Article
Multidisciplinary Sciences
Isabel Fuentes-Calvo, Cristina Cuesta, Sandra M. Sancho-Martinez, Omar A. Hidalgo-Thomas, Maria Paniagua-Sancho, Francisco J. Lopez-Hernandez, Carlos Martinez-Salgado
Summary: This study identified subclinical sequelae persisting after recovery from AKI in rats, including histological and functional alterations, as well as susceptibility to new AKI episodes. Additionally, potential diagnostic tools were found in the FST and urinary [TIMP-2]*[IGFBP7] product, to monitor the sequelae and kidney vulnerability after apparent recovery from AKI.
SCIENTIFIC REPORTS
(2021)
Article
Medical Laboratory Technology
Alfredo G. Casanova, Isabel Fuentes-Calvo, Maria T. Hernandez-Sanchez, Miguel Quintero, Paula Toral, Maria T. Caballero, Carlos Martinez-Salgado, Ana Morales, Anita T. Layton, Nelida Eleno, Francisco J. Lopez-Hernandez
Summary: Diagnosis of AKI relies on plasma creatinine concentration but also requires detection of alterations in other aspects of renal function. The furosemide stress test has been validated in rats for detecting subclinical tubular alterations. Impaired response to the FST was observed in predisposed rats with AKI.
TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Xinru Guo, Wanling Wang, Yangyang Ma, Yanjun Liang, Yena Zhou, Guangyan Cai
Summary: This study examined the impact of 24-h urinary calcium excretion (UCaE) on renal function decline in hospitalized patients, including those with chronic kidney disease (CKD) and those without CKD. The results showed that increasing UCaE was associated with a decreased risk of renal function decline in both CKD and non-CKD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Justin J. Lee, Jawad Alzamil, Saba Rehman, Wanling Pan, Henrik Dimke, R. Todd Alexander
Summary: Activation of the basolateral calcium sensing receptor (CaSR) increases claudin-14 expression in the renal tubular thick ascending limb (TAL), leading to reduced paracellular calcium permeability and increased urinary Ca2+ excretion. This process involves signaling through PLC-stimulated p38 pathway and inhibition of Sp1-mediated repression.
Review
Surgery
Mariusz Kowalewski, Michal Pasierski, Maged Makhoul, Maria Comanici, Emil Julian Dabrowski, Matteo Matteucci, Radoslaw Litwinowicz, Adam Kowalowka, Wojciech Wanha, Federica Jiritano, Dario Fina, Gennaro Martucci, Giuseppe Maria Raffa, Pietro Giorgio Malvindi, Lukasz Kuzma, Piotr Suwalski, Roberto Lorusso, Paolo Meani, Harold Lazar, Thoracic Res Ctr
Summary: The study found that topical application of vancomycin can significantly reduce the risk of sternal wound infection after cardiac surgery, especially for patients with diabetes. Topical vancomycin does not lead to vancomycin or methicillin resistance, and can even reduce the risk of gram-negative bacterial infection.
Article
Materials Science, Multidisciplinary
Harshulika Singh, Amit Ahlawat, Tarun Kumar Dhiman, Pratima R. Solanki
Summary: Antibiotics have contributed to increasing life expectancy in underdeveloped countries by reducing mortality rate, but the pollution caused by antibiotics is harmful to people. The study focused on the photocatalytic degradation of gentamicin using Titanium oxide nanoparticles (TiO2nps) under visible and UV light. TiO2nps were synthesized and characterized, and the photocatalytic degradation efficiency was evaluated. The results showed significant degradation of gentamicin under both visible light and UV light, with a degradation percentage of 84% and 95%, respectively.
Article
Microbiology
Yanping Xu, Olivia Milburn, Traci Beiersdorfer, Lizhong Du, Henry Akinbi, David B. Haslam
Summary: This study found that early brief exposure to antibiotics significantly disrupts the developmental trajectory of the neonatal microbiome, leading to a corresponding impairment in its metabolic functional capacity. Infants not exposed to antibiotics had higher abundance of butyrate-producing genera and increased metabolic pathways for short-chain fatty acid synthesis at 3 weeks postnatally.
