Article
Clinical Neurology
Sebastian Arts, Erik J. van Lindert, Rene Aquarius, Ronald H. M. A. Bartels, Hieronymus D. Boogaarts
Summary: External cerebrospinal fluid (CSF) drains are commonly used in patients with aneurysmal subarachnoid haemorrhage (aSAH) but can lead to complications. This study found a correlation between the presence of an external CSF drain and the risk of complications, with drain-related complications accounting for 32% of all complications. Prolonged drainage period was also associated with an increased number of complications, suggesting that reducing the drainage period could improve patient care.
ACTA NEUROCHIRURGICA
(2021)
Article
Clinical Neurology
Yonatan Serlin, Gal Ben-Arie, Svetlana Lublinsky, Hagit Flusser, Alon Friedman, Ilan Shelef
Summary: The study utilized MRI-based quantitative analysis to examine the neurological impact of BEH, identifying abnormalities in the ON in patients with enlarged CSF spaces and linking it to neurological complications. The results challenge the view of BEH as a benign condition, suggesting that ON deformity may serve as a potential marker for risk stratification in patients with enlarged CSF spaces.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Camilla de Laurentis, Paola Cristaldi, Andrea Arighi, Clarissa Cavandoli, Andrea Trezza, Erik P. Sganzerla, Carlo G. Giussani, Andrea Di Cristofori
Summary: This systematic review explores the role of aquaporins (AQPs) in the pathophysiology of hydrocephalus, finding a general increase of AQPs in hydrocephalic patients but a tendency towards reduction in patients with idiopathic normal pressure hydrocephalus, suggesting AQPs may serve as diagnostic tools or therapeutic targets for hydrocephalus management.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Diana Lolansen, Nina Rostgaard, Tenna Capion, Nicolas H. Norager, Markus Harboe Olsen, Marianne Juhler, Tiit Illimar Mathiesen, Nanna MacAulay
Summary: The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain unclear, but elevated cerebrospinal fluid (CSF) osmolality is not the cause of PHH. The pathological CSF accumulation observed in these patients is instead attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following subarachnoid hemorrhage (SAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Timothy Wong, Justin Gold, Ryan Houser, Yehuda Herschman, Raja Jani, Ira Goldstein
Summary: Cerebrospinal fluid (CSF) diversion is a common neurosurgical procedure, with ventriculoperitoneal (VP) shunting being a widely used technique. In addition to VP shunting, ventriculopleural (VPL) shunting is also used in some patients, but can lead to complications such as pleural effusion and pneumothorax.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Leroy ten Dam, Diederik van de Beek, Matthijs C. Brouwer
Summary: In patients with neurosarcoidosis and hydrocephalus, female patients are more common with clinical symptoms such as headache and vertigo. Treatment involves glucocorticoids and neurosurgical intervention, with generally favorable outcomes.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Joanna Palasz, Linda D'Antona, Sarah Farrell, Mohamed A. Elborady, Laurence D. Watkins, Ahmed K. Toma
Summary: This study compared the effects of continuous vs. intermittent CSF drainage and rapid vs. gradual weaning in external ventricular drainage procedures. The results showed that intermittent CSF drainage reduced the incidence of EVD-related infections and blockages, while patients who underwent rapid weaning had a shorter hospital stay.
NEUROSURGICAL REVIEW
(2022)
Review
Neurosciences
Yijian Yang, Chuansen Wang, Rui Chen, Yuchang Wang, Changwu Tan, Jingping Liu, Qinghua Zhang, Gelei Xiao
Summary: In this review, we summarize the astrocyte reactivity induced by hydrocephalus and their corresponding functions. We also discuss the therapeutic effects of regulating astrocytes in hydrocephalus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Infectious Diseases
Antonia Diederichs, Evelyn Pawlik, Anke Barnbrock, Stefan Schoening, Juergen Konczalla, Tobias Finger, Thomas Lehrnbecher, Stephan Goettig, Konrad Bochennek
Summary: Infection of the cerebrospinal fluid system is a serious medical complication. The incidence of infection did not significantly differ between children with and without cancer, but was highest in children younger than one year. Infection occurred earlier in external ventricular drain (EVD) than ventriculoperitoneal (VP) shunt, and in children with cancer compared with patients without cancer. The isolated pathogens were mainly Gram-positive bacteria, particularly Staphylococcus spp.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to investigate the potential of AQP1 and AQP4 proteins in CSF as biomarkers for iNPH, but ELISA analysis showed insufficient sensitivity to detect their presence. The study also revealed differences in vascular risk factors between patients with iNPH and AD.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to analyze the presence of AQP1 and AQP4 in the CSF of iNPH and AD patients as potential biomarkers. However, ELISA analysis showed insufficient sensitivity to detect these proteins, ruling out their use as biomarkers for diagnosing iNPH.
Article
Clinical Neurology
Ghassan Kerry, Markus Holtmannspoetter, Jens Christian Kubitz, Hans-Herbert Steiner
Summary: The study found that patients with generalized brain edema and midline shift are more likely to experience misplacement during EVD, while patients under oral anticoagulation and antiplatelet therapy are more prone to hemorrhage. Metal needles and polyurethane catheters are equivalent in terms of patient safety when there are no midline shift and generalized brain edema.
ACTA NEUROCHIRURGICA
(2022)
Article
Biochemistry & Molecular Biology
Trine L. Toft-Bertelsen, Soren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Marianne Juhler, Nanna Macaulay
Summary: The lipidomic signature of CSF in patients with subarachnoid hemorrhage suggests dysregulation of lipids and potential biomarkers for future treatment options.
Article
Biochemistry & Molecular Biology
Jose Luis Trillo-Contreras, Juan Jose Toledo-Aral, Javier Villadiego, Miriam Echevarria
Summary: Aquaporin-4 (AQP4) is the principal water channel in the brain, playing a crucial role in cerebrospinal fluid (CSF) homeostasis and hydrocephalus. The study found that alterations associated with hydrocephalic state may not be permanent, as some symptoms can be reversed by reexposure to normoxia, but deficits in CSF outflow and ventricular distensibility persist.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Yijian Yang, Jian He, Yuchang Wang, Chuansen Wang, Changwu Tan, Junbo Liao, Lei Tong, Gelei Xiao
Summary: The choroid plexus, consisting mainly of choroid plexus epithelium cells, is located in the lateral ventricles of the brain. Its main function is thought to be the secretion and regulation of cerebrospinal fluid, with additional functions such as assisting in waste removal, participating in apoptosis, and aiding in brain repair and immune response. Abnormalities in choroid plexus epithelium cells, along with inflammation and changes in cilia, may lead to abnormal conditions in cerebrospinal fluid and the development of hydrocephalus. This review discusses the pathophysiological mechanism of hydrocephalus and explores the potential use of choroid plexus epithelium cells as a therapeutic target.
JOURNAL OF NEUROINFLAMMATION
(2022)