Article
Immunology
Diederik L. H. Koelman, Merel N. van Kassel, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek, Arie van der Ende
Summary: The epidemiology of acute bacterial meningitis has significantly changed in the Netherlands since the introduction of conjugate vaccines, with a substantial decrease in overall incidence. Conjugate vaccines effectively reduced the burden of bacterial meningitis, especially in children, with a focus needed on neonates and elderly populations to further prevent the disease.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Joseph Walker, Heidi M. Soeters, Ryan Novak, Alpha Oumar Diallo, Jeni Vuong, Brice Wilfried Bicaba, Isaie Medah, Issaka Yameogo, Rasmata Ouedraogo-Traore, Kadidja Gamougame, Daugla Doumagoum Moto, Assetou Y. Dembele, Ibrehima Guindo, Souleymane Coulibaly, Djibo Issifou, Maman Zaneidou, Hamadi Assane, Christelle Nikiema, Adodo Sadji, Katya Fernandez, Jason M. Mwenda, Andre Bita, Clement Lingani, Haoua Tall, Felix Tarbangdo, Guetwende Sawadogo, Marietou F. Paye, Xin Wang, Lucy A. McNamara
Summary: With the widespread introduction of an effective serogroup A meningococcal conjugate vaccine, the burden of invasive Neisseria meningitidis serogroup A disease in Africa's meningitis belt has been nearly eliminated, but other bacterial meningitis pathogens still pose a significant public health challenge in the region. This study used case-based surveillance data from 5 countries in the meningitis belt to evaluate the accuracy of laboratory testing strategies in estimating the distribution of causative pathogens, providing insights that can guide testing thresholds for laboratory surveillance programs in the region.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Tomoka Nakamura, Adam L. Cohen, Stephanie Schwartz, Jason M. Mwenda, Goitom Weldegebriel, Joseph N. M. Biey, Reggis Katsande, Amany Ghoniem, Kamal Fahmy, Hossam Abdel Rahman, Dovile Videbaek, Danni Daniels, Simarjit Singh, Annemarie Wasley, Gloria Rey-Benito, Lucia de Oliveira, Claudia Ortiz, Emmanuel Tondo, Jayantha B. L. Liyanage, Mohammad Sharifuzzaman, Varja Grabovac, Nyambat Batmunkh, Josephine Logronio, James Heffelfinger, Kimberly Fox, Linda De Gouveia, Anne von Gottberg, Mignon Du Plessis, Brenda Kwambana-Adams, Martin Antonio, Samaa El Gohary, Aya Azmy, Asmaa Gamal, Elena Voropaeva, Ekaterina Egorova, Yulia Urban, Carolina Duarte, Balaji Veeraraghavan, Samir Saha, Ben Howden, Michelle Sait, Sangoun Jung, Songmee Bae, David Litt, Shila Seaton, Mary Slack, Sebastien Antoni, Mahamoudou Ouattara, Chris Van Beneden, Fatima Serhan
Summary: The global surveillance network for invasive bacterial vaccine-preventable diseases supports countries in detecting pediatric meningitis, with Streptococcus pneumoniae being the most common pathogen. As more countries implement pneumococcal conjugate vaccines, there is a decrease in the proportion of pneumococcal meningitis infections caused by vaccine serotypes.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Hieu Cong Truong, Thanh Van Phan, Hung Thanh Nguyen, Khanh Huu Truong, Viet Chau Do, Nguyet Nguyen My Pham, Thang Vinh Ho, Tram Thi Quynh Phan, Thang Anh Hoang, Antoine Soetewey, Thuy Nguyen Loc Ho, Quang Duy Pham, Quang Chan Luong, Dai Thi Trang Vo, Thuong Vu Nguyen, Niko Speybroeck
