Article
Dentistry, Oral Surgery & Medicine
Ali Esmaeili, Solmaz Dini, Azadeh Pourveiseh, Abolghasem Esmaeili
Summary: This study investigated the expression profile of TrkA, TrkB, TrkC, and p75NTR neurotrophin receptors in SHED cells before and after differentiation into neural-like cells. The results showed significant differences in the expression levels of these receptors, indicating their crucial roles in the differentiation of SHED cells into neuron cells. The findings suggest that derived cells from SHED cells could be an ideal source for tissue engineering due to their neurogenic potential and accessibility.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Plinio C. Casarotto, Mykhailo Girych, Senem M. Fred, Vera Kovaleva, Rafael Moliner, Giray Enkavi, Caroline Biojone, Cecilia Cannarozzo, Madhusmita Pryiadrashini Sahu, Katja Kaurinkoski, Cecilia A. Brunello, Anna Steinzeig, Frederike Winkel, Sudarshan Patil, Stefan Vestring, Tsvetan Serchov, Cassiano R. A. F. Diniz, Liina Laukkanen, Iseline Cardon, Hanna Antila, Tomasz Rog, Timo Petteri Piepponen, Clive R. Bramham, Claus Normann, Sari E. Lauri, Mart Saarma, Ilpo Vattulainen, Eero Castren
Summary: The study reveals that antidepressant drugs bind directly to the TRKB receptor, facilitating its activation at the synapse and potentially explaining the mechanism behind antidepressant action.
Review
Cell Biology
Suzan Kors, Joseph L. Costello, Michael Schrader
Summary: VAP proteins play crucial roles in various cellular processes such as organelle membrane tethering and lipid transfer. Viruses and intracellular bacteria can exploit VAPs to induce interactions between host ER and pathogen-containing compartments, supporting pathogen replication.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Davide Malagoli, Nicola Franchi, Sandro Sacchi
Summary: Reactive oxygen species (ROS) play important roles in physiological functions and the immune response. This review focuses on molluscs listed as the worst invasive species by IUCN and highlights their ability to manage ROS production during physiological challenges, which can also be advantageous during the immune response. The ability to buffer ROS action is advantageous in both environmental and immunological challenges, and should be considered when studying the potential invasiveness of emerging alien species and climate change.
Review
Biochemistry & Molecular Biology
HeeJue Hong, Lucy Sloan, Deepak Saxena, David A. Scott
Summary: CB2 receptor is a potential target for treating neurogenerative diseases, but its agonists also possess antimicrobial properties, which should be taken into consideration when developing new therapeutic drugs. Cannabinoids and cannabis-informed molecules show promise as microbicidal agents, but their clinical application as antimicrobials remains unrealized.
Review
Biotechnology & Applied Microbiology
Marcos Antonio de Oliveira, Carlos A. Tairum, Luis Eduardo Soares Netto, Ana Laura Pires de Oliveira, Rogerio Luis Aleixo-Silva, Vitoria Isabela Montanhero Cabrera, Carlos A. Breyer, Melina Cardoso dos Santos
Summary: The oxidative and nitrosative responses produced by animals and plants serve as crucial defenses against pathogenic microorganisms, including bacteria, fungi, and protozoa. Peroxiredoxins are enzymes that play a key role in decomposing hydroperoxides and can also function as molecular chaperones and phospholipases, contributing to microbial protection against host defenses. Some peroxiredoxins have been identified as virulence factors, indicating their significance in pathogenesis and potentially as targets for new antimicrobial drugs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C. Fuhrmann, Claus U. Pietrzik, Albrecht M. Clement, Hagen Koerschgen, Jana Schepers, Christian Behl
Summary: Misfolded proteins and calcium homeostasis disruption can cause endoplasmic reticulum stress, which is associated with neurodegenerative diseases. Investigating how neuronal cells adapt to chronic endoplasmic reticulum stress is important. In this study, clonal mouse hippocampal cell lines resistant to prolonged endoplasmic reticulum stress were established as in vitro models. The resistant cells showed increased vesicular and autophagosomal structures, with "giant lysosomes" particularly prominent. While autophagic activity increased, lysosomal function was slightly impaired. Enhanced ER-phagy was observed in both cell lines. Proteomic analysis revealed differential regulation of protein clusters and signaling pathways in response to chronic endoplasmic reticulum stress induced by thapsigargin or tunicamycin. Bioenergetic analysis showed a shift towards aerobic glycolysis and defective complex I of the oxidative phosphorylation machinery. ER stress-resistant cells activated the unfolded protein response pathways. These findings demonstrate the adaptive responses of neuronal cells to chronic ER stress. ER stress-resistant neuronal cells could be potential pharmacological targets for preventing neurodegeneration.
