Article
Environmental Sciences
Garthika Navaranjan, Miriam L. Diamond, Shelley A. Harris, Liisa M. Jantunen, Sarah Bernstein, James A. Scott, Tim K. Takaro, Ruixue Dai, Diana L. Lefebvre, Meghan B. Azad, Allan B. Becker, Piush J. Mandhane, Theo J. Moraes, Elinor Simons, Stuart E. Turvey, Malcolm R. Sears, Padmaja Subbarao, Jeffrey R. Brook
Summary: The study found an association between DEHP exposure in the first year of life and increased risks of asthma and recurrent wheezing among children at 5 years. These findings suggest the need to assess whether more stringent regulations are required to protect children's health, which can be informed by future work exploring the main sources of DEHP exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Naiela Anwar, Shelley Kirychuk, Chandima P. Karunanayake, Vivian Ramsden, Brooke Thompson, Eric Russell, Kathleen McMullin, Donna Rennie, Jeremy Seeseequasis, Mark Fenton, Sylvia Abonyi, Punam Pahwa, James Dosman
Summary: Inadequate housing in First Nations communities in Canada often leads to environmental issues such as dampness and mold, impacting residents' respiratory health. This study found significant associations between respiratory symptoms and factors such as body mass index, tobacco use, dampness, and mold presence in the house. Addressing housing inadequacies in these communities is crucial for preventing further health burdens.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Allergy
Kathleen Lee-Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Jessica Lasky-Su, Augusto A. Litonjua, Yang-Yu Liu, Scott T. Weiss
Summary: This study analyzed the relationship between gut microbiome and metabolome and wheeze frequency in children with asthma. The results showed that specific microbial taxa and metabolites were associated with high wheeze proportion in children. This finding suggests the impact of the gut microbiome on asthma morbidity in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Idun Holmdahl, Anastasia Filiou, Katarina Stenberg Hammar, Anna Asarnoj, Magnus P. Borres, Marianne van Hage, Gunilla Hedlin, Cilla Soderhall, Jon R. Konradsen
Summary: This study followed children with acute wheeze during early childhood to age 7 and found that acute wheeze caused by rhinovirus infection at inclusion was the main associated factor for developing persistent asthma. Cases who developed asthma also required more hospital time and care after inclusion.
Article
Engineering, Biomedical
Fizza Ghulam Nabi, Kenneth Sundaraj, Muhammad Shahid Iqbal, Muhammad Shafiq, Rajkumar Planiappan
Summary: The study proposed a telemedicine application based on machine learning techniques for automatically identifying the severity level of asthma patients, achieving high accuracy rates. The automatic detection and classification of wheezes were successfully accomplished through feature extraction and classifier utilization.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Maxwell Mathias, Jill Chang, Marta Perez, Ola Saugstad
Summary: Oxygen is crucial for cell survival, but excessive oxygen delivery can disrupt growth and development, induce inflammation, and cause oxidative damage. Newborns, especially premature infants, are particularly susceptible to hyperoxic injury due to their immature antioxidant defense system.
Article
Environmental Sciences
Derek Werthmann, Berna van Wendel de Joode, Michael T. Cuffney, Brian J. Reich, Manuel E. Soto-Martinez, Andrea Corrales-Vargas, Luis Palomo-Cordero, Jorge Penaloza-Castanedac, Jane A. Hoppin
Summary: This study evaluated the association between medical conditions and environmental exposures with fractional exhaled nitric oxide (FeNO) as a marker of airway inflammation. The results showed that rhinitis and wheeze were associated with elevated FeNO, and smoke from waste burning and para-occupational pesticide exposure may contribute to the increase of FeNO in rural communities.
ENVIRONMENTAL RESEARCH
(2023)
Article
Allergy
Philip J. Cooper, Irina Chis Ster, Martha E. Chico, Maritza Vaca, Yisela Oviedo, Augusto Maldonado, Mauricio L. Barreto, Thomas A. E. Platts-Mills, David P. Strachan
Summary: Early-life exposure to geohelminths may have a protective effect against wheeze/asthma and atopy. However, the relationship between geohelminths and airways is complex, with maternal geohelminths and childhood infections showing different effects on respiratory outcomes. Parasite-specific effects were observed in non-atopic children in terms of wheeze/asthma and airways reactivity/inflammation.
