Article
Pediatrics
Marilena Savoia, Francesca Rech Morassutti, Luigi Castriotta, Daisy Pavoni, Peter M. Mourani, Paola Freschi, Luigi Cattarossi, Antonio Tonutti
Summary: This study evaluated the feasibility of using neonatologist-performed echocardiography for follow-up of preterm infants with moderate/severe bronchopulmonary dysplasia (BPD) and described the course of pulmonary hypertension (PH) in these infants. NPE follow-up was found to be safe for infants with BPD, aiding in early detection of mild PH.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Camilla Rigotti, Daniela Doni, Emanuela Zannin, Abedulrhman S. Abdelfattah, Maria Luisa Ventura
Summary: By evaluating the trajectory of left ventricular diastolic function through serial echocardiographic evaluations and its association with respiratory outcomes, we found that abnormalities in left ventricular diastolic function may contribute to the pathophysiology of bronchopulmonary dysplasia. Serial echocardiographic measurements could help identify infants at risk of worse respiratory outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Irina Branescu, Sandeep Shetty, Justin Richards, Simona Vladareanu, Anay Kulkarni
Summary: This study aimed to describe the clinical characteristics of pulmonary hypertension (PH) associated with moderate to severe bronchopulmonary dysplasia (MSBPD) in premature infants. The incidence of BPD-associated PH (BPD PH) was 12.6%, with 41% of infants having severe PH. The need for positive pressure respiratory support at 36 weeks post menstrual age (PMA) was independently associated with PH. Babies with MSBPD and PH had a higher mortality rate.
Article
Obstetrics & Gynecology
Fahad M. S. Arattu Thodika, Mahesh Nanjundappa, Theodore Dassios, Aaron Bell, Anne Greenough
Summary: The study found that the development of late PH was associated with increased mortality, prolonged hospital stay, and higher healthcare cost.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Valentina Tomova, Diana Vlahova, Diana Diankova, Rumen Marinov, Anna T. Dasheva-Dimitrova, Ralitza Georgieva
Summary: BPD-associated pulmonary hypertension is a recognized complication in preterm infants, typically presenting with lower birth weight, complex clinical courses, and higher mortality rates. The incidence of PH is associated with severe BPD and duration of mechanical ventilation, while early detection through echocardiographic screening is crucial for vasodilator treatment. The use of vasodilators such as sildenafil and inhaled nitric oxide has shown improvement in PH without any observed side effects.
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Masato Ito, Shin Kato, Makoto Saito, Naoyuki Miyahara, Hirokazu Arai, Fumihiko Namba, Erika Ota, Hidehiko Nakanishi
Summary: This scoping review aimed to screen available evidence regarding perinatal risk factors associated with the development and severity of bronchopulmonary dysplasia (BPD). The results identified several risk factors for BPD, including male sex, maternal hypertensive disorders of pregnancy, low gestational age, small-for-gestational-age birth weight, and mechanical ventilation. Rating: 8 out of 10.
Article
Pediatrics
Kacie Dillon, Vineet Lamba, Ranjit R. Philip, Mark F. Weems, Ajay J. Talati
Summary: This study aimed to assess the efficacy of sildenafil in infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). The study found that sildenafil treatment led to improvement in PH as evaluated by transthoracic echocardiography (TTE), and infants showed improvement in their respiratory severity score (RSS) and FiO2 after prolonged therapy. However, TTE improvements did not correlate with clinical improvements.
