Article
Medicine, General & Internal
Nathalie De Beukelaer, Ines Vandekerckhove, Ester Huyghe, Geert Molenberghs, Nicky Peeters, Britta Hanssen, Els Ortibus, Anja Van Campenhout, Kaat Desloovere
Summary: This prospective longitudinal study modeled morphological muscle growth in 87 children with SCP, finding that children with moderate to severe SCP had slower muscle growth rates before the age of 2 compared to those with mild SCP, and had even worse muscle growth rates after the age of 9. These findings highlight the importance of early monitoring of SCP muscle pathology and its relationship to motor mobility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Meta N. Eek, Annika Blomkvist, Kristina Olsson, Karin Lindh, Kate Himmelmann
Summary: This study successfully measured the sitting position of children with cerebral palsy and severe motor impairment using pressure mapping and 2D motion analysis. Children with cerebral palsy had more movements in sitting compared to typically developing children. Differences were also found between different subgroups of cerebral palsy. After treatment with intrathecal baclofen, involuntary movements decreased and improvement in sitting was reported by parents. The two measurement systems showed consistent results and proved to be feasible for objective assessment of sitting position in this population.
Article
Orthopedics
Ali Asma, Jason J. Howard, Armagan Can Ulusaloglu, Kenneth J. Rogers, Freeman Miller, M. Wade Shrader
Summary: This study aimed to determine the risk factors for reconstructive hip surgery after intrathecal baclofen pump application in children with cerebral palsy. The results showed that male sex, pre-intrathecal baclofen migration percentage, age at intrathecal baclofen application, and delta migration percentage were significant risk factors for requiring reconstruction.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
(2023)
Article
Cell & Tissue Engineering
Kylie Crompton, Iona Novak, Michael Fahey, Nadia Badawi, Katherine J. Lee, Francoise Mechinaud-Heloury, Priya Edwards, Paul Colditz, Trisha Soosay Raj, Janet Hough, Xiaofang Wang, Simon Paget, Kuang-Chih Hsiao, Peter Anderson, Dinah Reddihough
Summary: This study investigated the safety and preliminary efficacy of sibling cord blood cell infusion in children with cerebral palsy. The findings suggest that sibling cord blood cell infusion is relatively safe for children with cerebral palsy when conducted in appropriate facilities, but the improvement in motor function and upper extremity skills is limited.
Article
Multidisciplinary Sciences
Sophie Wist, Lena J. Carcreff, Sjoerd M. Bruijn, Gilles Allali, Christopher J. Newman, Joel Fluss, Stephane Armand
Summary: This study compared the gait stability of children with cerebral palsy and typically developing children under dual-task conditions. The results showed that the dual task had a significant effect on the children with cerebral palsy, and both groups demonstrated significant changes in gait stability during dual tasks.
Review
Clinical Neurology
Amogh Kudva, Mickey E. Abraham, Justin Gold, Neal A. Patel, Julian L. Gendreau, Yehuda Herschman, Antonios Mammis
Summary: Cerebral palsy is a chronic congenital disorder caused by abnormal brain development. Recent literature has focused on chronic spasticity in children with CP. Various neuromodulation procedures, such as selective dorsal rhizotomy, intrathecal baclofen pumps, and extracorporeal shockwave therapy, have been found to effectively improve spasticity, but further studies are needed to determine optimal frequencies and application sites for these treatments.
NEUROSURGICAL REVIEW
(2021)
Article
Rehabilitation
Rodolphe Bailly, Mathieu Lempereur, Christelle Pons, Laetitia Houx, Matthias Thepaut, Bhushan Borotikar, Raphael Gross, Sylvain Brochard
Summary: This study revealed that children with unilateral CP have a greater neck shaft angle compared to control limbs, while children with bilateral CP have a smaller mechanical tibial angle and a greater femoral torsion. The bone shape complexity was higher in bilateral CP, with changes in all three dimensions of space compared to unilateral CP and control limbs.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Medicine, General & Internal
Damien Kiernan, Charikleia Nikolopoulou, Karen Brady
Summary: The prevalence of overweight and obesity in Irish ambulatory children with cerebral palsy is not increasing over a 20-year period. However, there is a higher prevalence of overweight and obesity in these children compared with their typically developed peers. Monitoring of prevalence and trends is therefore important.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Rehabilitation
Laura A. Bonouvrie, Helga Haberfehlner, Jules G. Becher, Johan S. H. Vles, R. Jeroen Vermeulen, Annemieke Buizer
Summary: This study assessed the achievement of individual treatment goals one year after intrathecal baclofen pump implantation in patients with dyskinetic cerebral palsy. The study found that 71% of individuals fully achieved one or more treatment goals, while 97% partially achieved one or more treatment goals. The attainment of treatment goals was associated with baseline dyskinesia impairment score and improvement in pain during treatment.