Article
Endocrinology & Metabolism
Suyan Duan, Lianqin Sun, Huanhuan Zhu, Guangyan Nie, Chengning Zhang, Zhimin Huang, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: In patients with T2DM, higher urinary calcium and phosphorus excretion were associated with a decreased risk of CKD progression, especially in patients with non-diabetic kidney disease (NDKD). This study suggests a potential protective effect of urinary calcium and phosphorus excretion on CKD progression in T2DM patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Hiie Soeorg, Helgi Padari, Karin Kipper, Mari-Liis Ilmoja, Irja Lutsar, Tuuli Metsvaht
Summary: The study aimed to describe the pharmacokinetics and nephrotoxic potential of gentamicin components in neonates. The results showed that once-daily dosing of 4 mg/kg/day resulted in low nephrotoxicity in neonates, with increasing nephrotoxicity observed for total gentamicin, C1, C1a, and C2/C2a/C2b.
Article
Immunology
Walaa Yehia Abdelzaher, Nashwa Fathy Gamal El-Tahawy, Abdel Hamid Sayed AboBakr Ali, Hatem A. Mohamed, Nermeen N. Welson, Dina A. Aly Labib
Summary: The current study aimed to investigate the protective effects of rivastigmine in gentamicin-induced acute kidney injury. The results demonstrated that rivastigmine could ameliorate renal dysfunction by reducing oxidative stress, inflammation, and apoptotic reactions induced by gentamicin, and by decreasing the concentration of gentamicin in renal tissue.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Physiology
Leticia Maria Monteiro, Celine Farias Barbosa, Debora Conte Kimura Lichtenecker, Rogerio Argeri, Guiomar Nascimento Gomes
Summary: After weaning, excessive consumption of fructose-rich processed foods can lead to renal changes in rats, with males being more affected. Fructose intake affected blood pressure, body weight, and triglyceride levels in all rats. Glomerular filtration rate was significantly reduced in males receiving fructose, and sodium and potassium excretion decreased in all fructose-treated rats, with females excreting more of these ions. Calcium excretion was higher in the female control group, and fructose overload increased magnesium excretion, macrophage infiltration, and reduced eNOS expression in both males and females.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Dong, Yanhui Liu, Longxuan Li, Yunhe Ding, Jun Qian, Zheng Jiao
Summary: This study evaluated the role of renal drug transporters in the excretion of meropenem and potential drug interactions. The results showed that the interactions between meropenem and five tested antibiotics are low.
CURRENT DRUG METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova
Summary: Infections pose significant risks for elderly patients, with high consumption of antimicrobial agents leading to increased toxicity, organ deterioration, longer hospital stays, ICU admissions, disability, and even death. The efficacy and safety of antibiotics in the elderly are influenced by age-related changes in physiological and pathological factors, affecting drug absorption, distribution, metabolism, and excretion. Pharmacokinetic changes in elderly patients are also influenced by factors like body composition, nutritional status, and concomitant drug use. Understanding these age-related pharmacokinetic alterations is crucial for optimizing antibiotic therapy in the elderly.
Article
Medicine, General & Internal
Joy Ito, Hector Lemus, Tianying Wu
Summary: The liver plays a crucial role in maintaining acid-base balance, but limited epidemiological studies have investigated how it contributes to this balance using non-invasive biomarkers. This study examined the associations between serum biomarkers related to acid-base balance and renal function with liver CYP1A2 activity. The findings suggest that serum bicarbonate, serum phosphorus, and estimated glomerular filtration rate (eGFR) have dynamic associations with CYP1A2 activity, which depend on the extent of liver damage and the specific caffeine metabolite used to assess CYP1A2 activity.