Article
Multidisciplinary Sciences
Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida
Summary: The study highlights the importance of communication between neuronal DAF-16 and intestinal DAF-16 in regulating organismal lifespan.
Article
Biotechnology & Applied Microbiology
Joana B. Caldeira, Ana Paula Chung, Paula V. Morais, Rita Branco
Summary: The study reveals the impact of aluminum, gallium, and indium on a bacterial strain and how an indium-sensitive mutant with disrupted feoA gene exhibited higher oxidative stress under metal exposure. Iron supplementation helped alleviate growth inhibition and oxidative stress in the mutant strain, indicating the importance of iron acquisition in controlling oxidative stress. Genome analysis of the strain also identified various iron transport-related genes that are crucial for bacteria-metal interactions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Dionysia Petratou, Martha Gjikolaj, Eva Kaulich, William Schafer, Nektarios Tavernarakis
Summary: The nervous system plays a crucial role in systemic stress response and maintaining neuronal sodium homeostasis. Imbalance in neuronal sodium homeostasis is linked to nervous system pathologies, but the effects of stress on this balance are not well understood. This study reveals that the DEG/ENaC family member DEL-4 functions as a proton-inactivated sodium channel in neuronal membranes and synapses, modulating locomotion in Caenorhabditis elegans. Heat stress and starvation influence DEL-4 expression, which in turn affects the expression and activity of stress-response transcription factors and leads to appropriate motor adaptations. Additionally, DEL-4 deficiency affects dopaminergic neurons and neurotransmission, while promoting neuronal survival in models of neurodegenerative diseases. These findings provide insights into the molecular mechanisms underlying the role of sodium channels in neuronal function and adaptation during stress.
Article
Neurosciences
Solen Rimbert, Joao B. Moreira, Sara Xapelli, Sabine Levi
Summary: This article reviews the expression and activity of the purinergic system during embryonic and postnatal development of the nervous system, highlighting its crucial role in various steps of brain development. The involvement of purinergic signaling in neural stem cell proliferation, neuronal differentiation and migration, as well as astrogliogenesis and oligodendrogenesis, is discussed. Additionally, the importance of purinergic signaling in the formation of peripheral neuromuscular junctions and central GABAergic and glutamatergic synapses is examined, along with the potential therapeutic implications of targeting the purinergic system in diseases.
Article
Immunology
Baosheng Zhou, Honglin Wang, Bo Zhang, Lianlian Zhang
Summary: The study demonstrated the neuroprotective effects of Lico B in MCAO rats, showing improvements in cerebral infarction, memory impairments, and neurological deficits, as well as a reduction in oxidative stress and inflammation levels. Additionally, Lico B attenuated neuronal injury and apoptosis by activating the Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maria Pechlivanidou, Elpinickie Ninou, Katerina Karagiorgou, Aikaterini Tsantila, Renato Mantegazza, Andreetta Francesca, Raffaello Furlan, Leon Dudeck, Johann Steiner, John Tzartos, Socrates Tzartos
Summary: In this review, the authors focus on the autoimmunity against neuronal nicotinic acetylcholine receptors (nAChRs), specifically the autoantibodies and their mechanisms in selected autoimmune diseases. They summarize the current knowledge from human diseases and experimental models, highlighting the infrequency of autoimmunity to neuronal nAChRs except for the autoantibodies to the alpha 3 subunit containing nAChR (alpha 3-nAChR). The authors also discuss the presence of autoantibodies to other neuronal nAChR subtypes and the need for further verification.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Gaili Yan, Xiangyu Zhang, Hongmin Li, Yan Guo, V. Wee Yong, Mengzhou Xue
Summary: This review comprehensively discusses the potential therapeutic effects of cannabidiol (CBD) in countering oxidative stress resulting from intracerebral hemorrhage (ICH). It highlights the sources of oxidative stress post-ICH and elaborates on CBD's ability to inhibit ROS/RNS generation from these sources. The review also delves into CBD's role in promoting ROS/RNS scavenging through the Nrf2/ARE pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Joshua Chiappelli, Mark Kvarta, Heather Bruce, Shuo Chen, Peter Kochunov, L. Elliot Hong
