Article
Physiology
Yu-Chi Hung, Yi-Ching Liu, Bin-Nan Wu, Jwu-Lai Yeh, Jong-Hau Hsu
Summary: Cinaciguat prevents postnatal DA closure by vasodilation and anti-remodeling through the cGMP/PKG pathway. Its mechanisms include anti-proliferation, anti-migration, attenuation of mitochondrial ROS production, and inhibition of MAPKs and Akt signaling. This study suggests that sGC activation may be a promising novel strategy to regulate DA patency.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zeming Zhou, Yuanrui Gu, Hong Zheng, Shiguo Li, Liang Xu, Qiong Liu, Junyi Wan, Jianhua Lv, Huijun Song, Chaowu Yan, Haibo Hu, Gejun Zhang, Zhongying Xu, Jinglin Jin
Summary: The study aimed to compare the advantages of different approaches for closure of patent ductus arteriosus (PDA) and guide clinical strategies. Retrospective analysis of patients undergoing transcatheter closure of PDA from 2019 to 2020 was conducted. The results showed that the simple vein approach (SVA) was associated with significantly reduced length of hospital stay, length of operation, and contrast medium usage compared to the conventional arteriovenous approach (CAA).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Naim Bouazza, Jean-Marc Treluyer, Frantz Foissac, Saik Urien, Outi Aikio, Jean-Christophe Roze, Mikko Hallman
Summary: In preterm infants, there is a high risk of hemodynamically significant patent ductus arteriosus (PDA), with current pharmacological options including ibuprofen or indomethacin. Early prophylactic treatment of ductus arteriosus with paracetamol may reduce life-threatening morbidity. Further studies are needed to assess the efficacy and toxicity of paracetamol specifically in extremely preterm neonates.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Ayala Gover, Philip T. Levy, Avi Rotschild, Marcelo Golzman, Michal Molad, Karen Lavie-Nevo, Irena Kessel
Summary: Oral administration of paracetamol as a first-line agent is more efficacious to constrict the patent ductus arteriosus (PDA) than the intravenous route, irrespective of gestational age or course duration.
PEDIATRIC RESEARCH
(2022)
Review
Obstetrics & Gynecology
Hannes Sallmon, Cassidy A. Delaney
Summary: Platelet plug formation is crucial for ductus arteriosus closure in mice, and thrombocytopenia in preterm infants can impede the closure process. Platelet dysfunction may also contribute to ductal patency, particularly in extremely premature infants. Neonatal platelets have multifunctional roles in ductal closure, including secretion of signaling molecules and facilitating cell-cell interactions. A randomized-controlled trial showed that liberal platelet transfusions in preterm infants with patent ductus arteriosus did not promote closure and was associated with increased intraventricular hemorrhage. This article discusses the mechanistic evidence and clinical implications of platelets in ductus arteriosus closure in preterm infants, as well as future research directions for understanding platelet-endothelial interactions in neonatal health and disease. (c)2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
SEMINARS IN PERINATOLOGY
(2023)
Review
Pediatrics
Mikko Hallman, Jean Marc Treluyer, Outi Aikio, Jean-Christophe Roze
Summary: The aim is to find optimal management strategies for early closure of patent ductus arteriosus without serious adverse effects. Although acetaminophen shows similar efficacy as ibuprofen or indomethacin in constricting the ductus, careful dosage control is necessary to prevent toxicity. Prophylactic treatments such as vitamin A and low-dose corticosteroid supplementation may enhance the safety and efficacy of acetaminophen.
Article
Pediatrics
Minyu He, Zhengchun Yang, Tian Gan, Jing Tang, Suzhen Ran, Kun Zhang
Summary: ObjectiveTo evaluate the value of echocardiographic parameters in predicting early spontaneous closure of ductus arteriosus in premature infants. Methods222 premature infants were selected and echocardiography was performed at 48 hours after birth to detect patent ductus arteriosus. The ductus arteriosus closure was observed on the 7th day. Echocardiographic parameters were analyzed and the maximum shunt velocity of ductus arteriosus was found to be correlated with early spontaneous closure.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pediatrics
Hannes Sallmon, Natalie Timme, Begum Atasay, Omer Erdeve, Georg Hansmann, Yogen Singh, Sven C. Weber, Elaine L. Shelton
Summary: Platelets play a critical role in the closure of patent ductus arteriosus (PDA) in preterm infants. Studies have shown that thrombocytopenia and platelet dysfunction contribute to the failure of both spontaneous and pharmacological closure of PDA. However, the clinical significance of platelet effects on PDA closure in preterm infants appears to be moderate, and platelet transfusions for this purpose may do more harm than good.