Review
Pediatrics
Adhisivam Bethou, Ballambattu Vishnu Bhat
Summary: Sepsis is a major cause of mortality and morbidity among neonates globally, particularly affecting preterm neonates in resource-limited settings. Infections can be acquired in various ways, and factors such as time of exposure, inoculum size, host immunity, and virulence of the infectious agent impact the severity and progression of the disease. Ongoing efforts to reduce the burden of neonatal sepsis include culture-independent diagnostics, sepsis prediction scores, antibiotic stewardship, and preventive strategies like hand hygiene.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Letter
Pediatrics
Arpitha Chiruvolu
Article
Education, Scientific Disciplines
Anisha Ganguly, Christopher Faulkner, Dorothy Sendelbach
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Alexis Medders, Yahya Daoud
Summary: The study found that UCM in term infants delivered by CS did not increase the incidence of phototherapy or symptomatic polycythemia. The short-term effects of UCM on infants were similar to immediate cord clamping.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Nursing
Karen Stanzo, Sujata Desai, Arpitha Chiruvolu
JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
(2020)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Lea H. Mallett, Vinayak P. Govande, Venkata N. Raju, Kendall Hammonds, Anup C. Katheria
Summary: Since 2012, multiple institutions in the US have adopted the practice of delayed cord clamping (DCC) and/or umbilical cord milking (UCM) in preterm and term infants. However, there are variations in practices regarding timing, method, and higher-risk deliveries. Further research is needed to optimize the procedure and impact of DCC.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Reshma George, Karen C. Stanzo, Cassandra M. Kindla, Sujata Desai
Summary: This study examined the short-term effects of placental transfusion on late preterm infants and found that it was not associated with increased incidence of hyperbilirubinemia needing phototherapy, symptomatic polycythemia, NICU admissions, or readmissions to the hospital for phototherapy. The DCC/UCM group showed higher mean hematocrit after birth and fewer infants with hematocrit <40% compared to the ICC group. Fewer infants in the DCC/UCM group were admitted to the NICU primarily for respiratory distress.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Kevin M. Claunch, Alberto J. Garcia, Barbara Petrey, Kendall Hammonds, Lea H. Mallett
Summary: The study revealed that in treating transient tachypnea of the newborn, using CPAP compared to NC resulted in significantly lower maximum FiO(2) levels in the CPAP group, with a 32% reduction in hours on oxygen.
JOURNAL OF PERINATOLOGY
(2021)
Article
Nursing
Karen Stanzo, Vivek Kumar, Arpitha Chiruvolu, Daisha J. Cipher
Summary: This study compared the glucose concentrations in different sections and among tubes of two commercially available oral glucose gels commonly used to treat neonatal hypoglycemia. The results showed that the distribution of glucose within these gels was uneven, which may account for the inconsistent efficacy of oral glucose gel as a treatment for neonatal hypoglycemia.
JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
(2022)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Emily Estes, Karen C. Stanzo, Sujata Desai, Brandon C. Cornelius
Summary: This study aimed to evaluate the effects of delayed cord clamping (DCC) on postpartum hemorrhage (PPH) and change in hematocrit in mothers. The results showed that in preterm and term cesarean deliveries, DCC or umbilical cord milking (UCM) was not associated with an increased risk of PPH or significant change in maternal hematocrit.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Abigail Bourland, Kirtan Patel, Sujata Desai
JOURNAL OF PERINATOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Karen Stanzo, Vivek Kumar, Alice Gallegos, Arpitha Chiruvolu
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Heather Hendrikson, Rachael Hanson, Amy Reedy, Jordan Reis, Sujata Desai, Mustafa Suterwala
Summary: The objective of this study was to evaluate the effects of prophylactic supplementation of a specific probiotic product on infants born very preterm or very low birth weight. The results showed that the incidence of necrotizing enterocolitis (NEC) decreased from 6.3% to 1.6%. After adjusting for multiple variables, there were no significant differences in primary or other outcomes of interest. No adverse effects related to probiotics supplementation were observed.
JOURNAL OF PERINATOLOGY
(2023)
Article
Critical Care Medicine
Arpitha Chiruvolu, Samantha Fine, Kimberly K. Miklis, Sujata Desai
Summary: The study aimed to evaluate the importance of additional independent ante- and intrapartum risk factors in determining the need for resuscitation in newborns born through meconium-stained amniotic fluid (MSAF). The results showed that primigravida, thick meconium, fetal distress, chorioamnionitis, rupture of membranes >= 18 hours, post-term (gestational age >= 42 weeks), cesarean section, or shoulder dystocia significantly increased the odds of a meconium-stained newborn needing resuscitation. Fetal distress, chorioamnionitis, or cesarean section further increased the odds of needing advanced resuscitation.
Article
Pediatrics
Arpitha Chiruvolu, Barbara Petrey, Karen C. Stanzo, Yahya Daoud
PEDIATRIC QUALITY & SAFETY
(2019)
Article
Obstetrics & Gynecology
Arpitha Chiruvolu, Huanying Qin, Elizabeth T. Nguyen, Robert W. Inzer
AMERICAN JOURNAL OF PERINATOLOGY
(2018)