Article
Obstetrics & Gynecology
Aydin Bozkaya, Sadik Yurttutan, Mehmet Yasar Ozkars, Adem Doganer
Summary: This study found that pulmonary hemorrhage is associated with respiratory morbidities in preterm infants, such as bronchopulmonary dysplasia and prolonged respiratory support. Infants with pulmonary hemorrhage also had higher rates of other morbidities, such as retinopathy of prematurity and prolonged hospitalization.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pediatrics
Silvia Martini, Iuri Corsini, Luigi Corvaglia, Pradeep Suryawanshi, Belinda Chan, Yogen Singh
Summary: Despite recent improvements in neonatal care, moderate to severe bronchopulmonary dysplasia (BPD) is still associated with high mortality and increased risk of pulmonary hypertension (PH). Echocardiographic and lung ultrasound biomarkers can reflect the development and severity of BPD and PH. Early assessment may not accurately predict later BPD, while lung ultrasound at day 7 after birth can predict later BPD development. Routine surveillance and echocardiographic assessment for PH in at-risk preterm infants may provide useful information for management. More studies are needed to validate proposed parameters and timing of assessment for routine clinical practice.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Yoo Jinie Kim, Seung Han Shin, Hye Won Park, Ee-Kyung Kim, Han-Suk Kim
Summary: The aim of this meta-analysis was to determine the incidence and risk factors of early pulmonary hypertension (PHT) in preterm infants and evaluate its association with morbidities such as bronchopulmonary dysplasia (BPD), late PHT, and in-hospital mortality. The study found that early PHT is significantly associated with BPD, in-hospital mortality, and late PHT in preterm infants. Oligohydramnios and small-for-gestational-age are potential risk factors for early PHT in preterm infants.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
L. Mao, Y. Wu, X. Shu, S. Li, L. Huang
Summary: Echocardiographic parameters can be used to understand the degree of impaired cardiac function in preterm infants and for early detection of PH, which may reduce the mortality rate to a certain extent. The risk of BPD is significantly increased when TR velocity is higher than 1.45 m/s.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Quinn A. Bonafiglia, Yu-Qing Zhou, Guangpei Hou, Rhidita Saha, Ying-Han R. Hsu, Jonah Burke-Kleinman, Michelle P. Bendeck
Summary: Pulmonary hypertension is a disease characterized by elevated pulmonary arterial pressure, leading to right ventricular dysfunction and failure. This study shows that the DDR1 gene deletion results in abnormal muscularization of pulmonary arteries and impaired alveolar development, causing pulmonary hypertension and bronchopulmonary dysplasia.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Pediatrics
Chenhong Wang, Xiaolu Ma, Yanping Xu, Zheng Chen, Liping Shi, Lizhong Du
Summary: The study aimed to establish a prediction model for bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in preterm infants. Four independent predictive factors were identified, and a prediction model was developed with high accuracy in predicting the development of BPD-PH.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Yueqin Ding, Zhifeng Chen, Yanling Lu
Summary: Vitamin A supplementation is beneficial for the prophylaxis of bronchopulmonary dysplasia in premature infants, but no significant differences were found in the incidence of other complications such as retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, and mortality. Further studies on administration approaches and dosages are warranted.
Article
Critical Care Medicine
Emilio Cendejas-Bueno, Iker Falces-Romero, Maria Laplaza-Gonzalez, Luis Escosa-Garcia, Cristina Schuffelmann-Gutierrez, Maria P. Romero-Gomez, Cristina Verdu-Sanchez, Belen Calderon-Llopis, Irene Amores-Hernandez, Javier Peman, Ana Gomez-Zamora, Miguel Rio-Garcia, Juan Jose Menendez-Suso, Diego Rodriguez-Alvarez, Iria Duran-Lorenzo, Elena Perez-Acosta, Miguel Rodriguez Rubio, Elena Alvarez-Rojas, Paloma Dorao Martinez-Romillo, Federico Goded-Rambaud, Abelardo Garcia de Lorenzo, Emilio Maseda, Jesus Mingorance, Pedro de la Oliva, Julio Garcia-Rodriguez
Summary: This study evaluated the utility of the T2Candida panel in diagnosing candidemia in pediatric patients admitted at the PICU, comparing the results with blood cultures. T2Candida showed more positive results than blood cultures, suggesting its potential usefulness in diagnosing candidemia in PICUs.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Israel Valverde, Yogen Singh, Joan Sanchez-de-Toledo, Paraskevi Theocharis, Ashish Chikermane, Sylvie Di Filippo, Beata Kucinska, Savina Mannarino, Amalia Tamariz-Martel, Federico Gutierrez-Larraya, Giridhar Soda, Kristof Vandekerckhove, Francisco Gonzalez-Barlatay, Colin Joseph McMahon, Simona Marcora, Carlo Pace Napoleone, Phuoc Duong, Giulia Tuo, Antigoni Deri, Gauri Nepali, Maria Ilina, Paolo Ciliberti, Owen Miller
Summary: The study documented cardiovascular clinical findings, cardiac imaging, and laboratory markers in children with multisystem inflammatory syndrome associated with COVID-19 infection. Most children in the study cohort had cardiac complications and significantly raised levels of inflammatory markers.