DISABILITY AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Karen Brady, Damien Kiernan, Andrea Marron
Summary: A retrospective analysis of 574 children with cerebral palsy showed that as they age, some children progress into overweight or obesity categories while the majority maintain a normal BMI. This highlights the importance of maintaining a healthy BMI status in children with cerebral palsy.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Guojun Yun, Meihuan Huang, Jianguo Cao, Xianming Hu
Summary: This study found a strong association between impaired selective motor control (SMC) and lower limb motor ability, functional balance, and gait performance in children with bilateral spastic cerebral palsy (CP). The results suggest that deficits in SMC are related to poor gross motor function, balance control, overall gait deviations, and decreased fast walking speed in these children.
Article
Rehabilitation
Clodagh Coman, Dara Meldrum, Damien Kiernan, Ailish Malone
Summary: This study aimed to assess the effects of Pilates-based exercise classes on gait kinematics and balance in children with Cerebral Palsy (CP). The results showed that the exercise classes did not significantly change gait kinematics or balance. The feasibility of the classes also prompted consideration for future interventions.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Gunnar Hagglund, Sandra Julsen Hollung, Matti Ahonen, Guro L. Andersen, Guobjorg Eggertsdottir, Mark S. Gaston, Reidun Jahnsen, Ira Jeglinsky-Kankainen, Kirsten Nordbye-Nielsen, Ilaria Tresoldi, Ann Alriksson-Schmidt
Summary: There are significant differences between countries in the proportion of children and adolescents with CP treated with the three spasticity-reducing methods, the mean age for treatment, and treatment related to GMFCS level. These differences may be due to variations in treatment availability and preferences among professionals and patients across countries.
Article
Rehabilitation
Soolim Lee, Cheolhwan Hyun, Kyungmin Kim, Hyo Eun Kwon, Minwoo Woo, Seong-Eun Koh
Summary: This systematic review examined the effect of intrathecal baclofen pump insertion on scoliosis in children with cerebral palsy (CP). Four retrospective comparative studies were included in the analysis, and the results showed that intrathecal baclofen pump insertion accelerated the progression of scoliosis. Therefore, the advantages and disadvantages of using intrathecal baclofen pumps in children with CP should be carefully evaluated.
ANNALS OF REHABILITATION MEDICINE-ARM
(2023)
Article
Clinical Neurology
Ann Mansur, Benjamin Morgan, Alexandre Lavigne, Nicolas Phaneuf-Garand, Jocelyne Diabira, Han Yan, Unni G. Narayanan, Darcy Fehlings, Golda Milo-Manson, Blythe Dalziel, Sara Breitbart, Claude Mercier, Dominic Venne, Pierre Marois, Alexander G. Weil, Jeffrey S. Raskin, Sruthi P. Thomas, George M. Ibrahim
Summary: The study compared the care needs, symptom burden, and complications in nonambulatory children with predominantly spastic cerebral palsy who underwent surgical treatment with either intrathecal baclofen pump insertion or selective dorsal rhizotomy. The results showed significant baseline differences between patients treated with these two surgical options, highlighting the importance of considering individual patient factors when determining the appropriate treatment.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Review
Clinical Neurology
Aurelie Bucaille, Christophe Jarry, Justine Allard, Sylvain Brochard, Sylviane Peudenier, Arnaud Roy
Summary: This systematic review aimed to verify the differences in cognitive functions and academic performances between intellectually gifted children and typically developing children. The results showed that intellectually gifted children exhibited better skills in attention, language, mathematics, and other domains, but were comparable to typically developing children in visuospatial processing, memory, and planning.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Psychology, Developmental
Roxane Varengue, Sylvain Brochard, Sandra Bouvier, Rodolphe Bailly, Laetitia Houx, Mathieu Lempereur, Christele Kandalaft, Alain Chatelin, Jacky Vagnoni, Carole Vuillerot, Vincent Gautheron, Elea Dheilly, Christelle Pons, Mickael Dinomais, Marine Cacioppo
Summary: The lockdown during the COVID-19 pandemic in France had a negative impact on the daily life and well-being of children with physical disabilities.
