Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Qinfan Yao, Cuili Wang, Yucheng Wang, Wenyu Xiang, Yin Chen, Qin Zhou, Jianghua Chen, Hong Jiang, Dajin Chen
Summary: This study identified key differentially expressed genes (DEGs) in acute allograft rejection (AR) and found that they have the potential to be used as biomarkers for early-stage AR diagnosis. The expression of these genes can reflect the immune status of patients with AR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Jakub Mizera, Justyna Pilch, Dorota Kaminska, Magdalena Krajewska, Piotr Donizy, Miroslaw Banasik
Summary: The purpose of this article is to assess the current knowledge about chronic active T-cell mediated rejection of a kidney. The research reviews the diagnostic criteria used in kidney rejection, investigates the role of molecular methods in diagnosis, and discusses the available treatment methods and their side effects. The study also examines the coincidence of chronic active rejection with other kidney rejection types and explores the possibility of non-HLA antibodies in CA TCMR patients and their impact on kidney function.
Article
Urology & Nephrology
Eric Langewisch, Roslyn B. Mannon
Summary: With the improved long-term kidney transplant survival, attention has shifted to understanding the causes of transplanted allograft failure. Chronic allograft injury involves both immune-mediated and nonimmune-mediated injuries, presenting an opportunity to identify those at greater risk and implement new strategies. The research highlights the need to identify markers of injury and mechanisms of injury in order to better understand late graft failure.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Greg Knoll, Patricia Campbell, Michael Chasse, Dean Fergusson, Tim Ramsay, Priscilla Karnabi, Jeffrey Perl, Andrew A. House, Joseph Kim, Olwyn Johnston, Rahul Mainra, Isabelle Houde, Dana Baran, Darin J. Treleaven, Lynne Senecal, Lee Anne Tibbles, Marie-Josee Hebert, Christine White, Martin Karpinski, John S. Gill
Summary: This study investigated the use of immunosuppressants in patients with kidney transplant failure and found that prolonged use of immunosuppressants for more than 2 years was not associated with an increased risk of death or hospitalized infection. However, continued use of immunosuppressants did not prevent rejection of the failed allograft or an increase in anti-HLA antibodies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Jinwen Lin, Ying Chen, Huijuan Zhu, Kai Cheng, Huiping Wang, Xianping Yu, Mengmeng Tang, Jianghua Chen
Summary: This study demonstrates that remodeling of lymphatic vessels plays a key role in antigen presentation and lymph node activation after kidney transplantation. Higher density of lymphatic vessels is associated with renal dysfunction and pathological changes post-transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Xu-Tao Chen, Jiang Qiu, Zi-Xuan Wu, Hui Zhang, Tong Chen, Shi-Cong Yang, Guo-Dong Zhao, Yu He, Xue Shen, Jin-Quan Luo, Yang Huang, Chang-Xi Wang, Li-Zhong Chen, Cheng-Lin Wu, Gang Huang
Summary: Both plasma and urine donor-derived cell-free DNA (dd-cfDNA) are sensitive markers for renal allograft injuries. The interpretation of a specific disease by dd-cfDNA should be combined with other clinical indicators.
CLINICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Urology & Nephrology
Christina Lai, Steven J. Chadban, Yik Wen Loh, Tony King-Tak Kwan, Chuanmin Wang, Julian Singer, Paula Niewold, Zheng Ling, Alanna Spiteri, Daniel Getts, Nicholas Jonathan Cole King, Huiling Wu
Summary: Inflammatory monocytes are a major component of acute kidney transplant rejection. This study investigates the therapeutic potential of immune-modifying nanoparticles (IMPs) in preventing kidney allograft rejection. The results show that IMPs significantly reduce acute rejection, improve kidney function, and inhibit inflammatory cell density and cytokine expression. However, IMPs do not offer protection against chronic rejection.
KIDNEY INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Jinwen Lin, Junhao Lv, Xianping Yu, Xing Xue, Shiping Yu, Huiping Wang, Jianghua Chen
Summary: A genetic engineered membrane-coated nanoparticle called DSA trapper, inspired by the affinity of bacterial proteins for antibodies, is able to efficiently adsorb and clear alloreactive antibodies, restoring single-cell transcriptional heterogeneity. DSA trappers absorbed antibodies through heterophagic clearance, reducing IgG deposition and complement activation, providing an immune tolerant niche for restoration of single-cell genetic architecture. In allogeneic transplantation mice, DSA trapper improved glomerular filtration rate and prolonged survival. Overall, DSA trapper offers a promising approach for treating alloantibody-mediated immune injury.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karsten Suhre, Darshana M. Dadhania, John Richard Lee, Thangamani Muthukumar, Qiuying Chen, Steven S. Gross, Manikkam Suthanthiran
Summary: Noninvasive biomarkers of kidney allograft status, measured through urine metabolites, can serve as indicators of rejection events; while metabolite profiles are effective for discriminating rejection biopsies, estimated Glomerular Filtration Rate (eGFR) also plays a significant role in the metabolite signal.
Article
Immunology
Claire Tinel, Baptiste Lamarthee, Jasper Callemeyn, Elisabet Van Loon, Virginia Sauvaget, Lise Morin, Laila Aouni, Marion Rabant, Wilfried Gwinner, Pierre Marquet, Maarten Naesens, Dany Anglicheau
Summary: miRNAs play key roles in antibody-mediated rejection in solid-organ transplantation by regulating cellular functions, such as endothelial cells, epithelial cells, and immune cells, impacting the development of microvascular inflammation as well as renal immune response and electrolyte homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Penghui Cheng, Rending Wang, Shasha He, Pengpeng Yan, Hongfeng Huang, Jianghua Chen, Jia Shen, Kanyi Pu
Summary: We report the development of Artificial bioMarker Probes (AMPros) for sensitive urinalysis of Acute renal allograft rejection (ARAR) in murine models. AMPros specifically react with immune biomarkers in the kidneys and activate their fluorescence signals to detect rejection. The urinalysis using AMPros is noninvasive, sensitive, and can detect ARAR earlier than current diagnostic methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Transplantation
Rui Zhi, Xiao-Dong Zhang, Ying Hou, Ke-Wen Jiang, Qiao Li, Jing Zhang, Yu-Dong Zhang
Summary: This study developed a hybrid deep-learning approach for diagnosing renal allograft dysfunction in kidney-allografted patients, achieving stable performance and providing important references for individualized diagnostics and treatment strategies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)