FRONTIERS IN PEDIATRICS
(2021)
Review
Cardiac & Cardiovascular Systems
Zahra Khajali, Ata Firouzi, Farshad Shakerian, Mohammad Javad Alemzadeh-Ansari, Ebrahim Ghobadi, Ehsan Khalilipur, Yasaman Khalili, Ladan Rezaei, Zahra Hosseini
Summary: This retrospective study aims to evaluate the long-term outcomes of percutaneous closure of patent ductus arteriosus (PDA) in adults and compare them with previous studies in adults and children.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Pediatrics
Adrianne Rahde Bischoff, Amy H. Stanford, Osamah Aldoss, Danielle R. Rios, Daniel McLennan, Bassel Mohammad Nijres, Regan E. Giesinger, Patrick J. McNamara
Summary: Percutaneous closure of patent ductus arteriosus leads to changes in left ventricular loading conditions, causing cardiovascular and respiratory instability in preterm infants. Post-closure cardiorespiratory instability is primarily characterized by oxygenation failure, which may be related to impaired diastolic performance.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sisca Natalia Siagian, Radityo Prakoso, Bayushi Eka Putra, Yovi Kurniawati, Olfi Lelya, Aditya Agita Sembiring, Indriwanto Sakidjan Atmosudigdo, Poppy Surwianti Roebiono, Anna Ulfah Rahajoe, Ganesja Moelia Harimurti, Brian Mendel, Christianto Christianto, Moira Setiawan, Oktavia Lilyasari
Summary: This study aimed to explore the feasibility and safety of percutaneous closure of patent ductus arteriosus (PDA) under echocardiography guidance. The study results showed that all patients had successful PDA closure, and there was no significant difference in procedural time between the fluoroscopy and echocardiography groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Marien Lenoir, Chloe Wanert, Damien Bonnet, Mathilde Meot, Barthelemy Tosello, Virginie Fouilloux, Caroline Ovaert, Sophie Malekzadeh-Milani
Summary: This study compared the short- and medium-term morbidity and mortality of surgical mini-invasive and transcatheter closure of PDA in preterm infants <1,600 g, finding equivalent efficiency and safety between the two methods.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Petra Lemmers, Daniel Vijlbrief, Manon Benders, Thomas Alderliesten, Moniek Veldhuis, Wim Baerts, Corine Koopman-Esseboom, Floris Groenendaal, Frank van Bel
Summary: This study investigated the relationship between the duration of patency of the ductus arteriosus (PDA), cerebral oxygenation, magnetic resonance imaging-determined brain growth, and neurodevelopmental outcome in preterm infants. The results showed that a prolonged duration of PDA was associated with reduced cerebellar growth and suboptimal neurodevelopmental outcome at the age of 2 years.
JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Megan Barcroft, Christopher McKee, Darren P. Berman, Rachel A. Taylor, Brian K. Rivera, Charles Smith, Jonathan L. Slaughter, Afif El-Khuffash, Carl H. Backes
Summary: Percutaneous-based patent ductus arteriosus closure is technically feasible among infants less than 1.5 kg. However, the current safety profile assessments are obscured by marked heterogeneity in adverse events and a lack of comparative trials for surgical ductal ligation, leading to inconsistent confidence in present estimates of safety and efficacy. Therefore, clinical studies of patent ductus arteriosus treatment should incorporate more robust assessments to include infants at highest risk for adverse ductal consequences.
CLINICS IN PERINATOLOGY
(2022)
Article
Genetics & Heredity
Yinghui Chen, Yizhuo Wu, Weiqi Feng, Xueyang Luo, Bing Xiao, Xiaowei Ding, Yongjia Gu, Yanan Lu, Yu Yu
Summary: This study reveals that reduced expression of Vav2 in human patent ductus arteriosus (PDA) is associated with impaired smooth muscle cell migration and closure of the ductus arteriosus. A deleterious Vav2 variant that weakens its function in smooth muscle cells was identified in PDA patients. These findings provide valuable insights into the genetic etiology of PDA and may contribute to improved prenatal diagnosis and treatment strategies.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)