Summary: This retrospective study examined the epidemiology, causative pathogens trend, and serotypes distribution of pneumococcal meningitis in children under 5 years of age in Southern Vietnam. Streptococcus pneumoniae was found to be the most common pathogen causing bacterial meningitis in this population, and policymakers may need to consider introducing pneumococcal vaccines into the immunization program to effectively prevent and control this disease.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Ying Luo, Ying Xue, Qun Lin, Liyan Mao, Guoxing Tang, Huijuan Song, Wei Liu, Shiji Wu, Weiyong Liu, Yu Zhou, Lingqing Xu, Zhigang Xiong, Ting Wang, Xu Yuan, Yong Gan, Ziyong Sun, Feng Wang
Summary: The study established a diagnostic model based on a combination of CSF chlorine, CSF nucleated cell count, CSF lymphocyte proportion, and the tuberculosis-specific antigen/phytohemagglutinin (TBAg/PHA) ratio, which showed excellent utility in discriminating between TBM and BM, with high sensitivity and specificity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Infectious Diseases
Rami H. Jaber, Nathan P. Beahm
Summary: This review evaluated the clinical evidence for the use of daptomycin in acute bacterial meningitis in both pediatric and adult patients. The results suggest that daptomycin could be a safe and effective alternative for the treatment of meningitis caused by Gram-positive bacteria. However, further research is needed to establish the optimal dosing regimen, duration of therapy, and place in therapy for the management of meningitis.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, General & Internal
Virginia Pomar, Natividad Benito, Pol Duch, Marc Colome, Alba Rivera, Pere Domingo
Summary: A long-term observational study of adult BM patients in Barcelona has found that in recent years, patients without underlying conditions who develop BM are older and more likely to have pneumococcal or listerial infections and systemic complications, although the in-hospital mortality has decreased compared to the first period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Milagritos D. Tapia, Samba O. Sow, Abdi Naficy, Fatoumata Diallo, Fadima C. Haidara, Amol Chaudhari, Lionel Martellet, Awa Traore, Kelly Townsend-Payne, Ray Borrow, Nancy Hosken, Igor Smolenov, Sambhaji S. Pisal, F. Marc LaForce, Rajeev M. Dhere, Dhananjay Kapse, Yuxiao Tang, Mark R. Alderson, Prasad S. Kulkarni
Summary: This study in Mali investigated the efficacy of a new pentavalent meningococcal vaccine including serogroup X, showing higher antibody titers compared to the standard quadrivalent vaccine.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Yuvaraj Jayaraman, Balaji Veeraraghavan, C. P. Girish Kumar, Bharathy Sukumar, Prabu Rajkumar, Boopathi Kangusamy, Valsan Philip Verghese, Rosemol Varghese, Ranjith Jayaraman, Ambujam Nair Kapoor, Nivedita Gupta, K. Kanagasabai, Joseph K. David, Jayasri Rajaraman, Gowtham Sockalingam, Ajay Khera, Pradeep Haldar, M. K. Aggarwal, Rajamohanan K. Pillai, Vikas Manchanda, Ramani Bai Joseph Theodore, Jyothi Rajahamsan, Girija Mohan, V. Jayalekshmi, Krishnamoorthy Nedunchelian, N. Devasena, Sujatha Sridharan, R. Selvi, T. Ravinder, R. Narayana Babu, G. Mathevan, C. Sugumari, P. Sugandhi Rao, Pushpa G. Kini, Bhagirathi Dwibedi, Anil Kanga, Neelam Grover, Harish Narayanan, Sanjay M. Mehendale
Summary: A hospital-based sentinel surveillance network for bacterial meningitis in India found Streptococcus pneumoniae as the most common pathogen, with high fatality rates for Haemophilus influenzae meningitis. PCV13 covered a significant portion of pneumococcal infections, with major serotypes being 14, 6B, and 19F. Unsurprisingly, non-susceptibility to penicillin and multidrug resistance were observed, highlighting the importance of timely PCV expansion to reduce antimicrobial resistance burden in India. Continued surveillance post-PCV expansion is crucial for understanding the trend.