Letter
Respiratory System
Marc Figueras-Coll, Anna Sabate-Rotes, Ignacio Iglesias-Serrano, Andreu Penas-Aguilera, Mercedes Perez-Lafuente
ARCHIVOS DE BRONCONEUMOLOGIA
(2021)
Article
Infectious Diseases
Belen Gutierrez-Gutierrez, Maria Dolores del Toro, Alberto M. Borobia, Antonio Carcas, Inmaculada Jarrin, Maria Yllescas, Pablo Ryan, Jeronimo Pachon, Jordi Carratala, Juan Berenguer, Jose Ramon Arribas, Jesus Rodriguez-Bano
Summary: This study examined the clinical phenotypes of COVID-19 patients through clinical data, identifying three distinct phenotypes (A, B, C) that correlate with prognosis. A simplified probabilistic model was developed for phenotype assignment, which could aid in clinical management of patients.
LANCET INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Roger Esmel-Vilomara, Paola Doladera, Anna Sabate-Rotes, Antoni Soriano-Arandes, Ferran Gran, Ferran Roses-Noguer
Summary: Pediatric patients with COVID-19 who received antiviral therapy experienced QTc interval prolongation after 72 hours, although no arrhythmic events were observed. Active monitoring of QTc is recommended when using hydroxychloroquine and antiviral drugs, and treatment should be discontinued if QTc exceeds 500 ms.
ANALES DE PEDIATRIA
(2022)
Article
Pediatrics
Ferran Gran, Andrea Fidalgo, Paola Dolader, Marta Garrido, Alexandra Navarro, Jaume Izquierdo-Blasco, Joan Balcells, Marta Codina-Sola, Paula Fernandez-Alvarez, Anna Sabate-Rotes, Pedro Betrian, Joaquin Fernandez-Doblas, Raul Abella, Ferran Roses-Noguer
Summary: Distinguishing between acute myocarditis and genetic cardiomyopathy in pediatric patients can be challenging, with differences in clinical presentation that may be effectively differentiated through invasive and non-invasive measures. Some patients with genetic cardiomyopathy can also fulfill the diagnostic criteria of inflammatory cardiomyopathy, highlighting the importance of further research to develop predictive models for differentiation.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Angela Lopez-Sainz, Laia Mila, Jose Rodriguez-Palomares, Javier Limeres, Chiara Granato, Lucia La Mura, Ana Sabate, Andrea Guala, Laura Gutierrez, Laura Galian-Gay, Augusto Sao-Aviles, Sergi Bellmunt, Rafael Rodriguez, Hug Cuellar-Calabria, Albert Roque, Ignacio Ferreira-Gonzalez, Artur Evangelista, Gisela Teixido-Tura
Summary: This study revealed that aortic branch aneurysms are present in approximately one-quarter of patients with MFS, are associated with patient age and aortic dilation, and independently predict the need for aortic surgery.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Marc Figueras-Coll, Joaquin Fernandez-Doblas, Anna Sabate-Rotes
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Letter
Cardiac & Cardiovascular Systems
Marc Figueras-Coll, Anna Sabate-Rotes, Ferran Gran-Ipina, Ferran Roses-Noguer
ARCHIVOS DE CARDIOLOGIA DE MEXICO
(2022)
Article
Cardiac & Cardiovascular Systems
Jose M. Siurana, Paula S. Ventura, Diego Yeste, Lucia Riaza-Martin, Larry Arciniegas, Maria Clemente, Marisa Torres, Nuria Amigo, Gemma Giralt, Ferran Roses-Noguer, Anna Sabate-Rotes
Summary: This study found that adolescents with morbid obesity exhibit abnormal left ventricular geometry and systolic and diastolic dysfunctions compared to normal-weight adolescents. Factors such as BMI, high blood pressure, hyperglycemia, low HDL-cholesterol, and hypertriglyceridemia are associated with impaired cardiac index. Adolescents labelled as metabolically healthy obesity (MHO) show similar pathological heart changes as those with metabolically unhealthy obesity (MUO) despite better BMI and insulin-resistance values.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Genetics & Heredity