CHILD CARE HEALTH AND DEVELOPMENT
(2022)
Article
Neurosciences
Rodolphe Bailly, Mathieu Lempereur, Matthias Thepaut, Christelle Pons, Laetitia Houx, Sylvain Brochard
Summary: The relationship between tibial-femoral bone morphology and kinematic gait variables in children with cerebral palsy was found to be weak. These findings indicate the need for a thorough clinical examination and gait analysis before making treatment decisions.
Article
Clinical Neurology
Josselin Demas, Mathieu Bourguignon, Xavier De Tiege, Vincent Wens, Nicolas Coquelet, Antonin Rovai, Sandra Bouvier, Rodolphe Bailly, Sylvain Brochard, Mickael Dinomais, Patrick Van Bogaert
Summary: The study developed an electrophysiological marker of proprioceptive spino-cortical tracts integrity in young children with UCP based on corticokinematic coherence (CKC). Results showed that CKC strength was weaker for affected hand movements compared to non-affected hand movements, influenced by the type of lesion, especially in children with cortico-subcortical lesions.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Gwenael Cornec, Sylvain Brochard, Gaelle Drewnowski, Isabelle Desguerre, Philippe Toullet, Audrey Fontaine, Yann Le Lay, Julia Boivin, Eric Berard, Maria Bodoria, Vincent Gautheron, Javier De la Cruz
Summary: This study aimed to investigate the changes in motor rehabilitation environmental factors, service use, and patient outcomes among children and adults with cerebral palsy. The results showed that it was difficult for both children and adults to find an available physiotherapist, with adults mainly receiving physiotherapy in private outpatient practices. Multidisciplinary rehabilitation decreased sharply from adolescence and was halved at adulthood. Satisfaction with the motor rehabilitation program decreased from childhood into adolescence and adulthood.
FRONTIERS IN NEUROLOGY
(2022)
Letter
Rehabilitation
Christelle Pons, Mathieu Lempereur, Laetitia Houx, Katharine Alter, Rodolphe Bailly, Matthias Thepaut, Diane Damiano, Sylvain Brochard
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc Garetier, Jean Rousset, Karim Makki, Sylvain Brochard, Francois Rousseau, Douraied Ben Salem, Bhushan Borotikar
Summary: This study aimed to assess and compare the image quality of the two most frequently used real-time sequences for joint dynamic magnetic resonance imaging (MRI). The results showed that the RF-spoiled sequence had higher scores for bone and joint evaluation and overall image appreciation, and had smaller standard deviations for SNR, CNR, and grading score during motion. Therefore, it is recommended to use the RF-spoiled real-time sequence for in vivo clinical evaluation of distal joints on a 3.0T MRI scanner.
Article
Pediatrics
Delphine Gaudin-Drouelle, Laetitia Houx, Mathieu Lempereur, Sylvain Brochard, Christelle Pons
Summary: This study reports the progress made by a 7-year-old boy with Angelman syndrome after an innovative intervention involving translingual neurostimulation (TLNS) and goal-oriented rehabilitation. The intervention resulted in significant improvements in gait and functionality, which partially sustained six months after the intervention.
Article
Psychology, Developmental
Pauline Lavenant, Marine Cacioppo, Helene Ansquer, Sophie Guillaumont, Laetitia Houx, Sylvain Brochard, Pascal Amedro, Christelle Pons
Summary: This study provides valuable information for clinicians, physical educators, and policy makers on the experiences of adolescents with congenital heart disease in participating in physical activities. The participants had a generally positive view of physical activity, but their physical condition limited their engagement. Environmental factors, such as social and school environments, played an important role. The findings emphasize the need for adapted activities and better medical guidance for these individuals.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Article
Chemistry, Analytical
Nicolas Bayle, Mathieu Lempereur, Emilie Hutin, Damien Motavasseli, Olivier Remy-Neris, Jean-Michel Gracies, Gwenael Cornec
Summary: This study compared the sensitivity of four smoothness metrics to handedness and movement type, and explored the correlations with other kinematic parameters. The results showed that LDLJ, NARJ, and N0C metrics found backward movements to be smoother, while SPARC metric found the opposite. SPARC had the lowest coefficients of variation. LDLJ, NARJ, and N0C metrics were correlated with each other and with movement time, unlike SPARC.