Article
Environmental Sciences
Elizabeth M. Kamai, Brandyn C. Ruiz, Yoshira Ornelas Van Horne, Dayane Duenas Barahona, Esther Bejarano, Luis Olmedo, Sandrah P. Eckel, Jill E. Johnston, Shohreh F. Farzan
Summary: This study focuses on the impact of agricultural field burning on air pollution in rural communities in the United States. It finds that smoke from agricultural burning contains air toxics that negatively affect respiratory health. The study uses questionnaire data from 735 students and finds a relationship between agricultural burning and respiratory symptoms in children.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Logan C. Dearborn, Marnie F. Hazlehurst, Christine T. Loftus, Adam A. Szpiro, Kecia N. Carroll, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Kaja Z. LeWinn, Nicole R. Bush, Joel D. Kaufman, Catherine J. Karr
Summary: This study found that early life air pollution can influence the development of asthma and wheezing in children aged 4-6 years with a history of bronchiolitis. The research was conducted by observing and evaluating a longitudinal cohort from six US cities, estimating the exposure of these children to fine particulate matter, nitrogen dioxide, and ozone pollution from ages 1 to 3 years, and controlling for other factors. The results showed that for every 2 ppb increase in ozone concentration, the risk of developing asthma in children increased by 1.4 times, and the risk of developing wheezing increased by 1.3 times.
Article
Pediatrics
Gemma Mas-Dalmau, Carmen Villanueva Lopez, Pedro Gorrotxategi Gorrotxategi, Emma Arguelles Prendes, Oscar Espinazo Ramos, Teresa Valls Duran, Maria Encarnacion Gonzalo Alonso, Maria Pilar Cortes Viana, Tatiana Menendez Bada, Marta Esther Vazquez Fernandez, Ana Isabel Perez Hernandez, Laura Munoz Ortiz, Paul Little, Mariam de la Poza Abad, Pablo Alonso-Coello
Summary: The study found that there was no statistically significant difference in symptom duration or severity in children with uncomplicated respiratory infections who received delayed antibiotic prescription (DAP) compared to immediate antibiotic prescription (IAP) or no antibiotic prescription (NAP); however, DAP reduced antibiotic use and gastrointestinal adverse effects.
Article
Medicine, Research & Experimental
Daniel Blumenthal, James A. A. Leonard, Andy Habib, Hengameh Behzadpour, Alexandra Espinel, Diego Preciado
Summary: There has been a notable increase in the number of extremely premature neonates requiring tracheostomy and laryngotracheal reconstruction (LTR). This study aimed to compare the outcomes of LTR in extremely premature infants to those born preterm and term, focusing on decannulation rates, time to decannulation, and complication rates.
Article
Pediatrics
Alexandros N. Zounas, Ioannis Giannakopoulos, Panagiotis Lampropoulos, Aggeliki Vervenioti, Eleana-Georgia Koliofoti, Styliani Malliori, Kostas N. Priftis, Gabriel Dimitriou, Michael B. Anthracopoulos, Sotirios Fouzas
Summary: The prevalence of childhood wheeze/asthma has significantly decreased over the past decade in Greece. The persistent and noncurrent wheeze/asthma groups followed the overall trend, while the recent-onset wheeze/asthma prevalence remained unchanged. Physicians and parents' changing perceptions of asthma may have contributed to this reversing trend, especially in younger children with troublesome respiratory symptoms.
PEDIATRIC PULMONOLOGY
(2021)
Article
Multidisciplinary Sciences
Davide De Francesco, Yair J. Blumenfeld, Ivana Maric, Jonathan A. Mayo, Alan L. Chang, Ramin Fallahzadeh, Thanaphong Phongpreecha, Alex J. Butwick, Maria Xenochristou, Ciaran S. Phibbs, Neda H. Bidoki, Martin Becker, Anthony Culos, Camilo Espinosa, Qun Liu, Karl G. Sylvester, Brice Gaudilliere, Martin S. Angst, David K. Stevenson, Gary M. Shaw, Nima Aghaeepour
Summary: The study introduces a multitask deep neural network model that can predict twelve neonatal morbidities, providing a new data-driven approach to defining prematurity. Analyzing data from 11,594,786 livebirths in California from 1991 to 2012, the model outperformed traditional models in assessing prematurity with better predictive performance.