Anthony Demolder, Lisa Bianco, Maryanne Caruana, Elena Cervi, Arturo Evangelista, Guillaume Jondeau, Lisa Lauren Buttigieg, Angela Lopez-Sainz, Elena Montanes Delmas, Alessandro Pini, Anna Sabate-Rotes, Katalin Szocs, Maria Tchitchinadze, Gisela Teixido-Tura, Yskert von Kodolitsch, Laura Muino-Mosquera, Julie De Backer
Summary: In patients with heritable thoracic aortic diseases (HTAD), non-aortic cardiac disease such as arrhythmia and impaired myocardial function mainly occurs in those with pathogenic variants in fibrillin1 (FBN1) and genes encoding components of the transforming growth factor (TGF)-beta signaling pathway, while patients with pathogenic variants in Actin Alpha2 (ACTA2) do not show such cardiac complications. Non-aortic cardiac disease should be acknowledged as potentially severe, even in young patients without significant valvular or aortic disease.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Pediatrics
Jose M. Siurana, Anna Sabate-Rotes, Nuria Amigo, Neus Martinez-Micaelo, Larry Arciniegas, Lucia Riaza, Eduard Mogas, Ferran Roses-Noguer, Paula S. S. Ventura, Diego Yeste
Summary: This study evaluated the relationship between advanced lipoprotein testing (ALT) and cardiac changes, metabolic syndrome, and inflammatory markers in morbidly obese adolescents. The results showed that ALT parameters and GlycA were more reliable indicators of cardiac change severity than traditional cardiovascular risk factors.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Carolina Juzga-Corrales, Ariadna Ayerza-Casas, Marc Figueras-Coll, Silvia Escriba-Bori, Beatriz Plata-Izquierdo, Rosa Collell, Maria Arantzazu Gonzalez-Marin, Jose Manuel Siurana, Moises Sorli, Leticia Albert de la Torre, Silvia Teodoro-Marin, Monica Rodriguez, Olga Dominguez-Garcia, Sara Rellan, Begona Manso, Bernardo Lopez-Abel, Roser Alvarez-Perez, Manuel Portillo-Marquez, Erika Rezola, Fernando Centeno-Malfaz, Ruth Solana-Gracia, Henar Rojo-Sombrero, Maria Teresa Cantero-Tejedor, Bibiana Riano, Maria Angeles Tejero-Hernandez, Marisol Jimenez-Casso, Ana Maria Perez-Pardo, Ana Moriano-Gutierrez, Manuel Marrero-Calvo, Maria Teresa Fernandez, Carlos Salido-Peracaula, Maria Jose Bravo, Federico Gutierrez-Larraya, Anna Sabate-Rotes
Summary: This study describes the clinical characteristics and outcomes of pediatric patients with bicuspid aortic valve in Spain, providing the first population-based description.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Jose M. Siurana, Lucia Riaza, Paula S. Ventura, Luis Riera, Elida Vazquez, Roser Ferrer-Costa, Marina Giralt, Ferran Gran, Ferran Roses-Noguer, Diego Yeste, Anna Sabate-Rotes
Summary: This study investigated the composition of the myocardial extracellular matrix (ECM) in an obese pediatric population, and found associations between gender, obesity parameters, and myocardial characteristics and fat tissue infiltration.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Obstetrics & Gynecology
Lucia Deiros-Bronte, Jesus Diez-Sebastian, Roberto Rodriguez Gonzalez, Angela Uceda Galiano, Maria de la Calle, Federico Gutierrez-Larraya Aguado
Summary: The study aimed to quantify the diagnostic accuracy of predictive anatomical factors of aortic coarctation (CoA) and design a postnatal CoA probability algorithm according to gestational age (GA) in prenatal period. The I/D ratio provided the best discrimination between healthy fetuses and those with CoA, with specific algorithms according to GA improving prenatal prediction accuracy for CoA. Using a serial testing strategy, the study achieved a high classification capacity for high or low probability of postnatal CoA.
FETAL DIAGNOSIS AND THERAPY
(2021)