junction proteins.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Shetal Shah, Emily Miller, Allison Rose, Krystle Perez
Summary: Pasteurized donor human milk (PDHM) has been shown to reduce the incidence of necrotizing enterocolitis in very low birth weight infants. However, lack of Medicaid and private insurance coverage for PDHM use in neonatal intensive care units leads to disparities based on birth state and socioeconomic status. Through collaboration between local and national American Academy of Pediatrics (AAP) chapters, a PDHM Advocacy Toolkit was created to promote Medicaid coverage. Over 5 years, advocacy efforts led by neonatologists and incentivized by AAP funds resulted in 5 additional states providing Medicaid payment for PDHM, increasing the coverage to over 55% of nationally born very low birth weight infants. This case study provides a template for other pediatric specialists to advocate for niche-focused issues at the state level.
Article
Pediatrics
Karishma Rao, Alain Cuna, Susana Chavez-Bueno, Heather Menden, Wei Yu, Ishfaq Ahmed, Pugazhendhi Srinivasan, Shahid Umar, Venkatesh Sampath
Summary: The study demonstrates that different preterm formulas have varying effects on intestinal inflammation, apoptosis, and microbiome composition in developing infants. Formula feeding with EleCare and Similac Special Care resulted in greater intestinal injury compared to NeoSure, but pre-treatment with Lactobacillus rhamnosus GG alleviated the severity of the damage.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Nicholas D. Embleton, Thomas Sproat, Sabita Uthaya, Gregory R. Young, Shalabh Garg, Vimal Vasu, Andrea C. Masi, Lauren Beck, Neena Modi, Christopher J. Stewart, Janet E. Berrington
Summary: This study investigated the effect of an exclusive human milk diet on the gut microbiome of preterm infants. The results showed that an exclusive human milk diet did not affect the overall diversity of gut bacteria but had an impact on specific bacterial taxa associated with human milk receipt.
Article
Food Science & Technology
Richard Y. Wu, Bo Li, Rachael G. Horne, Abdalla Ahmed, Dorothy Lee, Shaiya C. Robinson, Haitao Zhu, Marissa Cadete, Mashriq Alganabi, Rachel Filler, Kathene C. Johnson-Henry, Paul Delgado-Olguin, Agostino Pierro, Philip M. Sherman
Summary: Necrotizing enterocolitis (NEC) is a serious gastrointestinal emergency that affects premature infants. Breastmilk helps prevent NEC, in part due to human milk oligosaccharides (HMOs). This study found that different structural HMOs have varying effects on intestinal physiology, with unique mechanisms of action, providing a functional framework for screening and designing HMO-like compounds.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pediatrics
Joseph A. Asaro, Zarak Khan, Mariana Brewer, Karen Klose, Cynthia Pesce, Richard J. Schanler, Champa N. Codipilly
Summary: The study showed that feeding preterm infants with mother's own milk can increase fecal concentrations of MFG-E8 and decrease concentrations of proinflammatory cytokines, indicating its anti-inflammatory effects.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Yurika Yoshida, Minami Azuma, Haruhiro Kuwabara, Tokuo Miyazawa, Yuya Nakano, Kazuna Furukawa, Keli M. Hawthorne, Masahiko Izumizaki, Takashi Takaki, Mari Sakaue, Katsumi Mizuno
Summary: The study found that fortified milk with human milk-based fortifier (HMBF) had less impact on the size of human milk fat globules (MFG) compared to cow milk-based fortifier (CMBF). This difference may affect the feeding tolerance of very preterm infants.
Review
Biochemistry & Molecular Biology
Judith C. W. de Jong, Noortje Ijssennagger, Saskia W. C. van Mil
Summary: NEC, a deadly inflammatory disease of the preterm intestine, is likely triggered by a damaged epithelial layer due to incomplete maturation of different cell lineages. Dysregulation of Wnt and Notch signaling pathways by Toll-like-receptor-4 hyperactivation is observed in NEC. Breastfeeding decreases the risk of NEC, and interventions targeting these pathways may reduce the risk of NEC development in preterm infants.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Nadine Scholten, Alicia Fitzgerald, Katja Matthias, Mi-Ran Okumu, Tim Ohnhaeuser, Katharina Schmitz, Christine Schreiner, Isabella Schwab, Anna Stirner, Ricarda Wullenkord, Till Dresbach, Andreas Mueller, Till Dresbach, Martin Hellmich, Nicole Ernstmann, Antje Hammer, Friederike Eyssel, Angela Kribs, Juliane Koeberlein-Neu, Katharina Lugani, Eva Mildenberger, Jens Ulrich Rueffer, Katja Matthias, Anne Sunder-Plassmann, Daniel Wiesen, Dirk Horenkamp-Sonntag, Melanie Klein
Summary: Mother's own milk is the optimal nutrition for newborns, especially preterm infants with very low birth weight. If unavailable, human donor milk is the preferred alternative. Providing structured breastfeeding and lactation support, as well as promoting the establishment of human donor milk banks, is crucial for mothers of preterm infants who often struggle with insufficient milk production.