Article
Allergy
Chloe I. Bloom, Courtney Franklin, Andrew Bush, Sejal Saglani, Jennifer K. Quint
Summary: The study found that preschool wheeze in the United Kingdom causes a significant healthcare burden, affecting around 7.7% of preschool children. Wheeze events were least common in August and most common in late-autumn/early-winter. Various factors such as wheeze frequency and severity, atopy, maternal asthma, were associated with progression to asthma in preschool children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Neeta Thakur, Luisa N. Borrell, Morgan Ye, Sam S. Oh, Celeste Eng, Kelley Meade, Pedro C. Avila, Harold J. Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Rajesh Kumar, Kirsten Bibbins-Domingo, Shannon Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Esteban G. Burchard
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Allergy
Seong H. Cho, Ara Jo, Thomas Casale, Su J. Jeong, Seung-Jae Hong, Joong K. Cho, Janet T. Holbrook, Rajesh Kumar, Lewis J. Smith
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Medicine, General & Internal
George R. Washko, Laura A. Colangelo, Raul San Jose Estepar, Samuel Y. Ash, Surya P. Bhatt, Yuka Okajima, Kiang Liu, David R. Jacobs, Carlos Iribarren, Bharat Thyagarajan, Cora E. Lewis, Rajesh Kumar, MeiLan K. Han, Mark T. Dransfield, Mercedes R. Carnethon, Ravi Kalhan
AMERICAN JOURNAL OF MEDICINE
(2020)
Editorial Material
Allergy
Rajesh Kumar, Max A. Seibold, Esteban G. Burchard
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Genetics & Heredity
Angel C. Y. Mak, Satria Sajuthi, Jaehyun Joo, Shujie Xiao, Patrick M. Sleiman, Marquitta J. White, Eunice Y. Lee, Benjamin Saef, Donglei Hu, Hongsheng Gui, Kevin L. Keys, Fred Lurmann, Deepti Jain, Goncalo Abecasis, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Lara Winterkorn, Catherine Reeves, Scott Huntsman, Celeste Eng, Sandra Salazar, Sam S. Oh, Frank D. Gilliland, Zhanghua Chen, Rajesh Kumar, Fernando D. Martinez, Ann Chen Wu, Elad Ziv, Hakon Hakonarson, Blanca E. Himes, L. Keoki Williams, Max A. Seibold, Esteban G. Burchard
Article
Allergy
Rajesh Kumar, Ryan P. Ferrie, Lauren C. Balmert, Matthew Kienzl, Sheryl L. Rifas-Shiman, Diane R. Gold, Joanne E. Sordillo, Ken Kleinman, Carlos A. Camargo, Augusto A. Litonjua, Emily Oken, Joan M. Cook-Mills
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Eric M. Wohlford, Luisa N. Borrell, Jennifer R. Elhawary, Brian Plotkin, Sam S. Oh, Thomas J. Nuckton, Celeste Eng, Sandra Salazar, Michael A. LeNoir, Kelley Meade, Harold J. Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Rajesh Kumar, Shannon Thyne, Max A. Seibold, Jose R. Rodriguez-Santana, Esteban G. Burchard
Article
Critical Care Medicine
Hongsheng Gui, Albert M. Levin, Donglei Hu, Patrick Sleiman, Shujie Xiao, Angel C. Y. Mak, Mao Yang, Andrea J. Barczak, Scott Huntsman, Celeste Eng, Samantha Hochstadt, Ellen Zhang, Kyle Whitehouse, Samantha Simons, Whitney Cabral, Sami Takriti, Goncalo Abecasis, Thomas W. Blackwell, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, David E. Lanfear, Frank Gilliland, W. James Gauderman, Rajesh Kumar, David J. Erle, Fernando D. Martinez, Hakon Hakonarson, Esteban G. Burchard, L. Keoki Williams
Summary: This study identified a functional variant at the 17q12-21.1 locus associated with early-onset asthma in African American individuals. The lead signal, rs11078928, was found to be the top association for early-onset asthma after meta-analysis across cohorts. Additionally, a haplotype analysis suggested that the asthma association most closely with this variant.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Anastasia Ivanova, Elliot Israel, Lisa M. LaVange, Michael C. Peters, Loren C. Denlinger, Wendy C. Moore, Leonard B. Bacharier, M. Alison Marquis, Nathan M. Gotman, Michael R. Kosorok, Chalmer Tomlinson, David T. Mauger, Steve N. Georas, Rosalind J. Wright, Patricia Noel, Gary L. Rosner, Praveen Akuthota, Dean Billheimer, Eugene R. Bleecker, Juan Carlos Cardet, Mario Castro, Emily A. DiMango, Serpil C. Erzurum, John V. Fahy, Merritt L. Fajt, Benjamin M. Gaston, Fernando Holguin, Sonia Jain, Nicholas J. Kenyon, Jerry A. Krishnan, Monica Kraft, Rajesh Kumar, Mark C. Liu, Ngoc P. Ly, James N. Moy, Wanda Phipatanakul, Kristie Ross, Lewis J. Smith, Stanley J. Szefler, W. Gerald Teague, Michael E. Wechsler, Sally E. Wenzel, Steven R. White