Summary: This study found a significant association between stressful life events and openness to experience, with participants with a history of depression exhibiting higher levels of openness. Furthermore, openness to experience was related to overall intelligence but not processing speed or working memory. The findings suggest that openness to experience may partially mediate the relationship between stressful life events and depression in rural populations with high social and environmental homogeneity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Allison Eberhardt, Jeanne N. Hansen, Jan Koster, Louis T. Lotta, Simeng Wang, Emmett Livingstone, Kun Qian, Linda J. Valentijn, Yujun George Zheng, Nina F. Schor, Xingguo Li
Article
Biochemistry & Molecular Biology
Xingguo Li, Allison Eberhardt, Jeanne N. Hansen, Dirk Bohmann, Haitao Li, Nina F. Schor
Editorial Material
Clinical Neurology
Shafali S. Jeste, Nina F. Schor
Editorial Material
Clinical Neurology
Nina F. Schor
Article
Education, Scientific Disciplines
Nina F. Schor
Editorial Material
Clinical Neurology
Nina F. Schor
PEDIATRIC NEUROLOGY
(2018)
Editorial Material
Clinical Neurology
Nina F. Schor
ANNALS OF NEUROLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Nina F. Schor
Review
Biotechnology & Applied Microbiology
Jill A. Morris, Chris H. Boshoff, Nina F. Schor, Ling M. Wong, Guangping Gao, Beverly L. Davidson
Summary: NINDS organized a workshop on gene-targeted therapies for CNS disorders, bringing together experts from various fields to identify challenges and propose solutions. Prior to the workshop, key obstacles and research gaps were identified through pre-meeting teleconferences, allowing for problem-solving discussions and strategy development at the workshop.
Letter
Biotechnology & Applied Microbiology
Nina F. Schor, Amir P. Tamiz, Walter J. Koroshetz, Ann-Marie Broome, Julia L. Bachman, Chris Boshoff, Janice Cordell, Neel T. Dhruv, Amelie Gubitz, Adam L. Hartman, Walter J. Koroshetz, Genevieve E. Lind, Codrin I. Lungu, Jill A. Morris, Glen H. Nuckolls, Shantadurga Rajaram, Ranga Rangarajan, Rebecca A. Roof, Nina F. Schor, Mario H. Skiadopoulos, Natalia Strunnikova, Amir P. Tamiz, Ling M. Wong, Clinton B. Wright
NATURE BIOTECHNOLOGY
(2021)
Review
Clinical Neurology
Nina F. Schor, Diana W. Bianchi
Summary: Neurodegenerative disorders are typically associated with neuronal loss in late life, but recent studies have found protein abnormalities related to these disorders in childhood, suggesting a potential for identifying susceptibility and prevention clues before disease symptoms manifest.
PEDIATRIC NEUROLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Nina F. Schor, Paul Scott, Elizabeth Y. Litvina, Christine Torborg, Jenny Kim, Robert Zalutsky, Amy Bany Adams
Summary: The 2021-2026 Strategic Plan of the National Institute of Neurological Disorders and Stroke is a detailed explanation of the institute's vision, mission, and strategic objectives. It emphasizes cross-cutting operational principles including scientific rigor, communication, workforce culture, and equity.
Article
Clinical Neurology
Nina F. Schor, Paul Scott, Elizabeth Y. Litvina, Christine Torborg, Jenny L. Kim, Robert Zalutsky, Amy Bany Adams
Summary: This article presents the accomplishments, new initiatives, and opportunities of an institute of the National Institutes of Health (NIH) in implementing its strategic plan over the past year. It also provides a preview of the metrics and benchmarks that will be used to measure the future progress of the strategic plan.
Article
Clinical Neurology
Nina F. Schor, Merit E. Cudkowicz, Brenda Banwell
Summary: The COVID-19 pandemic has had a significant impact on the field of academic neurology, affecting research activities, clinical trials, and patient care. The pandemic has posed threats to neuroscience research and led to delays in clinical trial enrollment, but it has also prompted innovative remote engagement strategies. Clinical care has faced challenges, but telehealth has emerged as a valuable tool for neurologists to continue providing care and connecting with patients.
Review
Biochemistry & Molecular Biology
Jeanne N. Hansen, Xingguo Li, Y. George Zheng, Louis T. Lotta, Abhishek Dedhe, Nina F. Schor
ACS CHEMICAL NEUROSCIENCE
(2017)