Editorial Material
Rehabilitation
Marine Cacioppo, Clemence Lucas, Shenhao Dai, Rodolphe Bailly, Dominic Perennou, Roxane Varengue, Laetitia Houx, Mathieu Lempereur, Christele Kandalaft, Alain Chatelin, Jacky Vagnoni, Carole Vuillerot, Vincent Gautheron, Mickael Dinomais, Elea Dheilly, Sandra Bouvier, Sylvain Brochard, Christelle Pons
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Rehabilitation
Amandine Dubois, Caroline Hall, Emmanuelle Courtois-Communier, Arnaud Brasseur, Marine Cacioppo, Sylvain Brochard
Summary: This study aimed to determine the incidence and intensity of care-related pain in children with physical disabilities in pediatric rehabilitation centers and health facilities for children in France. The results showed that 6% of physical acts induced pain, and 48% of children experienced at least one painful act during the study period. Age, level of dependency, and type of act were identified as risk factors for care-related pain.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Review
Engineering, Biomedical
Marine Cacioppo, Anthea Loos, Mathieu Lempereur, Sylvain Brochard
Summary: This review summarizes the instrumented measurement tools used to assess bimanual movements in children with cerebral palsy and their metrological properties. The studies included 452 children who underwent quantitative bimanual assessments using tools such as 3D motion analysis and accelerometers. While these measurements showed moderate to good discriminant and convergent validity, there is a lack of reliability and responsiveness assessments.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Chemistry, Analytical
Marine Cacioppo, Mathieu Lempereur, Laetitia Houx, Sandra Bouvier, Rodolphe Bailly, Sylvain Brochard
Summary: The Be an Airplane Pilot (BE API) protocol was developed to evaluate upper limb kinematics in children with unilateral cerebral palsy during bimanual tasks. This study investigated the responsiveness of this protocol to changes in kinematics and movement quality after upper limb therapies, and analyzed the relationships between kinematic and functional changes.
Article
Computer Science, Artificial Intelligence
Nathan Decaux, Pierre-Henri Conze, Juliette Ropars, Xinyan He, Frances T. Sheehan, Christelle Pons, Douraied Ben Salem, Sylvain Brochard, Francois Rousseau
Summary: Fully automated approaches based on convolutional neural networks have achieved promising results on muscle segmentation from MR images, but they require a large amount of training data. Manual muscle segmentation is still necessary for pediatric and rare diseases cohorts. In this work, a registration-based label propagation method is proposed, which can generate 3D muscle delineations from a limited number of annotated 2D slices. The proposed semi-automatic multi-label segmentation model outperforms state-of-the-art techniques.
PATTERN RECOGNITION
(2023)
Article
Clinical Neurology
Ani Gok, Seha Kamil Saygili, Sebuh Kurugoglu, Sema Saltik, Nur Canpolat
Summary: This study examines the occurrence of nephrolithiasis in children with type 1 SMA and identifies hypercalciuria and high urine specific gravity as common risk factors. The study suggests that children with SMA type 1 may have an increased risk of nephrolithiasis compared to the general population.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Glenn S. Rivera, Jesse A. Stokum, Janet Dean, Cristina L. Sadowsky, Allan J. Belzberg, Matthew J. Elrick
Summary: This study evaluated the surgical efficacy of nerve transfer surgery in patients with acute flaccid myelitis (AFM) and found that preoperative clinical and neurophysiological data play a valuable role in preoperative planning and patient selection. The postoperative outcomes demonstrated that nerve transfer surgery is an effective strategy to restore strength.