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2020)
Article
Multidisciplinary Sciences
Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Jamie L. Everman, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Michael E. Wechsler, Angel C. Y. Mak, Celeste Eng, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Goncalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Wanda Phipatanakul, David T. Mauger, Theresa W. Guilbert, Leonard B. Bacharier, Sandy Durrani, Daniel J. Jackson, Fernando D. Martinez, Anne M. Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M. Wheatley, Cindy Bauer, Carla M. Davis, Bob Geng, Kirsten M. Kloepfer, Craig Lapin, Andrew H. Liu, Jacqueline A. Pongracic, Stephen J. Teach, James Chmiel, Jonathan M. Gaffin, Matthew Greenhawt, Meera R. Gupta, Peggy S. Lai, Robert F. Lemanske, Wayne J. Morgan, William J. Sheehan, Jeffrey Stokes, Peter S. Thorne, Hans C. Oettgen, Elliot Israel
Summary: Asthma in children is largely influenced by allergen sensitization, and early intervention targeting IgE and IgE-mediated responses may help prevent and reduce the severity of asthma development.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Medicine, Research & Experimental
William J. Sheehan, Ian M. Paul, David T. Mauger, James N. Moy, Stanley J. Szefler, Daniel J. Jackson, Anne M. Fitzpatrick, Michael D. Cabana, Ronina Covar, Rachel G. Robison, Wanda Phipatanakul
Summary: The study showed that over 85% of doses of acetaminophen or ibuprofen were adherence to the protocol of blinded study medications, while less than 15% were deviations to OTC medications. Better adherence was observed in the ibuprofen group compared to the acetaminophen group. In individual cases, over 75% of participants remained fully adherent by not receiving any OTC medications.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Pediatrics
Victor E. Ortega, Michelle Daya, Stanley J. Szefler, Eugene R. Bleecker, Vernon M. Chinchilli, Wanda Phipatanakul, Dave Mauger, Fernando D. Martinez, Esther Herrera-Luis, Maria Pino-Yanes, Gregory A. Hawkins, Elizabeth J. Ampleford, Susan J. Kunselman, Corey Cox, Leonard B. Bacharier, Michael D. Cabana, Juan Carlos Cardet, Mario Castro, Loren C. Denlinger, Celeste Eng, Anne M. Fitzpatrick, Fernando Holguin, Donglei Hu, Daniel J. Jackson, Nizar Jarjour, Monica Kraft, Jerry A. Krishnan, Stephen C. Lazarus, Robert F. Lemanske, John J. Lima, Njira Lugogo, Angel Mak, Wendy C. Moore, Edward T. Naureckas, Stephen P. Peters, Jacqueline A. Pongracic, Satria P. Sajuthi, Max A. Seibold, Lewis J. Smith, Julian Solway, Christine A. Sorkness, Sally Wenzel, Steven R. White, Esteban G. Burchard, Kathleen Barnes, Deborah A. Meyers, Elliot Israel, Michael E. Wechsler
Summary: Pharmacogenetic studies in asthma cohorts have identified loci associated with response to medications in individuals of European descent, but differences exist in individuals of African descent. This study aimed to understand pharmacogenetic mechanisms regulating therapeutic responsiveness in people of African descent and detected novel significant loci.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Article
Allergy
Autumn C. Guyer, Eric Macy, Andrew A. White, Merin E. Kuruvilla, Rachel G. Robison, Santhosh Kumar, David A. Khan, Elizabeth J. Phillips, Allison Ramsey, Kimberly Blumenthal
Summary: The allergy section of the electronic health record plays a crucial role in clinical decision-making and treatment planning, but current allergy modules do not meet the requirements. We recommend collaboration between EHR vendors and allergists to optimize and modernize allergy documentation, providing meaningful, accurate, timely, and comprehensive allergy information.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Letter
Infectious Diseases
Amanda M. Miceli, Shan Sun, Tonya L. Scardina, Ajay Bhasin, Larry K. Kociolek, Rachel G. Robison, Sameer J. Patel
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