Review
Clinical Neurology
Tatiana Barichello, Carlos Henrique Rocha Catalao, Ursula K. Rohlwink, Martijn van der Kuip, Dan Zaharie, Regan S. Solomons, Ronald van Toorn, Marceline Tutu van Furth, Rodrigo Hasbun, Federico Iovino, Vivian Ssonko Namale
Summary: Bacterial meningitis varies globally in terms of incidence, case fatality rates, and etiological agents. Africa has the highest prevalence of bacterial meningitis, particularly in the meningitis belt of sub-Saharan Africa. Streptococcus pneumoniae and Neisseria meningitidis are the main pathogens in adults and children over one year old, while Streptococcus agalactiae, Escherichia coli, and Staphylococcus aureus are common in neonatal meningitis.
FRONTIERS IN NEUROLOGY
(2023)
Review
Microbiology
Nicoline Schiess, Nora E. Groce, Tarun Dua
Summary: Neurological sequelae following meningitis can have devastating effects on patients, families, and communities, with high mortality rates and survivors often experiencing various neurological disabilities. Limited research exists on the long-term consequences, age-related outcomes, and socioeconomic impact of this condition, especially in low- and middle-income countries. Addressing these gaps is crucial for understanding and mitigating the burden of bacterial meningitis-related disabilities.
Article
Biochemistry & Molecular Biology
Y. Kalchev, P. Argirova, I. Boev, A. Yaneva, N. Vatev, M. Stoycheva, M. Murdjeva
Summary: The levels of interleukin (IL)-6, IL-8, IL-10, IL-12(p40), and tumor necrosis factor (TNF)-α are correlated with disease severity, complications, and outcome in patients with acute bacterial meningitis. The levels of IL-6, IL-8, IL-10, and TNF-α in cerebrospinal fluid (CSF) are significantly higher than in serum. Elevated serum IL-8 levels may indicate increased risk of neurological complications, severe clinical course, and fatal outcome.
Article
Infectious Diseases
Fereshte Sheybani, Ana Helena A. Figueiredo, Matthijs C. Brouwer, Diederik van de Beek
Summary: Concomitant vertebral osteomyelitis is rare in community-acquired bacterial meningitis patients, with back pain being a key diagnostic clue prompting MRI for treatment decision-making.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Philip H. C. Kremer, Bart Ferwerda, Hester J. Bootsma, Nienke Y. Rots, Alienke J. Wijmenga-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzcinski, Anne L. Wyllie, Paul Turner, Arie van der Ende, Matthijs C. Brouwer, Stephen D. Bentley, Diederik van de Beek, John A. Lees
Summary: This study identified genetic variations in pneumococcal carriage that differ between infants and adults. Serotypes and genetic background were found to explain a proportion of the heritability in carriage. The findings support the proposal for adaptive vaccination strategies targeting dominant circulating serotypes and tailored to the composition of the pathogen populations.