PEDIATRIC NEUROLOGY
(2024)
Review
Clinical Neurology
Tristan T. Sands, Jennifer N. Gelinas
Summary: This review explores the concept of epileptic encephalopathy (EE) in pediatric epilepsy, discussing the potential impact of epileptic activity on normal brain development and mechanisms underlying cognitive and behavioral impairments. The findings highlight the threat of epileptic activity to normal brain physiology and development.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Grace Gombolay, Melissa A. Walker
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Salman Rashid, Monisha Goyal, Kathryn Lalor, Khaled Al-Robaidi, Vivek Shukla, Fazlur Rahman, Manimaran Ramani
Summary: This study investigated the seizure risk in asymptomatic preterm infants with high-grade intraventricular hemorrhage who underwent long-term video electroencephalographic monitoring. The findings showed that approximately 16% of these infants had seizures, and those with seizures were younger and more likely to be remonitored.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Bernadeta Zabielska, Natalia Rzewuska, Sergiusz Jozwiak
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Kelly C. Burk, Maki Kaneko, Catherine Quindipan, My H. Vu, Maritza Feliz Cepin, Jonathan D. Santoro, Michele Van Hirtum-Das, Deborah Holder, Gordana Raca
Summary: This study compared the diagnostic yields of chromosomal microarray (CMA) and epilepsy-genes sequencing (EGS) for genetic epilepsy etiologies. It found that EGS had a significantly higher diagnostic yield than CMA, especially for patients with infantile seizure onset and additional neurological findings.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Ursula Thome, Larissa A. Batista, Renata P. Rocha, Vera C. Terra, Ana Paula A. Hamad, Americo C. Sakamoto, Antonio C. Santos, Marcelo Santos, Helio R. Machado
Summary: Rasmussen encephalitis (RE) is a characterized by pharmacoresistant epilepsy and progressive neurological deficits. Surgical disconnection of the affected hemisphere is considered the treatment of choice, although the precise etiology is still unknown. This study reports the clinical, electrographic, and neuroimaging features of children and adolescents who underwent hemispheric surgery (HS) for the treatment of RE.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Michal Tzadok, Rotem Gur-Pollack, Hadar Florh, Yael Michaeli, Tal Gilboa, Mirit Lezinger, Eli Heyman, Veronika Chernuha, Irina Gudis, Andreea Nissenkorn, Tally Lerman-Sagie, Bruria Ben Zeev, Shimrit Uliel-Sibony
Summary: Purified CBD is well-tolerated and effective in reducing seizure frequency in children and young adults with drug-resistant epilepsy.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Zimeng Ye, Sufang Lin, Xia Zhao, Mathew Wallis, Xinyi Gao, Li Sun, Jiarui Wu, Jing Duan, Yi Yao, Lin Li, Li Chen, Dezhi Cao, Zhanqi Hu, Victor W. Zhang, Samuel F. Berkovic, Ingrid E. Scheffer, Jianxiang Liao, Michael S. Hildebrand
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Nicolas J. Abreu, Madeline Chiujdea, Shanshan Liu, Bo Zhang, Sarah J. Spence
Summary: This study found a low completion rate of chromosomal microarray (CMA) testing for patients with autism spectrum disorder (ASD). Provider recommendation and more follow-up visits were associated with CMA completion. Age, intellectual disability or global developmental delay, first-degree relative with ASD, and public insurance were all related to CMA completion. Parental concern and cost/insurance coverage were the most frequently documented barriers.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Wafa Bouchaala, Sirine Laroussi, Yosra Mzid, Imen Maaloul, Olfa Jallouli, Salma Zouari, Sihem Ben Nsir, Zeineb Mnif, Fatma Kammoun, Chahnez Triki
Summary: Moyamoya angiopathy is a rare but serious cerebrovascular disease in children, which may result in arterial ischemic stroke. The clinical and radiological presentations can vary and are often overlooked. Early diagnosis and treatment are crucial.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Eline M. C. Hamilton, Pinar Topaloglu, Jigyasha Sinha, Francesco Nicita, Genevieve Bernard, S. Ali Fatemi, Marjo S. van der Knaap
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Muhamad Azamin Anuar, Muhammad'Adil Zainal Abidin, Soo Hong Tan, Cai Fong Yeap, Nor Azni Yahaya
Summary: This study conducted in Malaysia found that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and neuroimaging abnormalities.
PEDIATRIC NEUROLOGY
(2024)
