Article
Pediatrics
Maria Pia Falcone, Kathryn Pritchard-Jones, Jesper Brok, William Mifsud, Richard D. Williams, Kayo Nakata, Suzanne Tugnait, Reem Al-Saadi, Lucy Side, John Anderson, Catriona Duncan, Stephen D. Marks, Detlef Bockenhauer, Tanzina Chowdhury
Summary: The study found that nearly two-thirds of children with WT and constitutional WT1 pathogenic variant had sustained native kidney function, despite the high risk of kidney disease. This suggests that nephron-sparing surgery should be attempted when possible, and larger international studies are needed to accurately assess the correlation between WT1 genotype and kidney function phenotype.
PEDIATRIC NEPHROLOGY
(2022)
Review
Oncology
Janna A. Hol, Rosalyn Jewell, Tanzina Chowdhury, Catriona Duncan, Kayo Nakata, Takaharu Oue, Marion Gauthier-Villars, Annemieke S. Littooij, Yasuhiko Kaneko, Norbert Graf, Franck Bourdeaut, Marry M. van den Heuvel-Eibrink, Kathy Pritchard-Jones, Eamonn R. Maher, Christian P. Kratz, Marjolijn C. J. Jongmans
Summary: The updated Wilms tumour surveillance guidelines have been released for clinical geneticists, pediatricians, pediatric oncologists, and radiologists caring for children at risk of WT. These guidelines stress the importance of registering all patients with cancer predisposition syndromes in order to improve future tumor risk estimation and surveillance programs.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Summary: The study demonstrates that TG may alleviate the effects of EMT and apoptosis in DKD by upregulating autophagy through the mTOR/Twist1 signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Physiology
Kyle Dickinson, Leah Hammond, Murielle Akpa, Lee Lee Chu, Caleb Tse Lalonde, Alexandre Goumba, Paul Goodyer
Summary: Mammalian nephrons originate from nephron progenitor cells expressing WT1, which is crucial for their development. WT1 primes the cells for nephrogenesis by inducing the expression of DNA repair gene Neil3, which protects the genome during kidney development. This study reveals the importance of lineage-specific DNA repair mechanisms in kidney development.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Oncology
Ana Pavlic, Emanuela Bostjancic, Rajko Kavalar, Bojan Ilijevec, Serena Bonin, Fabrizio Zanconati, Nina Zidar
Summary: This study investigates the involvement of epithelial-mesenchymal transition (EMT) in tumor budding (TB) and poorly differentiated clusters (PDCs) in colorectal cancer (CRC). The results suggest that both TB and PDCs are associated with partial EMT, but they exhibit discrete differences in morphology and expression of EMT-related markers.
JOURNAL OF PATHOLOGY
(2022)
Article
Urology & Nephrology
Jingping Yang, Difei Zhang, Masaru Motojima, Tsutomu Kume, Qing Hou, Yu Pan, Aiping Duan, Mingchao Zhang, Song Jiang, Jinhua Hou, Jingsong Shi, Zhaohui Qin, Zhihong Liu
Summary: This study identified potential TFs in human glomerulus cells through analysis of superenhancer distribution, and elucidated the regulatory roles of FOXC1/2 in podocyte maintenance using transcriptomics and cistromics. The results suggest that FOXC1/2 maintain podocyte differentiation through transcriptional stabilization, with overexpression protecting podocytes from injury. The genome-wide chromatin resources support further investigation of TFs' regulatory roles in glomeruli transcription programs.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Oncology
Danny Legge, Ling Li, Whei Moriarty, David Lee, Marianna Szemes, Asef Zahed, Leonidas Panousopoulos, Wan Yun Chung, Yara Aghabi, Jasmin Barratt, Richard Williams, Kathy Pritchard-Jones, Karim T. A. Malik, Sebastian Oltean, Keith W. Brown
Summary: The study revealed that epigenetic inactivation of ESRP2 disrupts the mesenchymal to epithelial transition in early kidney development, leading to the formation of Wilms tumour (WT). Reactivation of ESRP2 expression by DNA methyltransferase inhibition suppressed cellular proliferation in WT cell lines and inhibited tumor growth in vivo.
MOLECULAR ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruixue Guo, Peipei Wang, Xuejun Zheng, Wen Cui, Jin Shang, Zhanzheng Zhao
Summary: This study demonstrates that the SGLT2 inhibitor dapagliflozin protects podocytes from diabetic nephropathy by regulating the IGF1R/PI3K signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaixuan Tian, Guoqiang Du, Xiaoqing Wang, Xiangyu Wu, Long Li, Wei Liu, Rongde Wu
Summary: M2-type macrophages enhance proliferation and metastasis of Wilms' tumour by secreting MMP9, thereby increasing the invasive ability of the tumour.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Floor A. A. Ruiter, Francis L. C. Morgan, Nadia Roumans, Anika Schumacher, Gisela G. Slaats, Lorenzo Moroni, Vanessa L. S. LaPointe, Matthew B. Baker
Summary: Pluripotent stem cell-derived kidney organoids can be effectively cultured using dynamic hydrogel structures, resulting in improved maturity and reduced expression of undesired proteins compared to conventional methods. This offers new opportunities for the treatment of renal failure and disease modeling applications.