Review
Pediatrics
Ester Maria Gill, Kristine Jung, Niels Qvist, Mark Bremholm Elleb
Summary: There is currently insufficient evidence to support any specific recommendations regarding antibiotic treatment, route of administration, or duration for infants with necrotizing enterocolitis (NEC) at Bell's stage II and III.
Article
Immunology
Xiao-Lin Yan, Xiao-Chen Liu, Yu-Ni Zhang, Ting-Ting Du, Qing Ai, Xiong Gao, Jing-Li Yang, Lei Bao, Lu-Quan Li
Summary: This study found that succinate plays an important role in the pathogenesis and severity of necrotizing enterocolitis, and the activation of the HIF-1α signaling pathway may lead to disease progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pediatrics
Natalie A. Strobel, Claire Adams, Daniel R. McAullay, Karen M. Edmond
Summary: In preterm and low birth weight infants, feeding with infant formula compared with mother's own milk has little effect on mortality, infection, growth, or neurodevelopment, but increases the risk of developing necrotizing enterocolitis.
Article
Nursing
Wenjing Peng, Junyan Han, Shujuan Li, Lan Zhang, Chuanzhong Yang, Jinzhen Guo, Yun Cao
Summary: Exclusive human milk feeding is associated with a reduction in necrotizing enterocolitis, bronchopulmonary dysplasia, severe retinopathy of prematurity, and mortality among very/extremely low-birth-weight infants.
JOURNAL OF HUMAN LACTATION
(2022)
Article
Obstetrics & Gynecology
Gregory Valentine, Steven Ford, Joseph Hagan, Heeju Yang, Jeffery Chen, Nancy Hurst, Kjersti Aagaard, Amy Hair
Summary: The study suggests that promoting mother's own milk consumption in the first 2-4 weeks is crucial for achieving exclusive mother's own milk feeding at discharge, with minimal impact of increasing mother's own milk consumption after 28 days.
JOURNAL OF PERINATOLOGY
(2021)
Review
Nutrition & Dietetics
Jogender Kumar, Jitendra Meena, Ankit Ranjan, Praveen Kumar
Summary: This systematic review examined the effect of oropharyngeal application of colostrum or mother's own milk on preterm infants, and found that it can reduce the risk of infection and necrotizing enterocolitis, and has benefits in early feeding.
Article
Anesthesiology
Federico Aletti, Nicol Gambarotta, Alexander H. Penn, Manuela Ferrario, Geert W. Schmid-Schonbein
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2017)
Article
Gastroenterology & Hepatology
Alexander H. Penn, Leslie J. Carver, Carrie A. Herbert, Tiffany S. Lai, Melissa J. McIntire, Jeffrey T. Howard, Sharon F. Taylor, Geert W. Schmid-Schoenbein, Karen R. Dobkins
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2016)
Article
Critical Care Medicine
Alexander H. Penn, Michael A. Dubick, Ivo P. Torres Filho
Article
Pediatrics
Sheila M. Gephart, Phillip V. Gordon, Alexander H. Penn, Katherine E. Gregory, Jonathan R. Swanson, Akhil Maheshwari, Karl Sylvester
SEMINARS IN PEDIATRIC SURGERY
(2018)
Article
Surgery
L. Pascarella, D. Lulic, A. H. Penn, T. Alsaigh, J. Lee, H. Shin, V. Kapur, J. J. Bergan, G. W. Schmid-Schonbein
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2008)
Article
Peripheral Vascular Disease
K. M. Edwards, B. Sheu, S. Hong, A. H. Penn, G. W. Schmid-Schoenbein, P. J. Mills
JOURNAL OF HUMAN HYPERTENSION
(2010)
Article
Gastroenterology & Hepatology
Alexander H. Penn, Angelina E. Altshuler, James W. Small, Sharon F. Taylor, Karen R. Dobkins, Geert W. Schmid-Schoenbein
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2014)
Article
Multidisciplinary Sciences
Angelina E. Altshuler, Alexander H. Penn, Jessica A. Yang, Ga-Ram Kim, Geert W. Schmid-Schoenbein
Article
Multidisciplinary Sciences
Angelina E. Altshuler, Itze Lamadrid, Diana Li, Stephanie R. Ma, Leena Kurre, Geert W. Schmid-Schoenbein, Alexander H. Penn
Article
Critical Care Medicine
Alexander H. Penn, Geert W. Schmid-Schoenbein
Article
Critical Care Medicine
Alexander H. Penn, Charnae E. Williams, Thomas J. Walters, Michael A. Dubick, Ivo P. Torres Filho
Article
Critical Care Medicine
Alexander H. Penn, Michael A. Dubick, Ivo P. Torres Filho
Summary: The study found that acute decompensation may be common after trauma and severe hemorrhage treated with tourniquet and permissive hypotensive resuscitation, and albumin presaturated with oleic acid may benefit early survival and reduce transfusion volume by improving venous constriction and preventing decompensation.
Article
Physiology
Angelina E. Altshuler, Michael D. Richter, Augusta E. Modestino, Alexander H. Penn, Michael J. Heller, Geert W. Schmid-Schonbein
PHYSIOLOGICAL REPORTS
(2013)
Proceedings Paper
Engineering, Biomedical
Geert W. Schmid-Schoenbein, Frank A. DeLano, Alexander H. Penn, Erik Kistler
2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2012)