Article
Cell Biology
Roman Eremichev, Maria Kulebyakina, Nataliya Alexandrushkina, Peter Nimiritsky, Nataliya Basalova, Olga Grigorieva, Mane Egiazaryan, Daniyar Dyikanov, Vsevolod Tkachuk, Pavel Makarevich
Summary: Healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. The endometrium is a unique mucous membrane in the human body that heals without scarring after various injuries, possibly due to tissue-specific features of its stromal cells and the effects of soluble factors secreted during menstruation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina S. Glazieva, Natalya A. Alexandrushkina, Peter P. Nimiritsky, Maria A. Kulebyakina, Roman Yu. Eremichev, Pavel I. Makarevich
Summary: This study aimed to investigate factors affecting the assembly time of cell sheet (CS). Through testing adipose-derived mesenchymal stromal cells (MSCs) from 14 healthy individuals, it was found that high contents of collagen I and collagen IV were associated with prolonged assembly time. Furthermore, MSCs with shorter lag phase assembled faster, while factors such as age, sex, fibronectin showed no significant correlation with assembly time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Summary: The SMARCA4 complex is found to play a crucial role in the response of airway epithelial cells to RSV infection, with its depletion leading to cellular state transition and chromatin opening that affect gene expression within cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Nicolas Collao, Donna D'Souza, Laura Messeiller, Evan Pilon, Jessica Lloyd, Jillian Larkin, Matthew Ngu, Alexanne Cuillerier, Alexander E. Green, Keir J. Menzies, Yan Burelle, Michael De Lisio
Summary: This study suggests that fibro/adipogenic progenitors (FAPs) play an important role in radiation-induced muscle pathology, leading to muscle atrophy and fibrosis. Radiation exposure induces senescence and fibrogenic differentiation of FAPs, impairing the differentiation and fusion of muscle satellite (stem) cells. Therefore, targeting FAPs may be a potential therapeutic approach to alleviate the negative late effects of radiation exposure in skeletal muscle.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Zheng Wang, Chengyan Chai, Rui Wang, Yimei Feng, Lei Huang, Yiming Zhang, Xia Xiao, Shijie Yang, Yunfang Zhang, Xi Zhang
Summary: This study utilized advanced single-cell RNA sequencing to construct a comprehensive atlas of over 130,000 single-MSC transcriptomes across multiple tissues and donors, revealing seven tissue-specific and five conserved MSC subpopulations with distinct gene expression signatures. The study demonstrated the significant contribution of extracellular matrix to MSC heterogeneity and identified potential improvements in MSC-based therapeutic efficacy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Tomas Gonzalez-Fernandez, Alejandro J. Tenorio, Augustine M. Saiz, J. Kent Leach
Summary: Loading cell-secreted extracellular matrix (ECM) into spheroids enhances the osteogenic potential of MSCs and improves their viability and responsiveness to differentiation signals. This study highlights the clinical significance of ECM-loaded spheroids for musculoskeletal tissue repair.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Prakash Shrestha, Shiva Pathak, Shobha Regmi, Kannan Badri Narayanan, Tiep Tien Nguyen, Simmyung Yook, Jong Oh Kim, Jee-Heon Jeong
Summary: Extracellular matrix (ECM) is crucial for cell biology, and artificial microfibers mimicking ECM can enhance cell-polymeric fiber interactions and improve cell viability. Loading antioxidant drugs into microfibers further enhances cell viability.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Baojie Guo, Yongchao Duan, Zhongwen Li, Yao Tian, Xuedi Cheng, Chunxu Liang, Wenjing Liu, Bin An, Wumei Wei, Tingting Gao, Shasha Liu, Xiyuan Zhao, Shuaishuai Niu, Chenxin Wang, Yukai Wang, Liu Wang, Guihai Feng, Wei Li, Jie Hao, Qi Gu, Qi Zhou, Jun Wu
Summary: The researchers developed a 21-day long-term serum-free culture system and successfully created cell sheets (CSs) with human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) that have stronger mechanical properties and greater extracellular matrix secretion capacity. These IMRC-CSs were effective in promoting corneal chemical injury repair and could be transformed into injectable temperature-sensitive hydrogels for uterine adhesion repair through a decellularization process.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Toxicology
Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang, Jie Chao
Summary: Chronic silica exposure can cause silicosis, a severe occupational lung disease with limited therapeutic options. This study used single-cell transcriptome sequencing and a mouse model to investigate the molecular mechanisms underlying epithelial mesenchymal transition (EMT) in silicosis. The researchers found that glycoprotein non-metastatic melanoma protein B (GPNMB) played a significant role in promoting EMT and persistent lung pathological changes in silicosis. GPNMB released extracellular vesicles that contributed to abnormal changes in the extracellular matrix and collagen structure. The findings suggest that GPNMB could be a potential target for preventing fibrosis in silicosis.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Retraction
Cell Biology
Feng-Na Yu, Ming-Lan Hu, Xin-Fang Wang, Xiang-Ping Li, Bei-Hao Zhang, Xiao-Qing Lu, Rui-Qiang Wang
Summary: The article investigated the effects of microRNA-370 on mesangial cell proliferation and extracellular matrix accumulation in a rat model of diabetic nephropathy, but was retracted due to image elements of the experimental data being published elsewhere in a different scientific context, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Ju Lee, Khurshid Ahmad, Shiva Pathak, SunJu Lee, Mohammad Hassan Baig, Jee-Heon Jeong, Kyung-Oh Doh, Dong-Mok Lee, Inho Choi
Summary: This study introduces novel peptides derived from fibronectin that enhance cell adhesion, proliferation, and differentiation, offering a new approach to cell culture. The peptides showed significant effects on primary cells and stem cells, increasing proliferation and promoting differentiation into specific cell types such as osteoblasts. The results suggest potential applications in the production of core materials for cell culture such as scaffolds and culture medium components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Paz de la Torre, Maria Jesus Perez-Lorenzo, Alvaro Alcazar-Garrido, Jennifer Collado, Mario Martinez-Lopez, Laura Forcen, Ana R. Masero-Casasola, Alicia Garcia, M. Carmen Gutierrez-Velez, Jose Medina-Polo, Eloy Munoz, Ana I. Flores
Summary: Stress urinary incontinence (SUI) is a condition that causes the involuntary loss of urine when making small efforts, seriously affecting daily life. Weakening of the pelvic floor tissues is the cause, and the cellular and molecular mechanisms are not fully understood. Mesenchymal stromal cells from the maternal side of the placenta, called decidual mesenchymal stromal cells (DMSC), are proposed as a therapeutic alternative due to their regenerative potential. Animal models show that DMSC transplantation can prevent a drop in pressure at the leak point and promote recovery of damaged pelvic tissue. In SUI patients, myofibroblasts isolated from suburethral connective tissue show premature replicative senescence, but co-culture with DMSC can reverse these effects through paracrine interactions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Muxin Yue, Yunsong Liu, Ping Zhang, Zheng Li, Yongsheng Zhou
Summary: The study investigates the interaction between stem cell transcriptional and metabolic signals in extracellular matrices with different stiffnesses. It reveals that the stiffness of the matrix plays a role in determining the fate of bone marrow mesenchymal stem cells, with different stiffnesses leading to different differentiation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kealan McElhinney, Mustapha Irnaten, Colm O'Brien
Summary: Fibrosis is a dysregulated wound repair response that leads to progressive disruption of tissue architecture and significant morbidity/mortality. Current treatments can slow disease progression but not restore organ function or reverse fibrotic changes. Myofibroblast apoptosis is absent in fibrosis, contributing to persistent myofibroblast activation and perpetuation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadav Kislev, Roza Izgilov, Raizel Adler, Dafna Benayahu
Summary: Adipose tissue is a complex organ composed of different cellular populations, and changes in these cells can lead to metabolic complications and insulin resistance. The interaction between immune cells and adipocytes is important for tissue regulation.