Review
Biochemistry & Molecular Biology
Lei Han, Shuyi Wang, Chen Wei, Yan Fang, Sihao Huang, Tailang Yin, Bin Xiong, Chaogang Yang
Summary: Cancer metastasis is closely related to the process of Epithelial-mesenchymal transition (EMT) and the tumor microenvironment (TME), which interact with each other and contribute to the progression of cancer metastasis.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2021)
Review
Oncology
Janna A. Hol, Illja J. Diets, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Marjolijn C. J. Jongmans, Roland P. Kuiper
Summary: TRIM28 has been identified as a predisposition gene for Wilms' tumour (WT), with germline pathogenic variants associated with epithelial WT. Loss of TRIM28 protein expression in tumour tissue is an effective strategy for identifying patients with TRIM28 variants. Further exploration of TRIM28-associated WT will help uncover the mechanisms underlying tumour development.
JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Wenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, Fei Gao, Wei Li
Summary: This study found that knockout of the Epg5 gene in mice results in reduced fertility and a phenotype similar to POI. Further investigation revealed that Epg5 knockout blocks the autophagy pathway, leading to the accumulation of WT1 and disruption of granulosa cell differentiation, which may contribute to POI pathogenesis.
Article
Oncology
Carolyn M. Jablonowski, Hyea Jin Gil, Emilia M. Pinto, Prahalathan Pichavaram, Andrew M. Fleming, Michael R. Clay, Dongli Hu, Christopher L. Morton, Shondra M. Pruett-Miller, Baranda S. Hansen, Xiang Chen, Karissa M. Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M. Davidoff, Gerard P. Zambetti, Andrew J. Murphy
Summary: The study identified potential mechanisms of TERT activation in Wilms tumor, including mutations in the TERT promoter, increased methylation of the promoter, and genomic copy number amplifications. Conversely, inactivating WT1 mutations were associated with low TERT RNA levels and telomerase activity. N-MYC overexpression led to increased TERT promoter activity and transcription.
Article
Biochemistry & Molecular Biology
Matthew L. Hupy, Michelle G. Pedler, Biehuoy Shieh, Dongyan Wang, Xiao-Jing Wang, J. Mark Petrash
Summary: Cataract surgery can lead to a secondary lens abnormality known as posterior capsule opacification (PCO), which can increase treatment costs and reduce quality of life for patients. Studies suggest that inhibiting TGF-beta-mediated Smad signaling is a promising approach to prevent PCO pathogenesis following cataract surgery.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Rachel L. Berry, Derya D. Ozdemir, Bruce Aronow, Nils O. Lindstroem, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cecile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D. Hastie, Peter Hohenstein
DISEASE MODELS & MECHANISMS
(2015)
Review
Cell Biology
Peter Hohenstein, Kathy Pritchard-Jones, Jocelyn Charlton
GENES & DEVELOPMENT
(2015)
Editorial Material
Urology & Nephrology
Derya D. Ozdemir, Peter Hohenstein
KIDNEY INTERNATIONAL
(2015)
Article
Biology
Nils O. Lindstroem, Melanie L. Lawrence, Sally F. Burn, Jeanette A. Johansson, Elvira R. M. Bakker, Rachel A. Ridgway, C-Hong Chang, Michele J. Karolak, Leif Oxburgh, Denis J. Headon, Owen J. Sansom, Ron Smits, Jamie A. Davies, Peter Hohenstein
Article
Cell & Tissue Engineering
Nils Olof Lindstroem, Neil Oliver Carragher, Peter Hohenstein
Article
Multidisciplinary Sciences
David A. D. Munro, Peter Hohenstein, Jamie A. Davies
SCIENTIFIC REPORTS
(2017)
Article
Anatomy & Morphology
Nils O. Lindstroem, C. -Hong Chang, M. Todd Valerius, Peter Hohenstein, Jamie A. Davies
JOURNAL OF ANATOMY
(2015)
Article
Multidisciplinary Sciences
Elise Cachat, Weijia Liu, Kim C. Martin, Xiaofei Yuan, Huabing Yin, Peter Hohenstein, Jamie A. Davies
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Rocio Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sanchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Veronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
NATURE COMMUNICATIONS
(2019)
Article
Endocrinology & Metabolism
Nabil A. Rashdan, Alisia M. Sim, Lin Cui, Kanchan Phadwal, Fiona L. Roberts, Roderick Carter, Derya D. Ozdemir, Peter Hohenstein, John Hung, Jakub Kaczynski, David E. Newby, Andrew H. Baker, Gerard Karsenty, Nicholas M. Morton, Vicky E. MacRae
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Review
Genetics & Heredity
Hao Li, Peter Hohenstein, Satu Kuure
Summary: The adult mammalian kidney lacks stem cells for regeneration, unlike the embryonic kidney which contains lineage-specific stem cells giving rise to various kidney components; current research focuses on these embryonic progenitor cells which can shed light on the formation of Wilms tumor, a pediatric renal cancer.
Article
Biochemistry & Molecular Biology
Yaron Trink, Achia Urbach, Benjamin Dekel, Peter Hohenstein, Jacob Goldberger, Tomer Kalisky
Summary: Wilms' tumors are pediatric malignancies that arise from faulty kidney development. Computational approaches were used to characterize the continuous heterogeneity in high-risk blastemal-type Wilms' tumors, revealing a triangle-shaped continuum in latent space bounded by three tumor archetypes with different characteristics resembling developmental stages of the fetal kidney. These findings provide insights into the relationship between Wilms' tumors and kidney development, and have the potential to improve tumor stratification and classification strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kathleen Grabert, Anuj Sehgal, Katharine M. Irvine, Evi Wollscheid-Lengeling, Derya D. Ozdemir, Jennifer Stables, Garry A. Luke, Martin D. Ryan, Antony Adamson, Neil E. Humphreys, Cheyenne J. Sandrock, Rocio Rojo, Veera A. Verkasalo, Werner Mueller, Peter Hohenstein, Allison R. Pettit, Clare Pridans, David A. Hume
JOURNAL OF IMMUNOLOGY
(2020)