Review
Clinical Neurology
Emma C. Wall, Jia Mun Chan, Eliza Gil, Robert S. Heyderman
Summary: Community-acquired bacterial meningitis is a dynamic disease with evolving epidemiology and pathogenesis data. Early antibiotic administration is crucial for improving survival, while unnecessary cranial imaging causes diagnostic delays. New treatments such as C5 inhibitors and daptomycin are currently in clinical trials.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Infectious Diseases
Serdar Pekuz, Ahmet Soysal, Gulsen Akkoc, Serkan Atici, Nurhayat Yakut, Gulsen Altinkanat Gelmez, Eda Kepenekli Kadayifci, Deniz Guneser, Sevliya Ocal Demir, Guner Soyletir, Mustafa Bakir
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Pinar Sagiroglu, Ayse Nedret Koc, Mustafa Altay Atalay, Gulsen Altinkanat Gelmez, Ozlem Canoz, Fatma Mutlu Sanguzel
INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Berna Karaismailoglu, Nese Saltoglu, Ilker Inanc Balkan, Bilgul Mete, Fehmi Tabak, Recep Ozturk
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2019)
Article
Public, Environmental & Occupational Health
Hayat Kumbasar Karaosmanoglu, Bilgul Mete, Alper Gunduz, Ozlem Altuntas Aydin, Fatma Sargin, Dilek Yildiz Sevgi, Bulent Durdu, Ilyas Dokmetas, Fehmi Tabak
CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
(2019)
Article
Immunology
Bilgul Mete, Alper Gunduz, Sibel Bolukcu, Hayat K. Karaosmanoglu, Dilek Yildiz, Meliha M. Koc, Ozlem A. Aydin, Ilyas Dokmetas, Fehmi Tabak
INTERNATIONAL JOURNAL OF STD & AIDS
(2019)
Article
Oncology
Serife Satilmis, Ufuk Hasdemir, Burak Aksu, Gulsen Altinkanat Gelmez, Guner Soyletir
JOURNAL OF CHEMOTHERAPY
(2020)
Article
Oncology
Buket Erturk Sengel, Gulsen Altinkanat Gelmez, Guner Soyletir, Volkan Korten
JOURNAL OF CHEMOTHERAPY
(2020)
Article
Infectious Diseases
Anna Akerlund, Emma Jonasson, Erika Matuschek, Lena Serrander, Martin Sundqvist, Gunnar Kahlmeter
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Immunology
Arzu Aksit Ilki, Sevim Ozsoy, Gulsen Gelmez, Burak Aksu, Guner Soyletir
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2020)
Article
Infectious Diseases
Gulsen Altinkanat Gelmez, Baris Can, Ufuk Hasdemir, Guner Soyletir
Summary: The study evaluated different methods for detecting carbapenemases, with mCIM-A showing better performance for OXA-48-like and NDM enzymes. The mCIM-A method is a simple and useful tool for identifying CPEs in clinical microbiology laboratories.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Immunology
Nurver Ulger Toprak, Oncu Akgul, Huseyin Bilgin, Ayse Nilufer Ozaydin, Gulsen Altinkanat Gelmez, Elvan Sayin, Uluhan Sili, Volkan Korten, Guner Soyletir
Summary: The study aimed to determine the frequency and associated factors for intestinal colonization by carbapenem-non-susceptible BFG among adult patients hospitalized at intensive care units, neurosurgery and internal medicine wards. The results showed that factors such as hospital admission, history of antibiotic use (including carbapenems), colonization with other accompanying carbapenem-resistant Gram negative bacteria, and surgical operations were significantly associated with RCS-BFG colonization.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Huseyin Bilgin, Gulsen Altinkanat Gelmez, Fatma Bayrakdar, Elvan Sayin, Fethi Gul, Nazli Pazar, Gulcan Culha, Serap Suzuk Yildiz, Ismail Cinel, Volkan Korten
Summary: The described outbreak of nosocomial infection caused by Burkholderia cepacia among six patients in Istanbul, Turkey, highlighted the genetic relatedness between environmental and patient samples, with contamination of medical solutions identified as a potential cause of outbreak.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Medicine, General & Internal
Gulsen Altinkanat Gelmez, Baris Can, Buket Erturk Sengel, Volkan Korten, Guner Soyletir
Summary: The study investigated the fosfomycin susceptibility of carbapenemase-producing K. pneumoniae strains isolated before the clinical use of intravenous fosfomycin formulation in Turkey, showing that at least two-thirds of carbapenemase-positive K. pneumoniae are susceptible to fosfomycin.
MARMARA MEDICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Gulsen Altinkanat Gelmez, Baris Can, Ufuk Hasdemir, Guner Soyletir
JOURNAL OF MICROBIOLOGICAL METHODS
(2020)
Article
Infectious Diseases
Sibel Bolukcu, Bilgul Mete, Alper Gunduz, Hayat Kumbasar Karaosmanoglu, Fatma Sargin, Bulent Durdu, Ozlem Altuntas Aydin, Dilek Yildiz, Ilyas Dokmetas, Turan Asian, Fehmi Tabak
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2019)