Article
Urology & Nephrology
Sonja Djudjaj, Hongqi Lue, Song Rong, Marios Papasotiriou, Barbara M. Klinkhammer, Stephanie Zok, Ole Klaener, Gerald S. Braun, Maja T. Lindenmeyer, Clemens D. Cohen, Richard Bucala, Andre P. Tittel, Christian Kurts, Marcus J. Moeller, Juergen Floege, Tammo Ostendorf, Juergen Bernhagen, Peter Boor
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Cell Biology
Jialin Wang, Sonja Djudjaj, Lydia Gibbert, Vera Lennartz, Daniel M. Breitkopf, Thomas Rauen, Daniela Hermert, Ina V. Martin, Peter Boor, Gerald S. Braun, Juergen Floege, Tammo Ostendorf, Ute Raffetseder
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Immunology
Lydia Gibbert, Daniela Hermert, Jialin Wang, Daniel M. Breitkof, Christina Alidousty, Matthias Neusser, Clemens D. Cohen, Elisabeth Groene, Iris Macheleidt, Thomas Rauen, Gerald S. Braun, Juergen Floege, Tammo Ostendorf, Ute Raffetseder
CLINICAL IMMUNOLOGY
(2018)
Article
Urology & Nephrology
Jennifer Eymael, Shagun Sharma, Markus A. Loeven, Jack F. Wetzels, Fieke Mooren, Sandrine Florquin, Jeroen K. Deegens, Brigith K. Willemsen, Vikram Sharma, Toin H. van Kuppevelt, Marinka A. Bakker, Tammo Ostendorf, Marcus J. Moeller, Henry B. Dijkman, Bart Smeets, Johan van der Vlag
KIDNEY INTERNATIONAL
(2018)
Article
Urology & Nephrology
Claudia R. C. van Roeyen, Ina Martin, Ana Drescher, Katharina A. Schuett, Daniela Hermert, Ute Raffetseder, Stephanie Otten, Eva M. Buhl, Gerald S. Braun, Christoph Kuppe, Elisa Liehn, Peter Boor, Ralf Weiskirchen, Ulf Eriksson, Oliver Gross, Frank Eitner, Juergen Floege, Tammo Ostendorf
KIDNEY INTERNATIONAL
(2019)
Article
Immunology
Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, Juergen Floege, Thomas Bertsch, Leo Cornelius Bollheimer, Tammo Ostendorf
JOURNAL OF INFLAMMATION-LONDON
(2019)
Article
Urology & Nephrology
Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Juergen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Daniela Hermert, Ina Martin, Lucy K. Reiss, Xiyang Liu, Daniel M. Breitkopf, Katharina C. Reimer, Christina Alidousty, Thomas Rauen, Juergen Floege, Tammo Ostendorf, Ralf Weiskirchen, Ute Raffetseder
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
Daniel M. Breitkopf, Vera Jankowski, Kim Ohl, Juliane Hermann, Daniela Hermert, Klaus Tenbrock, Xiyang Liu, Ina Martini, Jialin Wang, Fabian Groll, Elisabeth Groene, Juergen Floege, Tammo Ostendorf, Thomas Rauen, Ute Raffetseder
KIDNEY INTERNATIONAL
(2020)
Review
Urology & Nephrology
Justyna Wozniak, Juergen Floege, Tammo Ostendorf, Andreas Ludwig
Summary: Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs) play important roles in kidney diseases and could be therapeutic targets. Research has shown that these proteases are associated with profibrotic pathways involving various signaling pathways. Targeted approaches against these proteases may offer better treatment outcomes.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Medicine, General & Internal
Marcus J. Moeller, Rafael Kramann, Twan Lammers, Bernd Hoppe, Eicke Latz, Isis Ludwig-Portugall, Peter Boor, Juergen Floege, Christian Kurts, Ralf Weiskirchen, Tammo Ostendorf
Summary: Organ fibrogenesis, characterized by a common pathophysiological final pathway, independent of the progressive disease, offers potential therapeutic targets. The SFB/TRR57 consortium successfully identified new mechanisms and established novel therapeutic approaches to interfere with hepatic and renal fibrosis. This review focuses on the consortium's key findings related to renal fibrosis, addressing new relevant mechanisms, immunological contributors, and modulation strategies.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Francesca Solagna, Caterina Tezze, Maja T. Lindenmeyer, Shun Lu, Guochao Wu, Shuya Liu, Yu Zhao, Robert Mitchell, Charlotte Meyer, Saleh Omairi, Temel Kilic, Andrea Paolini, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Dominik Kylies, Julian Schulze Zur Wiesch, Jan-Eric Turner, Nicola Wanner, Viji Nair, Felix Eichinger, Rajasree Menon, Ina Martin, Barbara M. Klinkhammer, Elion Hoxha, Clemens D. Cohen, Pierre-Louis Tharaux, Peter Boor, Tammo Ostendorf, Matthias Kretzler, Marco Sandri, Oliver Kretz, Victor G. Puelles, Ketan Patel, Tobias B. Huber
Summary: This study investigated the mechanism of skeletal muscle wasting in CKD and found that the soluble pro-cachectic factor activin A is expressed in specific kidney cell populations, proposing a vicious signaling cycle between kidney and muscle. Blocking activin A signaling pharmacologically prevented muscle wasting in experimental CKD mouse models.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Meeting Abstract
Geriatrics & Gerontology
T. Laurentius, U. Raffetseder, C. Fellner, R. Kob, M. Nourbakhsh, J. Floege, T. Bertsch, C. Bollheimer, T. Ostendorf
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2019)
Meeting Abstract
Rheumatology
D. Breitkopf, D. Hermert, E. Groene, I. Martin, J. Floege, T. Ostendorf, U. Raffetseder, T. Rauen
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Physiology
Ina V. Martin, Annika Bohner, Peter Boor, Erdenechimeg Shagdarsuren, Ute Raffetseder, Frank Lammert, Juergen Floege, Tammo Ostendorf, Susanne N. Weber
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)